劉莉潔，女，東南大學醫學院生理學系教授，主要研究方向為噪聲暴露對聽覺系統及非聽覺系統的損傷效應及機制研究等。
基本介紹
- 中文名：劉莉潔
- 職業：教師
- 專業方向：噪聲暴露對聽覺系統及非聽覺系統的損傷效應及機制研究
- 職稱：教授
- 任職院校：東南大學醫學院生理學系
工作經歷,研究方向,學術成果,榮譽獎項,
工作經歷
現任東南大學醫學院生理學系教授。
研究方向
1、噪聲暴露對聽覺系統及非聽覺系統的損傷效應及機制研究
2、認知/情緒行為異常的神經機制研究
學術成果
主持參與項目
主持並完成國家自然科學基金面上項目一項（KCNQ1 通道在胰腺β細胞內分泌功能中的作用，2012-2014）；
現主持國家自然科學基金面上項目兩項（噪聲性聽力損失對認知功能的損傷效應及其海馬相關機制研究，2017-2020；小膠質細胞在噪聲性聽力 小鼠認知損傷中的作用及機制研究，2021-2023）；
曾為主參與國家自然科學基金面上項目三項（都已結題）。
論文論著
[1] Kim MJ, Haroon S, Chen GD, Ding D,Wanagat J, Liu L, Zhang Y, White K, Park HJ, Han C, Boyd K, Caicedo I, Evans K,Linser PJ, Tanokura M, Prolla T, Salvi R, Vermulst M, Someya S: Increasedburden of mitochondrial DNA deletions and point mutations in early-onsetage-related hearing loss in mitochondrial mutator mice. Exp Gerontol 2019,125:110675.
[2] LiuLJ, Huang Y, Fang C, Zhang HY, Yang J, Xuan CY, Wang FF, Lu HY, Cao SF, WangYF, Li SW, Sha J, Zha MM, Guo M, Wang J: Chronic noise-exposure exacerbatesinsulin resistance and promotes the manifestations of the type 2 diabetes in ahigh-fat diet mouse model. PloS one 2018, 13:16.
[3] Liu LJ, Fang C, Yang J, Zhang HY, Huang Y, XuanCY, Wang YF, Li SW, Sha J, Zha MM, Guo M: The effect of noise exposure oninsulin sensitivity in mice may be mediated by the JNK/IRS1 pathway.Environmental health and preventive medicine 2018, 23:8.
[4] Liu L, Xuan C, Shen P, He T, Chang Y, Shi L,Tao S, Yu Z, Brown RE, Wang J: Hippocampal Mechanisms Underlying Impairment inSpatial Learning Long After Establishment of Noise-Induced Hearing Loss in CBAMice. Frontiers in systems neuroscience 2018, 12:35.
[5] Liu L, Fang C, Yang J, Zhang H, Huang Y, XuanC, Wang Y, Li S, Sha J, Zha M, Guo M: The effect of noise exposure on insulinsensitivity in mice may be mediated by the JNK/IRS1 pathway. Environmentalhealth and preventive medicine 2018, 23:6.
[6] Chen H, Shi L, Liu L, Yin S, Aiken S, Wang J:Noise-induced Cochlear Synaptopathy and Signal Processing Disorders.Neuroscience 2018.
[7] Zhang GY, Yang M, Liu B, Huang ZC, Li J, ChenJY, Chen H, Zhang PP, Liu LJ, Wang J, Teng GJ: Changes of the directional brainnetworks related with brain plasticity in patients with long-term unilateralsensorineural hearing loss. Neuroscience 2016, 313:149-61.
[8] Song Q, Shen P, Li X, Shi L, Liu L, Wang J, YuZ, Stephen K, Aiken S, Yin S: Coding deficits in hidden hearing loss induced bynoise: the nature and impacts. Scientific reports 2016, 6:25200.
