Olga Maria Ferreira Pontes

簡歷：

1997葡萄牙里斯本大學，自然科學學院本科

1998-1999葡萄牙里斯本理工大學研究助理

2000-2004美國華盛頓大學訪問學者

2005葡萄牙里斯本理工大學博士

2005-2008美國華盛頓大學生物系博士後

2008-2011美國華盛頓大學生物系研究助理教授/成像平台主任

2011-2014美國新墨西哥大學助理教授

2014.5至今中科院上海植物逆境生物學研究中心研究組長、研究員

研究方向：

核結構和表觀遺傳學

職稱：

研究員

職務：

研究組長、博士生導師

代表論著：

30. Pontvianne F, Blevins T, Chandrasekhara C, Mozgová I, Hassel C, Pontes OM, Tucker S, Mokros P, Muchová V, Fajkus J, Pikaard CS. (2013). Subnuclear partitioning of rRNA genes between the nucleolus and nucleoplasm reflects alternative epiallelic states. Genes Dev. 27(14):1545-50.

29. Pontes O*, Vitins A, Ream T, Hong E, Pikard CS, Costa-Nunes P. (2013). Intersection of Small RNA pathways in Arabidopsis thaliana sub-nuclear domains. Plos One 8(6):e65652. *Corresponding author.

28. Qian W, Miki D, Zhang H, Liu Y, Zhang X, Tang K, Kan Y, La H, Li X, Li S, Zhu X, Shi X, Zhang K, Pontes O, Chen X, Liu R, Gong Z, Zhu JK. (2012). A Histone Acetyltransferase Regulates Active DNA Demethylation in Arabidopsis. Science 336:1445-8.

27. Martínez-Macías MI, Qian W, Miki D, Pontes O, Liu Y, Tang K, Liu R, Morales-Ruiz T, Ariza RR, Roldán-Arjona T, Zhu JK. (2012). A DNA 3' phosphatase functions in active DNA demethylation in Arabidopsis. Mol Cell. 45:357-70.

26. Xie M, Ren G, Costa-Nunes P, Pontes O, Yu B. (2012) A subgroup of SGS3-like proteins act redundantly in RNA-directed DNA methylation. Nucleic Acids Res. 40:4422-31.

25. Hoffer P, Ivashuta S, Pontes O, Vitins A, Pikaard CS, Mroczka A and Voelker T. (2010). Posttranscriptional Gene Silencing in Nuclei. Proc Natl Acad Sci USA. 108:409-14. (F1000 Recommended)

24. Earley KW, Pontvianne F, Wierzbicki AT, Blevins T, Tucker S, Costa-Nunes P, Pontes O, and Pikaard CS. (2010). Mechanisms of HDA6-mediated rRNA gene silencing: suppression of intergenic Pol II transcription and differential effects on maintenance versus siRNA directed cytosine methylation. Genes Dev 24:1119-32.

23. Searle IR, Pontes O, Melnyk CW, Smith L, and Baulcombe DC. (2010). A JmjC domain protein is required for RNA silencing and cell-to-cell movement of an RNA silencing signal in Arabidopsis. Genes Dev 24:986-91.

22. Gao Z*, Liu H*, Daxinger L*, Pontes O*, He L , Qian W, Xie M, Lorkovic ZJ, Zhang S, Pontier D, Lagrange T, Jacobsen SE, Jin H, Matzke A, Matzke M, Pikaard CS, and Zhu JK. (2010). A novel methyl DNA binding protein interacts with AGO4 and RNA polymerase II and functions in RNA-directed DNA methylation in Arabidopsis. Nature 465:106-9. *Equal contribution

21. Costa-Nunes P, Pontes O, Preuss SB, and Pikaard CS. 2010. RNA-dependent DNA methylation and the establishment of nucleolar dominance in Arabidopsis suecica. Nucleus 1: 1-6. (Cover issue)

20. He XJ, Hsu YF, Zhu S, Liu HL, Pontes O, Zhu J, Cui X, Wang C, and Zhu JK. (2009). A transcriptional regulator conserved from yeasts to humans is required for RNA-directed DNA methylation and plant development. Genes & Dev 23:2717-22.

19. Blevins T, Pontes O, Pikaard CS, and Meins F Jr. (2009). Heterochromatic siRNAs and DDM1 independently silence aberrant 5S rDNA transcripts in Arabidopsis. PLoS One 16:e5932.

18. He XJ, Hsu YF, Zhu S, Wierzbicki AT, Pontes O, Pikaard CS, Wang CS, and Zhu JK. (2009). An Effector of RNA-Directed DNA Methylation in Arabidopsis Is an ARGONAUTE 4- and RNA-Binding Protein. Cell 37:498-509.

