郝建原，理學博士，洪堡學者，教授，博士生導師。1994年7月畢業於合肥工業大學化學工程系，獲高分子材料專業工學學士；翌年進入中國科學院成都有機化學研究所，先後於1998年7月和2001年7月獲高分子化學和物理方面的碩士和博士學位；
基本介紹
- 中文名：郝建原
- 國籍：中國
- 民族：漢族
- 職業：教授
- 畢業院校：合肥工業大學
- 信仰：共產主義
- 主要成就：成為洪堡學者、教授、博士生導師
教育背景,工作履歷,學術兼職,研究領域,主要成就,代表性論文,
教育背景
1998.09－2001.07 中國科學院成都有機化學研究所，高分子化學與物理專業，博士學位
1995.09－1998.07 中國科學院成都有機化學研究所，高分子化學與物理專業，碩士學位
1990.09－1994.07 合肥工業大學，高分子材料專業，學士學位
工作履歷
2008.04－至今 電子科技大學微電子與固體電子學院，教授，博導
2005.12－2008.04 中國科學院成都有機化學研究所，研究員，博導
2005.06－2005.12 中國科學院成都有機化學研究所，副研究員
2004.03－2005.06 德國耶拿大學材料科學與技術研究所，洪堡訪問學者
2002.02－2004.03 英國諾丁漢大學化學學院，博士後
2001.07－2002.02 中國科學院成都有機化學研究所，助理研究員
學術兼職
中國生物材料學會會員，美國化學學會會員
研究領域
長期從事生物材料與生物電子相關的基礎研究和套用開發工作，曾先後主持國家科技支撐計畫、多項國家自然科學基金項目、中國科學院院長特別支持基金、四川省科技支撐計畫、廣東省產學研、成都市科技攻關等項目的研究和開發。目前在Chem. Commun., J. Mater. Chem., Biomaterials，J. Control. Release, J. Pharm. Sci.等SCI收錄的期刊上發表英文論文五十多篇，總被引用次數超過六百次；申請專利十多項，其中四項已被授權。
研究方向：生物感測器；具有光、電、磁、聲、熱等環境相應特性的生物材料及套用； 有機-無機納米複合生物材料；聚多肽及自組裝行為的調控；生物可降解聚酯及其在藥物控制釋放和植入器械領域中的套用。
主要成就
2002年1月到2004年1月，赴英國諾丁漢大學做博士後，在化學系Steve M Howdle教授的和藥學系Kevin M Shakesheff教授的領導下工作；2004年3月到2005年6月，獲德國洪堡獎學金，在德國耶拿大學的材料科學和技術研究所做訪問學者，合作教授為Klaus D Jandt；2005年6月到2008年4月在中國科學院成都有機化學研究所工作；2008年4月被電子科技大學作為傑出人才引進。曾先後主持和參加過國家“863”項目，多項國家自然科學基金項目，中國科學院院長特別支持基金，成都市科技攻關等項目的研究和開發。目前以第一作者或通訊聯繫人在Chem Communi, J Mater Chem, Biomaterials等SCI收錄的期刊上發表英文論文三十多篇，其中一篇發表在Biomaterials 的文章被SCI收錄期刊引用的次數已經超過60次，並擁有一項署名為第一的世界專利(WO 20050426230)，該專利目前已經在歐洲、加拿大、南非、澳大利亞等國進入了國家審查階段
代表性論文
1. Tianqiang Wang, Yu Liu，Jianyuan Hao*，“Synthesis of poly(p-dioxanone)- based block copolymers in supercritical carbon dioxide”,Colloid Polymer Science2014, 292, 2497-2508.
2. Tianqiang Wang, Jing Ding, Jiamin Li, Yu Liu，Jianyuan Hao*, “Blends of poly(d,l-lactide) with polyhedral oligomeric silsesquioxanes-based biodegradable polyesters: synthesis, morphology, miscibility and mechanical properties”,Journal of Applied Polymer Science2014, 131, 40776.
3. Lei Feng, Zhao Yang, Yu Liu,Jianyuan Hao*, et al, “Copolymerization of succinic anhydride and epoxide with diethylene glycol side chain”Iranian Polymer Journal2014, 23, 217-216.
4. Tianqiang Wang， Huizhen Zhao，Yu Liu，Jianyuan Hao*，“Correlation of chemical composition and microstructure with properties of poly(-caprolactone-co-p-dioxanone) random copolymers”,Journal of Applied Polymer Science2013, 130, 2978-2986.
5. Rui Chen,Jianyuan Hao*, “Preparation and characterization of poly(-caprolactone-co-p-dioxanone)-poly(ethylene glycol)-poly(ε-caprolactone -co-p-dioxanone)/bioactive inorganic particles”,Journal of Applied Polymer Science2013, 129, 2287-2293.
