朱蔚璞

朱蔚璞，男，博士，浙江大學高分子科學與工程學系副教授，博士生導師。

基本介紹

  • 中文名：朱蔚璞
  • 畢業院校：浙江大學高分子科學與工程學系
  • 學位/學歷：博士
  • 職業：教師
  • 專業方向：可控聚合與反應性高分子、高分子納米藥物、高分子口腔材料
  • 就職院校：浙江大學高分子科學與工程學系
個人經歷,研究方向,主講課程,學術成果,科研項目,發表論文,授權專利,

個人經歷

朱蔚璞，博士、副教授、博士生導師。
專長：高分子合成化學、生物醫用高分子材料。
1979年10月出生於上海市。2001年7月畢業於浙江大學高分子科學與工程學系，獲工學學士學位。
2001年9月～2005年11月於浙江大學高分子科學與工程學系攻讀博士學位，師從沈之荃院士，
2005年12月獲理學博士學位。
2005年12月起任浙江大學高分子科學與工程學系講師，
2007年12月晉升副教授。
2009年12月～2010年12月赴美國卡耐基梅隆大學（Carnegie Mellon University）Matyjaszewski教授課題組留學訪問

研究方向

  1. 可控聚合與反應性高分子
  2. 高分子納米藥物
  3. 高分子口腔材料

主講課程

  1. 《高分子化學實驗》 主講 本科生課程
  2. 《高分子科技英語交流》主講 博士研究生課程
  3. 《高等有機化學》 參與 碩士研究生課程

學術成果

科研項目

  1. 國家自然科學基金項目（No. 21875209），鹼土金屬催化脂肪族聚酯的縮聚合成及其在組織誘導再生術中的套用研究，2019.01-2022.12，項目負責人
  2. 浙江省傑出青年基金項目（No. LR18B040001），基於自催化單體的抗菌聚酯的合成與性能研究，2018.01-2021.12，項目負責人
  3. 國家自然科學基金項目（No. 21674094），基於反應性彈性體微球的可注射高韌性水凝膠的研究，2017.01-2020.12，項目負責人
  4. 國家自然科學基金項目（No. 21274121），稀土催化多官能度水溶性聚醚酯的“一鍋”縮聚合成及其“點擊”凝膠化研究，2013.01-2016.12，項目負責人
  5. 國家自然科學基金項目（No. 51173163），溫敏成骨活性水凝膠的設計、構建及其在口腔種植骨增量中的作用研究，2012.1－2015.12，項目主要成員
  6. 浙江省教育廳科研項目（No. Y201121828），可降解抗菌聚酯的合成與性能研究，2011.12－2012.12，項目負責人
  7. 國家自然科學基金項目（No. 20704036），含杯芳烴聚合物材料的製備與性能研究，2008.01-2010.12，項目負責人

