張家毓，畢業於加拿大不列顛哥倫比亞大學，上海交通大學醫學院附屬第九人民醫院上海精準醫學研究院研究員、研究組長、博士生導師。
基本介紹
- 中文名：張家毓
- 畢業院校：加拿大不列顛哥倫比亞大學
人物經歷,研究方向,研究成果,
人物經歷
2006年畢業於加拿大不列顛哥倫比亞大學，獲生物化學系學士學位。
2012年畢業於加拿大不列顛哥倫比亞大學，獲實驗醫學系博士學位。
2012年至2017年在美國史丹福大學巴斯特幹細胞實驗室從事博士後研究。
2017年至2018年在中美國史丹福大學巴斯特幹細胞實驗室以及斯坦福心血管系任講師、研究助理。
2018年起在上海交通大學醫學院附屬第九人民醫院上海精準醫學研究院任研究員、研究組長、博士生導師。
研究方向
長期從事遺傳性心肌病，通過臨床樣本、小鼠模型、人誘導性幹細胞（hiPSC）衍生心肌細胞為模型以及縮印水凝膠技術來闡明心肌衰老過程及心臟纖維化過程機理。張家毓實驗室還計畫通過建立疾病樣本和hiPSC，通過基因測序、臨床數據分析來建立遺傳性心肌病藥篩平台。
研究成果
1. Omer AD, Zago M, Chang A, Dennis PP*. Probing the structure and function of an archaeal C/D-box methylation guide sRNA. RNA. 12(9):1708-1720.
2. Fu Y, Chang A, Chang L, Niessen K, Eapen S, Setiadi A, and Karsan A*. Differential regulation of TGFbeta signaling pathways by notch in human endothelial cells. J Biol Chem 284(29): 19452-62.
3. Vrljicak P, Chang AC, Morozova O, Wederell ED, Niessen K, Marra MA, Karsan A and Hoodless PA*. Genomic Analysis Distinguishes Phases of Early Development of the Mouse Atrio-Ventricular Canal. Physiological Genomics 40(3): 150-7.
4. Fu Y#, Chang AC#, Fournier M, Chang L, Niessen K, and Karsan A*. RUNX3 maintains the mesenchymal phenotype after termination of the notch signal. (*co-author). J Biol Chem 286(13): 11803-13.
5. Chang AC, Fu YX, Garside VC, Niessen K, Chang L, Fuller M, Setiadi A, Smrz J, Kyle A, Minchinton A, Marra M, Hoodless P, and Karsan A*. Notch initiates the endothelial-to-mesenchymal transition in the atrioventricular canal through autocrine activation of soluble guanylyl cyclase. Developmental Cell 21(2): 288-300.
6. Vrljicak P, Cullum R, Xu E, Chang AC, Wederell ED, Bilenky M, Jones SJ, Marra MA, Karsan A and Hoodless PA*. Twist1 transcriptional targets in the developing atrio-ventricular canal of the mouse. PLoS One 7(7):e40815.
7. Garside VC, Chang AC, Karsan A and Hoodless PA*. Co-ordinating Notch, BMP, and TGFβ Signalling During Heart Valve Development. Cellular and Molecular Life Sciences 70(16):2899-917.
8. Chang AC, Patenaude A, Lu K, Fuller M, Ly M, Kyle A, Golbidi S, Wang Y, Walley K, Minchinton A, Laher I, Karsan A*. Notch-Dependent Regulation of the Ischemic Vasodilatory Response. Arterioscler Thromb Vasc Biol. 33(3):510-2.
9. El-Sehemy A, Chang A, Azad AK, Gupta N, Xu Z, Steed H, Karsan A, Fu Y*. Notch activation augments nitric oxide/soluble guanylyl cyclase signaling in immortalized ovarian surface epithelial cells and ovarian cancer cells. Cell Signal. 25(12):2780-7.
10. Chang AC, Garside VC, Fournier M, Smrz J, Vrljicak P, Umlandt P, Fuller M, Robertson G, Zhao Y, Tam A, Jones SJ, Marra MA, Hoodless PA, Karsan A*. A Notch-dependent transcriptional hierarchy promotes mesenchymal transdifferentiation in the cardiac cushion. Dev Dyn. 243(7): 894-905.
11. Burridge PW, Li YF, Matsa E, Wu H, Ong S-G, Sharma A, Holmstrom A, Chang AC, Coronado MJ, Ebert AD, Knowles JW, Telli ML, Witteles RM, Blau HM, Bernstein D, Altman RB and Wu JC*. Human induced pluripotent stem cell-derived cardiomyocytes recapulate the predilection of breast cancer patients to doxorubicin-induced cardiotoxicity. Nature Medicine 22(5):547-56. PMCID: PMC5086256
12. Chang AC, Ong SG, LaGory E, Kraft P, Giaccia AJ, Wu JC, Blau HM*. Telomere shortening and metabolic compromise underlie dystrophic cardiomyopathy. Proc Natl Acad Sci U S A. 113(46): 13120-13125. PMID: 27799523.
13. Yucel N, Chang AC, Day JW, Rosenthal N, Blau HM*. Humanizing the mdx mouse model of DMD: the long and the short of it. npj Regenerative Medicine. 2018 Feb 16
3:4. PMID: 29479480 PMCID: PMC5816599.
14. Chang AC* and Blau HM*. Short Telomeres - A Hallmark of Heritable Cardiomyopathies. Differentiation 100:31-36. PMID: 29482077 PMCID: PMC5889329.
