徐聰聰(蘇州大學國際創新藥學院特聘教授)

徐聰聰，博士，蘇州大學國際創新藥學院特聘教授。上海市白玉蘭計畫浦江人才。湖南大學化學學士學位，俄亥俄州立大學藥學院獲藥劑科學博士學位，導師郭培宣教授，2020-2023年於mRNA頭部企業擔任mRNA平台研發負責人，2023年受聘為蘇州大學國際創新藥學院青年特聘教授。以共同作者在Nature, ACS Nano, Molecular Therapy等國際期刊發表論文，主要研究方向為新型RNA疫苗和藥物。

基本介紹

• 中文名：徐聰聰
• 畢業院校：湖南大學、俄亥俄州立大學
• 教學職稱：特聘教授

研究方向

基於RNA平台技術的新型疫苗和創新藥物的發現及工程化改造研究：

• 新型RNA平台包括自複製型mRNA以及環狀RNA的開發及設計
• mRNA腫瘤疫苗和傳染病疫苗的開發和機制探究
• 人工智慧算法指導的mRNA序列最佳化及設計
• 核酸疫苗及藥物的遞送系統開發和探索

代表性論文

1. Xu, C., Zhang, L., Wang, W., Tang, Y., Wang, Q., An, J., ... & Li, H. (2023). Improving the Circularization Efficiency, Stability and Translatability of Circular RNA by circDesign. bioRxiv, 2023-07.

2. Zhang, H. †, Zhang, L. †, Lin, A. †, Xu, C. † (co-first author), Li, Z., Liu, K., ... & Huang, L. (2023). Algorithm for optimized mRNA design improves stability and immunogenicity. Nature, 1-3.

3. Fang, Y., Li, J.X., Duangdany, D., Li, Y., Guo, X.L., Phamisith, C., Yu, B., Shen, M.Y., Luo, B., Wang, Y.Z., Liu, S.J., Zhao, F.F., Xu, C., Qiu, X.H., Yan, R., Gui, Y.Z., and Mayxay, Mayfong. et al 2024. Safety, immunogenicity, and efficacy of a modified COVID-19 mRNA vaccine, SW-BIC-213, in healthy people aged 18 years and above: a phase 3 double-blinded, randomized, parallel controlled clinical trial in Lao PDR (Laos). eClinicalMedicine, 67.

4. Carcache PJ, Guo S, Li H, Zhang K, Xu C, Chiu W, Guo P. Regulation of reversible conformational change, size switching, and immunomodulation of RNA nanocubes. RNA. 2021 Sep 1;27(9):971-80.

5. Guo S., Xu C., Yin H., Hill J., Pi F., Guo P. (2019). Tuning the size, shape and structure of RNA nanoparticles for favorable cancer targeting and immunostimulation. WIREs Nanomedicine and Nanobiotechnology, 2019 Aug 27:e1582. doi: 10.1002/wnan.1582

6. Xu, C., Zhang, K., Yin, H., Li, Z., Krasnoslobodtsev, A., Zheng, Z., Ji, Z., Guo, S., Li, S., Chiu, W. and Guo, P., 2020. 3D RNA nanocage for encapsulation and shielding of hydrophobic biomolecules to improve the in vivo biodistribution. Nano Research, 13(12), pp.3241-3247.

7. Ghimire C, Wang H, Li H, Vieweger M, Xu C, Guo P. RNA nanoparticles as rubber for compelling vessel extravasation to enhance tumor targeting and for fast renal excretion to reduce toxicity. ACS Nano. 2020 Sep 9;14(10):13180-91.

8. Zheng Z, Li Z, Xu C, Guo B, Guo P. Folate-displaying exosome mediated cytosolic delivery of siRNA avoiding endosome trapping. J Control Release. 2019 Aug 22;. doi: 10.1016/j.jconrel.2019.08.021.

9. Yin H, Xiong G, Guo S, Xu C, Xu R, Guo P, Shu D. Delivery of Anti-miRNA for Triple-Negative Breast Cancer Therapy Using RNA Nanoparticles Targeting Stem Cell Marker CD133. Mol Ther. 2019 Jul 3;27(7):1252-1261. doi: 10.1016/j.ymthe.2019.04.018.

10. Xu Y, Pang L, Wang H, Xu C, Shah H, Guo P, Shu D, Qian SY. Specific delivery of delta-5-desaturase siRNA via RNA nanoparticles supplemented with dihomo-γ-linolenic acid for colon cancer suppression. Redox Biol. 2019 Feb;21:101085. doi: 10.1016/j.redox.2018.101085.

11. Xu C, Li H, Zhang K, Binzel DW, Yin H, Chiu W, Guo P. Photo-controlled release of paclitaxel and model drugs from RNA pyramids. Nano Res. 2019 Jan;12(1):41-48. doi: 10.1007/s12274-018-2174-x.

12. Xu C, Haque F, Jasinski DL, Binzel DW, Shu D, Guo P. Favorable biodistribution, specific targeting and conditional endosomal escape of RNA nanoparticles in cancer therapy. Cancer Lett. 2018 Feb 1;414:57-70. doi: 10.1016/j.canlet.2017.09.043.

13. Haque F†, Xu C†, Jasinski DL, Li H, Guo P. († Contributed equally) Using Planar Phi29 pRNA Three-Way Junction to Control Size and Shape of RNA Nanoparticles for Biodistribution Profiling in Mice. Methods Mol Biol. 2017;1632:359-380. doi: 10.1007/978-1-4939-7138-1_23.

14. Guo S, Xu C, Yin H, Guo P, Hill J, and Pi F. 2022. Tuning the Size, Shape, and Structure of RNA Nanoparticles for Favorable Cancer Targeting and Immunostimulation. RNA Nanotechnology and Therapeutics, pp.543-562.