金佳麗，女，同濟大學高等研究院研究員；中國抗癌協會腫瘤微環境專業委員會青年委員；Discovery Medicine編委。研究方向為營養應激與腫瘤細胞命運。
人物經歷,研究方向,主要成就,
人物經歷
金佳麗，女，同濟大學高等研究院研究員；中國抗癌協會腫瘤微環境專業委員會青年委員；Discovery Medicine編委。
研究方向
研究方向為營養應激與腫瘤細胞命運。
主要成就
【發表論文 (publications)】
1.Jiali Jin*, Tong Meng*, Yuanyuan Yu*, Shuheng Wu*, Chen-Chen Jiao, Sihui Song, Ya-Xu Li,Yu Zhang, Yuan-Yuan Zhao, Xinran Li, Zixin Wang, Yu-Fan Liu, Runzhi Huang, Jieling Qin, Yihua Chen, Hao Cao, Xiao Tan, Xin Ge, Cong Jiang, Jianhuang Xue, Jian Yuan, Dianqing Wu, Wei Wu, Ci-Zhong Jiang, Ping Wang#. Human HDAC6 senses valine abundancy to regulate DNA damage. Nature, 2025, 637(8044): 215-223
2.Jiali Jin#, Ping Wang#. The role of nutrient stress in DNA damage. Trends in Cell Biology, 2025 Aug 26: S0962-8924(25)00182-5.
3.Yaxu Li*, Qiao Ran*, Qiuhui Duan*, Jiali Jin* ,Yanjin Wang, Lei Yu, Chaojie Wang, Zhenyun Zhu, Xin Chen, Linjun Weng, Zan Li, Jia Wang, Qi Wu, Hui Wang, Hongling Tian, Sihui Song, Zezhi Shan, Qiwei Zhai, Huanlong Qin, Shili Chen, Lan Fang, Huiyong Yin, Hu Zhou, Xuejun Jiang, Ping Wang#. 7-Dehydrocholesterol dictates ferroptosis sensitivity and surveillance. Nature, 2024 Feb;626(7998):411-418.
4.Jianxuan Gao*, Jiali Jin*, Runzhi Huang, Siqiao Wang, Sihui Song, Yu Zhang, Yongai Li, Jun Lin, Zhengyan Chang, Zongqiang Huang, Wei Sun, Huabin Yin, Dianwen Song#, Jianru Xiao#, Ping Wang#, Tong Meng#. RAB3B Dictates mTORC1/S6 Signaling in Chordoma and Predicts Response to mTORC1-Targeted Therapy. Advanced Science, 2025 May;12(19):e2415384. doi: 10.1002/advs.202415384.
5.Chenchen Jiao, Tong Meng, Chenyu Zhou, Xinbo Wang, Ping Wang, Meiling Lu, Xiao Tan, Qing Wei, Xin Ge, Jiali Jin#. TGF-β signaling regulates SPOP expression and promotes prostate cancer cell stemness. Aging. 2020 May 1;12(9):7747-7760.
6.Tong Meng*, Runzhi Huang*, Jiali Jin*, Jianxuan Gao, Fuyan Liu, Ziheng Wei, Xiaowen Xu, Zhengyan Chang, Jun Lin, Na Ta, Zongqiang Huang, Huabin Yin, Wang Zhou, Dianwen Song. The comparative integrated multi-omics analysis identifies CA2 as a novel target for chordoma. Neuro Oncol. 2021 Jul 2; noab156. doi: 10.1093/neuonc/noab156.
7. Wen Zhang*, Jiali Jin*, Yanjin Wang*, Lan Fang, Min Liu, Xinbo Wang, Lin Ding, Linjun Weng, Xiao Tan, Tianhua Zhou, Ping Wang#. PD-L1 regulates genomic stability via interaction with Cohesin-SA1 in the Nucleus. Signal Transduction and Targeted Therapy, 2021 Feb 25;6(1):81.doi: 10.1038/s41392-021-00463-0.
