鮑錦庫

鮑錦庫，漢族，四川大學博士，四川大學生命科學學院教授，博士生導師。

基本介紹

• 中文名：鮑錦庫
• 國籍：中國
• 民族：漢族
• 畢業院校：四川大學
• 學位/學歷：博士
• 職務：四川大學博士生導師
• 職稱：教授

社會任職

中國生物化學與分子生物學會糖複合物專業委員會委員、常務委員
中國生物化學與分子生物學會生物化學與分子生物學教學專業委員會委員、常務委員
中國生物化學與分子生物學會農業生物化學分委會理事

中國生物工程學會糖工程專業委員會委員
國際凝集素委員會委員

人物經歷

學習經歷

1987.09-1991.07：浙江大學生物系生物化學與微生物學專業，本科
1991.09 –1994.07：四川大生物系生物化學專業，理學碩士
2000.09 –2003.12：四川大學生命科學學院，理學博士

工作經歷

1994.07–1996.07：四川大學生命科學學院，助教
1994.09 –1995.09：在中國農科院植保所植物病蟲害生物學國家重點實驗室和中國農科院畜牧研究所客座研究
1996.07–1998.07：四川大學生命科學學院，講師
1998.07–2005.07：四川大學生命科學學院副教授
2005.07-2006.07：四川大學生命科學學院教授博士生導師
2006.07 –至今：四川大學生命科學學院教授，博士生導師

學術成果

立足我國豐富的天然藥用資源寶庫，圍繞愛滋病等傳染性疾病、臨床常見惡性腫瘤等疾病及新藥創製等國家戰略需求，以具有特異糖結合能力的非免疫來源的凝集素為主線，集成現代生命科學技術方法，進行具有自主智慧財產權、抗病毒和抗腫瘤活性的凝集素等活性大分子的篩選、規模製備、基因克隆與蛋白序列、重組蛋白表達、生物活性及其基於腫瘤發生髮展調控網路的分子機制、基於結構的分子設計和改造以及蛋白多肽資料庫的構建和利用轉基因植物大量獲取活性蛋白等系統研究。發揮生命科學、醫學和信息科學等學科特點及學科交叉優勢，引入系統生物學整體性、信息化和網路調控的研究策略和理念，集成生物化學與分子生物學、細胞生物學、分子藥理學、組學和系統生物學等技術方法，系統研究中草藥蛋白多肽抗腫瘤分子機制及其潛在靶標，拓辟了“凝集素探針-腫瘤細胞程式性死亡相關蛋白-miRNA相互調控網路”研究新方向，為基於中藥源活性蛋白多肽為先導或候選化合物的功能機制研究提供示範性的新思路並為源頭創新藥物研發提供通用模式。

科研項目

國家自然科學基金項目：
1、寡糖鏈、胺基酸側鏈基團與黃精凝集素生物學活性研究(批准號:39770178),1998 -2000,項目負責人
2、黃精凝集素結構與生物學活性關係研究（批准號：30000032),2001－2003,項目負責人
3、定點突變研究黃精凝集素II結構與功能關係（批准號：30270331),2003－2005，項目負責人
4、重組和突變抗愛滋病毒黃精凝集素II及其複合物晶體結構研究(批准號:30670469),2007－2009，項目負責人
5、黃精凝集素誘導腫瘤細胞自噬和凋亡的分子機制研究(批准號:30970643),2010-2012,項目負責人
6、凝集素誘導腫瘤細胞程式性死亡的分子機制(批准號:81173093)，2012-2015, 項目負責人
7、高效低免疫原性黃精凝集素的分子設計（批准號: 81373311)，2014-2017, 項目負責人

8、十八屆國際凝集素會議18th International Lectin Meeting, July, 1999, U.K），英國

9、第十九屆國際凝集素會議（19th International Lectin Meeting, March, 2001, Brazil), 巴西

10、第二十屆國際凝集素會議（20th International Lectin Meeting, May,2002，Denmark), 丹麥

11、第二十一屆國際凝集素會議(21th International Lectin Meeting, May, 2004, Japan),日本

國家重大科技專項-轉基因生物新品種培育：
“西南地區抗水稻脅迫因子基因克隆及功能驗證”（2009ZX8009-072B）子課題負責人
國家高技術研究發展計畫（863計畫）：
番茄營養品質改良的基因工程技術研究(2007AA10Z122)，2007-2010，課題副組長

