美國Baylor College of Medicine細胞生物系訪問教授：真核基因轉錄調控機制研究
研究方向
真核基因轉錄及其表觀遺傳調控。
科研任務
國家自然基金重大研究計畫（90408007）課題負責人；
科技部中匈政府間科技合作項目（MT1:01）項目負責人
教學任務
《真核基因表達調控》
代表性論著
1． Zhang Y, Wang JS, Chen LL, Zhang Y, Cheng XK, Heng FY, Wu NH, Shen YF. Repression of hsp90 beta gene by p53 in UV Irradiation-induced Apoptosis of Jurkat Cells. J Biol Chem 2004 279 (41): 42545-42551.
2． Jian-Min Wu, Lei Xiao, Xiao Kuan Cheng, Lian-Xian Cui, Ning-Hua Wu & Yu-Fei Shen. PKC epsilone is a unique regulator for hsp90β gene in heat shock response. J Biol. Chem. 278(51):51143-51149, 2003
3． Bing-Sheng Liu, Ning Wang, Xiao-Kuan Cheng, Ning-Hua Wu & Yu-Fei Shen Differential hypersensitivity to DNase I in the regulatory region of human hsp90 beta gene in heat shock and constitutive expression. Int’l J. Biochem. Cell Biol. 35(3): 310-315，2003
4． Sreedhar AS, Kalmar E, Csermely P and Shen Y-F. Hsp90 isoforms: functions, expression and clinical importance (Minireview). FEBS Lett. 2004
5． Zhang, SL, Yu, J, Cheng, XK, Ding L, Heng, FY, Wu, NH and Shen, YF. Regulation of human hsp90 alpha gene expression. FEBS Lett. (1999) 444, 130-135.
6． Yu-fei Shen, Ju-hong Liu, Xiao-zhe Wang, Xiao-kuan Cheng, Yan-lin Wang, Ning-hua Wu. Essential role of the first intron in the transcription of hsp90 beta gene. FEBS Letters (1997) 413: 92-98.
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