血紅素加氧酶1

血紅素加氧酶1

血紅素加氧酶(heme oxygenase, HO)是血紅素分解代謝過程中的限速酶，人體內的CO主要是由血紅素氧化酶(HO)代謝產生的。HO有三種類型:氧應激誘導型(HO-1)、組成型 (HO-2)及尚未明確的HO-3。

基本介紹

  • 中文名：血紅素加氧酶1
  • 外文名：heme oxygenase 1
  • 縮寫：HMOX1或HO-1
  • 類型：血紅素加氧酶
血紅素加氧酶1（英語：heme oxygenase 1，縮寫HMOX1或HO-1）是一種血紅素加氧酶（EC 1.14.99.3），是血紅素代謝過程中的重要酶，它將血紅素轉化為膽綠素。
Heme oxygenase (decycling) 1
血紅素加氧酶1（脫環）



PDBrendering based on 1n3u.
有效結構
PDB直系同源檢索：PDBe,RCSB
[隱藏]PDB查詢代碼列表
1N3U,1N45,1NI6,1OYK,1OYL,1OZE,1OZL,1OZR,1OZW,1S13,1S8C,1T5P,1TWN,1TWR,1XJZ,1XK0,1XK1,1XK2,1XK3,3CZY,3HOK,3K4F,3TGM
[隱藏]PDB查詢代碼列表
1N3U,1N45,1NI6,1OYK,1OYL,1OZE,1OZL,1OZR,1OZW,1S13,1S8C,1T5P,1TWN,1TWR,1XJZ,1XK0,1XK1,1XK2,1XK3,3CZY,3HOK,3K4F,3TGM
代號
HMOX1; HMOX1D; HO-1; HSP32; bK286B10
擴展標識
遺傳學：141250鼠基因：96163同源基因：31075ChEMBL:2823GeneCards:HMOX1 Gene
EC編號
1.14.99.3
[隱藏]基因本體論描述
分子功能·heme oxygenase (decyclizing) activity
·phospholipase D activity
·signal transducer activity
·enzyme binding
·heme binding
·protein homodimerization activity
·metal ion binding
細胞成分·extracellular space
·nucleus
·nucleolus
·endoplasmic reticulum
·endoplasmic reticulum membrane
·cytosol
·caveola
·membrane
生物過程·angiogenesis
·endothelial cell proliferation
·wound healing involved in inflammatory response
·negative regulation of leukocyte migration
·porphyrin-containing compound metabolic process
·heme oxidation
·cellular iron ion homeostasis
·response to oxidative stress
·intracellular protein kinase cascade
·small GTPase mediated signal transduction
·excretion
·regulation of blood pressure
·cell death
·intrinsic apoptotic signaling pathway in response to DNA damage
·smooth muscle hyperplasia
·cellular response to nutrient
·negative regulation of mast cell cytokine production
·erythrocyte homeostasis
·low-density lipoprotein particle clearance
·response to nicotine
·heme catabolic process
·response to hydrogen peroxide
·negative regulation of apoptotic process
·positive regulation of I-kappaB kinase/NF-kappaB cascade
·negative regulation of mast cell degranulation
·negative regulation of DNA binding
·negative regulation of sequence-specific DNA binding transcription factor activity
·negative regulation of neuron apoptotic process
·regulation of transcription from RNA polymerase II promoter in response to oxidative stress
·response to estrogen stimulus
·small molecule metabolic process
·positive regulation of chemokine biosynthetic process
·regulation of angiogenesis
·positive regulation of angiogenesis
·positive regulation of vasodilation
·positive regulation of smooth muscle cell proliferation
·negative regulation of smooth muscle cell proliferation
·regulation of sequence-specific DNA binding transcription factor activity
·protein homooligomerization
·iron ion homeostasis
·transmembrane transport
·cellular response to cadmium ion
·cellular response to hypoxia
Sources:Amigo/QuickGO
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