蔣爭凡， 教育部長江學者特聘教授，傑出青年基金獲得者。
北京大學-清華大學生命科學聯合中心，教授/研究員。
北京大學生命科學學院，教授。
基本介紹
- 中文名：蔣爭凡
- 國籍：中國
- 民族：漢
- 職業：教授
- 畢業院校：北京大學
任職,工作經歷,教育經歷,執教課程,榮譽,國內外主要學術組織兼職情況,科研領域,天然免疫及其相關的細胞信號轉導研究,關鍵科學問題,發表論文,
任職
蔣爭凡教授北京大學 生命科學學院， 博士生導師，教授/研究員
北京大學-清華大學生命科學聯合中心，教授/研究員
工作經歷
- 2011-，教授/研究員，北京大學-清華大學生命聯合中心
2. 2006-，教授/研究員，北京大學生命科學學院
3. 2003-2006，Research associate (博士後)，Bruce Beutler’s lab，The Scripps Research Institute, La Jolla, CA, USA
4. 1999-2003，Research associate (博士後) , Xiaoxia Li’s lab & George Stark’s lab, The Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USA
5. 1997-1999，博士後，北京大學生命科學學院
教育經歷
1. 1994 - 1997，理學博士，細胞生物學，北京大學
2. 1991 - 1994，理學碩士，細胞生物學，蘭州大學
3. 1987 - 1991，理學學士，細胞生物學，蘭州大學
執教課程
1. 天然免疫及細胞信號轉導（研究生）
2. 細胞生物學進展（研究生）
3. 細胞生物學（本科生）
4. 高級細胞生物學（本科生）
榮譽
- 2014年全國優秀科技工作者；
- 2014年立項國家‘973計畫項目’首席科學家；
- 2013年榮獲第六屆“談家楨生命科學創新獎”；
- 2013年獲評“全國優秀博士學位論文指導教師”；
- 2012年入選教育部“創新團隊發展計畫”；
- 2011年教育部“長江學者”特聘教授；
- 2010年國家傑出青年科學基金；
- 2007年教育部“新世紀優秀人才”；
- 2002年獲國際細胞因子學會優秀博士後論文一等獎。
國內外主要學術組織兼職情況
1、Editor, J. Biol. Chem. (2016- )
2、國家自然科學基金委專家組成員（2010- ）
3、國家自然科學基金委重大研究計畫專家組成員（2010-2017）
科研領域
天然免疫及其相關的細胞信號轉導研究
天然免疫系統是多細胞生物抵抗病原微生物感染的第一道防線。天然免疫受體通過識別病原體和內源有害分子所特有的分子特徵，激活細胞內的一系列信號轉導通路，繼而引起特異性細胞因子的表達，快速發揮免疫防禦作用。同時，天然免疫反應還可以進一步激活獲得性免疫反應。天然免疫應答與機體抗病原感染的能力，自身免疫病的發生，過敏性疾病及炎症引起的癌症等密切相關。
實驗室利用多種技術：大規模、高通量克隆表達及功能篩選、規模化酵母雙雜交和蛋白質分離-肽譜技術，對調控天然免疫的相關蛋白進行大規模、高通量篩選、克隆及功能研究，尋找並發現天然免疫中調控不同細胞信號通路的新基因及已知基因在天然免疫中的新功能；利用免疫學、細胞生物學、分子生物學、生物化學、遺傳學、結構生物學等技術來研究這些基因的功能及作用機制，深入而系統地研究天然免疫反應的分子機制，為相關疾病的預防和治療提供理論依據。
關鍵科學問題
我們圍繞細胞受到病原微生物感染後的天然免疫激活，並最終產生、分泌細胞因子這一重要生理過程，通過新基因、新通路的發現與機制研究，探討細胞進行天然免疫反應的分子機制，揭示天然免疫應答失控導致各種與感染免疫相關的疾病，包括過敏性反應、自身免疫病、慢性炎症（及導致腫瘤發生）的可能原因。
1）細胞識別病原微生物，激活天然免疫的分子機制；
2）泛素化參與抗病毒信號通路的機制；
3）天然免疫活化引發I型干擾素及其它重要細胞因子產生與調控的分子機制；
4）天然免疫活化後細胞因子分泌的機制；
5）天然免疫關鍵信號分子的調節和多種疾病（過敏反應、自身免疫病及慢性炎症）的相互關係；
6）重要信號分子的結構及功能。
1）細胞識別病原微生物，激活天然免疫的分子機制；
2）泛素化參與抗病毒信號通路的機制；
3）天然免疫活化引發I型干擾素及其它重要細胞因子產生與調控的分子機制；
4）天然免疫活化後細胞因子分泌的機制；
5）天然免疫關鍵信號分子的調節和多種疾病（過敏反應、自身免疫病及慢性炎症）的相互關係；
6）重要信號分子的結構及功能。
發表論文
1) Wang C, Guan Y, Lv M, Zhang R, Guo Z, Wei X, Du X, Yang J, Li T, Wan Y, Su X, Huang X, Jiang Z*. 2018, Manganese Increases the Sensitivity of the cGAS-STING Pathway for Double-stranded DNA and Is Required for the Host Defense against DNA Viruses. Immunity, 48: 675-687.