17. Pontes O*, Costa-Nunes P, Vithayathil P, and Pikaard CS. (2009). RNA polymerase V functions in Arabidopsis interphase heterochromatin organization independent of the siRNA-directed DNA methylation pathway. Mol Plant 2: 700-710. *Corresponding author. (Cover issue)

16. He JX, Hsu YF, Pontes O, Zhu J, Lu J, Bressan RA, Pikaard CS, Wang CS, and Zhu JK. (2009). NRPD4, a protein related to the RPB4 subunit of RNA polymerase II, is a component of RNA polymerases IV and V and is required for siRNA production, RNA-directed DNA methylation, and transcriptional gene silencing. Genes Dev 23:318-30.

15. Haag JR, Pontes O, and Pikaard CS. (2009). Metal A and Metal B sites of nuclear RNA polymerases Pol IV and Pol V are required for siRNA-dependent DNA methylation and gene silencing. PLoS One. 4(1):e4110.

14. Preuss S, Costa-Nunes P, Tucker S, Pontes O, Lawrence RJ, Mosher R, Kasschau KC, Carrington JC, Baulcombe DC, Viegas W, and Pikaard CS. (2008). Multi-megabase silencing in nucleolar dominance: evidence for siRNA-directed de novo DNA methylation recognized by specific methylcytosine binding proteins. Mol Cell 32: 673-84.

13. Zheng X, Pontes O, Zhu Z, Miki D, Iida K, Kapoor A, Pikaard CS, and Zhu JK. (2008). ROS3, a small RNA-binding protein required for DNA demethylation in Arabidopsis. Nature 455:1259-62.

12. Pontes O, Lawrence RJ, Silva M, Preuss S, Costa-Nunes P, earley K, Neves N, Viegas W and Pikaard CS. (2007). Postembryonic establishment of megabase-scale gene silencing in nucleolar dominance. PLoS One 2(11):e1157.

11. Smith LM, Pontes O, Searle I, Yelina N, Yousafzai KF, Herr AJ, Pikaard CS, and Baulcombe DC. (2007). A SNF2 protein associated with nuclear RNA silencing and spread of a silencing signal between cell in Arabidopsis. Plant Cell 19:1507-21.

10. Woo HR, Pontes O, Pikaard CS, and Richards EJ. (2007). VIM1, a non-MBD class methylcytosine binding protein required for centromeric heterochromatinization. Genes Dev 21:267-277. (Cover issue)

9. Li C, Pontes O, El-Shami M, Henderson R, Bernatavichute Y, Chan S, Lagrange T, Pikaard C, and Jacobsen S. (2006). An ARGONAUTE4-containing nuclear processing center co-localized with Cajal bodies in Arabidopsis thaliana. Cell 126: 93-106. (Faculty 1000 Exceptional)

8. Pontes O, Li CF, Costa-Nunes P, Haag JR, Ream T, Vitins A, Jacobsen SJ, and Pikaard C. (2006). The Arabidopsis chromatin-modifying nuclear siRNA pathway involves a nucleolar RNA processing center. Cell 126: 79-92. (Faculty 1000 Must read)

7. Earley K, Lawrence R, Pontes O, Reuther R, Enciso AJ, Silva M, Neves N, Gross M, Viegas W, and Pikaard CS. (2006). Erasure of histone acetylation by Arabidopsis HDA6 mediates large-scale gene silencing in nucleolar dominance. Genes Dev 20: 1283-1293. (Cover issue, NIH Biomedical Beat Cool Image)

6. Earley KW, Haag JR, Pontes O, Opper K, Juehne T, Song K, and Pikaard CS. (2006). Gateway-compatible vectors for plant functional genomics and proteomics. Plant J 45: 616-629.

5. Onodera Y, Haag JR, Ream T, Costa-Nunes P, Pontes O, and Pikaard CS. (2005). Plant Nuclear RNA Polymerase IV Mediates siRNA and DNA Methylation-Dependent Heterochromatin Formation. Cell 120: 613-622. (Faculty 1000 Must read, Science Editor’s choice)

4. Pontes O, Neves N, Silva M, Lewis M, Madlung A, Comai L, Viegas W, and Pikaard CS. (2004). Rapid chromosomal locus rearrangements accompany formation of the allotetraploid Arabidopsis suecica genome. Proc Natl Acad Sci USA 101: 18210-18245.

3. Lawrence RJ, Early K, Pontes O, Silva M, Chen ZJ, Neves N, Viegas W, and Pikaard CS. (2004). A concerted DNA methylation/histone methylation switch controlling rRNA gene dosage and nucleolar dominance requires nuclear histone deacetylase, HTD1. Mol Cell 13: 599-609. (Faculty 1000 Must Read)

2. Pontes O, Lawrence RJ, Neves N, Silva M, Lee JH, Z. Chen JZ, Viegas, W, and Pikaard CS (2003). Natural variation in nucleolar dominance reveals the relationship between nucleolus organizer chromatin topology and rRNA gene transcription in Arabidopsis. Proc Natl Acad Sci USA 100:11418-11423.

1. Pontes O, Cotrim H, Pais S, and Viegas W. (2000). Physical mapping, expression patterns and interphase organisation of rDNA loci in Portuguese endemic Silene cintrana and Silene rothmaleri. Chrom Res 8: 313-317.

Olga Maria Ferreira Pontes

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