kit ligand

幹細胞因子（SCF），也稱為KIT配體或鋼因子[1]，是一種結合CD117（c-KIT）的細胞因子。SCF也被稱為“鋼鐵因子”或“c-kit配體”。SCF以兩種形式存在，細胞表面結合的SCF和可溶性（或游離）的SCF。可溶性SCF是由金屬蛋白酶分解表面結合的SCF產生的。

Stem cell factor (SCF), otherwise known as KIT ligand or Steel factor[1],is a cytokine which binds CD117 (c-Kit). SCF is also known as "steel factor" or "c-kit ligand". SCF exists in two forms, cell surface bound SCF and soluble (or free) SCF. Soluble SCF is produced by the cleavage of surface bound SCF by metalloproteases.

SCF is a growth factor important for the survival, proliferation, and differentiation of hematopoietic stem cells and other hematopoietic progenitor cells. One of its roles is to change the BFU-E(burst-forming unit-erythroid) cells, which are the earliest erythrocyte precursors in the erythrocytic series, into the CFU-E (colony-forming unit-erythroid) . SCF, along with bFGF (basic fibroblast growth factor) and LIF (lymphocyte inhibitory factor), prevents spontaneous differentiation of primitive embryonic stem cell in cell culture[1].

Ancestim is a recombinant form of SCF.

幹細胞因子（SCF）,或者所知的KIT配體或Steel因子[1]，是一種綁定CD117（C-kit）的細胞因子。SCF存在兩種形式，細胞表面綁定的SCF和可溶性（或游離的）SCF。可溶性SCF通過金屬蛋白酶作用由表面綁定SCF分裂而成。

SCF對於造血幹細胞和其它造血祖細胞的生存、增生和分化是一種重要的生長因子。其中一個重要作用是使BFU-E（爆式紅細胞集落形成單元）細胞（在紅細胞系中是一種早期前驅紅細胞）向CFU-E（紅細胞集落形成單元）細胞轉變。SCF，伴隨bFGF（鹼性成纖維細胞生長因子）和LIF（淋巴細胞抑制因子），在細胞培養中阻止原始胚胎幹細胞的自發性分化。[1]

安塞司亭(ancestim)是SCF的重組形式。

References（摘自）

^ a b Freshney, Ian R. Culture of Animal Cells: A manual of basic technique. John Wiley & Sons, Inc., Hoboken, New Jersey. ISBN 13 978-0-471-45329-1

^ da Silva MG, Pimentel P, Carvalhais A, et al (2004). "Ancestim (recombinant human stem cell factor, SCF) in association with filgrastim does not enhance chemotherapy and/or growth factor-induced peripheral blood progenitor cell (PBPC) mobilization in patients with a prior insufficient PBPC collection". Bone Marrow Transplant. 34 (8): 683–91. doi:10.1038/sj.bmt.1704602. PMID 15322567