靳國瑞，男，博士，西安交通大學生命科學與技術學院副教授，碩士生導師， 西安交通大學“十大學術新人”。
基本介紹
- 中文名：靳國瑞
- 畢業院校：新加坡國立大學
- 學位/學歷：博士
- 職業：教師
- 專業方向：功能螢光納米探針的開發及其在腫瘤診斷與治療及再生醫學中的套用
- 任職院校：西安交通大學生命科學與技術學院
- 職稱：副教授
個人經歷,教育經歷,工作經歷,榮譽獎項,研究方向,學術成果,論文,項目,
個人經歷
於2009年畢業於哈爾濱工業大學獲材料科學與工程學士學位，2014年2月畢業於新加坡國立大學（National University of Singapore）獲機械工程博士學位。同年受聘於新加坡科技研究局（A*Star）-材料研究與工程所，任博士後。2015年9月，全職回到西安交通大學，被聘為生命科學與技術學院，生物醫學信息工程教育部重點實驗室副教授，碩士生導師。
2016年獲邀成為Drug Discovery Today（IF=5.625）的Therapeutic Nanomaterials特刊的特邀編輯，長期擔任Scientific Report等期刊的審稿人。
教育經歷
2009/09-2014/02，新加坡國立大學，機械工程，博士
工作經歷
2015/09-至今，西安交通大學，生命科學與技術學院，副教授
2013/09-2015/09，新加坡科技研究局（A*Star）-材料研究與工程所，博士後
榮譽獎項
2016年獲得獲得國際組織工程與再生醫學學會亞太年會最佳論文獎。
研究方向
致力於功能螢光納米探針的開發及其在腫瘤診斷與治療及再生醫學中的套用研究。
學術成果
針對幹細胞促進組織再生機理不清楚和癌症診療等臨床問題取得了一系列具有轉化潛力的科研成果。
科研成果在多個國際知名雜誌如Chemical Reviews（ESI高被引論文），Chemical Society Reviews（ESI高被引論文），Advanced Functional Materials，Biomaterials，Theranostics, ACS Applied Materials & Interfaces, Acta Biomaterilia，Chemical Communications等上發表高水平專業文章42篇，H因子21，累計影響因子超過180，引用次數超過1400次，其中通訊，第一及共同第一作者文章20篇，平均影響因子超過6.5。其中利用共軛聚合物螢光納米粒子實現了間充質幹細胞的長期在體示蹤的研究成果作為共同第一發明人申報新加坡專利一項並已通過PCT國際專利合作條約。
主持國家自然科學基金青年基金1項，中國博士後特助項目1項，中國博士後科學基金面上資助項目1項，西安交通大學綜合交叉類項目1項，西安交通大學新教師支持計畫1項。
論文
Guorui Jina,b*, Wenfang Lia,b*, Fan Songc*, Jing Zhaoa, Mengqi Wangd, Qian Liua,b, Ang Lid, Guoyou Huanga,b, Feng Xu, Fluorescent Conjugated Polymer Nanovector for In Vivo Tracking and Regulating the Fate of Stem Cells for Restoring Infarcted Myocardium, Acta Biomaterialia, 2020.
