賀新義

1998年畢業於華中農業大學食品科技系並獲得食品科學工學學士；2001年畢業於華中農業大學生命科學與技術學院獲得微生物學碩士；隨後進入上海交通大學生命科學技術學院工作，從助教（2001.7-2003.8）升至講師（2003.8-至今），2004年 3月-2008年3月攻讀在職博士研究生。

基本介紹

• 中文名：賀新義
• 國籍：中國
• 職業：講師
• 畢業院校：華中農業大學
• 性別：男
• 學歷：博士

研究方向

研究興趣一直聚焦於核苷酸代謝，包括基礎代謝中DNA磷硫醯化，羥甲基化，糖羥甲基化等異常修飾形成和識別的分子機理；以及次級代謝中具有良好生物活性的核苷類抗生素的生物合成，如殺稻瘟菌素，米多黴素和精黴素的生物合成的酶學研究。

目前主持國家自然科學基金面上項目1項；作為863子課題項目負責人參與項目2項；作為大洋協會子課題項目負責人參與項目1項。

發表論文

1, L Li, Z Xu, X Xu, J Wu, Y Zhang, X He*, T. M. Zabriskie and Z Deng (2008). The Mildiomycin Biosynthesis: Initial steps for sequential generation of 5-hydroxymethylcytidine 5’-monophosphate and 5-hydroxymethylcytosine in Streptoverticillium rimofaciens ZJU5119. ChemBioChem, in press. (*通訊作者)

2, X. He, H.Y. Ou, Q. Yu, X. Zhou, J. Wu, J. Liang, W. Zhang, K. Rajakumar and Z. Deng (2007). Analysis of a genomic island housing genes for DNA S-modification system in Streptomyces lividans 66 and its counterparts in other distantly related bacteria. Mol Microbiol. 65(4):1034-48.

3, H.Y. Ou, X. He, E.M. Harrison, B.R. Kulasekara, A.B. Thani, A. Kadioglu, S. Lory, J.C. Hinton, M.R. Barer, Z. Deng and K. Rajakumar (2007). MobilomeFINDER: web-based tools for in silico and experimental discovery of bacterial genomic islands. Nucleic Acids Res., 35, W97-W104.

4, J. Liang, Z. Wang, X. He, J. Li, X. Zhou, and Z. Deng (2007). DNA modification by sulphur: analysis of the sequence recognition specificity surrounding the modification sites. Nucleic Acids Research, 35(9):2944-54.

5, Li W, Wu J, Tao W, Zhao C, Wang Y, He X, Chandra G, Zhou X, Deng Z, Chater KF, Tao M. (2007) A genetic and bioinformatic analysis of Streptomyces coelicolor genes containing TTA codons, possible targets for regulation by a developmentally significant tRNA. FEMS Microbiol Lett., 266,20-28.

6, Wang L, Yu Y, He X, Zhou X, Deng Z, Chater KF, Tao M. (2007) Role of an FtsK-Like Protein in Genetic Stability in Streptomyces coelicolor A3(2). J Bacteriol., 189, 2310-2318.

7, D. Zhu, X. He, X. Zhou, Z. Deng (2005). Expression of the melC operon in several Streptomyces strains is positively regulated by AdpA, an AraC family transcriptional regulator involved in morphological development in Streptomyces coelicolor. J. Bacteriol. 187, 3180-3187.

8, X. Zhou, X. He, J. Liang, A. Li, T. Xu, T. Kieser, J.D. Helmann, Z. Deng (2005). A novel DNA modification by sulphur. Mol Microbiol. 57, 1428-1438.。