省部級課題：
　　1、中國農科院植物病蟲害生物學國家重點實驗室開放課題：蔥蓮凝集素的基因克隆，2002，項目負責人
2、四川大學科技創新基金：傳統中草藥中具抗病毒活性的甘露糖結合蛋白的基因克隆與表達研究, 2004-2006，項目負責人
3、四川省傑出青年科技基金：轉植物凝集素基因培養抗蟲新品種（批准號：06ZQ026-035），2006－2008，項目負責人
4、四川省科技攻關項目：傳統中草藥中抗病毒抗腫瘤蛋白的分離、基因克隆表達及活性研究 (批准號：2006Z08－010),2006－2008，項目負責人

發表論文

2016

Lei Wu, Tao Liu, Yan Xiao, Xing Li, Yanan Zhu, YanZhao, Jinku Bao*, Chuanfang Wu, Polygonatum odoratum lectin induces apoptosis and autophagy by regulation of microRNA-1290 and microRNA-15a -3p in human lung adenocarcinoma A549 cells, International Journal of Biological Macromolecules, 2016, 85:217–226

Wei Zhang, Jianzong Li, Haiyang Wang, Hao Luo, Xin Wang, Nan Zhou, Chuanfang Wu, Jinku Bao*, Computer-aided identification of potential TYK2 inhibitors from drug database, Journal of Molecular Structure, 2016, 309-317

Jian-zong Li, Hao Luo, Xin Wana, Dan-feng Liang, Kai-min Lu, Jin-ku Bao*, In silico identification of novel kinase inhibitors targeting HER2 from Natural Products for the treatment of HER2-positive breast cancer,International Journal of Molecular Sciences, 2016, In press

Tao Liu, Lei Wu, Di Wang, Haiyang Wang, Jinwu Chen, Chunlan Yang, Jinku Bao*, Chuanfang Wu, Role of reactive oxygen species mediated MAPK and NF-κB activation in Polygonatum cyrtonema lectin induced apoptosis and autophagy in human lung adenocarcinoma A549 cells, The Journal of Biochemistry, 2016, In press

Ya-nan Zhu, Li-kun Long, Yuan-yuan Li, Chuan-fang Wu, Jin-ku Bao*, Purification and Characterization of a Mannose-binding Lectin from the Allium macrostemon Bunge with apoptosis-inducing activity, Phytomedicine, 2016, In press

2015

Zhining Wan, Xin Li, Rong Sun, Yuanyuan Li, Xiaoyun Wang , Xinru Li, Li Rong a, Zheng Shi, Jinku Bao*, Computer-assisted identification of novel small molecule inhibitors targeting GLUT1, Journal of Molecular Structure, 2015, 1101: 57-65

Jing Li, Nan Zhou, Wen Liu, Jianzong Li, Yu Feng, Xiaoyun Wang, Chuanfang, Wu, Jinku Bao*, Discover natural compounds as potential phosphodiesterase-4B inhibitors via computational approaches, Journal of Biomolecular Structure and Dynamics, 2015, DOI: 10.1080/07391102.2015.1070749

Zi-jie Wang, Zhi-ning Wan, Xu-dong Chen, Chuan-fang Wu, Guo-long Gao,Rong Liu, Zheng Shi, Jin-ku Bao*, In silico identification of novel kinase inhibitors by targeting B-Raf from natural products database, J Mol Model, 2015, 21:102

Rong Sun, Xin Li, Yuanyuan Li, Xun Zhang, Xinru Li, Xiaoyu Li, Zheng Shi, Jinku Bao*, Screening of novel inhibitors targeting lactate dehydrogenase A via four molecular docking strategies and dynamics simulations, J Mol Model, 2015,21: 133

Jianzong Li , Yu Feng , Xiaoyun Wang , Jing Li , Wen Liu , Li Rong and Jinku Bao*, An Overview of Predictors for Intrinsically Disordered Proteins over 2010–2014, Int. J. Mol. Sci. 2015, 16, 23446-23462

2014

Li C, Chen J, Lu B, Shi Z, Wang H, Zhang B, Zhao K, Qi W, Bao J*, Wang Y: Molecular switch role of Akt in Polygonatum odoratumlectin-induced apoptosis and autophagy in human non-small cell lung cancer A549 cells. PloS one 2014, 9(7):e101526-e101526.

