韓管助，南京師範大學生命科學學院教授、博士生導師，國家自然科學基金優秀青年科學基金獲得者，現任南京師範大學生命科學學院副院長。主要從事病毒進化和多樣性以及病原與宿主間互作進化方面的研究工作，共發表SCI收錄論文70餘篇，其中作為通訊作者在PNAS、Nature Communications、Molecular Biology and Evolution、The Plant Cell、PLOS Pathogens、mBio等期刊發表論文50餘篇。研究工作多次獲得Nature Reviews Microbiology、Trends in Plant Science、The Plant Cell等期刊評述或推薦。多次受邀為Nature Plants、Trends in Microbiology等期刊撰寫綜述或評述文章。
基本介紹
- 中文名：韓管助
- 學位/學歷：博士
主要科研項目,學術交流,榮譽獎項,
研究方向
病毒性傳染病正嚴重威脅全球公共衛生安全和社會經濟發展。理解病毒進化和多樣性對於病毒性傳染病的監測、防控以及預測具有十分重要的意義。韓管助實驗室主要利用進化生物學、基因組學、分子生物學等方法來研究病毒進化和多樣性以及病原與宿主間互作的進化。主要研究方向包括：
· 病毒起源、進化和多樣性；
· 病毒性新發傳染病監測、溯源和進化；
· 病原與宿主間互作驅動的進化創新。
代表性論文（*通訊作者）
1. Chu L, Gong Z, Wang W, Han GZ*. (2023). Origin of the OAS-RNase L innate immune pathway before the rise of jawed vertebrates via molecular tinkering. Proceedings of the National Academy of Sciences 120: e2304687120.
2. Wang J, Han GZ*. (2023). Genome mining shows that retroviruses are pervasively invading vertebrate genomes. Nature Communications 14: 4968.
3. Wang W, Han GZ*. (2023). A long-running arms race between APOBEC1 genes and retroviruses in tetrapods. Journal of Virology 97: e0179522.
4. Gong Z, Qi J, Hu M, Bi G, Zhou JM*, Han GZ*. (2022). The origin and evolution of a plant resistosome. The Plant Cell 34: 1600-1620.（The Plant Cell發表了題為Inventing the wheel: new insights into resistosome evolution的In Brief文章對該研究進行了評述）
5. Wang J, Han GZ*. (2022). A missing link between retrotransposons and retroviruses. mBio 13: e00187-22.
6. Gong Z, Shao ZQ*, Chen JQ*, Han GZ*. (2022). Plant immune receptors evolved hand in hand. Nature Plants 8: 1138-1139. （News and Views文章）
7. Wang J, Han GZ*. (2021). Unearthing LTR retrotransposon gag genes co-opted in the deep evolution of eukaryotes. Molecular Biology and Evolution 38: 3267-3278.
8. Wang J, Han GZ*. (2021). A sister lineage of sampled retroviruses corroborates the complex evolution of retroviruses. Molecular Biology and Evolution 38: 1031-1039.
9. Zheng J, Wang J, Gong Z, Han GZ*. (2021). Molecular fossils illuminate the evolution of retroviruses following a macroevolutionary transition from land to water. PLOS Pathogens 17: e1009730.
10. Wang Q, Wang Y, Wang J, Gong Z, Han GZ*. (2021). Plants acquired a major retrotransposon horizontally from fungi during the conquest of land. New Phytologist 232: 11-16.
11. Gong Z, Han GZ*. (2021). Flourishing in water: the early evolution and diversification of plant receptor-like kinases. The Plant Journal 106: 174-184.
12. Wang W, Han GZ*. (2021). Pervasive positive selection on virus receptors driven by host-virus conflicts in mammals. Journal of Virology 95: e01029-21.
13. Wang J, Han GZ*. (2020). Frequent retroviral gene co-option during the evolution of vertebrates. Molecular Biology and Evolution 37:3232-3242.
