趙勤實，男，1964年3月生，博士學位，研究員，博士生導師。現任植物化學與西部植物資源可持續利用國家重點室副主任。
基本介紹
- 中文名：趙勤實
- 國籍：中國
- 出生日期：1964
- 性別：男
個人簡介,教育背景：,研究領域：,研究成果：,論文專著：,承擔科研項目情況：,
個人簡介
教育背景：
1993-1995年 中國科學院昆明植物所，獲博士學位；
1995-1998年 軍事醫學科學院毒理藥理所博士後；
1999年－2000年3月在日本靜岡縣立大學客座研究
2006年在日本作為高級訪問學者在日本展開與禽流感相關的生物化學研究。
研究領域：
創新藥與中藥現代化 主要學術成就：在國際性刊物和國內刊物發表SCI收錄的論文50餘篇，有兩個新藥研究項目正進行三期臨床研究和臨床研究。研究方向為創新藥與中藥現代化的研究。
研究成果：
在國際性刊物和國內刊物發表SCI收錄的論文一百餘篇，受邀作為國際著名雜誌Organic Letters審稿人，獲得授權專利三項。在孫漢董院士的指導下開展“注射用燈盞細辛酚”新藥研究，該項目2003年獲臨床研究批文，現在完成三期臨床研究，已經提交SFDA審評；與李朝明教授合作進行“抗腫瘤一類新藥GC-51”研究。
論文專著：
1. Yu Zhao, Na Guo Li Guang Long, Yu Wen Cong, Li Yan Peng, Qin Shi Zhao, Synthesis, cytotoxic activity, and SAR analysis of the derivativesof taxchinin A and brevifoliol，Bioorganic & Medicinal Chemistry, 2008, 16, 4860-4871.
2. Xiao Li Li , Lin Tu, Yu Zhao, Li Yan Peng, Gang Xu, Xiao Cheng, Qin shi Zhao, Terpenoids from Two Dicranopteris Species，Helvetica Chimica Acta, 2008, 91, 856-861.
3. Peng Li, Gang Xu, Shao Ping Li, Yi Tao Wang, Tai Ping Fan, Qin Shi Zhao and Qing Wen Zhang, Optimizing Ultraperformance Liquid Chromatographic Analysis of 10 Diterpenoid Compounds in Salvia miltiorrhiza Using Central Composite Design, J. Agric, Food Chem., 2008, 56, 1164-1171.
4. Qin shi Zhao, Yu wen Cong，Michael Reaction Acceptor Molecules in Chemical Biology，Progress in Chemistry, 2007, 19(12), 1972-1976.
5. Yu Zhao, Xue Mei Niu, Li Ping Qian, Ze Yuan Liu, Qin Shi Zhao, Han Dong Sun, Synthesis and cytotoxicity of some new eriocalyxin B derivatives, Eur, J. Med. Chem., 2007, 42, 494-502.
6. Xiao Li LI, Liu Meng Yang, Yu Zhao, Rui Rui Wang, Gang Xu, Yong Tang Zheng, Lin Tu, Li Yan Peng, Xiao Cheng and Qin Shi Zhao, Tetranorclerodanes and Clerodane-Type Diterpene Glycosides from Dicranopteris dichotoma, J. Nat. Prod., 2007, 70,265-268.
7. Xiao Li Li, Yu Zhao, Xiao Cheng, L in Tu, Li Yang Peng, Gang Xu and Qin Shi Zhao, Japonicumins A-D: Four New Compounds from Lycopodium japonicum, Helvetica Chimica Acta, 2006, 89, 1467-1473.
8. Yu Zhao, Fu Sheng Wang, Li Yan Peng, Xiao Li Li, Gang Xu, Xiao Xin Luo, Yang Lu, Li Wu, Qi Tai Zheng and Qin Shi Zhao, Taxoids from Taxus chinensis, J. Nat. Prod., 2006, 69, 1813-1815.
9. Gang Xu, Ai Jun Hou, ,Yong Tang Zheng, Yu Zhao, Xiao Li Li, Li Yan Peng and Qin Shi Zhao, Przewalskin B: a Novel Diterpenoid with an Unprecedented Skeleton from Salvia przwalskii Maxim, Organic Letters, 2007, 9(2), 291-293.
10. Gang Xu, Ai Jun Hou, Rui Rui Wang, Guang Yu Liang, Yong Tang Zheng, Ze Yuan Liu, Xiao Li Li, Yu Zhao, Sheng Xiong Huang, Li Yan Peng and Qin Shi Zhao, Przewalskin A: A New C23 Terpenoid with a 6/6/7 Carbon Ring Skeleton from Salvia przwalskii Maxim, Organic Letters, 2006, 8(20), 4453-4456.
11. Xiao Li Li, Xiao Cheng, Liu Meng Yang, Rui Rui Wang, Yong Tong Zheng, Wei Lie Xiao, Yu Zhao, Gang Xu, Yang Li, Ying Chang, Qi Tai Zheng, Qin Shi Zhao, Han Dong Sun, Dichotomains A and B: Two New Highly Oxygenated Phenolic Derivatives from Dicranopetris dichotoma. Org. Lett. 2006, 8 (9), 1937-1940.