Li X, Sun R, Chen W, Lu B, Li X, Wang Z, Bao J*: A Systematic In Silico Mining of the Mechanistic Implications and Therapeutic Potentials of Estrogen Receptor (ER)-alpha in Breast Cancer. Plos One 2014, 9(3).

Yu Y, Deng Y, Lu B-m, Liu Y-x, Li J, Bao J-k* : Green tea catechins: a fresh flavor to anticancer therapy. Apoptosis 2014, 19(1):1-18.

Xu H-l, Wang Z-j, Liang X-m, Li X, Shi Z, Zhou N, Bao J-k*: In silico identification of novel kinase inhibitors targeting wild-type and T315I mutant ABL1 from FDA-approved drugs. Molecular Biosystems 2014, 10(6):1524-1537.

Fu LL, Liu J, Chen Y, Wang FT, Wen X, Liu HQ, Wang MY, Ouyang L, Huang J, Bao JK* et al: In silico analysis and experimental validation of azelastine hydrochloride (N4) targeting sodium taurocholate co-transporting polypeptide (NTCP) in HBV therapy. Cell Proliferation 2014, 47(4):326-335.

Wu L, Zhou N, Sun R, Chen XD, Feng SC, Zhang B, Bao JK*: Network-based identification of key proteins involved in apoptosis and cell cycle regulation. Cell Proliferation 2014, 47(4):356-368.

Shi Z, An N, Lu BM, Zhou N, Yang SL, Zhang B, Li CY, Wang ZJ, Wang F, Wu CF, Bao JK*: Identification of novel kinase inhibitors by targeting a kinase-related apoptotic protein-protein interaction network in HeLa cells. Cell Proliferation 2014, 47(3):219-230.

Wang H-L, Li C-Y, Zhang B, Liu Y-D, Lu B-M, Shi Z, An N, Zhao L-K, Zhang J-J, Bao J-K* : Mangiferin Facilitates Islet Regeneration and beta-Cell Proliferation through Upregulation of Cell Cycle and beta-Cell Regeneration Regulators. International Journal of Molecular Sciences 2014, 15(5):9016-9035.

Shi Z, Chen J, Li C-y, An N, Wang Z-j, Yang S-l, Huang K-f, Bao J-k*: Antitumor effects of concanavalin A and Sophora flavescens lectin in vitro and in vivo. Acta Pharmacologica Sinica 2014, 35(2):248-256.

Bangmin Lu , Bin Zhang, Wei Qi, Yanan Zhu, Yan Zhao, Nan Zhou, Rong Sun, Jinku Bao*, and Chuanfang Wu, Conformational study reveals amino acid residues essential for hemagglutinating and anti-proliferative activities of Clematis montana lectin, Acta Biochim Biophys Sin 2014, 46: 923–934.

Zhou N, Zhang Y, Zhang J-C, Feng L, Bao J-K*: The receptor binding domain of MERS-CoV: The dawn of vaccine and treatment development. Journal of the Formosan Medical Association 2014, 113(3):143-147.

Jing Li , Nan Zhou , Kun Luo , Wei Zhang , Xinru Li , Chuanfang Wu， Jinku Bao*:In Silico Discovery of Potential VEGFR-2 Inhibitors from Natural Derivatives for Anti-Angiogenesis Therapy，International Journal of Molecular Sciences 2014, 15(9):15994-16011.

Xu G-B, Yang T, Bao J-K*, Fang D-M, Li G-Y: Isochaetomium A(2), a new bis(naphthodihydropyran-4-one) with antimicrobial and immunological activities from fungus Chaetomium microcephalum. Archives of Pharmacal Research 2014, 37(5):575-579.

Xu G-B, Wang N-N, Bao J-K*, Yang T, Li G-Y: New Orsellinic Acid Esters from Fungus Chaetomium globosporum. Helvetica Chimica Acta 2014, 97(1):151-159.

