李嬌嬌，女，博士，1986年12月生，雲南省祥雲縣人。現任雲南大學生態與環境學院環境科學與工程系副教授，碩士生導師。主要從事污染生態學、生態毒理學方面的研究。先後承擔國家級、省級等多項項目；在國內外核心刊物上發表學術論文10餘篇，其中SCI刊物上發表10餘篇。
基本介紹
- 中文名：李嬌嬌
- 國籍：中國
- 出生日期：1986年12月
- 職務：雲南大學生態與環境學院環境科學與工程系副教授，碩士生導師
研究成果,人物經歷,科研項目,學術論文,
研究成果
在生態毒理學及套用方面取得進展，主要包括以下幾個方面：
（1）水華藍藻次生代謝物生態毒理及風險分析；
（2）有害結局路徑和效應導向分析集合下的環境毒理體系構建、生物標誌物鎖定、水體污染源解析；
（3）從個體、免疫器官、病理組織、免疫細胞、免疫分子等多層次闡述水華藍藻胞外分泌物對生物體的免疫毒性機制、致畸性機制等。
（4）新型碳點材料對新污染物降解的研發。
人物經歷
2005.08－2010.07: 昆明醫科大學學習，臨床醫學專業，獲理學學士學位
2012.08－2017.08: 美國佛羅里達國際大學學習，生物醫學科學專業，獲理學博士（PhD）學位
科研項目
近十年主持或承擔的科研項目
2023-2027：雲南省興滇英才科研經費支持項目:基於有害結局路徑（AOP）框架對水體複合污染物的監測和風險評估,項目負責人,經費63萬元；
2022-2025：雲南省科技廳套用基礎研究面上項目:水華藍藻胞外分泌物對滇池金線䰾的毒性效應及機制研究,項目負責人，經費10萬元；
2022-2024：國家基金委青年基金項目:水華藍藻胞外分泌物及其主要成分植物鞘氨醇有害結局路徑研究,項目負責人,經費30萬元；
2021-2023：雲南省科技廳套用基礎研究青年項目:銅綠微囊藻胞外分泌物中維A酸對滇池金線䰾胚胎的致畸性研究,項目負責人,經費5萬元。
學術論文
近十年發表主要學術論文
1. Sen Zhao, Xuexiu Chang, Jun Li, Yanhua Zhu, Xiaofu Pan, Zexiang Hua, Jiaojiao Li*. The two-way immunotoxicity in native fish induced by exudates of Microcystis aeruginosa: Immunostimulation and immunosuppression. J Hazard Mater. 2024 Jan 5;461:132554.
2. Jiaojiao Li, Xinshuo Chen, Shixiang Zhao, and Jian Chen. Arsenic-Containing Medicine Treatment Disturbed the Human Intestinal Microbial Flora. Toxics. 2023, 11, 458.
3. Chunxiao Sun, Xuexiu Chang, Hugh J MacIsaac, Jiayao Wen, Lixing Zhao, Zhi Dai, Jiaojiao Li*. Phytosphingosine inhibits cell proliferation by damaging DNA in human cell lines. Ecotoxicol Environ Saf. 2023 Mar 29;256:114840.
4. Jiaojiao Li, Jiayao Wen, Chunxiao Sun, Yuan Zhou, Jun Xu, Hugh J MacIsaac, Xuexiu Chang, Qinghua Cui. Phytosphingosine-induced cell apoptosis via a mitochondrially mediated pathway. Toxicology. 2022 Dec;482:153370.
5. Jiaojiao Li*, Chunxiao Sun, Wenwen Cai, Barry P. Rosen, Jian Chen. Insights into S-adenosyl-L-methionine (SAM)-dependent methyltransferase related diseases and genetic polymorphisms. Mutation Research/Reviews in Mutation Research. 2021, 108396, ISSN 1383-5742.
6. Li, J. J.*, L. Yang, C . P. Miao, Y. J. Teng, Z. H. Fu, C. L. Cheng, X. X. Chang, Y. Qian, and L. X. Zhao. 2021. Impact of rhizosphere microorganisms on arsenic (As) transformation and accumulation in a traditional Chinese medical plant. Environ Sci Pollut Res Int. 2021 Nov;28(43):60923-60934.
7. Zhili Peng*，Tianshu Zhao，Yiqun Zhou，Shanghao Li，Jiaojiao Li*，Roger M Leblanc*. Bone Tissue Engineering via Carbon‐based Nanomaterials. Advanced Healthcare Materials 2020, 9, 1901495.
8. Charles Packianathan, Jiaojiao Li, Palani Kandavelu, Banumathi Sankaran, and Barry P. Rosen*，Reorientation of the Methyl Group in MAs(III) is the Rate-Limiting Step in the ArsM As(III) S‐Adenosylmethionine Methyltransferase Reaction，ACS Omega 2018, 3, 3104−3112.
9. Jiaojiao Li，Charles Packianathan，Toby G. Rossman，Barry P. Rosen, Nonsynonymous Polymorphisms in the Human As3mt Arsenic Methylation Gene: Implications for Arsenic Toxicity, Chemical Research in Toxicology, 2017, 30 (7): 1481-1491.
10. Jiaojiao Li，Goutam Mandal，Barry P. Rosen, Expression of Arsenic Resistance Genes in the Obligate Anaerobe Bacteroides Vulgatus Atcc 8482, a Gut Microbiome Bacterium, Anaerobe, *2016, 39: 117-123.
11. Jiaojiao Li，Shashank S. Pawitwar，Barry P. Rosen, The Organoarsenical Biocycle and the Primordial Antibiotic Methylarsenite, Metallomics, 2016, 8 (10): 1047-1055.
12. Zhili Peng, Jiaojiao Li, Shanghao Li, Joel Pardo, Yiqun Zhou, Abdulrahman O. Al-Youbi,Abdulaziz S. Bashammakh, Mohammad S. El-Shahawi, Roger M. Leblanc, Quantification of Nucleic Acid Concentration in the Nanoparticle or Polymer Conjugates Using Circular Dichroism Spectroscopy, Analytical Chemistry, 2018, 90 (3): 2255-2262.
13. Charles Packianathan, Jiaojiao Li, Palani Kandavelu, Banumathi Sankaran, and Barry P. Rosen，Reorientation of the Methyl Group in MAs(III) is the Rate-Limiting Step in the ArsM As(III) S‐Adenosylmethionine Methyltransferase Reaction，ACS Omega 2018, 3, 3104−3112.
14. Jian Chen，Jiaojiao Li，Xuan Jiang，Barry P. Rosen, Conserved Cysteine Residues Determine Substrate Specificity in a Novel as(Iii)-S-Adenosylmethionine Methyltransferase from Aspergillus Fumigatus, Molecular Microbiology, 2017, 104 (2): 250-259.