12. Xiao Li Li, Ping Li Qian, Ze Yuan Liu, Yu Zhao, Gang Xu, De Ding Tao, Qin Shi Zhao, Han Dong Sun, Sesquiterpenoids from Cynara scolymus, Heterocycles, 2005, 65 (2), 287-291.
13. Gang Xu, Li Yan Peng, Xiao Li Li, Yu Zhao, Lin Tu, Qin Shi Zhao, Han Dong Sun, Yang Lu, Li Mao, Qi Tai Zheng, New Sesquiterpenoids from Salvia castanea Diels f. tomentosa, Helvetica Chimica Acta, 2005, 88, 2370-2374.
2. Xiao Li Li , Lin Tu, Yu Zhao, Li Yan Peng, Gang Xu, Xiao Cheng, Qin shi Zhao, Terpenoids from Two Dicranopteris Species，Helvetica Chimica Acta, 2008, 91, 856-861.
3. Peng Li, Gang Xu, Shao Ping Li, Yi Tao Wang, Tai Ping Fan, Qin Shi Zhao and Qing Wen Zhang, Optimizing Ultraperformance Liquid Chromatographic Analysis of 10 Diterpenoid Compounds in Salvia miltiorrhiza Using Central Composite Design, J. Agric, Food Chem., 2008, 56, 1164-1171.
4. Qin shi Zhao, Yu wen Cong，Michael Reaction Acceptor Molecules in Chemical Biology，Progress in Chemistry, 2007, 19(12), 1972-1976.
5. Yu Zhao, Xue Mei Niu, Li Ping Qian, Ze Yuan Liu, Qin Shi Zhao, Han Dong Sun, Synthesis and cytotoxicity of some new eriocalyxin B derivatives, Eur, J. Med. Chem., 2007, 42, 494-502.
6. Xiao Li LI, Liu Meng Yang, Yu Zhao, Rui Rui Wang, Gang Xu, Yong Tang Zheng, Lin Tu, Li Yan Peng, Xiao Cheng and Qin Shi Zhao, Tetranorclerodanes and Clerodane-Type Diterpene Glycosides from Dicranopteris dichotoma, J. Nat. Prod., 2007, 70,265-268.
7. Xiao Li Li, Yu Zhao, Xiao Cheng, L in Tu, Li Yang Peng, Gang Xu and Qin Shi Zhao, Japonicumins A-D: Four New Compounds from Lycopodium japonicum, Helvetica Chimica Acta, 2006, 89, 1467-1473.
8. Yu Zhao, Fu Sheng Wang, Li Yan Peng, Xiao Li Li, Gang Xu, Xiao Xin Luo, Yang Lu, Li Wu, Qi Tai Zheng and Qin Shi Zhao, Taxoids from Taxus chinensis, J. Nat. Prod., 2006, 69, 1813-1815.
9. Gang Xu, Ai Jun Hou, ,Yong Tang Zheng, Yu Zhao, Xiao Li Li, Li Yan Peng and Qin Shi Zhao, Przewalskin B: a Novel Diterpenoid with an Unprecedented Skeleton from Salvia przwalskii Maxim, Organic Letters, 2007, 9(2), 291-293.
10. Gang Xu, Ai Jun Hou, Rui Rui Wang, Guang Yu Liang, Yong Tang Zheng, Ze Yuan Liu, Xiao Li Li, Yu Zhao, Sheng Xiong Huang, Li Yan Peng and Qin Shi Zhao, Przewalskin A: A New C23 Terpenoid with a 6/6/7 Carbon Ring Skeleton from Salvia przwalskii Maxim, Organic Letters, 2006, 8(20), 4453-4456.
11. Xiao Li Li, Xiao Cheng, Liu Meng Yang, Rui Rui Wang, Yong Tong Zheng, Wei Lie Xiao, Yu Zhao, Gang Xu, Yang Li, Ying Chang, Qi Tai Zheng, Qin Shi Zhao, Han Dong Sun, Dichotomains A and B: Two New Highly Oxygenated Phenolic Derivatives from Dicranopetris dichotoma. Org. Lett. 2006, 8 (9), 1937-1940.
12. Xiao Li Li, Ping Li Qian, Ze Yuan Liu, Yu Zhao, Gang Xu, De Ding Tao, Qin Shi Zhao, Han Dong Sun, Sesquiterpenoids from Cynara scolymus, Heterocycles, 2005, 65 (2), 287-291.
13. Gang Xu, Li Yan Peng, Xiao Li Li, Yu Zhao, Lin Tu, Qin Shi Zhao, Han Dong Sun, Yang Lu, Li Mao, Qi Tai Zheng, New Sesquiterpenoids from Salvia castanea Diels f. tomentosa, Helvetica Chimica Acta, 2005, 88, 2370-2374.
承擔科研項目情況：
1、抗流感病毒先導化合物的研究，知識創新工程重要方向項