6. Huizhen Zhao Tianqiang Wang, Xiuli Zhao, Yu Liu,Jianyuan Hao*, “Synthesis and properties of poly(d,l-lactide-co-p-dioxanone) random and segmented copolymers”,Journal of Polymers and the Environment2013, 21, 405-414.
7. Rui Chen,Jianyuan Hao*, “Sol stability of crystalline thermogelling poly(-caprolactone-co-p-dioxanone)-poly(ethylene glycol)-poly(ε-caprolactone -co- p-dioxanone) copolymers”,Journal of Polymer Research2013, 20, 133(1-7).
8. Jing He, Bo Jiang, Yun Dai,Jianyuan Haoet al, “Regulation of the osteoblastic and chondrocytic differentiation of stem cells by the extracellular matrix and subsequent bone formation modes”,Biomaterials2013, 34, 6568-6588.
9. Tianqiang Wang,Jianyuan Hao*, Yu Liu, Zhongwei Gu, “Formation of well-defined spherical particles during suspension polymerization of bidegradable poly(glycolide-co-p-dioxanone) in supercritical carbon dioxide”,RSC Advances2012, 2, 10365-10371.
10. Lei Feng, Yu Liu,Jianyuan Hao*, Chengdong Xiong, Xianmo Deng, “Alternating copolymers with degradability and quantitatively controlled thermosensitivity”,Journal of Polymer Science, Polymer Chemistry2012, 50(9), 1812-1818.
11. Tianqiang Wang, Jing Ding, Xiuli Zhao, Yu Liu,Jianyuan Hao*, “Suspension polymerization of poly(L-lactide-co-p-dioxanone) in supercritical carbon dioxide”,Journal of the Polymers and Environment2012, 20, 157-163.
12. Lei Feng, Yu Liu,Jianyuan Hao*, Chengdong Xiong, Xianmo Deng, “Synthesis and properties of novel thermoresponsive polyesters with oligo(ethylene glycol) pendent chains”,Macromolecular Chemistry and Physics2011, 212(24), 2626-2632.
13. Lei Feng, Yu Liu,Jianyuan Hao*,Journal of Controlled Release2011, 153, e205-e206.
14. Tianqiang Wang, Xiuli Zhao,Jianyuan Hao*, “In situ generation of biodegradable poly(p-dioxanone) microparticles by polymerization in supercritical carbon dioxide”,Chinese Chemical Letters,2011(22), 1509-1502.
15. Rui Chen, Jianyuan Hao*, et al, “Biodegradable thermogelling poly(d,l-lactide-co-p-dioxanone)-poly(ethylene glycol)-poly(d,l-lactide-co-p- dioxanone) triblock copolymer”,Advanced Engineering Materials2010, 12(9), B504-510.
16. Rui Chen, Jianyuan Hao*, et al, “Rapid synthesis of biodegradable poly(caprolactone-co-p-dioxanone) random copolymers under microwave irradiation”, Chinese Chemical Letters 2010, 21, 249-252.
17. Chuanbao Wu,Jianyuan Hao*, Xianmo Deng, “A randomly branched poly(hydroxyl-β-amino amide): synthesis and complexation”, Journal of Polymer Research 2010, 17(6), 869-876.
18. Lei Feng,Jianyuan Hao*, et al, “A novel biodegradable and thermosensitive polymer with PEG-analogue macromolecular structure”,Chemical Communications2009, 4411-4413.
19. Lei Feng,Jianyuan Hao*, et al, “Synthesis of novel biodegradable poly(ethylene glycol) analogue: water-soluble aliphatic polyester with pendent ologo(ethylene glycol) chains”,Chinese Chemical Letters2009, 20(12), 1502-1505.
20. Zhiqing Jiang,Jianyuan Hao*, Xianmo Deng, “Biodegradable thermogelling hydrogel of (CL-GL)-PEG-P(CL-GL) triblock copolymer: degradation and drug release behaviour”,Journal of Pharmaceutical Sciences, 2009, 98, 2603-2610
21. Huizhen Zhao,Jianyuan Hao*, et al, “Different crystallinity of poly(d,l-lactide-co-p-dioxanone) copolymers acquired by control of chain microstructure”,Chinese Chemical Letters2009, 20(12), 1506-1509.
22. Yan Hu, Kaiyong Cai, Zhong Luo, Chong Chen, Haide Dong, Jianyuan Hao, et al, “Fabrication of galactosylated polyethylenimine and plasmid DNA multilayers on poly(D,L-lactic acid) films for in situ targeted gene transfection”,Advanced Engineering Materials2009, 11(5), B30-B34.
23. Zhiqiang Jiang, Yujing You, Qun Gu,Jianyuan Hao, Xianmo Deng, “Effect of microstructures on the phase transition behaviour of P(CL-GL)-PEG-P(CL-GL) triblock copolymer aqueous solutions”,Macromol Rapid Communi. 2008, 29(14), 1264-1268.
