黃建耿，男，博士，華中科技大學藥學院副教授，碩士研究生導師。
基本介紹
- 中文名：黃建耿
- 畢業院校：華中科技大學
- 學位/學歷：博士
- 職業：教師
- 專業方向：藥代動力學
- 任職院校：華中科技大學
研究方向,個人經歷,學術成果,
研究方向
藥代動力學研究（藥物體內轉運與代謝）
個人經歷
教育背景:
博士 2008.07 華中科技大學同濟醫學院藥學院
本科 2003.07 華中科技大學同濟醫學院(原同濟醫科大學)藥學院
工作經歷:
副教授 2012.04-至今 華中科技大學同濟醫學院藥學院
博士後 2010.08-2012.03 美國University of Iowa藥學院
兼職講師 2011.08-2011.11 美國Drake University藥學院
博士後 2008.10-2010.07 美國University of Nebraska Medical Center藥學院
學術任職
2018.04--至今 國家食品藥品監督管理局藥物臨床試驗數據核查檢查員
2017.11--至今 中國藥理學會藥物代謝專業委員會青年委員會委員
2017.11--至今 國際藥物及化學異物代謝學會（ISSX）會員
2015.05--至今 國家自然科學基金委評審專家
2015.01--至今 教育部學位論文評審專家
2014.05--至今 《醫藥導報》編委
2013.04--至今 武漢市藥學會藥學教育專業委員會委員
2012.12--2017.11 中國抗癌協會納米腫瘤學專業委員會委員
2010.10--至今 美國藥學科學家協會（AAPS）會員
學術成果
主持科研課題：
2. 企業委託項目：苦蕎麥提取物體內代謝譜研究 2018.03-2018.12
3. 國家自然科學基金項目：基於NTCP/Ntcp和BSEP/Bsep介導的膽汁酸轉運受阻導致托伐普坦藥物性肝損傷機理研究 2014.01-2016.12
4. 湖北省自然科學基金項目：基於膽汁酸代謝的藥物性肝損傷診斷研究2014.01-2015.12
5. 湖北省衛生廳青年科技人才項目：普拉克索鼻黏膜給藥腦靶向治療帕金森及其跨鼻黏膜轉運機制研究 2013.01-2014.12
代表作：
1. Yang Hu, Wenwen Zhu, Yeli Guan, Sanlan Wu, Xiaoyin Zhang, Gao Li, Luqin Si*, Jiangeng Huang*. Accurate determination of a novel vasodilatory β‐blocker TJ0711 using LC‐MS/MS: Resolution of an isobaric metabolite interference in dog plasma. Biomed Chromatogr. 2018 Jun(Both authors contributed equally)
2. Sijie He, Sanlan Wu, Wenwen Zhu, Yeli Guan, Gao Li, Luqin Si*, Jiangeng Huang*. Enantioselective determination of 1-[4-(2-methoxyethyl)phenoxy]-3-[2-(2-methoxyphenoxy)ethylamino]-2-propanol hydrochloride, a novel antihypertensive agent, in rat plasma and tissues by LC–MS/MS. J Sep Sci. 2017(Both authors contributed equally)
3. Li Kang, Luqin Si, Jing Rao, Dan Li, Ya Wu, Sanlan Wu, Minghui Wu, Sijie He, Wenwen Zhu, Yang Wu, Jiaqiang Xu, Gao Li, Jiangeng Huang*. Polygoni Multiflori Radix derived anthraquinones alter bile acid disposition in sandwich-cultured rat hepatocytes. Toxicol In Vitro. 2017, . (#Both authors contributed equally)
4. Mengzhu Zheng, Weiguang Sun, Suyu Gao, Shanshan Luan, Dan Li, Renqi Chen, Qian Zhang, Lixia Chen*, Jiangeng Huang* and Hua Li*. Structure based discovery of clomifene as a potent inhibitor of cancer-associated mutant IDH1. Oncotarget. 2017
5. Jiaqiang Xu, Gao Li, Zhuoyi Wang, Luqin Si, Sijie He, Jialing Cai, Jiangeng Huang*, Maureen D. Donovan*. The role of L-type amino acid transporters in the uptake of glyphosate across mammalian epithelial tissues. Chemosphere. 2016,
6. Peng Cao, Gao Li, Ling Huang, Shouwei Zhao, Yang Hu, Lixia Qin, Lihui Qiu, Wenwen Zhu, Luqin Si*, Jiangeng Huang*. Screening of stabilizers for LC-MS/MS analysis of clevidipine and its primary metabolite in dog whole blood. Bioanalysis. 2015
7. Kewen Xue, Gao Li, Xiao Sun, Yang Hu, Lei Hu, Jiangeng Huang*, Luqin Si*. Simultaneous quantification of fosinopril and its active metabolite fosinoprilat in rat plasma by UFLC-MS/MS: Application of formic acid in the stabilization of an ester-containing drug. J Chromatogr B Analyt Technol Biomed Life Sci. 2015