14. Wang W, Zhao H, Han GZ*. (2020). Host-virus arms races drive elevated adaptive evolution in viral receptors. Journal of Virology 94: e00684-20.（Journal of Virology發表了題為Elevated adaptive evolution in viral receptors的Spotlight文章對該研究進行了評述）
15. Han GZ*. (2019). Origin and evolution of the plant immune system. New Phytologist 222: 70-83.（特邀Tansley Review）
16. Wang J, Gong Z, Han GZ*. (2019). Convergent co-option of the retroviral gag gene during the early evolution of mammals. Journal of Virology 93: e00542-19.
17. Xu X, Zhao H, Gong Z, Han GZ*. (2018). Endogenous retroviruses of non-avian/mammalian vertebrates illuminate diversity and deep history of retroviruses. PLOS Pathogens 14: e1007072.（Nature Reviews Microbiology發表了題為An aquatic origin of retroviruses的文章對該研究進行了推薦）
18. Gong Z, Han GZ*. (2018). Insect retroelements provide novel insights into the origin of hepatitis B viruses. Molecular Biology and Evolution 35: 2254-2259.（Molecular Biology and Evolution對該研究進行了封面推薦）
19. Gong Z, Han GZ*. (2018). Euphyllophyte paleoviruses illuminate hidden diversity and macroevolutionary mode of Caulimoviridae. Journal of Virology 92: e02043-17.
20. Gao Y, Wang W, Zhang T, Gong Z, Zhao H, Han GZ*. (2018). Out of water: the origin and early diversification of plant R-genes. Plant Physiology 177: 82-89.（Plant Physiology發表了題為Origin of plant R genes的On the Inside文章對該研究進行了評述；Trends in Plant Science發表了題為Plant NLR origins traced back to green algae的文章對該研究進行了評述）
21. Wang C, Liu Y, Li S*, Han GZ*. (2015). Insights into the origin and evolution of plant hormone signaling machinery. Plant Physiology 167: 872-886.（Plant Physiology發表了題為The evolution of plant hormone signaling pathways的On the Inside文章對該研究進行了評述）
22. Han GZ*, Worobey M*. (2015). A primitive endogenous lentivirus in a colugo: insights into the early evolution of lentiviruses. Molecular Biology and Evolution 32: 211-215.
23. Worobey M*, Han GZ, Rambaut A*. (2014). A synchronized global sweep of the internal genes of modern avian influenza virus. Nature 508: 254-257.（Nature Reviews Microbiology發表了題為Past, present and future of influenza viruses的文章對該研究進行了評述；Nature發表了題為Study revives bird origin for 1918 flu pandemic的News文章對該研究進行了報導）
24. Worobey M*, Han GZ, Rambaut A. (2014). The genesis and pathogenesis of the 1918 influenza pandemic. Proceedings of the National Academy of Sciences 111: 8107-8112.（PNAS發表了題為Evidence for a mild H1 pandemic in the early 1900s的Commentary文章對該研究進行了評述）
25. Han GZ*, Worobey M*. (2012). An endogenous foamy-like viral element in the coelacanth genome. PLOS Pathogens 8: e1002790.
26. Han GZ*, Worobey M*. (2012). Endogenous lentiviral elements in the weasel family (Mustelidae). Molecular Biology and Evolution 29: 2905-2908.
27. Han GZ*, Worobey M*. (2012). An endogenous foamy virus in the aye-aye (Daubentonia madagascariensis). Journal of Virology 86: 7696-7698.
主要科研項目
國家優秀青年科學基金項目（2020-2022年）：
- 研究內容：病毒進化機制與多樣性形成規律
- 批准金額：130萬元
- 學科分類：微生物學（C010103）
- 核心成果：建立病毒分子化石分析新方法
學術交流
榮譽獎項
- 挑戰杯全國大學生課外學術科技作品競賽一等獎（2005年）
- 南京師範大學中青年領軍人才（2019年）
- 江蘇省科協青年科技人才托舉工程入選者
- 南京師範大學'十位年度人物'（2020年）
