“長江學者獎勵計畫”特聘教授,博導 ,國家傑出青年科學基金獲得者,新世紀百千萬人才工程國家級人選。
基本介紹
- 中文名:張健
- 外文名:zhangjian
- 屬於:“長江學者獎勵計畫”特聘教授
- 出生時間:1963年
- 出生地:湖南長沙縣
人物簡介
主要成果
(1)首次從牛的組織和人的HepG2細胞中分別克隆了DNA聚合酶催化亞基及小亞基,並用計算機軟體對DNA及蛋白質序列進行了分析。(2)通過轉錄因子AP-2a基因的敲除及敲除AP-2a基因後老鼠的表型的分析,發現該基因是哺乳動物顱面部發育的基本調控因子,並為眼球晶狀體小泡的早期形態發生所必需。此結果發表在世界著名學術雜誌《Nature》上,被國際同行引用達220次。(3)用轉基因小鼠模型觀察到AP-2a在乳腺中的大量表達能抑制乳腺的發育,並發現AP-2基因家族(AP-2a、β、γ)的相互作用可能在乳腺癌變過程中起重要作用。(4)發現並克隆了PDIP1基因家族的三個基因,並發現該基因家族具有抗細胞調亡和促進肝切除術後肝臟修復的作用。1991年至今,張健在國外著名學術雜誌上發表論文10餘篇,均被SCI收錄,被國際同行引用次數達500餘次。
主要代表作
- Zhang,J.,Donaldson,S.,Serbedzjia,G.,Elsemore,J.,Plehn-Dujowich,D.,McMahon,A.,Flavell, R. A. and T.Williams (1996) Neural tube, skeletal and body-wall defects in mice lacking the transcription factor AP-2.Nature,381,238-241.
- J. Zhang, Y. Sun, Y. Liu, Y. Sun and D.J. Liao(2004) Synergistic effects of androgen and estrogen on the mouse uterus and mammary gland. Oncology Reports,12(4):709-716
- Zhang J, Brewer S, Huang J, Williams T.(2003)Overexpression of transcription factor AP-2 alpha suppresses mammary gland growth and morphogenesis. Developmental Biology, 256(1):128-146
- Zhang J., T. Williams,(2003)Identification and regulation of tissue-specific cis-acting elements associated with the human AP-2 gene. Developmental Dynamics,228(2): 194-207.
- Sanjay Anand, Wayne C. H. Wang, Dennis R. Powell, Stacey A. Bolanowski, Jian Zhang, Christina Ledje, Aruna B. Pawashe, Chris T. Amemiya, and Cooduvalli S. Shashikant. Divergence of Hoxc8 early enhancer parallels diverged axial morphologies between mammals and fishes, PNAS 2003 100: 15666-15669
- Zhang J.,Tan, C.-K., McMullen B., Downey, K.M. and A.G. So(1995)Cloning of the small subunits of bovine and human DNA polymerase delta and chromosomal location of the human gene. Genomics,29(1),179-186.
- Zhang, J., Chung, D., Tan, C.-K., Downay, K. M., Davie, E. W. and A. G. So (1991) Primary structure of the catalytic calf thymus DNA polymerase δ: sequence similarities with other DNA polymerase. Biochemistry 30, 11742-11750.
- West-Mays, J. A.,Zhang, J., Nottoli, T., Donaldson, S., Libby, D., Strissel, K.J. and T.Williams(1999)AP-2a transcription factor is required for early morphogenesis of the lens vesicle. Developmental Biology, 206,46-62.
- Turner, B.C., Zhang, J., Gumbs, A.A., Maher, M.G.,Kaplan, L.,Carter, D., Glazer, P.M.,Hurst, H.C.,Haffty, B.G. and T. Williams(1998)A high incidence of AP-2 gene expression in human breast cancer correlates with the regulation of multiple growth factor pathways. Cancer Research,58,5466-5472.
- Nottoli, T., Donaldson,S., Zhang, J., Perkins, A. and T. Williams (1998) AP-2-null cells disrupt morphogenesis of the eye, face, and limbs in chimeric mice. Proc.Natl.Acad.Sci.USA, 95,13714-13719.
- Chung, D., Zhang, J., Tan, C.-K., Davie, E. W., So, A. G. and K. M. Downey (1991) Primary structure of the catalytic subunit of human DNA polymerase δand chromosomal location of the gene. Proc.Natl.Acad.Sci.USA,88, 11197-11201.
- Tan, C.-K., Zhang, J., Li, Z.-Y., Tarpley, W. G., Downey, K. M. and A. G. So (1991) Functional characterization of RNA-dependent DNA polymerase and RNase H activitiesof a recombinant reverse transcriptase. Biochemistry ,30, 2651-2655 .