Yoji Kawano

Yoji Kawano，植物逆境生物學研究中心研究員。

簡歷：

1993-1997日本鳥取大學農學專業,學士; 1997-1999日本奈良先端科學技術大學院大學,生物科學,碩士; 1999-2001日本奈良先端科學技術大學院大學,生物科學,博士; 2001.4-2005.3日本名古屋大學,博士後; 2005.4-2005.9日本獨協醫科大學,助理教授; 2006.1-2014.12日本奈良先端科學技術大學院大學,助理教授、博士後; 2015.1-至今中科院上海植物逆境生物學研究中心,青年研究組長、碩士生導師

研究方向：

信號轉導和免疫學

職稱：

研究員

職務：

研究組長、博士生導師

代表論著：

Akamatsu, A., Uno, K., Kato, M., Wong, HL., Shimamoto, K., and Kawano, Y. (2015) New insights into the dimerization of small GTPase Rac/ROP guanine nucleotide exchange factors in rice. Plant Signal Behav. In press; Liu, L., Park, CH., He, F., Nagano, M., Wang, M., Bellizzi, M., Zeng, X., Liu, W., Ning, Y.,Kawano, Y., and Wang, GL. (2015) The RhoGAP SPIN6 Associates with SPL11 and OsRac1 and Negatively Regulates Programmed Cell Death and Innate Immunity in Rice. PLoS Pathog. 11:e1004629. 2014; Kawano, Y. (Corresponding author), Kawano-Kaneko, T., and Shimamoto, K. (2014) Rho family GTPase-dependent immunity in plants and animals. Front. Plant Sci. 5:522; Kawano, Y. (Corresponding author), Fujiwara, T., Yao, A., Housen, Y., Hayashi, K., and Shimamoto, K. Palmitoylation-dependent membrane localization of the rice R protein Pit is critical for the activation of the small GTPase OsRac1. J Biol Chem. 2014 289:19079-88; Césari, S., Kanzaki, H., Fujiwara, T., Bernoux, M., Chalvon, V., Kawano, Y., Shimamoto, K., Dodds, P., Terauchi, R. Kroj, T., The NB-LRR proteins RGA4 and RGA5 interact functionally and physically to confer disease resistance. EMBO J. In press; Kosami, K, Ohki, I., Nagano,M., Furuita, K., Sugiki, T., Kawano, Y., Kawasaki,Y., Fujiwara, T., Nakagawa, A., Shimamoto, K., and Kojima, C. The crystal structure of the plant small GTPase OsRac1 reveals its mode of binding to NADPH oxidase. J Biol Chem. In press; Sakane, H., Horii, Y, Nogami, S., Kawano, Y., Kaneko-Kawano, T., and Shirataki, H. (2014) α-Taxilin forms a complex with sorting nexin 4 and participates in the recycling pathway of transferrin receptor. PLoS One 9, e93509 2012; Kawano, Y., and Shimamoto, K. (2013) Early signaling network in rice PRR- and R-mediated immunity. Curr Opin Plant Biol. 16: 496-504; Dang, TT. Shimatani, Z., Kawano, Y. (Corresponding author), Terada, R and Shimamoto, K. (2013) Gene editing a constitutively active OsRac1 by homologous recombination-based gene targeting induces immune responses in rice Plant Cell Physiol 54, 2058-2070; Akamatsu, A., Wong, H., Fujiwara, M., Okuda, J., Nishide, K., Uno, K., Imai, K., Umemura, K., Kawasaki, T., Kawano, Y., and Shimamoto, K. (2013) An OsCEBiP/OsCERK1-OsRacGEF1-OsRac1 module is an essential component of chitin-induced rice immunity. Cell Host Microbe 13, 465-476; Kim, S. H., Oikawa, T., Kyozuka, J., Wong, H. L., Umemura, K., Kishi-Kaboshi, M., Takahashi, A., Kawano, Y., Kawasaki, T., and Shimamoto, K. (2012) The bHLH Rac immunity1 (RAI1) is activated by OsRac1 via OsMAPK3 and OsMAPK6 in rice immunity. Plant Cell Physiol 53, 740-754; Wamaitha, M., Yamamoto, R., Wong, H., Kawasaki, T., Kawano, Y., and Shimamoto, K. (2012) OsRap2.6 transcription factor contributes to rice innate immunity through its interaction with Receptor for Activated Kinase-C 1 (RACK1). Rice 5, 35; Kaneko-Kawano, T., Takasu, F., Naoki, H., Sakumura, Y., Ishii, S., Ueba, T., Eiyama, A., Okada, A., Kawano, Y., and Suzuki, K. (2012) Dynamic regulation of myosin light chain phosphorylation by Rho-kinase. PLoS One 7, e39269; Horii, Y., Nogami, S., Kawano, Y., Kaneko-Kawano, T., Ohtomo, N., Tomiya, T., and Shirataki, H. (2012) Interaction of alpha-taxilin localized on intracellular components with the microtubule cytoskeleton. Cell Struct Funct 37, 