發表論文

  1. Ting Liu, Haimo Zhang, Min Zuo*, Wenqing Zhang, Weipu Zhu, Qiang Zheng. Selective location and migration of poly(methyl methacrylate)- grafted clay nanosheets with low grafting density in poly(methyl methacrylate)/poly (styrene-co-acrylonitrile) blends. Compos Sci Technol, 2019, 169: 110-119
  2. Qiuquan Cai, Shuliang Yang, Chao Zhang, Zimeng Li, Xiaodong Li*, Zhiquan Shen, Weipu Zhu*. Facile and Versatile Modification of Cotton Fibers for Persistent Antibacterial Activity and Enhanced Hygroscopicity. ACS Appl Mater Interfaces, 2018, 10 (44): 38506-38516
  3. Xuefei Sun, Weipu Zhu*, Krzysztof Matyjaszewski*. Protection of Opening Lids: Very High Catalytic Activity of Lipase Immobilized on Core–Shell Nanoparticles. Macromolecules, 2018, 51 (2): 289–296
  4. Chao Zhang, Zhimin Ying, Qiaojie Luo, Hong Du, Ying Wang, Kai Zhang, Shigui Yan, Xiaodong Li*, Zhiquan Shen, Weipu Zhu*.Poly(hexamethylene guanidine)-based hydrogels with long lasting antimicrobial activity and low toxicity. J Polym Sci Pol Chem, 2017, 55 (12): 2027-2035
  5. Jian Sheng, Ying Wang, Qiaojie Luo, Xiaodong Li,* Zhiquan Shen, Weipu Zhu*. Injectable doxorubicin-loaded hydrogel based on dendron-like β-cyclodextrin-poly(ethylene glycol) conjugate.Polym Chem, 2017, 8 (10): 1680-1688
  6. Hong Du, Ying Wang, Xuxia Yao*, Qiaojie Luo, Weipu Zhu*, Xiaodong Li,* Zhiquan Shen. Injectable cationic hydrogels with high antibacterial activity and low toxicity. Polym Chem, 2016, 7 (36): 5620-5624
  7. Ying Wang, Qiaojie Luo, Weipu Zhu*, Xiaodong Li*, Zhiquan Shen. Reduction/pH dual-responsive nano-prodrug micelles for controlled drug delivery. Polym Chem, 2016, 7 (15): 2665-2673
  8. Lilong, Gao, Yadong Chen, Qiaojie Luo, Ying Wang, Xiaodong Li*, Zhiquan Shen, Weipu Zhu*. Injectable camptothecin conjugated hydrogels with simultaneous drug release and degradation. RSC Adv, 2016, 6 (91): 94661-94668
  9. Lilong Gao, Xiaojun Li, Qiaojie Luo, Ying Wang, Weipu Zhu*, Zhiquan Shen, Xiaodong Li*. Injectable thiol-epoxy 'click' hydrogels. J Polym Sci Pol Chem, 2016, 54 (17): 2651-2655
  10. Ying Huang, Rui Sun, Qiaojie Luo, Ying Wang, Kai Zhang, Xuliang Deng, Weipu Zhu*, Xiaodong Li*, Zhiquan Shen.In situ fabrication of paclitaxel-loaded core-crosslinked micelles via thiol-ene 'click' chemistry for reduction-responsive drug release.J Polym Sci Pol Chem, 2016, 54 (1): 99-107
  11. Lilong, Gao, Guangyu Zha, Ying Wang, Qiaojie Luo, Weipu Zhu*, Zhiquan Shen, Xiaodong Li*.An injectable drug-loaded hydrogel using a “clickable” amphiphilic triblock copolymer as a precursor.Polym Chem, 2015, 6 (48): 8240-8243
  12. Lu Xiong, Qiaojie Luo, Ying Wang, Xiaodong Li*, Zhiquan Shen, Weipu Zhu*.An injectable drug-loaded hydrogel based on a supramolecular polymeric prodrug. Chem Commun, 2015, 51 (78): 14644-14647
  13. Weipu Zhu, Lu Xiong, Huan Wang, Guangyu Zha, Hong Du, Xiaodong Li*, Zhiquan Shen.Sustained drug release from an ultrathin hydrogel film. Polym Chem, 2015, 6 (40): 7097-7099
  14. Weipu Zhu, Ying Wang, Xia Cai, Guangyu Zha, Qiaojie Luo, Rui Sun, Xiaodong Li*, Zhiquan Shen. Reduction-triggered release of paclitaxel from in situ formed biodegradable core-cross-linked micelles. J Mater Chem B, 2015, 3 (15): 3024-3031
  15. Ying Wang, Qiaojie Luo, Rui Sun, Guangyu Zha, Xiaodong Li, Zhiquan Shen and Weipu Zhu*. Acid-triggered drug release from micelles based on amphiphilic oligo(ethylene glycol)-doxorubicin alternative copolymer. J Mater Chem B, 2014, 2 (43): 7612-7619
  16. Huan Wang, Guangyu Zha, Hong Du, Lilong Gao, Xiaodong Li*, Zhiquan Shen, Weipu Zhu*. Facile fabrication of ultrathin antibacterial hydrogel films via layer-by-layer “click” chemistry. Polym Chem, 2014, 5 (22): 6489-6494
  17. Ying Huang, Guangyu Zha, Qiaojie Luo, Jianxiang Zhang, Feng Zhang, Xiaohui Li, Shifang Zhao,Weipu Zhu Xiaodong Li*. The construction of hierarchical structure on Ti substrate with superior osteogenic activity and intrinsic antibacterial capability. Sci Rep, 2014, 4: 6172
