c-kit的配體為幹細胞生長因子·c-kit受體正常表達於造血乾/祖細胞。
基本介紹
- 中文名：c-kit受體
- 配體：幹細胞生長因子
- 表達於：造血乾/祖細胞
- 用於：逆轉AL細胞對化療的凋亡耐受
簡介,中文介紹,
簡介
CD117, also called KIT or C-kit receptor, is a cytokine receptor expressed on the surface of hematopoietic stem cells as well as other cell types. This receptor binds to stem cell factor (a substance that causes certain types of cells to grow). Altered forms of this receptor may be associated with some types of cancer.[1]
This gene encodes the human homolog of the proto-oncogene c-kit. C-kit was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. This protein is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). Mutations in this gene are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous lukemia, and piebaldism. Multiple transcript variants encoding different isoforms have been found for this gene.
