張香蘭，女，1974年出生，朝鮮族，病理學博士，延邊大學醫院病理科副主任、碩士生導師，兼任韓國延世大學醫院研究教授。
研究方向為腫瘤病理。
基本介紹
人物經歷,教育經歷,工作經歷,科學研究,研究領域,科研項目,期刊論文,
人物經歷
教育經歷
1993/9-1998/7 延邊大學醫學院 臨床醫學 學士
1998/9-2001/7 延邊大學醫學院 病理學 碩士
2002/3-2005/2 韓國高麗大學 病理學 博士
工作經歷
2001/9-2002/2 延邊大學醫院 病理科 醫師
2005/3-2006/12 韓國高麗大學 進修
2007/1-2010/09 韓國延世大學 博士後
2010/10-2010/12 韓國延世大學醫院 研究教授
2011/01-2015.12 延邊大學醫院 病理科 醫師 兼 韓國延世大學醫院 研究教授
2016.01-現在 延邊大學醫院 病理科 副主任 兼 韓國延世大學醫院 研究教授
科學研究
研究領域
腫瘤病理
科研項目
國家自然科學基金項目 一項 （2014.01.01~2017.12.31）
期刊論文
[1] Bazarsad S, Zhang X, Kim KY, Illeperuma R, Jayasinghe RD, Tilakaratne WM, Kim J: Identification of a combined biomarker for malignant transformation in oral submucous fibrosis. Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 2016. (Co-first author)
[2] Hwang YS, Ahn SY, Moon S, Zheng Z, Cha IH, Kim J, Zhang X: Insulin-like growth factor-II mRNA binding protein-3 and podoplanin expression are associated with bone invasion and prognosis in oral squamous cell carcinoma. Archives of oral biology 2016, 69:25-32. (Corresponding author)
[3] Zhang X, Cha IH, Kim KY: Use of a Combined Gene Expression Profile in Implementing a Drug Sensitivity Predictive Model for Breast Cancer. Cancer research and treatment : official journal of Korean Cancer Association 2016.
[4] Zhang X, Jung IH, Hwang YS: EGF enhances low-invasive cancer cell invasion by promoting IMP-3 expression. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2016, 37:2555-63.
[5] Chang H, Oh J, Zhang X, Kim YJ, Lee JH, Lee CT, Chung JH, Lee JS: EGFR protein expression using a specific intracellular domain antibody and PTEN and clinical outcomes in squamous cell lung cancer patients with EGFR-tyrosine kinase inhibitor therapy. OncoTargets and therapy 2016, 9:5153-62.
[6] Hwang YS, Lee J, Zhang X, Lindholm PF: Lysophosphatidic acid activates the RhoA and NF-kappaB through Akt/IkappaBalpha signaling and promotes prostate cancer invasion and progression by enhancing functional invadopodia formation. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2016, 37:6775-85.
[7] Zhang X, Shin YK, Zheng Z, Zhu L, Lee IJ: Risk of radiation-induced pneumonitis after helical and static-port tomotherapy in lung cancer patients and experimental rats. Radiation oncology 2015, 10:195.
[8] Zhang X, Park JS, Park KH, Kim KH, Jung M, Chung HC, Rha SY, Kim HS: PTEN deficiency as a predictive biomarker of resistance to HER2-targeted therapy in advanced gastric cancer. Oncology 2015, 88:76-85.
[9] Zhang X, Choi EJ, Zheng Z, Zhu L, Cho SB, Kim KY, Kim J, Cha IH: Apoptotic effect of pheophorbide a-mediated photodynamic therapy on DMBA/TPA-induced mouse papillomas. Lasers in medical science 2015, 30:51-7.
[10] Zheng Z, Zhu L, Zhang X, Li L, Moon S, Roh MR, Jin Z: RUNX3 expression is associated with sensitivity to pheophorbide a-based photodynamic therapy in keloids. Lasers in medical science 2015, 30:67-75.
[11] Kim KY, Zhang X, Cha IH: Identification of human papillomavirus status specific biomarker in head and neck cancer. Head & neck 2015, 37:1310-8.
[12] Zhang X, Zheng Z, Shin YK, Kim KY, Rha SY, Noh SH, Chung HC, Jeung HC: Angiogenic factor thymidine phosphorylase associates with angiogenesis and lymphangiogenesis in the intestinal-type gastric cancer. Pathology 2014, 46:316-24.
[13] Zhang X, Zheng Z, Yingji S, Kim H, Jin R, Renshu L, Lee DY, Roh MR, Yang S: Downregulation of glutathione peroxidase 3 is associated with lymph node metastasis and prognosis in cervical cancer. Oncology reports 2014, 31:2587-92.
[14] Kim KY, Zhang X, Cha IH: Combined genomic expressions as a diagnostic factor for oral squamous cell carcinoma. Genomics 2014, 103:317-22.