  18. Ying Wang, Qiaojie Luo, Lilong Gao, Hong, Du, Guangyu Zha, Xiaodong Li, Zhiquan Shen, Weipu Zhu*. A facile strategy to prepare redox-responsive amphiphilic PEGylated prodrug with high drug loading content and low critical micelle concentration. Biomater Sci, 2014, 2 (10):1367-1376
  19. Saadyah Averick, Orsolya Karácsony, Jacob Mohin, Xin Yong, Nicholas M. Moellers, Bradley F. Woodman, Weipu Zhu, Ryan A. Mehl, Anna C. Balazs*, Tomasz Kowalewski*, and Krzysztof Matyjaszewski*. Cooperative, reversible self-assembly of covalently pre-linked proteins into giant fibrous structures. Angew Chem Int Edit, 2014, 53 (31): 8050-8055
  20. Rui Sun, Qiaojie Luo, Chen Gao, Ying Wang, Lilong Gao, Hong Du, Ying Huang, Xiaodong Li, Zhiquan Shen, Weipu Zhu*. Facile fabrication of reduction-responsive nanocarriers for controlled drug release. Polym Chem, 2014, 5 (17): 4879-4883
  21. Hong Du, Guangyu Zha, Lilong Gao, Huan Wang, Zhiquan Shen, Xiaodong Li, Weipu Zhu*. Fully biodegradable antibacterial hydrogels via thiol-ene “click” chemistry. Polym Chem, 2014, 5 (13): 4002-4008 (Cover story, paper of the week)
  22. Weipu Zhu, Lilong Gao, Qiaojie Luo, Chen Gao, Guangyu Zha, Zhiquan Shen, Xiaodong Li*. Metal and light free “click” hydrogels for prevention of postoperative peritoneal adhesions. Polym Chem, 2014, 5 (5): 2018-2026
  23. Lilong Gao, Qiaojie Luo, Ying Wang, Hong Du, Xiaodong Li, Zhiquan Shen, Weipu Zhu*. Facile preparation of shell crosslinked micelles for redox-responsive anticancer drug release.RSC Adv,2014, 4 (8): 4177-4180
  24. Weipu Zhu*, Hong Du, Ying Huang, Shuai Sun, Ning Xu, Huagang Ni, Xia Cai, Xiaodong Li, Zhiquan Shen. Cationic poly(ester-phosphoester)s: Facile synthesis and antibacterial properties.J Polym Sci Pol Chem, 2013, 51 (17): 3667-3673 (Spotlight)
  25. Chen Gao, Ying Wang, Pengfei Gou, Xia Cai, Xiaodong Li, Weipu Zhu*, Zhiquan Shen. Synthesis and characterization of resorcinarene-centered amphiphilic A8B4 miktoarm star copolymers based on poly(ε-caprolactone) and poly(ethylene glycol) by combination of CROP and “click” chemistry. J Polym Sci Pol Chem, 2013, 51 (13): 2824-2833
  26. Ying Wang, Hong Du, Lilong Gao, Huagang Ni, Xiaodong Li, Weipu Zhu*, Zhiquan Shen. Reductively and hydrolytically dual degradable nanoparticles by “click” crosslinking of a multifunctional diblock copolymer. Polym Chem, 2013, 4 (5): 1657-1663
  27. Yu Wang, Mingjiang Zhong, Weipu Zhu, Chi-How Peng, Yaozhong Zhang, Dominik Konkolewicz, Nicola Bortolamei, Abdirisak A. Isse, Armando Gennaro, Krzysztof Matyjaszewski*. Reversible-deactivation radical polymerization in the presence of metallic copper: comproportionation–disproportionation equilibria and kinetics. Macromolecules, 2013, 46 (10): 3793-3802
  28. Chi-How Peng, Mingjiang Zhong, Yu Wang, Yungwan Kwak, Yaozhong Zhang, Weipu Zhu, Matthew Tonge, Johannes Buback, Sangwoo Park, Pawel Krys, Dominik Konkolewicz, Armando Gennaro, Krzysztof Matyjaszewski*. Reversible-deactivation radical polymerization in the presence of metallic copper: activation of alkyl halides by Cu. Macromolecules, 2013, 46 (10): 3803-3815
  29. Weipu Zhu*, Ying Wang, Shuai Sun, Qiujin Zhang, Xiaodong Li, Zhiquan Shen. Facile synthesis and characterization of biodegradable antimicrobial poly(ester-carbonate). J Mater Chem, 2012, 22 (23): 11785-11791
  30. Yaozhong Zhang, Yu Wang, Chihow Peng, Mingjiang Zhong, Weipu Zhu, Dominik Konkolewicz, Krzysztof Matyjaszewski*. Copper-mediated CRP of methyl acrylate in the presence of metallic copper: effect of ligand structure on reaction kinetics. Macromolecules, 2012, 45 (1): 78-86
  31. Kai Zhang, Ying Wang, Weipu Zhu*, Xiaodong Li, Zhiquan Shen. Synthesis, characterization, and micellization of PCL-g-PEG copolymers by combination of ROP and 'Click' chemistry via 'Graft onto' method. J Polym Sci Pol Chem, 2012, 50 (10): 2045-2052