2013

Lu G, Hu Y, Wang Q, Qi J, Gao F, Li Y, Zhang Y, Zhang W, Yuan Y, Bao J* et al: Molecular basis of binding between novel human coronavirus MERS-CoV and its receptor CD26. Nature 2013, 500(7461):227

Shi Z, Li C-y, Zhao S, Yu Y, An N, Liu Y-x, Wu C-f, Yue B-s, Bao J-k*: A systems biology analysis of autophagy in cancer therapy. Cancer Letters 2013, 337(2):149-160.

Lin Y, Wang F, Yang L-j, Chun Z, Bao J-k*, Zhang G-l: Anti-inflammatory phenanthrene derivatives from stems of Dendrobium denneanum. Phytochemistry 2013, 95:242-251.

Fu LL, Yang Y, Xu HL, Cheng Y, Wen X, Ouyang L, Bao JK*, Wei YQ, Liu B: Identification of novel caspase/autophagy-related gene switch to cell fate decisions in breast cancers. Cell Proliferation 2013, 46(1):67-75.

Shi Z, An N, Zhao S, Li X, Bao JK*, Yue BS: In silico analysis of molecular mechanisms of legume lectin-induced apoptosis in cancer cells. Cell Proliferation 2013, 46(1):86-96.

Li CY, Wang Y, Wang HL, Shi Z, An N, Liu YX, Liu Y, Zhang J, Bao JK*, Deng SP: Molecular mechanisms of Lycoris aurea agglutinin-induced apoptosis and G2/M cell cycle arrest in human lung adenocarcinoma A549 cells, both in vitro and in vivo. Cell Proliferation 2013, 46(3):272-282.

Li X, Xu H-l, Liu Y-x, An N, Zhao S, Bao J-k*: Autophagy modulation as a target for anticancer drug discovery. Acta Pharmacologica Sinica 2013, 34(5):612-624.

Wu L, Bao J-k*: Anti-tumor and anti-viral activities of Galanthus nivalis agglutinin (GNA)- related lectins. Glycoconjugate Journal 2013, 30(3):269-279.

Pu X, Qu X, Chen F, Bao J*, Zhang G, Luo Y: Camptothecin-producing endophytic fungus Trichoderma atroviride LY357: isolation, identification, and fermentation conditions optimization for camptothecin production. Applied Microbiology and Biotechnology 2013, 97(21):9365-9375.

Shi Z, Wang Z-j, Xu H-l, Tian Y, Li X, Bao J-k*, Sun S-r, Yue B-s: Modeling, docking and dynamics simulations of a non-specific lipid transfer protein from Peganum harmala L. Computational Biology and Chemistry 2013, 47:56-65.

Zhou N, Zhang J, Feng L, Lu B, Wang Z, Sun R, Wu C, Bao J*: IntApop: A web service for predicting apoptotic protein interactions in humans. Biosystems 2013, 114(3):238-244.

Liu B, Bao J-K*, Yang J-M, Cheng Y: Targeting autophagic pathways for cancer drug discovery. Chinese Journal of Cancer 2013, 32(3):113-120.

Gao F, Bao J*: Preliminary crystallographic analysis of neuraminidase N2 from a new influenza A virus. Acta Crystallographica Section F-Structural Biology and Crystallization Communications 2013, 69:861-863.

Gao F, Bao J*: Crystallization and preliminary X-ray crystallographic analysis of the rhesus macaque MHC class I molecule Mamu-B*17 complexed with an immunodominant SIVmac239 Env epitope. Acta Crystallographica Section F-Structural Biology and Crystallization Communications 2013, 69:643-645.

Lv J, Wang Z, Zhang L, Wang H-L, Liu Y, Li C, Deng J, Yi W, Bao J-K*: Mangiferin Induces Apoptosis and Cell Cycle Arrest in MCF-7 Cells Both in vitro and in vivo. Journal of Animal and Veterinary Advances 2013, 12(3):352-359.

2012

Li W-w, Li J, Bao J-k*: Microautophagy: lesser-known self-eating. Cellular and Molecular Life Sciences 2012, 69(7):1125-1136.

Fu L-L, Wen X, Bao J-k*, Liu B: MicroRNA-modulated autophagic signaling networks in cancer. International Journal of Biochemistry & Cell Biology 2012, 44(5):733-736.

Ouyang L, Shi Z, Zhao S, Wang FT, Zhou TT, Liu B, Bao JK*: Programmed cell death pathways in cancer: a review of apoptosis, autophagy and programmed necrosis. Cell Proliferation 2012, 45(6):487-498.

