都浩(浙江大學百人計畫研究員，博士生導師)

都浩(浙江大學百人計畫研究員，博士生導師)

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都浩，男，浙江大學農業與生物技術學院百人計畫研究員，博士生導師，浙江大學杭州國際科創中心”青年人才卓越計畫“研究員，生物與分子智造研究院PI。

基本介紹

人物經歷,研究方向,研究成果,研究論文,

人物經歷

2003年考入華中農業大學生科院生命科學技術人才培養基地班。
2007年取得理學學士學位。
2006年進入華中農業大學作物遺傳改良國家重點實驗室熊立仲教授實驗室，從事水稻逆境生物學研究。
2013年6月取得生物化學與分子生物學博士學位。
2013年至2015年4月在華中農業大學作物遺傳改良國家重點實驗室熊立仲教授實驗室做Research Associate。
2015年5月進入哈佛大學醫學院Jen Sheen教授實驗室做博士後研究，主要從事蛋白激酶AMPK，CPK、TOR及單細胞生物學和基因編輯相關的研究。
2019年底以‘百人計畫’研究員加入浙江大學農業與生物技術學院。
2021年初入選浙江大學杭州國際科創中心卓越人才計畫，成為浙江大學杭州國際科創中心生物與分子智造研究院雙聘研究員，與浙江大學醫學院、化學工程與生物工程學院、計算機科學與技術學院、生命科學研究院等開展交叉學科研究。
累計發表SCI收錄研究論文27篇，累計引用2600次以上。

研究方向

蛋白激酶SnRK1, TOR調控水稻生長發育與抗性機制的研究。
生物合成模組庫創建和利用，用於醫藥、食品、能源智造的植物細胞工廠創建。
植物原生質體基因編輯、染色體改造及植株再生平台創建。

研究成果

課題組已經在植物功能基因研究、生物技術開發等方面發表SCI收錄研究論文21篇，論文主要發表在Nature，Mol Plant，Plant J，Plant Physiol，J Exp Bot,J Integr Plant Biol，Theor Appl Genet，Plant Mol Biol，Front Plant Sci，PLOS Comp Biol，New Phytol等雜誌，他引1500次以上，H指數16。