  32. Weipu Zhu, Mingjiang Zhong, Wenwen Li, Hongchen Dong, Krzysztof Matyjaszewski*. Clickable stars by combination of AROP and aqueous AGET ATRP. Macromolecules, 2011, 44 (7): 1920-1926
  33. Weipu Zhu, Alper Nese, Krzysztof Matyjaszewski*. Thermoresponsive star triblock copolymers by combination of ROP and ATRP: from micelles to hydrogels. J Polym Sci Pol Chem, 2011, 49 (9): 1942-1952
  34. Weipu Zhu*, Shuai Sun, Ning Xu, Zhiquan Shen*. Synthesis, characterization, and properties of poly(ester-phosphoester)s by lanthanum triphenolate-catalyzed ring-opening copolymerization. J Polym Sci Pol Chem, 2011, 49 (23): 4886-4893
  35. Weipu Zhu*, Ying Wang, Qiujin Zhang, Zhiquan Shen*. Amphiphilic PEG-grafted poly(ester-carbonate)s: Synthesis and diverse nanostructures in water. J Polym Sci Pol Chem, 2011, 49 (22): 4987-4992
  36. Pengfei Gou, Weipu Zhu*, Zhiquan Shen. Synthesis, self-assembly, and drug-loading capacity of well-defined cyclodextrin-centered drug-conjugated amphiphilic A(14)B(7) miktoarm star copolymers based on poly(epsilon-caprolactone) and poly(ethylene glycol). Biomacromolecules, 2010, 11 (4): 934-943
  37. Pengfei Gou, Weipu Zhu*, Zhiquan Shen. Drug-grafted seven-arm amphiphilic star poly(epsilon-caprolactone-co-carbonate)-b-poly(ethylene glycol)s based on a cyclodextrin core: synthesis and self-assembly behavior in water. Polym Chem, 2010, 1 (8): 1205-1214
  38. Pengfei Gou, Weipu Zhu*, Zhiquan Shen. Calixarene-centered amphiphilic A(2)B(2) miktoarm star copolymers based on poly(epsilon-caprolactone) and poly(ethylene glycol) synthesis and self-assembly behaviors in water. J Polym Sci Pol Chem,2010, 48 (24): 5643-5651
  39. Pengfei Gou, Weipu Zhu*, Ning Xu, Zhiquan Shen*. Synthesis and self-assembly of well-defined cyclodextrin-centered amphiphilic A(14)B(7) multimiktoarm star copolymers based on poly(epsilon-caprolactone) and poly(acrylic acid). J Polym Sci Pol Chem, 2010,48 (14): 2961-2974
  40. Pengfei Gou, Weipu Zhu*, Ning Xu, Zhiquan Shen*. Synthesis, self-assembly and drug-loading capacity of well-defined drug-conjugated amphiphilic A2B2 type miktoarm star copolymers based on poly(epsilon-caprolactone) and poly(ethylene glycol). J Polym Sci Pol Chem, 2009, 47 (24): 6962-6976
  41. Pengfei Gou, Weipu Zhu*, Ning Zhu, Zhiquan Shen*. Synthesis and characterization of novel resorcinarene-centered amphiphilic star-block copolymers consisting of eight ABA triblock arms by combination of ROP, ATRP, and click chemistry. J Polym Sci Pol Chem, 2009, 47 (11): 2905-2916
  42. Feng Chen, Weipu Zhu*, Ning Xu, Zhiquan Shen*. Ring-opening copolymerization of ethylene carbonate and epsilon-caprolactone catalyzed by neodymium tris(2,6-di-tert-buty-4-methylphenolate): Synthesis, characterization, and dynamic mechanic analysis. J Polym Sci Pol Chem, 2008, 46 (12): 4050-4055
  43. Pengfei Gou, Weipu Zhu*, Ning Xu, Zhiquan Shen*. Synthesis and characterization of well-defined cyclodextrin-centered seven-arm star poly(epsilon-caprolactone)s and amphiphilic star poly(epsilon-caprolactone-b-ethylene glycol)s. J Polym Sci Pol Chem, 2008, 46 (19): 6455-6465
  44. Pengfei Gou, Weipu Zhu*, Zhiquan Shen*. Synthesis and characterization of resorcinarene-centered eight-arm poly(epsilon-caprolactone) stars catalyzed by yttrium complex. J Polym Sci Pol Chem, 2008, 46 (6): 2108-2118
  45. Weihui Xie, Weipu Zhu, Zhiquan Shen*. Synthesis, isothermal crystallization and micellization of mPEG-PCL diblock copolymers catalyzed by yttrium complex. Polymer, 2007, 48 (23): 6791-6798
  46. Weipu Zhu, Weihui Xie, Xiaowei Tong, Zhiquan Shen*. Amphiphilic biodegradable poly(CL-b-PEG-b-CL) triblock copolymers prepared by novel rare earth complex: Synthesis and crystallization properties. Eur Polym J, 2007, 43 (8): 3522-3530