Fu LL, Zhao X, Xu HL, Wen X, Wang SY, Liu B, Bao JK*, Wei YQ: Identification of microRNA-regulated autophagic pathways in plant lectin-induced cancer cell death. Cell Proliferation 2012, 45(5):477-485.

Wang Y, Liu Y, Wang H, Li C, Qi P, Bao J*: Agaricus bisporus lectins mediates islet beta-cell proliferation through regulation of cell cycle proteins. Experimental Biology and Medicine 2012, 237(3):287-296.

Wang Y, Wang H, Liu Y, Li C, Qi P, Bao J*: Antihyperglycemic Effect of Ginsenoside Rh2 by Inducing Islet beta-cell Regeneration in Mice. Hormone and Metabolic Research 2012, 44(1):33-40.

Xu H-l, Li C-y, He X-m, Niu K-q, Peng H, Li W-w, Zhou C-c, Bao J-k*: Molecular modeling, docking and dynamics simulations of GNA-related lectins for potential prevention of influenza virus (H1N1). Journal of Molecular Modeling 2012, 18(1):27-37.

Wang N, Xu H-l, Zhao X, Wen X, Wang F-t, Wang S-y, Fu L-l, Liu B, Bao J-k*: Network-Based Identification of Novel Connections Among Apoptotic Signaling Pathways in Cancer. Applied Biochemistry and Biotechnology 2012, 167(3):621-631.

2011

Liu JJ, Lin M, Yu JY, Liu B*, Bao JK*. Targeting apoptotic and autophagic pathways for cancer therapeutics. Cancer Letters. 2011. 300(2):105-114.

Wang SY, Yu QJ, Bao JK*, Liu B. Polygonatum cyrtonema lectin, a potential antineoplastic drug targeting programmed cell death pathways. Biochemical and Biophysical Research Communications. 2011. 406(4):497-500.

Li WW, Yu JY, Xu HL, Bao JK*. Concanavalin A: a potential anti-neoplastic agent targeting apoptosis, autophagy and anti-angiogenesis for cancer therapeutics. Biochemical and Biophysical Research Communications. 2011. 414(2):282-286.

Li CY, Luo P, Liu JJ, Wang EQ, Li WW, Ding ZH, Mou L, Bao JK*. Recombinant expression of Polygonatum cyrtonema lectin with anti-viral, apoptosis-inducing activities and preliminary crystallization. Process Biochemistry. 2011. 46(2): 533-542.

Li CY, Wang EQ, Cheng Y, Bao JK*. Oridonin: An active diterpenoid targeting cell cycle arrest, apoptotic and autophagic pathways for cancer theraputics. The International Journal of Biochemistry & Cell Biology. 2011. 43(5):701-704.

Fu LL, Zhou CC, Yao S, Yu JY, Liu B, Bao JK*. Plant lectins: targeting programmed cell death pathways as antitumor agents. The International Journal of Biochemistry & Cell Biology. 2011. 43(10):1442-1449.

Yang Y, Xu HL, Zhang ZT, Liu JJ, Li WW, Ming H, Bao JK*. Characterization, molecular cloning, and in silico analysis of a novel mannose-binding lectin from Polygonatum odoratum (Mill.) with anti-HSV-II and apoptosis-inducing activities. Phytomedicine. 2011, 18(8-9):748-755.

He XM, Ji N, Xiang XC, Luo P, Bao JK*. Purification, characterization, and molecular cloning of a novel antifungal lectin from the roots of Ophioglossum pedunculosum. Applied Biochemistry and Biotechnology. 2011. 165(7-8):1458-1472.

Yu QJ, Li ZY, Yao S, Ming M, Wang SY, Liu B, Bao JK*. In silico analysis of molecular mechanisms of Galanthus nivalis agglutinin-related lectin-induced cancer cell death from carbohydrate-binding motif evolution hypothesis. Applied Biochemistry and Biotechnology. 2011. 165(3-4):1037-1046.

Zhang F, Li CY, Wang EQ, Li WW, Yu QJ, Wen X, Liu JJ, Bao JK*. The Global Component-Target Network in Panax Ginseng C. Letters in Drug Design & Discovery, 2011, 8, 181-188.

