博士，副教授，生物反應器工程國家重點實驗室固定成員。2009年3月取得東京大學博士學位。2009年4月至2014年8月先後在東京大學和日本筑波大學做博士後研究工作。2011年4月至 2013年3月期間任職日本學術振興會(JSPS)特別研究員。2014年11月受聘於華東理工大學生物工程學院納米生物工程實驗室“千人計畫”團隊。入選上海市浦江人才（A類），華理青年英才引進與培育計畫，生工學院優秀青年教師培育計畫。主持國家自然科學基金面上項目，上海市浦江人才項目，國家重點實驗室開放課題等多個項目。以第一作者身份在Nature Chemical Biology, Applied Environmental Microbiology等著名期刊上發表論文多篇。
基本介紹
- 中文名：周勝敏
- 國籍：中國
- 民族：漢
- 出生地：河北省石家莊市
- 職業：教育及科研工作者
- 學位/學歷：博士
研究及工作經歷,研究內容,研究方向,代表論文,
研究及工作經歷
2009年4月——2014年8月東京大學、日本筑波大學博士後研究工作
2011年4月——2013年3月日本學術振興會(JSPS)特別研究員
2014年11月——至今 華東理工大學生物工程學院納米生物工程實驗室千人計畫科研團隊
研究內容
研究領域為環境微生物、病原微生物及工業微生物的分子生物學。探索微生物環境脅迫、信號傳導及次級代謝調控等相關的諸多功能基因，活用這些基因使之服務於工業，農業，醫療衛生等領域。長期以來以模型真菌為研究對象，探索了天然免疫殺菌分子一氧化氮（NO）的殺菌機制及病原菌應對NO的抗逆機制，鑑定出一系列新型NO抗性功能基因，並闡明了其抗性原理，為新型抗真菌藥物開發提供了理論基礎。近期又開展了微生物氧化應激及與之對應的信號傳導、細胞凋亡與衰老等相關機制研究。
研究方向
1.真菌的NO抗性分子機制解析及抗真菌藥物殺菌靶點的定位
2.真菌的氧化應激抗性體系的解析及新型殺菌靶點的探索
3.真菌有用次級代謝產物合成途徑及其調控機制的研究
2.真菌的氧化應激抗性體系的解析及新型殺菌靶點的探索
3.真菌有用次級代謝產物合成途徑及其調控機制的研究
4.工業微生物生物被膜形成的分子機制及其集群效應
5.智慧型型絲狀真菌蛋白表達體系的開發
6.活體檢測生物探針的開發
代表論文
(1).Yao Zhou,Shengmin Zhou*, Haijun Yu, Jingyi Li, Yang Xia, Baoyi Li, Xiaoli Wang, Ping Wang*. Cloning and characterization of filamentous fungal S-nitrosoglutathione reductase from Aspergillus nidulans. Journal of Microbiology and Biotechnology. In press, doi: 10.4014/jmb.1512.12009, Feb, 2016
(2).Jia Wei, Xiaodan Cao,Shengmin Zhou, Chao Chen, Haijun Yu, Yao Zhou, Ping Wang. Soluble expression and purification of the catalytic domain of human vascular endothelial growth factor receptor 2 in Escherichia coli.Journal of Microbiology and Biotechnology. 25(8): 1227-1233, 2015
(3).Shunsuke Masuo, Lisa Osada, Shengmin Zhou, Tomoya Fujita, Naoki Takaya. Aspergillus oryzae pathways that convert phenylalanine into the flavor volatile 2-phenylethanol.Fungal Genetics and Biology. 77: 22-30, 2015.
(4).Shengmin Zhou and Naoki Takaya. Novel fungal nitrosothionein peptide involved in tolerance to nitric oxide. Bioscience&industry. 72(2): 55-56, 2014.
(5).Masanori Toyofuku, Shengmin Zhou, Isao Sawada, Naoki Takaya, Hiroo Uchiyama and Nobuhiko Nomura. Membrane vesicle formation is associated with pyocin production under denitrifying conditions in Pseudomonas aeruginosa PAO1.Environmental Microbiology.16(9):2927-2938, Sep, 2014,
(6).Shengmin Zhou, Toshiaki Narukami, ShunsukeMasuo, Motoyuki Shimizu, Tomoya Fujita, Yuki Doi, Yosuke Kamimura, Naoki Takaya. NO-inducible nitrosothionein mediates NO removal in tandem with thioredoxin. Nature Chemical Biology. 9(10): 657-663, Aug, 2013.