研究論文

  1. Ruiqiang Ye, Meiyue Wang, Hao Du, Shweta Chhajed, Jin Koh, Kun-hsiang Liu,Jinwoo Shin, Yue Wu, Lin Shi, Lin Xu, Sixue Chen, Yijing Zhang, Jen Sheen* Glucose-Driven TOR-FIE-PRC2 signalling controls plant development. Nature, 2022, in press.
  2. Wu N, Yao Y, Xiang D, Du H, Geng Z, Yang W, Li X, Xie T, Xiong L. A MITE variation-associated heat-inducible isoform of a heat-shock factor confers heat tolerance through regulation of JASMONATE ZIM-DOMAIN genes in rice. New Phytol. 2022 May;234(4):1315-1331.
  3. Liu X, Sun J, Huang Y, Li C, Zheng P, Yuan Y, Chen H, Jan M, Zheng H, Du H*, Tu J* .Osj10gBTF3-mediated import of chloroplast protein is essential for pollen development in rice. Front Plant Sci. 2021 Aug 6;12:713544
  4. Chen Y, Shen J, Zhang L, Qi H, Yang L , Wang H, Wang J, Wang Y, Du H, Tao Z, Zhao T, Deng P, Shu Q, Qian Q, Yu H, Song S* (2021) Nuclear translocation of OsMFT1 that is impeded by OsFTIP1 promotes drought tolerance in rice. Molecular Plant, 2021 Aug 2;14(8):1297-1311.
  5. Zheng P, Liu Y, Liu X, Huang Y, Sun F, Chen H, Wang W, Jan M, Zhang C, Yuan Y, Tan B, Du H*,Tu J*.OsPPR939, a nad5 splicing factor, is essential for plant growth and pollen development in rice. Theor Appl Genet 2021.134(3):923-940.
  6. Zheng P, Wang D, Huang Y, Chen H, Du H*, Tu J*. Detection and Analysis of C-to-U RNA Editing in Rice Mitochondria-Encoded ORFs.Plants (Basel). 2020. 28;9(10):E1277
  7. Tan, Y. Du, H. Wu, X. Liu, Y. Jiang, M. Song, S.Wu, L. Shu, Q*. Gene editing: an instrument for practical application of gene biology to plant breeding. J Zhejiang Univ Sci B. 2020. 21(6):460-473
  8. Tan, Y. Du, H. Wu, X. Liu, Y. Jiang, M. Song, S.Wu, L. Shu, Q. (2020)Gene editing: an instrument for practical application of gene biology to plant breeding. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), ISSN 1673-1581 (Print); ISSN 1862-1783 (Online)
  9. Maheshwari, P. Du, H. Sheen, J. Assman, S. and Albert, R. (2019) Model-driven discovery of calcium-related protein-phosphatase inhibition in plant guard cell signaling. PLoS Comput Biol. 2019 Oct 28;15(10):e1007429.
  10. Zhang, R. Ge, S. He, Ji. Li, S. Hao, Y. Du, H. Liu, Z. Cheng, R. Feng, Y. Xiong, L. L,i C. Hetherington.M. Liang, Y. (2019). BIG regulates stomatal immunity and jasmonate production in Arabidopsis. New Phytol. 222(1):335-348
  11. Du, H. Huang, F. Wu, N. Li, X. Hu, H. and Xiong, L. (2018). Integrative Regulation of Drought Escape through ABA-Dependent and -Independent Pathways in Rice. Mol Plant 11:584-597.
  12. Liu, K. Niu, Y. Konishi, M. Wu, Y. Du, H. Sun Chung, H. Li, L. Boudsocq, M. McCormack, M. Maekawa, S. et al. (2017). Discovery of nitrate-CPK-NLP signalling in central nutrient-growth networks. Nature 545:311-316.
  13. Fang, Y. Liao, K. Du, H. Xu, Y. Song, H. Li, X. Xiong, L. (2015) A stress-responsive NAC transcription factor SNAC3 confers heat and drought tolerance through modulation of reactive oxygen species in rice. J Exp Bot. 66(21):6803-17
  14. Zhu, N. Cheng, S. Liu, X. Du, H. Dai, M. Zhou, D. Yang, W. Zhao, Y. (2015)The R2R3-type MYB gene OsMYB91 has a function in coordinating plant growth and salt stress tolerance in rice. Plant Sci. 236:146-56
  15. Du, H*. Chang, Y. Huang, F, Xiong, L. (2015) GID1 modulates stomatal response and submergence tolerance involving ABA and GA signaling in rice. J Integr Plant Biol. 57(11):954-68. ( *Corresponding author)
  16. Du, H. Wu, N. Cui, F. You, L. Li, X. Xiong, L. (2014) A homolog of ETHYLENE OVERPRODUCER, OsETOL1, differentially modulates drought and submergence tolerance in rice. Plant J. 78: 834-849
  17. Weng, X. Wang, L. Wang, J. Hu, Y. Du, H. Xu, C. Xing, Y. Li, X. Xiao, J. Zhang, Q. (2014) Grain number, plant height, and heading date7 is a central regulator of growth, development, and stress response. Plant Physiol. 164:735-747
  18. You,J. Zong,W. Du,H. Hu,H. Xiong,L.(2014)A special member of the rice SRO family, OsSRO1c, mediates responses to multiple abiotic stresses through interaction with various transcription factors.Plant Mol Biol. Apr;84(6):693-705
  19. Du, H. and Xiong, L. (2014) Improvement of Stress Tolerance in Crops by Genetic Manipulation of ABA Metabolism, Signaling, and Regulation. (Chapter 22), ISBN: 978-94-017-9423-7 (Print) 978-94-017-9424-4 (Online). (springer)
  20. Du, H. Liu, H. Xiong, L. (2013) Endogenous auxin and jasmonic acid levels are differentially modulated by abiotic stresses in rice. Front Plant Sci. 2013 Oct. eCollection 2013
  21. Du, H. Wu, N. Chang, Y. Li, X. Xiao, J. Xiong, L. (2013) Carotenoid deficiency impairs ABA and IAA biosynthesis and differentially affects drought and cold tolerance in rice. Plant Mol Biol. Nov;83(4-5):475-488
  22. Du, H. Wu, N. Fu, J. Wang, S. Li, X. Xiao, J. Xiong, L. (2012) A GH3 family member, OsGH3-2, modulates auxin and abscisic acid levels and differentially affects drought and cold tolerance in rice.J Exp Bot. 63: 6467-6480
  23. Du, H. Liu, L. You, L. Yang, M. He, Y. Li, X. Xiong, L. (2011) Characterization of an inositol 1,3,4-trisphosphate 5/6-kinase gene that is essential for drought and salt stress responses in rice. Plant Mol Biol. 77: 547-563
  24. Du, H. Wang, N. Cui, F. Li, X. Xiao, J. Xiong, L. (2010) Characterization of the beta-carotene hydroxylase gene DSM2 conferring drought and oxidative stress resistance by increasing xanthophylls and abscisic acid synthesis in rice. Plant Physiol. 154:1304-1318
  25. Ye, H. Du, H. Tang, N. Li, X. Xiong, L. (2009) Identification and expression profiling analysis of TIFY family genes involved in stress and phytohormone responses in rice. Plant Mol Biol. 71: 291-305
  26. Islam, M. Du, H. Ning, J. Ye, H. Xiong, L. (2009) Characterization of Glossy1-homologous genes in rice involved in leaf wax accumulation and drought resistance. Plant Mol Biol. 70: 443-456
  27. Xiang, Y. Tang, N. Du, H. Ye, H. Xiong, L. (2008) Characterization of OsbZIP23 as a key player of the basic leucine zipper transcription factor family for conferring abscisic acid sensitivity and salinity and drought tolerance in rice. Plant Physiol. 148: 1938-1952

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