陳香嵩，博士，武漢大學生命科學學院研究員。
基本介紹
- 中文名：陳香嵩
- 學位/學歷：博士
- 職業：教師
- 專業方向：植物表觀遺傳學
- 任職院校：武漢大學
個人經歷,研究方向,學術成果,
個人經歷
學習經歷
2003.09-2007.06 華中農業大學，生命科學技術學院，國家生命科學與技術基地班，本科
2007.09-2012.12 華中農業大學，生命科學技術學院，作物遺傳改良國家重點實驗室，博士
主要工作經歷與任職情況：
2013.01-2013.12 華中農業大學，作物遺傳改良國家重點實驗室，科研助理
2014.01-2018.12 美國威斯康星大學-麥迪遜分校，博士後
2019.01至今， 武漢大學生命科學學院，雜交水稻國家重點實驗室，研究員
研究方向
研究方向：植物表觀遺傳學
主要研究領域及興趣：
真核生物的DNA纏繞在組蛋白八聚體上以染色質的形式存在於細胞核中，作為“骨架”的組蛋白上存在著動態的化學修飾，包括乙醯化、甲基化、磷酸化等。這些修飾對染色質的活動（DNA的複製及損傷修復、RNA轉錄等）有重要的調控作用。我們以模式植物擬南芥和水稻為材料，重點關註：1.組蛋白修飾（現階段以乙醯化為主）調控染色質活動的具體機制，例如組蛋白修飾的相關酶或者識別蛋白是如何感知細胞內外的信號，並知道在何時作用於何處的；2.組蛋白修飾的相關調控蛋白在植物的生長發育和逆境回響等重要生物學進程中扮演的角色。
學術成果
代表性論文：
1. Kevin S. Mayer#, Xiangsong Chen#, Dean Sanders, Jiani Chen, Jianjun Jiang, Phu Nguyen, Mark Scalf, Lloyd M. Smith, and Xuehua Zhong. HOS15 acts with HISTONE DEACETYLASE 9 to modulate transcription and development. Plant Physiology. Accepted. # Co-first author
2. Xiangsong Chen, Li Lu, Shuiming Qian, Mark Scalf, Lloyd M. Smith, Xuehua Zhong. Canonical and non-canonical actions of Arabidopsis histone deacetylases in ribosomal RNA processing. Plant Cell (2018), 30:134–152. (Highlighted in Plant Cell (2018), 30:5–6.)
3. Li Lu#, Xiangsong Chen#, Shuiming Qian, Xuehua Zhong. The plant-specific histone residue Phe41 is important for genome-wide H3.1 distribution. Nature Communications (2018), 9:630. # co-first author. # Co-first author
4. Xiangsong Chen, Li Lu, Kevin Mayer, Mark Scalf, Shuiming Qian, Aaron Lomax, Lloyd Smith, Xuehua Zhong. POWERDRESS interacts with HISTONE DEACETYLASE 9 to promote aging in Arabidopsis. eLife (2016), 5:e17214.
5. Yun Ju Kim, Ruozhong Wang, Lei Gao, Dongming Li, Chi Xu, Hyunggon Mang, Jien Jeon, Xiangsong Chen, Xuehua Zhong, June M. Kwak, Beixin Mo, Langtao Xiao, and Xuemei Chen. POWERDRESS and HDA9 interact and promote histone H3 deacetylation at specific genomic sites in Arabidopsis. PNAS (2016), 113: 14858-14863.
6. Li Lu, Xiangsong Chen, Dean Sanders, Shuiming Qian, Xuehua Zhong. High-resolution mapping of H4K16 and H3K23 acetylation reveals conserved and unique distribution patterns in Arabidopsis and rice. Epigenetics (2015), 10:1044-1053.
7. Xiangsong Chen, Xiaoyun Liu, Yu Zhao, Dao-Xiu Zhou. Histone H3K4me3 and H3K27me3 regulatory genes control stable transmission of an epimutation in rice. Scientific Reports (2015), 5:13251.
8. Qingfeng Chen#, Xiangsong Chen#, Quan Wang, Faben Zhang, Zhiyong Lou, Qifa Zhang, Dao-Xiu Zhou. Structural basis of a histone H3 lysine 4 demethylase required for stem elongation in rice. PLoS Genetics. (2013), 9:e1003239. # Co-first author
9. Xiangsong Chen, Dao-Xiu Zhou. Rice epigenomics and epigenetics: challenges and opportunities. Current Opinion in Plant Biology (2013), 16:164-169.
10. Tiantian Li, Xiangsong Chen, Xiaochao Zhong, Yu Zhao, Xiaoyun Liu, Shaoli Zhou, Saifeng Cheng, Dao-Xiu Zhou. Jumonji C domain protein JMJ705-mediated removal of histone H3 lysine 27 trimethylation is involved in defense-related gene activation in rice. Plant Cell (2013), 25:4725-4736.
11. Xiangsong Chen, Yongfeng Hu, Dao-Xiu Zhou. Epigenetic gene regulation by plant Jumonji group of histone demethylase. Biochimica et Biophysica Acta. (2011), 1809:421-426.
12. Fujun Qin, Qianwen Sun, Liming Huang, Xiangsong Chen, Dao-Xiu Zhou. Rice SUVH histone methyltransferase genes display specific functions in chromatin modification and retrotransposon repression. Molecular Plant (2010), 3: 773-782.