8. Xinbo Wang*, Jiali Jin*, Fangning Wan*, Linlin Zhao*, Hongshang Chu, Cong Chen, Guanghong Liao, Jian Liu, Yue Yu, Hongqi Teng, Lan Fang, Cong Jiang, Weijuan Pan, Xin Xie, Jia Li, Xiaolin Lu, Xuejun Jiang, Xin Ge#, Dingwei Ye#, and Ping Wang#. AMPK Promotes SPOP-Mediated NANOG Degradation to Regulate Prostate Cancer Cell Stemness. Developmental Cell. 2019 Feb 11;48(3):345-360.
9. Tong Meng*, Jiali Jin*, Cong Jiang, Runzhi Huang, Huabin Yin, Dianwen Song and Liming Cheng. Molecular Targeted Therapy in the Treatment of Chordoma: A Systematic Review. Front Oncol. 2019 Feb 1;9:30. doi: 10.3389/fonc.2019.00030. eCollection 2019.
10. Jiali Jin*, Jian Liu*, Cong Chen, Zhenping Liu, Cong Jiang, Hongshang Chu, Weijuan Pan, Xinbo Wang, Lingqiang Zhang, Bin Li, Cizhong Jiang, Xin Ge, Xin Xie & Ping Wang. The deubiquitinase USP21 maintains the stemness of mouse embryonic stem cells via stabilization of Nanog. Nature Communications. 2016 Nov 25; 7:13594.
11. Peng Liao*, Weichao Wang*, Yu Li*, Rui Wang*, Jiali Jin*,Weijuan Pan, Yunfei Chen, Mingyue Shen, Xinbo Wang, Dongyang Jiang, Jinjiang Pang, Mingyao Liu, Xia Lin, Xin-Hua Feng, Ping Wang & Xin Ge. Palmitoylated SCP1 is targeted to the plasma membrane and negatively regulates angiogenesis. eLife. 2017 Mar 31;6:e22058. doi: 10.7554/eLife.22058.
【主持項目 (Chaired project)】
項目來源：國家自然科學基金面上項目；項目名稱：纈氨酸限制促進DNA去甲基化抑制腫瘤的機制與功能研究
(Grants from the National Natural Science Foundation of China; Mechanism and function of valine restriction inhibiting tumor progression by promoting DNA demethylation)
項目來源：國家自然科學基金面上項目；項目名稱：醯基轉移酶SAT1通過調控組蛋白琥珀醯化影響腫瘤免疫微環境的機制與功能研究
(Grants from the National Natural Science Foundation of China; The mechanism and function of acyltransferase SAT1 on tumor immune microenvironment via regulating histone succinylation)
項目來源：國家自然科學基金青年項目；項目名稱：TGF-β/SPOP負反饋環路在腫瘤轉移中的調控作用及分子機制研究
(Grants from the National Natural Science Foundation of China; The function and mechanism of TGF-β/SPOP negative feedback loop in cancer metastasis)
項目來源：上海市東方英才計畫青年科技平台優秀學術帶頭人專題；項目名稱：營養代謝應激與腫瘤細胞命運
(Grants from the Shanghai Oriental Talent Program Youth Science and Technology Platform Outstanding Academic Leader; Nutrient stress and tumor cell fate)
項目來源：上海市“科技創新行動計畫”啟明星項目；項目名稱：營養代謝感應調控腫瘤代謝穩態的機制與功能研究
(Grants from the Shanghai Rising-Star Program; The mechanism and function of nutrient metabolism induction in regulating tumor metabolic homeostasis)
項目來源：上海市青年科技英才揚帆計畫；項目名稱：TGFβ信號通路調控腫瘤幹細胞在腫瘤轉移與復發中的功能與機制研究
(Grants from the Shanghai Sailing Program; The function and mechanism of TGFβ signaling pathway in tumor metastasis and recurrence via regulating cancer stem cells self-renewal)
項目來源：上海高校青年科研骨幹培養計畫（“晨光”計畫）；項目名稱：胺基酸感應體的鑑定及其功能與機制的研究
(Grants from the Shanghai Education Development Foundation and Shanghai Municipal Education Commission; Identification of amino acid sensors and its function and mechanism)