授權專利

  1. 朱蔚璞，徐寧，苟鵬飛，沈之荃. 利用稀土催化劑製備磷酸酯聚合物的方法. 專利號：ZL 2010 1 0040017.1，授權日：2012-02-01
  2. 李曉東，朱蔚璞，李曉輝. 一種半互穿網路結構水凝膠敷料的製備方法及套用. 專利號：ZL 2009 1 0154053.8，授權日：2010-04-14
  3. 朱蔚璞，張秋瑾，沈之荃.一種季胺化的可降解抗菌劑的製備方法. 專利號：ZL 2011 1 0007713.7，授權日：2013-06-12
  4. 朱蔚璞，高利龍，李曉東，沈之荃. 可原位注射聚乙二醇型水凝膠及其製備方法. 專利號：ZL 2012 1 0395047.3，授權日：2014-01-08
  5. 朱蔚璞，高利龍，李曉東，沈之荃. 具有溶膠-凝膠轉變特性的溫敏型抗菌嵌段聚合物及其製備方法. 專利號：ZL 2013 1 0228264.8，授權日：2015-04-22
  6. 朱蔚璞，王歡，杜紅，高利龍，沈之荃. 一種超薄抗菌水凝膠薄膜的製備方法 專利號：ZL 2013 1 0672291.4，授權日：2015-07-08
  7. 朱蔚璞，蔡秋泉，朱燕輝. 一種植物油基熱塑性聚酯的合成方法 專利號：ZL 2017 1 0439379.X，授權日：2018-12-07

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