(7).Tomoya Fujita, HieuDuc Nguyen, Takashi Ito, Shengmin Zhou, Lisa Osada, Seiji Tateyama, Tatsuo Kaneko, Naoki Takaya. Microbial monomers custom-synthesized to build true bio-derived aromatic polymers. Applied Microbiology and Biotechnology. 97(20):8887-8894, Aug, 2013.
(8).Wenjing Cui, Xiaoyan Yang, Yueqin Fang, Shengmin Zhou, Song Liu, Guocheng Du, Kun Du, Jian Chen, Guanjun Tao and Zhemin Zhou. Discovery of two transglutaminases derived from same zymogen for the Streptomyces hygroscopicus and analysis of their formation processes. Journal of the Science of Food and Agriculture. 93(7): 1711-1717, May, 2013.
(9).Morio Miyahara, Sang-Wan Kim,Shengmin Zhou, Shinya Fushinobu, Takeshi Yamada, Wakako Ikeda-Ohtsubo, Akira Watanabe, Keisuke Miyauchi, Ginro Endo and Hirofumi Shoun. Survival of the aerobic denitrifier Pseudomonas stutzeri strain TR2 during co-culture with activated sludge under denitrifying conditions. Bioscience, Biotechnology, and Biochemistry. 76(3): 495-500, Mar, 2012.
(10).Shengmin Zhou, Toshiaki Narukami, Misuzu Nameki, Tomoko Ozawa, Yosuke Kamimura, Takayuki Hoshino and Naoki Takaya. Heme-biosynthetic porphobilinogen deaminase protects Aspergillus nidulans from nitrosative stress. Applied and Environmental Microbiology. 78(1): 103-109, Jan, 2012.
(11).Shengmin Zhou, Shinya Fushinobu, Sang-Wan Kim, Yoshito Nakanishi, Jun-ichi Maruyama, Katsuhiko Kitamoto, Takayoshi Wakagi, and Hirofumi Shoun. Functional analysis and subcellular location of two flavohemoglobins from Aspergillus oryzae. Fungal Genetics and Biology.48(2): 200-207, Feb, 2011.
(12).Sang-Wan Kim, Shinya Fushinobu, Shengmin Zhou, Takayoshi Wakagi and Hirofumi Shoun. The possible involvement of copper-containing nitrite reductase (NirK) and flavohemoglobin in denitrification by the fungus Cylindrocarpon tonkinense. Bioscience, Biotechnology, and Biochemistry.74 (7): 1403-1407, Jul, 2010.
(13).Shengmin Zhou*, Yoshito Nakanishi*, Shinya Fushinobu, Sang-Wan Kim, Jun-ichi Maruyama, Katsuhiko Kitamoto, Takayoshi Wakagi, and Hirofumi Shoun. A eukaryotic copper-containing nitrite reductase derived from a NirK homolog gene of Aspergillus oryzae. Bioscience, Biotechnology, and Biochemistry.74(5):984-991, May, 2010.
(14).Shengmin Zhou, Shinya Fushinobu, Sang-Wan Kim, Yoshito Nakanishi, TakayoshiWakagi, and Hirofumi Shoun. Aspergillus oryzae flavohemoglobins promote oxidative damage by hydrogen peroxide. Biochemical and Biophysical Research Communications.394(3):558-561, Apr, 2010.
(15).Sang-Wan Kim, Shinya Fushinobu, Shengmin Zhou, Takayoshi Wakagi, and Hirofumi Shoun. Eukaryotic nirK genes encoding copper-containing nitrite reductase: originating from the protomitochondrion? Applied and Environmental Microbiology. 75 (9): 2652-2658, Mar, 2009.
(16).Shengmin Zhou, Shinya Fushinobu, Yoshito Nakanishi, Sang-Wan Kim, Takayoshi Wakagi and Hirofumi Shoun. Cloning and characterization of two flavohemoglobins from Aspergillus oryzae.Biochemical and Biophysical Research Communications.381 (1): 7-11, Jan, 2009.
(2).Jia Wei, Xiaodan Cao,Shengmin Zhou, Chao Chen, Haijun Yu, Yao Zhou, Ping Wang. Soluble expression and purification of the catalytic domain of human vascular endothelial growth factor receptor 2 in Escherichia coli.Journal of Microbiology and Biotechnology. 25(8): 1227-1233, 2015
(3).Shunsuke Masuo, Lisa Osada, Shengmin Zhou, Tomoya Fujita, Naoki Takaya. Aspergillus oryzae pathways that convert phenylalanine into the flavor volatile 2-phenylethanol.Fungal Genetics and Biology. 77: 22-30, 2015.
(4).Shengmin Zhou and Naoki Takaya. Novel fungal nitrosothionein peptide involved in tolerance to nitric oxide. Bioscience&industry. 72(2): 55-56, 2014.