Huaibin Qinga,b*, Yuan Jia,b*, Wenfang Lia,b, Qingzhen Yanga,b, Xiaohui Zhanga,b, Zhengtang Luoc, Tian Jian Lud,e, Guorui Jin#, Feng Xu#, Microfluidic Printing of 3D Graphene Electroactive Microfibrous Scaffolds, ACS Applied Materials & Interfaces, 2019 (IF 8.097, 共同通訊)
Guorui Jin1,2*, Rongyan He1,2*, Qian Liu1,2, Min Lin1,2, Yuqing Dong2,3, Kai Li4, Ben Zhong Tang5,6, Bin Liu7, Feng Xu, Near-infrared light-regulated cancer theranostic nanoplatform based on aggregation-induced emission luminogen encapsulated upconversion nanoparticles, Theranostics 2019 (IF 8.537)
Guorui Jin, Rongyan He, Qian Liu, Yuqing Dong, Min Lin, Wenfang Li, Feng Xu, Theranostics of Triple-Negative Breast Cancer Based on Conjugated Polymer Nanoparticles, ACS Applied Materials & Interfaces, 2018 (Front Cover, IF 8.097)
Guorui Jin, R.Y. He, B.Y. Sha, W.F. Li, H.B. Qing, R. Teng, F. Xu, Electrospun threedimensional aligned nanofibrous scaffolds for tissue engineering, Materials Science & Engineering C, 2018 (IF 5.01)
Huaibin Qing, Guorui Jin, Guoxu Zhao, Guoyou Huang, Yufei Ma, Xiaohui Zhang, Baoyong Sha, Tom Luo, Tian Jian Lu, Feng Xu,Silk Nanofibers-Reduced Graphene Oxide Heterostructure Composite Scaffold for Neural Stem Cell Alignment and Differentiation,ACS Applied Materials & Interfaces, 2018 (Co-first author,IF 8.097)
Y.Q. Dong, Guorui Jin, Y. Hong, H.Y. Zhu, T.J. Lu, F. Xu, D. Bai, M. Lin, Engineering Cell Microenvironment using Novel Photo-responsive Hydrogels, ACS Applied Materials & Interfaces, 2018 (co-first author，IF 8.097)
R. Zhou, Y. Han, J.Y. Cao, M. Li, Guorui Jin, Y.Z. Du, H.T. Luo, Y.C. Yang, L.Z. Zhang, B. Su, Enhanced osseointegration of hierarchically structured Ti implant with electrically bioactive SnO2-TiO2 bi-layered surface, ACS Applied Materials & Interfaces, 2018 (IF 8.097)
R. Zhou, Y. Han, J.Y. Cao, M. Li, Guorui Jin, H.T. Luo, L.Z. Zhang, B. Su, Electrically bioactive coating on Ti with bi-layered SnO2–TiO2 hetero-structure for improving osteointegration, Journal of Materials Chemistry B, 2018 (IF 4.776)
Guorui Jin, Xin Zhao, Feng Xu, Therapeutic nanomaterials for cancer therapy and tissue regeneration. Drug Discovery Today, 2017 (IF 6.36)
Guorui Jin, Jun Li, Kai Li. Photosensitive semiconducting polymer-incorporated nanofibers for promoting the regeneration of skin wound. Mater. Sci. Eng. C, 2017
J. Zhao, Guorui Jin*, G. J. Weng, J.J. Li, J. Zhu and J.W. Zhao*, Recent advances in activatable fluorescence imaging probes for tumor imaging, Drug Discovery Today, 2017 (Co-corresponding author IF 6.36)
Y.Q. Dong, Guorui Jin, C.C. Ji, R.Y. He, M. Lin, X. Zhao, A. Li, F. Xu, T.J. Lu, Non-Invasive Tracking of Hydrogel Degradation Using Upconversion Nanoparticles, Acta Biomaterilia, 2017 (Co-first author, IF 6.31)
G.Y. Huang, F. Li, X. Zhao, Y.F. Ma, Y.H. Li, M. Lin, Guorui Jin, T.J. Lu, G. Genin, F. Xu, Functional and Biomimetic Materials for Eineering of the Three-Dimensional Cell Microenvironment, Chemical Reviews, 2017
Y.Q. Dong, M. Lin, Guorui Jin, Y. Park, M.S. Qiu, Y. Zhao, H. Yang, A. Li, T.J. Lu, Fabrication of Fluorescent Composite Hydrogel Using in situ Synthesis of Upconversion Nanoparticles, Nanotechnology, 2017
S.J. Peng, Guorui Jin,L.L. Li, K. Li, M. Srinivasan, S. Ramakrishna, J. Chen, Multi-functional electrospun nanofibres for advances in tissue regeneration, energy conversion & storage, and water treatment, Chemical Society Reviews, 2016 (co-first author，IF 40.128, ESI Highly Cited Paper)
Guorui Jin, Guangxue Feng, Wei Qin, Ben Zhong Tang, Bin Liu and Kai Li. Multifunctional organic nanoparticles with aggregation-induced emission (AIE) characteristics for targeted photodynamic therapy and RNA interference therapy. Chem. Commun.
