儲茂泉

儲茂泉，男，同濟大學教授，博士生導師。

基本介紹

  • 中文名：儲茂泉
  • 學位/學歷：博士
  • 專業方向：新型納米載藥粒子在腫瘤局部和靶向治療中的套用及機制研究
  • 職務：博士生導師
研究方向,教學課程,研究項目,榮譽獎勵,出版專著,發表論文,

研究方向

納米生物醫學、新型納米載藥粒子在腫瘤局部和靶向治療中的套用及機制研究

教學課程

納米生物學

研究項目

本課題組在納米載藥粒子合成、組裝及腫瘤治療方面開展了很多工作。我們設計合成的納米複合粒子及納米載藥粒子能通過光熱效應、光動力效應、機械力等效應殺傷腫瘤細胞，抑制小鼠腫瘤生長，在腫瘤局部治療方面有重要作用；我們根據腫瘤特殊的微環境設計的納米載藥粒子，能減少被體內免疫系統的清除，能將化療藥物和光動力治療藥物有效輸送至腫瘤部位，並與免疫治療相結合，在近紅外雷射誘導下，能發揮納米載藥粒子協同靶向抑制腫瘤生長與轉移的目的；我們還深入研究生物發光共振能力轉移誘導下納米載藥粒子的光動力治療和載藥雙歧桿菌在腫瘤靶向治療中的作用；從分子和細胞水平上研究抑制腫瘤生長與轉移的機理。
納米生物醫學是多學科交叉融合的前沿領域，歡迎來自生物、醫學、藥學、食品及材料化學等背景的青年學生加入本課題組。

榮譽獎勵

近年來，本課題組有2名研究生獲得國家獎學金（教育部頒發），1名研究生獲得安發國際獎學金，2名研究生分別獲得同濟大學優秀博士生獎學金，1名獲得優秀碩士生獎學金，1名研究生獲得上海市優秀畢業生稱號，多名學生獲得同濟大學優秀畢業生稱號，多名學生獲得同濟大學研究生社會活動獎學金，多名學生獲得同濟大學優秀學生幹部及標兵稱號等多種榮譽。

出版專著

  1. Maoquan Chu(author).《Semiconductor Quantum Dots and Rods for in Vivo Imaging and Cancer Phototherapy》. World scientific publishing, Singapore, Aug 2017.
  2. Maoquan Chu(editor).《Advanced Nanomaterials for Bioimaging and Cancer Therapy》, World scientific publishing, Singapore, Sep 2017.
  3. Maoquan Chu (editor). 《Synthesis and Biomedical Applications of Graphene Quantum Dots》, World scientific publishing, Singapore, Sep 2017.

發表論文

  1. Fangjie Wo, Rujiao Xu, Yuxiang Shao, Zheyu Zhang, Maoquan Chu *, Donglu Shi & Shupeng Liu. A multimodal system with synergistic effects of magneto-mechanical, photothermal, photodynamic and chemo therapies of cancer in graphene-quantum dot-coated hollow magnetic nanospheres. Theranostics, 2016, 6(4):485-500.
  2. Qiang Wu, Maoquan Chu*,Yuxiang Shao, Fangjie Wo & Donglu Shi. Reduced graphene oxide conjugated with CuInS2/ZnS nanocrystals with low toxicity for enhanced photothermal and photodynamic cancer therapies. Carbon, 2016, 108: 21-37
  3. Maoquan Chu*, Wangxi Hai, Zheyu Zhang, Fangjie Wo, Qiang Wu, Zefei Zhang, Yuxiang Shao, Ding Zhang & Donglu Shi.Melanin nanoparticlesderived from a homology of medicine and food for sentinel lymph node mapping and highly efficient photothermal in vivo cancer therapy. Biomaterials, 2016, 91: 182-199.
  4. Ding Zhang, Zheyu Zhang, Yayun Liu, Maoquan Chu*,Chengyu Yang, Wenhao Li, Yuxiang Shao, Yan Yue & Rujiao Xu. The short- and long-term effects of orally administered high-dose reduced graphene oxide nanosheets on mouse behaviors. Biomaterials, 2015, 68:100-113.
  5. Shun Xu, Zheyu Zhang & Maoquan Chu*. Long-term toxicity of reduced graphene oxide nanosheets: effects on female mouse reproductive ability and offspring development. Biomaterials, 2015,54:188-200.
  6. Shanlu Liang, Shun Xu, Ding Zhang, Junmin He & Maoquan Chu*.Reproductive toxicity of nanoscale graphene oxide in male mice. Nanotoxicology, 2015, 19(1):92-105.
  7. Maoquan Chu*,Haikuo Li, Qiang Wu, Fangjie Wo & Donglu Shi. Pluronic-encapsulated natural chlorophyll nanocomposites for in vivo cancer imaging and photothermal/photodynamic therapies. Biomaterials, 2014, 35: 8357-8373.
  8. Maoquan Chu*, Yuxiang Shao, Jinliang Peng, Xiangyun Dai, Haikuo Li, Qingsheng Wu & Donglu Shi. Near-infrared laser light mediated cancer therapy by photothermal effect of Fe3O4 magnetic nanoparticles. Biomaterials, 2013,34:4078-4088.
  9. Maoquan Chu*,Jinliang Peng, Jiajia Zhao, Shanlu Liang, Yuxiang Shao & Qiang Wu. Laser light triggered-activated carbon nanosystem for cancer therapy. Biomaterials, 2013, 34(7),1820-1832.
  10. Maoquan Chu*,Xiaojing Pan, Ding Zhang, Qiang Wu, Jinliang Peng & Wangxi Hai. The therapeutic efficacy of CdTe and CdSe quantum dots for photothermal cancer therapy. Biomaterials, 2012, 33(29): 7071-7083.
  11. Lina Fan, Qiang Wu & Maoquan Chu*. Near-infrared fluorescent chlorophyll nanoscale liposomes for sentinel lymph node mapping. International Journal of Nanomedicine, 2012,7: 3071–3080.
  12. Qiang Wu & Maoquan Chu*. Self-illuminating quantum dots for highly sensitive in vivoreal-time luminescent mapping of sentinel lymph nodes. International Journal of Nanomedicine, 2012,7: 3433–3443.
  13. Wu Congyu, Yu Cong & ChuMaoquan *. A gold nanoshell with a silica inner shell synthesized using liposome templates for doxorubicin loading and near-infrared photothermal therapy. International Journal of Nanomedicine, 2011, 6: 807–813.
  14. Maoquan Chu*, Qiang Wu, Hui Yang, Ruiqi Yuan, Shengke Hou, Yifeng Yang, Yajuan Zou, Shi Xu, Kaiyi Xu, Ailing Ji & Lingyi sheng.Transfer of quantum dots from pregnant mice to pups across the placental barrier. Small, 2010, 6: 670-678.
  15. Maoquan Chu*, Fang Wu, Quan Zhang, Tiantian Liu, Yang Yu, Ailing Ji, Kaiyi Xu, Zhenhua Feng & Jian Zhu. A novel method for preparing quantum dot nanospheres with narrow size distribution. Nanoscale. 2010, 2: 542-547.

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