111-126; Kawano, Y., Akamatsu, A., Hayashi, K., Housen, Y., Okuda, J., Yao, A., Nakashima, A., Takahashi, H., Yoshida, H., Wong, H. L., Kawasaki, T., and Shimamoto, K. (2010a) Activation of a Rac GTPase by the NLR family disease resistance protein Pit plays a critical role in rice innate immunity. Cell Host Microbe 7, 362-375; Kawano, Y., Chen, L., and Shimamoto, K. (2010b) The function of Rac small GTPase and associated proteins in rice innate immunity. Rice 3, 112-121; Kawasaki T, Imai K, Wong H, Kawano Y, Nishide K, Okuda J, and Shimamoto K. Rice guanine nucleotide exchange factors for small GTPase OsRac1 involved in innate immunity of rice. In Advances in Genetics, Genomics and Control of Rice Blast Disease. 179-184, 2009; Yoshimura, T., Arimura, N., Kawano, Y., Kawabata, S., Wang, S., and Kaibuchi, K. (2006) Ras regulates neuronal polarity via the PI3-kinase/Akt/GSK-3beta/CRMP-2 pathway. Biochem Biophys Res Commun 340, 62-68; Kawano, Y., Yoshimura, T., Tsuboi, D., Kawabata, S., Kaneko-Kawano, T., Shirataki, H., Takenawa, T., and Kaibuchi, K. (2005) CRMP-2 is involved in kinesin-1-dependent transport of the Sra-1/WAVE1 complex and axon formation. Mol Cell Biol 25, 9920-9935; Kawano, Y., Kaneko, T., Yoshimura, T., Kawabata, S., and Kaibuchi, K. (2005) RhoA/C and the Actin Cytoskeleton. RHO Family GTPases, 113-136; Yoshimura, T., Kawano, Y., Arimura, N., Kawabata, S., Kikuchi, A., and Kaibuchi, K. (2005) GSK-3beta regulates phosphorylation of CRMP-2 and neuronal polarity. Cell 120, 137-149; Arimura, N., Menager, C., Kawano, Y., Yoshimura, T., Kawabata, S., Hattori, A., Fukata, Y., Amano, M., Goshima, Y., Inagaki, M., Morone, N., Usukura, J., and Kaibuchi, K. (2005) Phosphorylation by Rho kinase regulates CRMP-2 activity in growth cones. Mol Cell Biol 25, 9973-9984; Kaneko, T., Maeda, A., Takefuji, M., Aoyama, H., Nakayama, M., Kawabata, S., Kawano, Y., Iwamatsu, A., Amano, M., and Kaibuchi, K. (2005) Rho mediates endocytosis of epidermal growth factor receptor through phosphorylation of endophilin A1 by Rho-kinase. Genes Cells 10, 973-98; Kawano, Y., Yoshimura, T., and Kaibuchi, K. (2002) Smooth muscle contraction by small GTPase Rho. Nagoya J Med Sci 65, 1-8; Inagaki, N., Chihara, K., Arimura, N., Menager, C., Kawano, Y., Matsuo, N., Nishimura, T., Amano, M., and Kaibuchi, K. (2001) CRMP-2 induces axons in cultured hippocampal neurons. Nat Neurosci 4, 781-782; Kandabashi, T., Shimokawa, H., Miyata, K., Kunihiro, I., Kawano, Y., Fukata, Y., Higo, T., Egashira, K., Takahashi, S., Kaibuchi, K., and Takeshita, A. (2000) Inhibition of myosin phosphatase by upregulated rho-kinase plays a key role for coronary artery spasm in a porcine model with interleukin-1beta. Circulation 101, 1319-1323; Kawano, Y., Fukata, Y., Oshiro, N., Amano, M., Nakamura, T., Ito, M., Matsumura, F., Inagaki, M., and Kaibuchi, K. (1999) Phosphorylation of myosin-binding subunit (MBS) of myosin phosphatase by Rho-kinase in vivo. J Cell Biol 147, 1023-1038; Fukata, Y., Oshiro, N., Kinoshita, N., Kawano, Y., Matsuoka, Y., Bennett, V., Matsuura, Y., and Kaibuchi, K. (1999) Phosphorylation of adducin by Rho-kinase plays a crucial role in cell motility. J Cell Biol 145, 347-361; Yamamoto, T., Harada, N., Kawano, Y., Taya, S., and Kaibuchi, K. (1999) In vivo interaction of AF-6 with activated Ras and ZO-1. Biochem Biophys Res Commun 259, 103-107; Taya, S., Yamamoto, T., Kano, K., Kawano, Y., Iwamatsu, A., Tsuchiya, T., Tanaka, K., Kanai-Azuma, M., Wood, S. A., Mattick, J. S., and Kaibuchi, K. (1998) The Ras target AF-6 is a substrate of the fam deubiquitinating enzyme. J Cell Biol 142, 1053-1062