B. Gao, Q.Z. Yang, X. Zhao, Guorui Jin, Y.F. Ma, F. Xu, 4D Bioprinting for Biomedical Applications, Trends in Biotechnology, 2016
Zibiao Li, Du Yuan, Guorui Jin, Beng H. Tan, Chaobin He. Facile Layer-by-Layer Self-Assembly toward Enantiomeric Poly(lactide) Stereocomplex Coated Magnetite Nanocarrier for Highly Tunable Drug Deliveries. ACS Appl. Mater. Inter. 2016
Y.F. Ma, Y. Ji, M.L. You, S.R. Wang, Y.Q. Dong, Guorui Jin, M. Lin, Q. Wang, A, Li, X.H. Zhang, F. Xu, Labeling and long-term tracking of bone marrow mesenchymal stem cells in vitro using NaYF4:Yb,Erupconversion nanoparticles, Acta Biomaterialia, 2016
M.L. You, M. Lin, S.R. Wang, X.M. Wang, G. Zhang, Y. Hong, Y.Q. Dong, Guorui Jin, F. Xu, Three-Dimensional Quick Response Code based on Inkjet Printing of Upconversion Fluorescence Nanoparticles for Drug Anti-Counterfeitin, Nanoscale, 2016
Guorui Jin, Duo Mao, Pingqiang Cai, Jie Liu, Xiaodong Chen, Deling Kong, Dan Ding, Bin Liu, Kai Li, Conjugated Polymer Nanodots as Ultrastable Long-term Trackers to Understand Mesenchymal Stem Cell Therapy in Skin Regeneration. Adv. Funct. Mater.
Guorui Jin, Molamma P Prabhakaran, Dan Kai, Sathesh Kumar Annamalai, Kantha D. Arunachalam, Seeram Ramakrishna. Tissue engineered plant extracts as nanofibrous wound dressing. Biomaterials. 2012
Guorui Jin, Molamma P Prabhakaran, Seeram Ramakrishna. Mesenchymal stem cell differentiation to epidermal lineages on electrospun nanofibrous substrates for skin tissue engineering. Acta Biomateria, 2011
Guorui Jin, Molamma P Prabhakaran, Kai Dan, Seeram Ramakrishna. Controlled release of multiple epidermal induction factors through core-shell nanofibers for skin regeneration. Eur. J. Pharm. Biopharm. 2013
Guorui Jin, Li Kai. The electrically conductive scaffold as the skeleton of stem cell niche in regenerative medicine. Mater. Sci. Eng., 2014
Guorui Jin, Yong Li, Molamma P Prabhakaran, Weiming Tian, Seeram Ramakrishna. In vitro and in vivo evaluation of the wound healing capability of electrospun gelatin/PLLCL nanofibers. J. Bioact. Compat. Pol. 2014
Guorui Jin, Molamma P Prabhakaran, Seeram Ramakrishna. Photosensitive and biomimetic core-shell nanofibrous scaffolds as wound dressing. Photochem. Photobiol. 2014
Guorui Jin, Molamma P Prabhakaran, Kai Dan, Seeram Ramakrishna. Electrospun photosensitive nanofibers: Potential for photocurrent therapy in skin regeneration. Photochem Photobiol Sci. 2012
Guorui Jin, Molamma P. Prabhakaran, Susan Liao, Seeram Ramakrishna. Photosensitive materials and potential of photocurrent mediated tissue regeneration. J Photoch Photobio B, 2011
Guorui Jin, Molamma P Prabhakaran, Dan Kai, Seeram Ramakrishna. Electrospun Silver nanoparticles containing PLLCL nanofibers for skin tissue engineering. J Biomater Sci Polym Ed.