(5).Masanori Toyofuku, Shengmin Zhou, Isao Sawada, Naoki Takaya, Hiroo Uchiyama and Nobuhiko Nomura. Membrane vesicle formation is associated with pyocin production under denitrifying conditions in Pseudomonas aeruginosa PAO1.Environmental Microbiology.16(9):2927-2938, Sep, 2014,
(6).Shengmin Zhou, Toshiaki Narukami, ShunsukeMasuo, Motoyuki Shimizu, Tomoya Fujita, Yuki Doi, Yosuke Kamimura, Naoki Takaya. NO-inducible nitrosothionein mediates NO removal in tandem with thioredoxin. Nature Chemical Biology. 9(10): 657-663, Aug, 2013.
(7).Tomoya Fujita, HieuDuc Nguyen, Takashi Ito, Shengmin Zhou, Lisa Osada, Seiji Tateyama, Tatsuo Kaneko, Naoki Takaya. Microbial monomers custom-synthesized to build true bio-derived aromatic polymers. Applied Microbiology and Biotechnology. 97(20):8887-8894, Aug, 2013.
(8).Wenjing Cui, Xiaoyan Yang, Yueqin Fang, Shengmin Zhou, Song Liu, Guocheng Du, Kun Du, Jian Chen, Guanjun Tao and Zhemin Zhou. Discovery of two transglutaminases derived from same zymogen for the Streptomyces hygroscopicus and analysis of their formation processes. Journal of the Science of Food and Agriculture. 93(7): 1711-1717, May, 2013.
(9).Morio Miyahara, Sang-Wan Kim,Shengmin Zhou, Shinya Fushinobu, Takeshi Yamada, Wakako Ikeda-Ohtsubo, Akira Watanabe, Keisuke Miyauchi, Ginro Endo and Hirofumi Shoun. Survival of the aerobic denitrifier Pseudomonas stutzeri strain TR2 during co-culture with activated sludge under denitrifying conditions. Bioscience, Biotechnology, and Biochemistry. 76(3): 495-500, Mar, 2012.
(10).Shengmin Zhou, Toshiaki Narukami, Misuzu Nameki, Tomoko Ozawa, Yosuke Kamimura, Takayuki Hoshino and Naoki Takaya. Heme-biosynthetic porphobilinogen deaminase protects Aspergillus nidulans from nitrosative stress. Applied and Environmental Microbiology. 78(1): 103-109, Jan, 2012.
(11).Shengmin Zhou, Shinya Fushinobu, Sang-Wan Kim, Yoshito Nakanishi, Jun-ichi Maruyama, Katsuhiko Kitamoto, Takayoshi Wakagi, and Hirofumi Shoun. Functional analysis and subcellular location of two flavohemoglobins from Aspergillus oryzae. Fungal Genetics and Biology.48(2): 200-207, Feb, 2011.
(12).Sang-Wan Kim, Shinya Fushinobu, Shengmin Zhou, Takayoshi Wakagi and Hirofumi Shoun. The possible involvement of copper-containing nitrite reductase (NirK) and flavohemoglobin in denitrification by the fungus Cylindrocarpon tonkinense. Bioscience, Biotechnology, and Biochemistry.74 (7): 1403-1407, Jul, 2010.
(13).Shengmin Zhou*, Yoshito Nakanishi*, Shinya Fushinobu, Sang-Wan Kim, Jun-ichi Maruyama, Katsuhiko Kitamoto, Takayoshi Wakagi, and Hirofumi Shoun. A eukaryotic copper-containing nitrite reductase derived from a NirK homolog gene of Aspergillus oryzae. Bioscience, Biotechnology, and Biochemistry.74(5):984-991, May, 2010.
(14).Shengmin Zhou, Shinya Fushinobu, Sang-Wan Kim, Yoshito Nakanishi, TakayoshiWakagi, and Hirofumi Shoun. Aspergillus oryzae flavohemoglobins promote oxidative damage by hydrogen peroxide. Biochemical and Biophysical Research Communications.394(3):558-561, Apr, 2010.
(15).Sang-Wan Kim, Shinya Fushinobu, Shengmin Zhou, Takayoshi Wakagi, and Hirofumi Shoun. Eukaryotic nirK genes encoding copper-containing nitrite reductase: originating from the protomitochondrion? Applied and Environmental Microbiology. 75 (9): 2652-2658, Mar, 2009.
(16).Shengmin Zhou, Shinya Fushinobu, Yoshito Nakanishi, Sang-Wan Kim, Takayoshi Wakagi and Hirofumi Shoun. Cloning and characterization of two flavohemoglobins from Aspergillus oryzae.Biochemical and Biophysical Research Communications.381 (1): 7-11, Jan, 2009.