2010
Liu B, Wu JM, Li J, Liu JJ, Li WW, Li CY, Xu HL, Bao JK*. Polygonatum cyrtonema lectin induces murine fibrosarcoma L929 cell apoptosis and autophagy via blocking Ras-Raf and PI3K-Akt signaling pathways. Biochimie. 2010. 92(12):1934-1938.

Liu B, Bian HJ, Bao JK*. Plant lectins: Potential antineoplastic drugs from bench to clinic. Cancer Letters. 2010. 287(1):1-12.

Yao Q, Wu CF, Luo P, Xiang XC, Liu JJ, Mou L, Bao JK*. A new chitin-binding lectin from rhizome of Setcreasea purpurea with antifungal, antiviral and apoptosis-inducing activities. Process Biochemistry. 2010. 45(9): 1477-1485.

Zhang ZT, Peng H, Li CY, Liu JJ, Zhou TT, Yan YF, Li Y, Bao JK*. Polygonatum cyrtonema lectin induces murine fibrosarcoma L929 cell apoptosis via a caspase-dependent pathway as compared to Ophiopogon japonicus lectin. Phytomedicine. 2010. 18(1):25-31.

Li CY, Xu HL, Liu B, Bao JK*. Concanavalin A, from an old protein to novel candidate antineoplastic drug. Current Molecular Pharmacology. 2010. 3(3):123-128.

Liu B, Cheng Y, Liu Q, Bao JK*, Yang JM. Autophagic pathways as new targets for cancer drug development. Acta Pharmacologica Sinica. 2010. 31(9):1154-64.

Ding J, Bao J*, Zhu D, Zhang Y, Wang DC. Crystal structures of a novel anti-HIV mannose-binding lectin from Polygonatum cyrtonema Hua with unique ligand-binding property and super-structure. Journal of Structural Biology. 2010. 171(3):309-17.

2009

Liu B, Min MW, Bao JK*. Induction of apoptosis by Concanavalin A and its molecular mechanisms in cancer cells. Autophagy, 2009. 5(3): 432-433.

Liu B, Cheng Y, Bian HJ, Bao JK*. Molecular mechanisms of Polygonatum cyrtonema lectin-induced apoptosis and autophagy in cancer cells. Autophagy. 2009. 5(2):253-255.

Liu B, Cheng Y, Zhang B, Bian HJ, Bao JK*. Polygonatum cyrtonema lectin induces apoptosis and autophagy in human melanoma A375 cells through a mitochondria-mediated ROS-p38-p53 pathway. Cancer Letters. 2009. 275(1):54-60.

Liu B, Li CY, Bian HJ, Min MW, Chen LF, Bao JK*. Antiproliferative activity and apoptosis-inducing mechanism of Concanavalin A on human melanoma A375 cells. Archives of Biochemistry and Biophysics. 2009. 482(1-2):1-6

Liu B, Zhang B, Min MW, Bian HJ, Chen LF, Liu Q, Bao JK*. Induction of apoptosis by Polygonatum odoratum lectin and its molecular mechanisms in murine fibrosarcoma L929 cells. Biochimica et Biophysica Acta (BBA) - General Subjects. 2009. 1790(8):840-844.

Peng H, Lv H, Wang Y, Liu YH, Li CY, Meng L, Chen F, Bao JK*. Clematis montana lectin, a novel mannose-binding lectin from traditional Chinese medicine with antiviral and apoptosis-inducing activities. Peptides. 2009. 30(10):1805-1815.

Lv H, Kong Y, Yao Q, Zhang B, Leng FW, Bian HJ, Balzarini J, Van Damme E, Bao JK*. Nebrodeolysin, a novel hemolytic protein from mushroom Pleurotus nebrodensis with apoptosis-inducing and anti-HIV-1 activities. Phytomedicine. 2009. 16(2-3):198-205.

Chen J, Liu B, Ji N, Zhou J, Bian HJ, Li CY, Chen F, Bao JK*. A novel sialic acid-specific lectin from Phaseolus coccineus seeds with potent antineoplastic and antifungal activities. Phytomedicine. 2009. 16(4):352-360.