Zibiao Li, Beng H. Tan, Guorui Jin, Kai Li and Chaobin He. Design of polyhedral oligomeric silsesquioxane (POSS) based thermo-responsive amphiphilic hybrid copolymers for thermally denatured protein protection applications. Polym. Chem., 2014
Kai, D, Low, ZW, Liow, SS, Ye, HY, Guorui Jin, Li, K, Loh, XJ. Elastic poly(epsilon-caprolactone)-polydimethylsiloxane copolymer fibers with shape memory effect for bone tissue engineering. Biomedical Materials. 2016
Kai Dan, Molamma P Prabhakaran, Guorui Jin, Seeram Ramakrishna. Biocompatibility evaluation of electrically conductive nanofibrous scaffolds for cardiac tissue engineering. J. Mater. Chem. B
Hongyuan Zhua,Min Lin, Guorui Jin, Tian Jian Lu, Feng Xu. A modified energy transfer model for determination of upconversion emission of β-NaYF4:Yb,Er: Role of self-quenching effect. Journal of Luminescence, 2017
Dan Kai, MP Prabhakaran, Guorui Jin, Lingling Tian, Seeram Ramakrishna, Potential of VEGF-encapsulated electrospun nanofibers for in vitro cardiomyogenic differentiation of human mesenchymal stem cells. J Tissue Eng Regen Med.
Elham Vatankhah, Molamma P Prabhakaran, Guorui Jin, Seeram Ramakrishna. Development of nanofibrous Cellulose acetate/gelatin skin substitutes for variety wound treatment applications. J. Biomater. Appl.
Dan Kai,Guorui Jin, Molamma P Prabhakaran, Seeram Ramakrishna.Electrospun synthetic and natural nanofibers for regenerative medicine and stem cells.Biotechnol J
L. Ghasemi-Mobarakeh, M.P. Prabhakarn, Preethi,Guorui Jinet al.Advance in electrosupun nanofibers for bone and cartilage regeneration.J Nanosci Nanotechnol
M.P. Prabhakaran, J. Venugopal, L. Ghasemi-Mobarakeh, D. Kai,Guorui Jin, S. Ramakrishna. Stem cells and nanostructures for advanced tissue regeneration.Adv Polym Sci
Dan Kai, Molamma P Prabhakaran,Guorui Jin, Seeram Ramakrishna.Guided orientation of cardiomyocytes on electrospun aligned nanofibers for cardiac tissue engineering.J Biomed Mater Res B
Su Yan, Su Qianqian, Liu Wei,Guorui Jin, Mo Xiumei, Ramakrishna Seeram.Dual-Drug Encapsulation and Release from Core–Shell Nanofiber.J Biomater Sci Polym Ed.
M.P. Prabhakaran, L. Ghasemi-Mobarakeh,Guorui Jin, S. Ramakrishna. Electrospun conducting polymer nanofibers and electrical stimulation of nerve stem cells. J Biosci Bioeng
Kai D, Prabhakaran MP, Guorui Jin, Ramakrishna S. Polypyrrole-contained electrospun conductive nanofibrous membranes for cardiac tissue engineering. J Biomed Mater Res A
項目
2020-2023，溫度回響型聚集誘導發光納米探針的製備及其在腫瘤診療中的套用，國家自然科學基金面上項目，項目負責人
2017-2019，基於共軛高分子螢光探針的幹細胞-生物支架雙示蹤研究，國家自然科學基金青年項目，項目負責人
2019-2021，基於共軛高分子螢光探針的基因遞送及幹細胞示蹤研究，國家博士後特助基金，項目負責人
2016-2018，基於包裹聚集誘導發光分子膠束的癌症近紅外光動力治，西安交通大學，項目負責人
2016-2019，基於高穩定性的螢光納米粒子的幹細胞及支架雙示蹤研究，西安交通大學，項目負責人
2016-2018，基於共軛高分子螢光探針的生物支架示蹤研究，國家博士後基金面上基金，項目負責人
2016-2018，共軛高分子螢光探針用於生物支架示蹤研究，陝西省博士後基金面上基金，項目負責人
2017-2019，基於4D生物列印的皮膚組織戰場快速修復，裝備預研教育部聯合基金，參與人，細胞示蹤粒子的開發與組織再生
2017-2019，前沿生物感測技術創新團隊，陝西省創新能力支撐計畫-陝西省創新團隊，參與人，生物醫用納米材料
2018-2021，基於石墨烯的多功能水凝膠平台用於神經組織構建和體外原位檢測，國家自然科學基金國際(地區)合作與交流項目，參與人，石墨烯水凝膠的製備及神經功能檢測
2018-2021，皮膚-肌肉組織快速原位3D生物列印的裝備及工藝研究，陝西省重點研發計畫，參與人，皮膚組織再生及原理研究