24. Zhiqiang Jiang,Jianyuan Hao*, Xianmo Deng, “Biodegradable and thermo-reversible hydrogels of poly(ethylene glycol)-poly(ε-caprolactone-co- glycolide)-poly(ethylene glycol) aqueous solutions”,J Biomed Mater Res2008, 97A, 45-51.
25.Jianyuan Hao, Thomas Keller, Kaiyong Cai, Elisabeth Klemm, Jorg Bossert, Klaus D. Jandt, “The effect of D,L-Lactidyl/ε-caproyl weight ratio and chemical microstructure on surface properties of biodegradable poly(d,l-lactide)-co-poly (ε-caprolactone) ramdom copolymers”,Advanced Engineering Materials2008, 10(8), 1-11.
26. Chuanbao Wu,Jianyuan Hao*, Xianmo Deng, Xiaohong Li, “Copolymer of tetraethylenepentamine and ethylene glycol diacrylate: synthesis and degradation”,Polym Degrad Stab2008, 93(5), 932-940.
27. Hui Miao,Jianyuan Hao*, Yu Liu, Yan Liu, Xianmo Deng, “Synthesis, crystallinity and degradation properties of biodegradable poly(sebacic anhydride-co-caprolactone) triblock copolymers”,Polymer International2008, 57, 316-323.
28. Chuanbao Wu,Jianyuan Hao*, Xianmo Deng, Yu Liu, “Random branched poly(hydroxyetheramine): a novel polycation with proton sponge effect and high density of discrete charge”,Polym Bull2008, 60(5), 635-645.
29. Chuanbao Wu,Jianyuan Hao*, Xianmo Deng, “A novel poly(amido amine) with methoxy carbonyl groups and high charge density: synthesis and nanoscopic assembly with polyanion”,e-Polymers2007, no.152.
30. Zhiqiang Jiang, xianmo Deng,Jianyuan Hao*, “Injectable hydrogels of P(CL-DLLA)-PEG-P(CL-DLLA) and P(CL-LLA)-PEG-P(CL-LLA) aqueous solutions”,Journal Polymer Science, Polymer Chemistry2007, 45(17), 4091-4099.
31. Zhiqiang Jiang, Yujing You, Xianmo Deng,Jianyuan Hao*, “Biodegradable thermogelling triblock copolymers of poly(ε-caprolactone-co- glycolide)-poly (ethylene glycol)-poly (ε-caprolactone-co-glycolide) in aqueous solution”,Polymer2007, 48(16), 4786-4792.
32. Zhiqiang Jiang, Xianmo Deng,Jianyuan Hao*,“Novel thermogelling poly(ε-caprolactone-co-lactide)-poly(ethylene glycol) -poly(ε-caprolactone-co- lactide) aqueous solutions”,Chinese Chemical Letters 2007, 18(6), 747-749.
33. Chuanbao Wu,Jianyuan Hao*, Xianmo Deng, “A novel degradable poly(beta-amino ester) and its nano-complex with poly(acrylic acid)”,Polymer2007, (21), 6272-6285.
34. Wuchuan Bao,Jianyuan Hao*, xianmo Deng, “A novel potential cationic polymeric gene vector containing hydroxyl groups and all grades of amino groups”,Journal of Applied Polymer Science2007, 105(3), 1533-1542.
35. Hui Miao, Yang Fan, Yan Liu, Yu Liu,Jianyuan Hao*, Xianmo Deng, “Poly(sebacic anhydride-co-caprolactone) multi-block copolymers: synthesis, characterization, crystallinity and crystalline morphology”,European Polymer Journal2007, 43(3), 1055-1064.
36.Jianyuan Hao, Martin J. Whitaker, Kevin M. Shakesheff, Steven M. Howdle, “Processing spherical poly(ethylene glycol) particles at ambient temperatures by a solvent-free supercritical method”,Journal of Material Chemistry2005, 15(11), 1148-1151.
37. Kaiyong Cai, Annett Rechtenbach,Jianyuan Hao, Jorg Bossert, Klaus D. Jandt, “Polysaccharide-protein surface modification of titanium via a layer-by-layer technique: characterization and cell behavior aspects”,Biomaterials2005，26，5960-5971.
38. Martin J. Whitcker,Jianyuan Hao, Owen R. Davies, Gulay Serhatkulu, Snjezana Stolnik, Steven M. Howdle and Kevin M. Shakesheff, “Supercritical fluid mixing as a fabrication method for protein encapsulated microparticles”,Journal of Controlled Release2005, 101(1-3), 85-92.
39.Jianyuan Hao, Martin J. Whitaker, Ben Wong, Gulay Shehatkulu, Kevin M. Shakesheff, Steven M. Howdle, “Control of Poly(DL-lactic acid) Particle Size During Spraying from a Supercritical Carbon Dioxide Environment”,Journal of Pharmaceutical Science2004, 93(4): 1083-1090.