Liu B, Peng H, Yao Q, Li J, Van Damme E, Balzarini J, Bao JK*. Bioinformatics analyses of the mannose-binding lectins from Polygonatum cyrtonema, Ophiopogon japonicus and Liparis noversa with antiproliferative and apoptosis-inducing activities. Phytomedicine. 2009. 16(6-7):601-608.

Ye SH, Chen S, Zhang F, Wang W, Tian Q, Liu JZ, Chen F, Bao JK*. Transgenic tobacco expressing Zephyranthes grandiflora agglutinin confers enhanced resistance to aphids. Applied Biochemistry and Biotechnology. 2009. 158(3):615-30.

Li CY, Wang Y, Peng H, Bian HJ, Min MW, Chen LF, Liu Q, Bao JK*. In silico Analysis of the Potential Infection Mechanisms of Magnaporthe grisea from Horizontal Gene Transfer Hypothesis. Genomics, Proteomics & Bioinformatics. 2009. 7(3):77-86.
Li CY, Meng L, Liu B, Bao JK*. Galanthus nivalis agglutinin (GNA)-related lectins: Traditional proteins, Burgeoning drugs? Current Chemical Biology. 2009. 3:324-333.

Zhao Q, Wu CF, Wang WG, Yuan S, Bao JK*, Chen F. In vitro plantlet regeneration system from rhizomes and mannose-binding lectin analysis of Polygonatum cyrtonema Hua. Plant Cell, Tissue and Organ Culture. 2009. 99(3): 269-275.

2008

Liu B, Xu XC, Cheng Y, Huang J, Liu YH, Liu Z, Min MW, Bian HJ, Chen J, Bao JK*. Apoptosis-inducing effect and structural basis of Polygonatum cyrtonema lectin and chemical modification properties on its mannose-binding sites. BMB Reports. 2008. 41(5):369-375.

Liu C, Zhao X, Xu XC, Li LR, Liu YH, Zhong SD, Bao JK*. Hemagglutinating activity and conformation of a lactose-binding lectin from mushroom Agrocybe cylindracea. International Journal of Biological Macromolecules. 2008. 42(2):138-144.

Liu Z, Liu B, Zhang ZT, Zhou TT, Bian HJ, Min MW, Liu YH, Chen J, Bao JK*. A mannose-binding lectin from Sophora flavescens induces apoptosis in HeLa cells. Phytomedicine. 2008. 15(10):867-875.

Tian Q, Wang W, Miao C, Peng H, Liu B, Leng FW, Dai L, Chen F, Bao JK*. Purification, characterization and molecular cloning of a novel mannose-binding lectin from rhizomes of Ophiopogon japonicus with antiviral and antifungal activities. Plant Science. 2008. 175(6): 877-884.

Xu XC, Zhong SD, Kai F, Li LR, Liu C, Liu B, Bao JK*. Preparation and characterization of a novel recombinant human parathyroid hormone (1-34) analog (Gly1-Gln26-rhPTH(1-34)) with enhanced biological activity. Protein & Peptide Letters. 2008. 15(8):854-860.

Ding JJ, Bao JK, Zhu DY, Zhang Y, Wang DC. Crystallization and Preliminary X-Ray Diffraction Analysis of a Novel Mannose-Binding Lectin with Antiretroviral Properties from Polygonatum cyrtonema Hua. Protein and Peptide Letters. 2008. 15(4):411-414.

2007

Luo YT, Xu XC, Liu JW, Li J, Sun YS, Liu Z, Liu JZ, Van Damme E, Balzarini J, Bao JK*. A novel mannose-binding tuber lectin from Typhonium divaricatum (L.) Decne (family Araceae) with antiviral activity against HSV-II and anti-proliferative effect on human cancer cell lines. Journal of Biochemistry and Molecular Biology. 2007. 40(3):358-367.

Liu JW, Xu XC, Liu JZ, Balzarini J, Luo YT, Kong Y, Li J, Chen F, Van Damme E, Bao JK*. A novel tetrameric lectin from Lycoris aurea with four mannose-binding sites permonomer. Acta Biochimica Polonica. 2007. 54(1):159-166.