[15] Chang H, Zhang X, Cho BC, Park HJ, Kim JH: Tumor MET expression profile predicts the outcome of non-small cell lung cancer patients receiving epidermal growth factor receptor tyrosine kinase inhibitors. Thoracic cancer 2014, 5:517-24.
[16] Bae JY, Kim EK, Yang DH, Zhang X, Park YJ, Lee DY, Che CM, Kim J: Reciprocal interaction between carcinoma-associated fibroblasts and squamous carcinoma cells through interleukin-1alpha induces cancer progression. Neoplasia 2014, 16:928-38.
[17] Kim JM, Jeung HC, Rha SY, Yu EJ, Kim TS, Shin YK, Zhang X, Park KH, Park SW, Chung HC, Powis G: The effect of disintegrin-metalloproteinase ADAM9 in gastric cancer progression. Molecular cancer therapeutics 2014, 13:3074-85.
[18] Pang NS, Lee SJ, Kim E, Shin DM, Cho SW, Park W, Zhang X, Jung IY: Effect of EDTA on attachment and differentiation of dental pulp stem cells. Journal of endodontics 2014, 40:811-7.
[19] Zhang X, Han S, Han HY, Ryu MH, Kim KY, Choi EJ, Cha IH, Kim J: Risk prediction for malignant conversion of oral epithelial dysplasia by hypoxia related protein expression. Pathology 2013, 45:478-83.
[20] Hwang YS, Zhang X, Park KK, Chung WY: An orthotopic and osteolytic model with a newly established oral squamous cell carcinoma cell line. Archives of oral biology 2013, 58:218-25.
[21] Hwang YS, Xianglan Z, Park KK, Chung WY: Functional invadopodia formation through stabilization of the PDPN transcript by IMP-3 and cancer-stromal crosstalk for PDPN expression. Carcinogenesis 2012, 33:2135-46.
[22] Kim KY, Li S, Cha JD, Zhang X, Cha IH: Significance of molecular markers in survival prediction of oral squamous cell carcinoma. Head & neck 2012, 34:929-36.
[23] Choi EJ, Zhang X, Kim HJ, Nam W, Cha IH: Prognosis of gingival squamous cell carcinoma diagnosed after invasive procedures. Asian Pacific journal of cancer prevention : APJCP 2011, 12:2649-52.
[24] Zhang X, Yang JJ, Kim YS, Kim KY, Ahn WS, Yang S: An 8-gene signature, including methylated and down-regulated glutathione peroxidase 3, of gastric cancer. International journal of oncology 2010, 36:405-14.
[25] Ahn JB, Rha SY, Shin SJ, Jeung HC, Kim TS, Zhang X, Park KH, Noh SH, Roh JK, Chung HC: Circulating endothelial progenitor cells (EPC) for tumor vasculogenesis in gastric cancer patients. Cancer letters 2010, 288:124-32.
[26] Moon YW, Rha SY, Zhang X, Jeung HC, Yang WI, Kwon O, Jeong JH, Cheon SH, Yoo NC, Chung HC: Increments of alpha-dystroglycan expression in liver metastasis correlate with poor survival in gastric cancer. Journal of surgical oncology 2009, 100:459-65.
[27] Lee JH, Zhang X, Shin BK, Lee ES, Kim I: Mac-2 binding protein and galectin-3 expression in mucinous tumours of the ovary: an annealing control primer system and immunohistochemical study. Pathology 2009, 41:229-33.
[28] Kim HO, Yang KM, Kang IS, Koong MK, Kim HS, Zhang X, Kim I: Expression of CD44s, vascular endothelial growth factor, matrix metalloproteinase-2 and Ki-67 in peritoneal, rectovaginal and ovarian endometriosis. The Journal of reproductive medicine 2007, 52:207-13.
[29] Lee JH, Cho SJ, Zhang X, Zheng Z, Lee ES, Kim A, Kim YS, Chae YS, Kim I: nm23-H1 protein expression and gene mutation in 150 patients with non-Hodgkin's lymphomas. Journal of Korean medical science 2006, 21:645-51.
[30] Lin Z, Gao M, Zhang X, Kim YS, Lee ES, Kim HK, Kim I: The hypermethylation and protein expression of p16 INK4A and DNA repair gene O6-methylguanine-DNA methyltransferase in various uterine cervical lesions. Journal of cancer research and clinical oncology 2005, 131:364-70.
[31] Lee JH, Zhang X, Jung WY, Chae YS, Park JJ, Kim I: DNA ploidy and c-Kit mutation in gastrointestinal stromal tumors. World journal of gastroenterology 2004, 10:3475-9.
[32] Zhang X, Lin Z, Kim I: Pax5 expression in non-Hodgkin's lymphomas and acute leukemias. Journal of Korean medical science 2003, 18:804-8.