40.Jianyuan Hao, Yu Liu, Shaobing Zhou, Zhen Li, Xianmo Deng, “Investigation of nanocomposites based on semi-interpenetrating network of [poly(-caprolactone)]/[net-poly(-caprolactone)] and hydroxyapatite nanocrystals”,Biomaterials2003, 24(9), 1531-1539.
41. Xianmo Deng, Likun Guo, Yu Liu,Jianyuan Hao, “The degradation of PLCLE in different pH values and accelerated degradation by increasing temperature or performing in 6% H2O2-PBS”,Journal of Polymer Materials2003, 20(3), 285-291.
42. Zhen Li,Jianyuan Hao, Minglong Yuan, Xianmo Deng, “Ring opening polymerization of adipic anhydride initiated by dibutylmagnesium initiator”,European Polymer Journal2003, 39(2), 313-317.
43. Zhen Li, Mingyuan Gao, Minglong Yuan,Jianyuan Hao, Xianmo Deng, “Synthesis and characterization of biodegradable poly(ester anhydride) based on ε-caprolactone and adipic anhydride initiated by potassium poly(ethylene glycol)ate”,Journal of Polymer Science, Polymer Chemistry2003, 41(10), 1511-1520.
44. Xianmo Deng, Zhen Li, Minglong Yuan,Jianyuan Hao, “Anionic ring-opening polymerization of adipic anhydride initiated by potassium poly(ethylene glycol)ate”,Journal of Applied Polymer Science2003, 88(9), 2194-2201.
45.Jianyuan Hao,Minglong Yuan, Xianmo Deng, “Biodegradable and biocompatible nanocomposites of poly (-caprolactone) with hydroxyapatite nanocrystals: Thermal and mechanical properties”,Journal of Applied Polymer Science2002, 86(3), 676-683.
46. Xianmo Deng,Jianyuan Hao, Changsheng Wang, “Preparation and mechanical properties of nanocomposites of poly (d,l-lactide) with Ca-deficient hydroxyapatite nanocrystals”,Biomaterials2001, 22 (21), 2867-2873.
47.Jianyuan Hao, Xianmo Deng, “Semi-interpenetrating network of bacterial poly (3-hydroxyapatite) with net-poly (ethylene glycol)”,Polymer2001, 42(9), 4091-4097.
48. Xianmo Deng ,Jianyuan Hao, minglong Yuan, Shujie Zhao, “Miscibility, thermal behavior, morphology and mechanical properties of binary blends of poly [(R)-3-hydroxybutyrate] with poly (γ-benzyl-L-glutamate)”,Polymer International2001, 50(1), 37-44.
49. Xianmo Deng,Jianyuan Hao, Yuanming Long, “Influence of poly (d,l-lactide-b-ethylene glycol) copolymer on morphology and tensile moduli of poly (d,l-lactide) composites containing hydroxyapatite nanocrystals”,Journal of Materials Science Letters2001, 20(3), 281-282.
50. Xianmo Deng,Jianyuan Hao, “Synthesis and characterization of poly (3-hydroxybutyrate) macromer of bacterial origin”,European Polymer Journal2001, 37(1), 211-214.
邀請報告
1. 2014年11月6-8日在成都參加了2014全國納米生物與醫學學術會議，並作邀請報告“聚乙二醇-聚多肽在水溶液中的聚集態結構及溶膠-凝膠轉變行為”。
2.2014年9月17日在成都參加了第五屆聯合利華－英國皇家化學學會功能化材料科學國際研討會，並作邀請報告“Biodegradable and thermoresponsive polymers used as drug delivery carriers”。
3. 2014年7月5-7日在成都參加了2014中國材料大會，並作邀請報告“聚乙二醇-聚多肽在水溶液中的聚集態結構及溶膠-凝膠轉變行為“。
4. 2013年12月20-23日在深圳參加了中國生物材料學會2013年大會，並作邀請報告“用於藥物控制釋放載體的溫敏性可生物降解聚合物”。
5. 2011年9月6日-9日在德國柏林參加了第二屆中德多功能生物材料和聚合物藥物控制釋放體系研討會（The second Sino-Germany Symposium on “Multifunctional Biomaterials and Polymer-based Controlled Drug Release Systems”）,並作邀請報告“Processing and Polymerization of Biodegradable Polymers into Particles”。
6. 2010年9月6日-9日在成都參加了第一屆中德藥物、蛋白、基因控制釋放體系研討會（The first Sino-Germany Symposium on “Bioinspired Systems for Drug, Protein, and Gene Delivery”）,並作邀請報告“Biodegradable and Thermo-responsive Polymers Used as Drug Delivery Carriers”。
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