2) Wang Y, Ning X, Gao P, Wu S, Sha M, Lv M, Zhou X, Gao J, Fang R, Meng G, Su X, Jiang Z*. 2017, Inflammasome activation triggers caspases-mediated cleavage of cGAS to regulate responses to DNA virus infection. Immunity, 46: 393-404.
3) Fang R, Jiang Q, Zhou X, Wang C, Guan Y, Tao J, Xi J, Feng J, Jiang Z*. 2017, MAVS activates TBK1 and IKKε through TRAFs in NEMO dependent and independent manner. PLoS Pathogens, 13: e1006720. doi: 10.1371/journal. ppat.1006720.
4) Fang R, Lin Y, Zhou X, Wang C, Guan Y, Tao J, Xi J, Feng J, Jiang Z*. 2017, NEMO-IKKβ Are Essential for IRF3 and NF-κB Activation in the cGAS-STING Pathway. J. Immunol., 199: 3222-3233.
5) Tao J, Zhang X, Jin J, Du X, Lian T, Yang J, Zhou X, Jiang Z*, Su X*, 2017, Non-specific DNA binding by N-terminal domain promotes activation of human cyclic GMP-AMP synthase. J. Immunol. 198: 3627-3636.
6) Chen H, Ning X, Jiang Z*. 2017, Caspases control antiviral innate immunity. Cellular & Molecular Immunology, 14: 736-747.
7) Gao J, Tao J, Liang W, Zhao M, Du X, Cui S, Duan H, Kan B, Su X, Jiang Z*. 2015, Identification and characterization of phosphodiesterase V-cGAPs that specifically degrade 3’3’-cyclic GMP-AMP. Cell Research. 25: 539-550.
8) Chen H, Sun H, You F, Sun W, Zhou X, Chen L, Yang J, Wang Y, Tang H, Guan Y, Xia W, Gu J, Ishikawa H, Gutman D, Barber G, Qin Z, Jiang Z*. 2011, Activation of STAT6 by STING is Critical for Antiviral Innate Immunity. Cell. 147: 436-446.
9) You FP, Sun H, Zhou X, Sun WX, Liang SM, Zhai ZH & Jiang Z*. 2009, PCBP2 mediates degradation of the adaptor MAVS via the HECT ubiquitin ligase AIP4. Nature Immunology. 10: 1300-1308.
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11) Xiao H, Qian W, Staschke K, Qian Y, Cui G, Deng L, Ehsani M, Wang X, Qian YW, Chen ZJ, Gilmour R, Jiang Z*, Li X*. 2008, Pellino 3b negatively regulates interleukin-1-induced TAK1-dependent NF kB activation. J Biol Chem. 283: 14654-64.
12) Gao J, Tao J, Liang W, Jiang Z*. 2016, Cyclic (di)nucleotides: the common language shared by Microbe and Host. Current Opinion in Microbiology. 30: 79–87.
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14) Zhou X, You F, Chen H, Jiang Z*. 2012, Poly(C)-binding protein 1 mediates house-keeping degradation of mitochondrial antiviral signaling (MAVS). Cell Research. 22: 717-727.
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28) Qian Y, Zhao Z, Jiang Z, Li X. 2002, Role of NF kappa B activator Act1 in CD40-mediated signaling in epithelial cells. Proc Natl Acad Sci USA. 99: 9386-91.
29) Li X, Commane M, Jiang Z, Stark GR. 2001, IL-1-induced NFk B and JNK activation diverge at IRAK. Proc Natl Acad Sci USA. 98: 4461-5.
30) Jiang Z, Hong X, Long H, Zhai ZH, 2000, Ceramides induce apoptosis in Hela cells and enhance cytochrome c-induced apoptosis in Xenopus egg extracts. Cell Mol Life Sci. 57: 1117-25.
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39) Hoebe K, Jiang Z, Tabeta K, Du X, Georgel P, Crozat K, Beutler B. 2006, Genetic analysis of innate immunity. Adv Immunol. 91: 175-226.
40) Beutler B, Georgel P, Rutschmann S, Jiang Z, Croker B, Crozat K. 2005, Genetic analysis of innate resistance to mouse cytomegalovirus (MCMV). Brief Funct Genomic Proteomic. 4: 203-13. Review.
41) Zhou Z, Hoebe K, Du X, Jiang Z, Shamel L, Beutler B. 2005, Antagonism between MyD88- and TRIF-dependent signals in B7RP-1 up-regulation. Eur J Immunol. 35: 1918-27.
42) Qin J,Jiang Z, Qian Y, Casanova JL, Li X. 2004, IRAK4 kinase activity is redundant for interleukin-1 (IL-1) receptor-associated kinase phosphorylation and IL-1 responsiveness. J Biol Chem. 279: 26748-53.
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