8. Lei Hu, Zhenhua Lv, Gao Li, Xiaolong Xu, Chenghao Zhang, Peng Cao, Jiangeng Huang*, Luqin Si*. Study of the in vitro metabolism of TJ0711 using ultra high performance liquid chromatography with quadrupole time-of-flight and ultra fast liquid chromatography with quadrupole linear ion trap mass spectrometry. J Sep Sci. 2015
9. Weilin Guo, Gao Li, Yanxia Yang, Conglian Yang, Luqin Si*, Jiangeng Huang*. LC-MS/MS analysis of pramipexole in mouse plasma and tissues: Elimination of lipid matrix effects using weak cation exchange mode based solid-phase extraction. J Chromatogr B Analyt Technol Biomed Life Sci. 2015
10. Jiangeng Huang, Lei Hu, Li Xu, Minghui Sun, Zhaoze Fan, Jun Qiu, Gao Li, Luqin Si*. In vitro enantioselective metabolism of TJ0711 hydrochloride by human liver microsomes using a novel chiral liquid chromatography-tandem mass spectrometry method. J Chromatogr B Analyt Technol Biomed Life Sci. 2012,
11. Jiangeng Huang, Juanjuan Liu, Cong Zhang, Jiaojiao Wei, Li Mei, Shan Yu, Gao Li*, Li Xu*. Determination of sulfonamides in food samples by membrane-protected micro-solid phase extraction coupled with high performance liquid chromatography. J Chromatogr A. 2012
12. Jiangeng Huang, Luqin Si, Zhaoze Fan, Lei Hu, Jun Qiu, Gao Li*. In vitro metabolic stability and metabolite profiling of TJ0711 hydrochloride, a newly developed vasodilatory β-blocker, using a liquid chromatography-tandem mass spectrometry method. J Chromatogr B Analyt Technol Biomed Life Sci. 2011,
13. Jiangeng Huang, Nagsen Gautam, Sai Praneeth R. Bathena, Upal Roy, JoEllyn McMillan, Howard E. Gendelman, Yazen Alnouti*. UPLC-MS/MS quantification of nanoformulated ritonavir, indinavir, atazanavir, and efavirenz in mouse serum and tissues. J Chromatogr B Analyt Technol Biomed Life Sci. 2011
14. Jiangeng Huang, Sai Praneeth R. Bathena, Ivan L. Csanaky, Yazen Alnouti*. Simultaneous characterization of bile acids and their sulfate metabolites in mouse liver, plasma, bile, and urine using LC-MS/MS. J Pharm Biomed Anal. 2011
15. Jiangeng Huang, Sai Praneeth R. Bathena, Yazen Alnouti*. Metabolite profiling of Praziquantel and its analogs during the analysis of in vitro metabolic stability using information-dependent acquisition on a hybrid triple-quadrupole linear ion trap mass spectrometer. Drug Metab Pharmacokinet. 2010,
16. Jiangeng Huang, Sai P. Bathena, Jing Tong, Megan Roth, Bruno Hagenbuch, Yazen Alnouti*. Kinetic analysis of bile acid sulfation by stably expressed human sulfotransferase 2A1 (SULT2A1). Xenobiotica. 2010,
17. Jiangeng Huang, Luqin Si, Lingli Jiang, Zhaoze Fan, Jun Qiu, Gao Li. Effect of pluronic F68 block copolymer on P-glycoprotein transport and CYP3A4 metabolism. Int J Pharm. 2008