[9] Shi LJ, Chang Y, Li XW, Aiken SJ, Liu LJ, WangJ: Coding Deficits in Noise-Induced Hidden Hearing Loss May Stem fromIncomplete Repair of Ribbon Synapses in the Cochlea. Frontiers in neuroscience2016, 10:6.
[10] Shi L, Chang Y, Li X, Aiken S, Liu L, Wang J:Cochlear Synaptopathy and Noise-Induced Hidden Hearing Loss. Neural plasticity2016, 2016:6143164.
[11] Liu LJ, Wang FF, Lu HY, Cao SF, Du ZW, WangYF, Feng X, Gao Y, Zha MM, Guo M, Sun ZL, Wang J: Effects of Noise Exposure onSystemic and Tissue-Level Markers of Glucose Homeostasis and Insulin Resistancein Male Mice. Environ Health Perspect 2016, 124:1390-8.
[12] Liu LJ, Shen P, He TT, Chang Y, Shi LJ, Tao S,Li XW, Xun QY, Guo XJ, Yu ZP, Wang J: Noise induced hearing loss impairsspatial learning/memory and hippocampal neurogenesis in mice. Scientificreports 2016, 6:9.
[13] Zhang GY, Yang M, Liu B, Huang ZC, Chen H,Zhang PP, Li J, Chen JY, Liu LJ, Wang J, Teng GJ: Changes in the default modenetworks of individuals with long-term unilateral sensorineural hearing loss.Neuroscience 2015, 285:333-42.
[14]Shi L, Guo X, Shen P, Liu L, Tao S, Li X, SongQ, Yu Z, Yin S, Wang J: Noise-induced damage to ribbon synapses withoutpermanent threshold shifts in neonatal mice. Neuroscience 2015, 304:368-77.
[15] Jie H, Tao S, Liu L, Xia L, Charko A, Yu Z,Bance M, Yin S, Robertson GS, Wang J: Cochlear protection against cisplatin byviral transfection of X-linked inhibitor of apoptosis protein across roundwindow membrane. Gene therapy 2015, 22:546-52.
[16] Chen YC, Li X, Liu L, Wang J, Lu CQ, Yang M,Jiao Y, Zang FC, Radziwon K, Chen GD, Sun W, Krishnan Muthaiah VP, Salvi R,Teng GJ: Tinnitus and hyperacusis involve hyperactivity and enhancedconnectivity in auditory-limbic-arousal-cerebellar network. eLife 2015,4:e06576.
[17] Liu LJ, Wang FF, Lu HY, Ren XM, Zou JH:Chromanol 293B, an inhibitor of KCNQ1 channels, enhances glucose-stimulatedinsulin secretion and increases glucagon-like peptide-1 level in mice. Islets2014, 6:8.
[18] Shi L, Liu L, He T, Guo X, Yu Z, Yin S, WangJ: Ribbon synapse plasticity in the cochleae of Guinea pigs after noise-inducedsilent damage. PloS one 2013, 8:e81566.
[19] Liu LJ, Wang H, Shi LJ, Almuklass A, He TT,Aiken S, Bance M, Yin SK, Wang J: Silent Damage of Noise on Cochlear AfferentInnervation in Guinea Pigs and the Impact on Temporal Processing. PloS one2012, 7:11.
榮譽獎項
2016年，東南大學“醫學院最受歡迎老師”稱號
2016年，全國大學生基礎醫學創新論壇暨實驗設計大賽二等獎（任指導教師）。
2015年，全國微課優質資源展示會一等獎
2015年，江蘇省繼續教育微課大賽特等獎
2014年，中南集團獎教金
2013年，東南大學第一屆微課競賽二等獎
2010年，恆瑞獎教金
2010年，教育部科學技術進步二等獎
2008年，東南大學教學二等獎
2008年，東南大學本科教學評估工作一等獎
2003年，東南大學第十屆青年教師授課競賽一等獎
2003年，常州市人民政府獎教金
