catabolite,英語單詞,主要用作名詞,作名詞時譯為“新陳代謝作用之副產物;[生化] 分解代謝物;副產物;分解產物”。
基本介紹
- 外文名:catabolite
- 詞性:名詞
- 英式發音:[kə'tæbəlaɪt]
- 美式發音:[kə'tæbə,laɪt]

catabolite,英語單詞,主要用作名詞,作名詞時譯為“新陳代謝作用之副產物;[生化] 分解代謝物;副產物;分解產物”。
分解代謝物抑制是微生物實現優先利用優選碳源的一種代謝調控方式。碳分解代謝物抑制(catabolite repression),或簡單地分解代謝物抑制,是各種細菌和其他微生物的全局調控系統的重要部分。 分解代謝物抑制通過抑制參與除優選碳源之外的碳源分解代謝的酶的合成,來實現對優選(可快速代謝的)碳碳源的優先利用。
分解代謝物抑制作用(catabolite repression)又稱代謝物阻遏作用,是葡萄糖或代謝物或葡萄糖的降解產物對一個基因或操縱子的阻遏作用。案例 例如當培養基中同時含有葡萄糖和乳糖時,由於細菌生長優先利用葡萄糖,lac操縱子的表達就會被葡萄糖抑制,這種現象稱為分解代謝物抑制。這種抑制作用是一種隨著細胞的生理狀態變化...
分解代謝物基因激活蛋白(catabolite gene activator protein,CAP),細菌中有一種能與cAMP特異結合的蛋白,在與cAMP結合後能夠發生空間構象變化而被活化,故稱cAMP激活蛋白(cAMP activated protein,CAP),CAP能以二聚體的方式與CAP結合位點(CAP binding site)結合,增強RNA聚合酶的轉錄活性,正性調控糖類利用酶類...
代謝物阻遏效應 代謝物阻遏效應(catabolite repression)是指:有葡萄糖存在時,不論誘導物存在與否,操縱子都沒有活性,結構基因都不表達。代謝物阻遏效應
分解代謝物阻遏蛋白 分解代謝物阻遏蛋白(catabolite repression protein)是2012年公布的微生物學名詞。定義 在分解代謝產物阻遏某些操縱子的基因表達時該代謝產物所結合的起調控作用的蛋白質。出處 《微生物學名詞》第二版。
分解代謝物控制蛋白 分解代謝物控制蛋白(catabolite control protein)是2012年公布的微生物學名詞。定義 革蘭氏陽性菌中介導碳代謝物抑制過程的蛋白質。出處 《微生物學名詞》第二版。
後來觀察到酶合成的抑制不僅限於葡萄糖,而在葡糖醛酸、甘油中也存在;受合成抑制的酶一般其反應生成物(如色氨酸酶時是丙酮酸)與葡萄糖等的分解產物相一致,所以由此認為這些酶的合成阻遏(repression),使分解產物(catabolite)不過剩產生,就是由於調節作用。從這一情況來看,馬格桑尼克(B.Magasanik)提議用...
catabolite gene activator protein;CAP 結合在操縱子上啟動子區域的蛋白質。它和cAMP結合於靠近RNA聚合酶結合位點。CAP和啟動子的反應有利於RNA聚合酶—啟動子複合物的形成。該複合物起正調控作用,使轉錄得以進行。添加葡萄糖會降低cAMP水平,並使CAP不表現活性,從而降低轉錄水平。
cAMP-CRP複合物是一種化學物質。cAMP-CRP複合物是激活lac操縱子的重要組成部分,其結合在lac操縱子的啟動子區域上;大腸桿菌中的代謝物激活蛋白(cataboliteactivatorprotein,CAP),能結合cAMP,又被稱為環腺苷酸受體蛋白(CAMPreceptorprotein,CRP),由Crp基因編碼。CRP和cAMP都是合成lacmRNA所必需的,凡Crp及腺苷酸...
它通過識別並結合至靶基因的特定位點執行其轉錄調控功能,進而形成複雜的調控網路,這類結合位點被稱為cre(catabolite response elements)序列。目前已發現的被CcpA識別的cre通常是14-16個核苷酸的反向迴文序列,其基序在長度和核苷酸組成上均比較相近。課題組前期以革蘭氏陽性菌—丙酮丁醇梭菌為研究對象,通過比較轉錄譜...
(12)Zhan, Y., H. Yu, Y. Yan, S. Ping, W. Lu, W. Zhang, M. Chen, and M. Lin. 2009. Benzoate catabolite repression of the phenol degradation in Acinetobacter calcoaceticus PHEA-2. Curr Microbiol 59:368-73 (13)Li, L., W. Lu, Y. Han, S. Ping, W. Zhang, M. Chen, Z. ...
本課題利用我們通過免疫蛋白質組學方法篩選的、對2型豬鏈球菌毒力及免疫應答具有調節作用的ccpA蛋白(catabolite control protein A,ccpA)進行分析,通過構建ccpA基因缺失菌株及互補菌株,套用蛋白質組學方法探索其對細胞壁相關蛋白的影響,並鑑定其對細胞黏附、溶血活性、糖代謝途徑及生化特性的影響,進而通過動物模型...
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Chen, Jinli,Nam, Ki Hyun,Xu, Yongbin,Shang, Fei,Wang, Lulu,Zou, Linhai,Bu, Tingting,Jin, Liming,Dong, Yuesheng,Ha, Nam-Chul,Quan, Chunshan.Structural and Biochemical Analysis of the Citrate-Responsive Mechanism of the Regulatory Domain of Catabolite Control Protein E from Staphylococcus aureus...
[3] Jiaofang Huang,Elisabeth Sonnleitner, Bin Ren, Yuquan Xu, and Dieter Haas*. Catabolite Repression Control of Pyocyanin Biosynthesis at an Intersection of Primary and Secondary Metabolism inPseudomonas aeruginosa.Applied and Environmental Microbiology.[4] Jiaofang Huang,Yuquan Xu*, Hongyan Zhang, ...
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