姜天霞,北京師範大學生命科學學院副教授。
基本介紹
- 中文名:姜天霞
- 職業:教師
- 任職院校:北京師範大學
個人簡歷,代表性研究成果,
個人簡歷
2008年,本科畢業於武漢大學生命科學學院;2013年,博士畢業於中國科學學院生物物理研究所,師從閻錫蘊院士;2013年-2014年, 於中國科學院遺傳與發育研究所任助理研究員;2015年1月-至今,任教於北京師範大學生命科學學院。2018年獲得碩士研究生導師資格。2020年獲得博士研究生導師資格。主持國家自然科學基金青年項目、北京市自然科學基金面上項目、以及國家重點研發計畫分課題,參與國家自然科學基金重點項目和藥企橫向項目等。承擔本科生雙語《分子生物學》國家精品課程,《腫瘤靶向治療與人類健康》及《細胞生物學實驗》等課程。曾任2016級生科院本科生輔導員,並於2019年12月,榮獲“北京師範大學優秀輔導員”稱號。2021年,榮獲北京師範大學第十五屆勵耘青年教師二等獎。2023年獲北京師範大學“仲英青年學者”稱號。
代表性研究成果
研究性論文:(共同第一作者;*通訊作者)
1. Shuo-Shuo Liu; Tian-Xia Jiang; Fan Bu; Ji-Lan Zhao; Guang-Fei Wang; Guo-Heng Yang; Jie-Yan Kong; Yun-Fan Qie; Pei Wen; Li-Bin Fan; Ning-Ning Li*; Ning Gao*; Xiao-Bo Qiu*; Molecular mechanisms underlying the BIRC6-mediated regulation of apoptosis and autophagy, Nature Communications, 2024, Jan 30;15(1):891.(IF:16.6)
2. Zi-Yu Luo; Tian-Xia Jiang; Tao Zhang; Ping Xu* and Xiao-Bo Qiu*; Ubiquitin Ligase Nrdp1 Controls Autophagy-Associated Acrosome Biogenesis and Mitochondrial Arrangement during Spermiogenesis. Cells, 2023, 12, 2211 (IF: 6.0)
3.Chen YS, Han X, Lin K, Jiang TX*, Qiu XB*. (2021). Proteasome Activator Blm10 Regulates Transcription Especially During Aging. Curr Genomics. 2021 Dec 16;22(4):306-317.
4. Jiang, T.X., Ma Shuang, Han Xia, ..., Lin Kui* and Qiu, X.B*. (2021). Proteasome activator PA200 maintains stability of histone marks during transcription and aging. Theranostics, 2021; 11(3): 1458-1472. doi: 10.7150/thno.48744. (IF:11.6)
5. Zi-Hui Zhang, Tian-Xia Jiang*, Lian-Bin Chen, Wenhui Zhou, Yixun Liu, Fei Gao, and Xiao-Bo Qiu*. (2021) Proteasome subunit a4s is essential for formation of spermatoproteasomes and histone degradation during meiotic DNA repair in spermatocytes. The Journal of Biological Chemistry, 2021 Jan-Jun;296:100130. (IF:4.23)
6. Jiang, T.X., ..., Goldberg*, A.L. and Qiu, X.B*. (2019). SIP/CacyBP promotes autophagy by regulating levels of BRUCE/Apollon, which stimulates LC3-I degradation. Proc. Natl. Acad. Sci. USA, 2019.116(27):13404-13413. (IF:9.5)
7. Jiang, T.X, …, Yan XY*. CD146 is a coreceptor for VEGFR-2 in tumor angiogenesis. Blood, 2012, Sep 13;120(11):2330-9. (IF:10.8)
8. Hao Yang; Tianxia Jiang; Libin Fan; Xiaobo Qiu ; lncRNA LINC00960 promotes apoptosis by sponging ubiquitin ligase Nrdp1-targeting miR-183-5p, Acta Biochimica et Biophysica Sinica, 2023,55(1): 91-102.
9.Lian-Bin Chen, Shuang Ma, Tian-Xia Jiang, Xiao-Bo Qiu*. Transcriptional upregulation of proteasome activator Blm10 antagonizes cellular aging. Biochem Biophys Res Commun. 2020 Nov 5;532(2):211-218. doi: 10.1016/j.bbrc.2020.07.003. Epub 2020 Aug 27.
10. Zijian Li, Luming Zhou, Tian-xia Jiang, Xiaobo Qiu*.Proteasomal deubiquitinase UCH37 inhibits degradation of β-catenin and promotes cell proliferation and motility., Acta Biochim Biophys Sin, 2019, Volume 51, Issue 3, 277–284.
11. Yesheng Yin†, Qianqian Zhu†, Tian-xia Jiang, Libin Fan* & Xiaobo Qiu*. Targeting histones for degradation in cancer cells as a novel strategy in cancer treatment. Science China Life Sciences, 2019, Aug;62(8):1078-1086.
12. Ya-nan Liang,Yue Zhuang, Tian-xia Jiang *, Xiao-bo Qiu *. Long Noncoding RNA YLB regulates expression of multiple genes in subtelomeric region.中國生化藥物雜誌,2017.01.001
13. Jie Zhuang, Tian-xia Jiang, …, Yan XY. NADPH oxidase 4 mediates reactive oxygen species induction of CD146 dimerization in VEGF signal transduction. Free radical biology & medicine, 2010, 49, 227-236.
14. 陳禹杉,姜天霞,周魯明,馮仁田,邱小波*. 泛素-蛋白酶體通路與藥物研發.中國生化藥物雜誌,2016.12.001
15. 魏文毅;…,姜天霞; …,邱小波*;類泛素蛋白及其中文命名, 科學通報, 2018, (25): 2564-2569.
綜述:
1. 姜天霞*,邱小波*. PA200蛋白酶體介導蛋白質降解的功能及作用機制,中國科學:生命科學,2022,第52 卷第8 期: 1129 ~ 1136.
2. Jiang, T.X.*, Zhao, M., and Qiu, X.B*. Substrate receptors of proteasomes. Biological Reviews, 2018, 93, 1765-1777. (IF:11.6)
專著:
1. 邱小波、張宏、王琛和王琳芳 主編。《泛素家族介導的蛋白質降解和細胞自噬》,科學出版社 (2020年),本人任編委。