15. Parikh VN, Liu J, Shang C, Woods C, Chang AC, Zhao M, Charo DN, Grunwald Z, Huang Y, Seo K, Tsao PS, Bernstein D, Ruiz-Lozano P, Quertermous T, and Ashley EA*. (2018) Apelin and APJ orchestrate complex tissue-specific control of cardiomyocyte hypertrophy and contractility in the hypertrophy-heart failure transition. American Journal of Physiology-Heart and Circulatory Physiology 315(2):H348-H356. PMID: 29775410.
16. Chang ACY*, Chang ACH, Kirillova A, Sasagawa K, Su W, Weber G, Lin J, Termglinchan V, Karakikes I, Seeger T, Dainis AM, Hinson JT, Seidman J, Seidman CE, Day JW, Ashley E, Wu JC, and Blau HM*. (2018) Telomere shortening is a hallmark of genetic cardiomyopathies. Proc Natl Acad Sci U S A. 115(37): 9276-9281. PMID: 30150400
17. Chang ACY*, Chang ACH, Nicin L, Weber GJ, Holbrook C, Davis MF, Blau HM, and Bertaccini EJ*. An In Vitro Model for Identifying Cardiac Side Effects of Anesthetics. Anesth Analg 2020 Jan
130(1):e1-e4. PMID: 30198930
18. Zhang JZ, Termglinchan V, Shao NY, Itzhaki I, Liu C, Ma N, Tian L, Wang VY, Chang ACY, Guo H, Kitani T, Wu H, Lam CK, Kodo K, Sayed N, Blau HM, Wu JC*. A Human iPSC Double-Reporter System Enables Purification of Cardiac Lineage Subpopulations with Distinct Function and Drug Response Profiles. Cell Stem Cell. 2019 May 2
24(5):802-811.
19. Wu H, Yang H, Rhee JW, Zhang JZ, Lam CK, Sallam K, Chang ACY, Ma N, Lee J, Zhang H, Blau H, Bers DM, and Wu JC*. Modelling diastolic dysfunction in induced pluripotent stem cell-derived cardiomyocytes from hypertrophic cardiomyopathy patients. Eur Heart Journal. 2019 Dec 1
40(45):3685-3695.
20. Cordero P, Parikh VN, Chin ET, Erbilgin A, Gloudemans MJ, Shang C, Huang Y, Chang AC, Smith KS, Dewey F, Zaleta K, Morley M, Brandimarto J, Glazer N, Waggott D, Pavlovic A, Zhao M, Moravec CS, Tang WHW, Skreen J, Malloy C, Hannenhalli S, Li H, Ritter S, Li M, Bernstein D, Connolly A, Hakonarson H, Lusis AJ, Margulies KB, Depaoli-Roach AA, Montgomery SB, Wheeler MT, Cappola T, Ashley EA*. Pathologic gene network rewiring implicates PPP1R3A as a central regulator in pressure overload heart failure. Nat Commun. 2019 Jun 24
10(1):2760. doi: 10.1038/s41467-019-10591-5.
21. LaRocca TJ , Seeger T, Prado M , Perea-Gil I, Neofytou E, Mecham BH, Ameen M, Chang ACY, Pandey G, Wu JC, Karakikes I*. Pharmacological Silencing of MicroRNA-152 Prevents Pressure Overload-Induced Heart Failure. Circ Heart Fail. 2020 Mar
13(3):e006298. doi: 10.1161/CIRCHEARTFAILURE.119.006298. Epub 2020 Mar 12.
22. Dainis A, Zaleta-Rivera K, Ribeiro A, Chang ACH, Shang C, Lan F, Burridge PW, Liu WR, Wu JC, Chang ACY, Pruitt BL, Wheeler M, Ashley E*. Silencing of MYH7 ameliorates disease phenotypes in human iPSC-cardiomyocytes. Physiol Genomics. 2020 Jul 1
52(7):293-303. doi: 10.1152/physiolgenomics.00021.2020. Epub 2020 Jun 22.
23. Li B, Xiong W, Liang WM, Chiou JS, Lin YJ, Chang ACY*. Targeting of CAT and VCAM1 as Novel Therapeutic Targets for DMD Cardiomyopathy. Front Cell Dev Biol. 2021 Apr 1
9:659177. doi: 10.3389/fcell.2021.659177
24. Chang ACY*, Pardon G, Chang ACH, Wu H, Ong SG, Eguchi A, Ancel S, Holbrook C, Ramunas J, Ribeiro AJS, LaGory EL, Wang H, Koleckar K, Giaccia A, Mack DL, Childers MK, Denning C, Day JW, Wu JC, Pruitt BL, and Blau HM*. Increased Tissue Stiffness Triggers Contractile Dysfunction and Telomere Shortening in Dystrophic Cardiomyocytes. Stem Cell Reports. 2021 June in press.
2024年4月，上海交通大學醫學院附屬第九人民醫院、上海精準醫學研究院張家毓團隊、卞遷團隊和第四軍醫大學馬恆團隊合作在《核酸研究》（《Nucleic Acids Research》）（影響因子14.16）上發表一項研究成果，揭示了非分裂端粒縮短誘發心肌細胞衰老的分子機制，確定了短端粒驅動心肌加速衰老的關鍵因素FOXC1，並為抗心臟衰老提供了新靶向治療的理論依據。