Xu XC, Wu CF, Liu C, Luo YT, Li J, Zhao XP, Damme EV, Bao JK*. Purification and Characterization of a Mannose-Binding Lectin from the Rhizomes of Aspidistra elatior Blume with Antiproliferative Activity. Acta Biochimica et Biophysica Sinica (Shanghai). 2007. 39(7): 507-519

學術專著
1. Jin-Ku Bao. Autophagy pathways and drug targets in cancer. In: Autophagy: Principles, Regulation and Roles in Disease. 2011. Nova Science Publisher. Hauppauge NY, USA。
2. 鮑錦庫，《自噬：生物學與疾病》第二十八章：針對自噬的藥物開發和治療的展望。科學出版社（2015，第二版）。

其它論著
An J, Liu JZ, Wu CF, Li J, Dai L, Van Damme E, Balzarini J, De Clercq E, Chen F, Bao JK*. Anti-HIV I/II activity and molecular cloning of a novel mannose/sialic acid-binding lectin from rhizome of Polygonatum cyrtonema Hua. Acta Biochimica et Biophysica Sinica (Shanghai). 2006. 38(2):70-8.
Wu CF, Li J, An J, Chang LQ, Chen F, Bao JK*. Purification, Biological Activities, and Molecular Cloning of a Novel Mannose-Binding Lectin from Bulbs of Zephyranthes candida Herb (Amaryllidaceae). Journal of Integrative Plant Biology. 2006. 48(2):223-231.

Gao S, An J, Wu CF, Gu Y, Chen F, Yu Y, Wu QQ, Bao JK*. Effect of amino acid residue and oligosaccharide chain chemical modifications on spectral and hemagglutinating activity of Millettia dielsiana Harms. ex Diels. Lectin. Acta Biochimica et Biophysica Sinica (Shanghai). 2005. 37(1): 47-54.

Gong M, An J, Lü HZ, Wu CF, Li YJ, Cheng JQ, Bao JK*. Effects of denaturation and amino acid modification on fluorescence spectrum and hemagglutinating activity of Hericium erinaceum Lectin. Acta Biochimica et Biophysica Sinica (Shanghai). 2004. 36(5):343-350

Wu CF, An J, He XJ, Deng J, Hong ZX, Liu Chao, Lu HZ, Li YJ, Wang CJ, Chen F, Bao JK*. Molecular Cloning of a Novel Mannose-binding Lectin Gene from Bulbs of Amaryllis vittata (Amaryllidaceae). Acta Botanica Sinica. 2004. 46(11):1301-1306.
Jiang FB, Du J, Yu XQ, Bao JK, Zeng XC. Metallomicellar catalysis: accelerated hydrolysis of BNPP by copper(II), zinc(II), and nickel(II) complexes of long alkanol-imidazole in CTAB micellar solution. Journal of Colloid and Interface Science. 2004. 273(2):497-504.

Cai YF, Zhang H, Zeng Y, Mo JC, Bao JK, Miao C, Bai J, Yan F, Chen F. An optimized gossypol high-performance liquid chromatography assay and its application in evaluation of different gland genotypes of cotton. Journal of Biosciences. 2004. 29(1):67-71.

Biological Activity Analysis of Polygonatum cyrtonema Hua. Lectin by Site-Directed Mutagenesis, Trends in Glycoscience and Glycotechnology, 2004,16:pp.s1–s32

In Vitro Plantlet Regeneration from Rhizome Lumps and Mannose-Binding Lectin Analysis of Polygonatum cyrtonema Hua.(Family Liliaceae) ,Trends in Glycoscience and Glycotechnology(TIGG), 2004,16: pp.S 33–S 64（IF 0.863）
Miao C, Gou XP, Lan LQ, Bao JK, Xu Y, Wang SH, Chen F. Molecular cloning and expression of RSSSG58 gene in rice sperm cells. Acta Botanica Sinica. 2003. 45(2):234-241.
Xiang QX, Zhou H, Wang XY, Yu XQ, Bao JK, Xie RG. Interaction between Bifunctional Kioxo Macrocyclic Polyamine Co(II) Complex and DNA in Metallomicellar System. Chinese Chemical Letters. 2002. 13(3):223-226.

Bao JK, Zeng ZK. Purification and biological activity of a lectin from Polygonatum cyrtonema Hua. Eur J Cell Biol 1997, 74(Suppl.46): 8.

Bao JK, Zhou H, Zeng ZK. Conformation and activity of Millettia dielsianna Harms lectin, Eur J Cell Biol,1997,74(Suppl.46):8

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