基本介紹
- 中文名：莫秀梅
- 國籍：中國
- 出生日期：1961年12月
- 職業：東華大學生物醫學工程學科“生物材料與組織工程” 課題組組長
- 主要成就：首屆浦江人才
- 代表作品：國家自然科學基金：甲殼素的結構性能及套用研究
研究方向,主要研究成果,榮譽,科研項目,發表論文,國際交流,
研究方向
生物材料，納米纖維，組織工程，再生醫學。
1、靜電紡納米纖維在生物醫學中的套用，包括小血管、神經、皮膚、骨和軟骨等組織的再生，藥物及活性物質的緩釋
2、新型生物材料的研究開發，包括醫用水凝膠，可降解聚合物的合成及套用研究
3、三維快速成型製備組織工程支架及在骨和軟骨再生中的套用
主要研究成果
1、製備出蛋白-多糖雙組份醫用膠粘合劑
2、製備出蛋白-多糖複合納米纖維並成功地用於大鼠的皮膚缺損修復
3、製備出絲素-P(LLA-CL)複合納米纖維導管並成功地用於大鼠的坐骨神經修復
4、製備出膠原蛋白-殼聚糖-P(LLA-CL)複合納米纖維管狀支架並成功地用於狗的股動脈缺損的修復
5、已發表文章及會議論文200多篇，申請專利20多項，獲權專利7項
榮譽
1、首屆浦江人才
2、2008桑麻科教獎
3、2008上海市技術發明一等獎“水溶性醫用幾丁糖的製備技術及套用”
4、2009國家科技進步二等獎“水溶性幾丁糖醫用製品的研製及臨床套用”
5、2009-2010年度東華大學“三八”紅旗手
科研項目
1、國家自然科學基金：甲殼素的結構性能及套用研究
2、國家自然科學基金：PEG接枝殼聚糖的備及性能研究
3、國家自然科學基金: 膠原蛋白-甲殼胺複合納米纖維仿生組織細胞間質及與細胞相互作用的研究
4、國家自然科學基金：小口徑血管的體內再生研究
5、國家高技術研究發展863計畫納米材料與器件專題:蛋白－多糖複合納米纖維用於組織修復的研究
6、教育部歸國留學人員基金: 納米纖維的製備表征及在組織工程中的套用開發
7、上海市2005年重大基礎研究課題子課題: 組織工程相關生物材料的基礎科學問題研究 中的小血管組織工程再建
8、上海市白玉蘭科技人才基金：小口徑血管組織再生的研究
9、上海市科委非政府國際合作項目: 控釋型活性納米纖維神經導管及心臟瓣膜的研製
10、上海市科委納米專項：納米纖維仿生材料用於組織修復的研究
11、上海市科委納米專項：蛋白-多糖-P（LLA-CL）複合納米纖維用於小血管組織再生
發表論文
1、Chun-Yang Wang, Jun-Jian Liu, Cun-Yi Fan, Xiu-Mei Mo, Hong-Jiang Ruan, Feng-Feng Li, The Effect of Aligned Core-Shell Nanofibres Delivering NGF on the Promotion of Sciatic Nerve Regeneration, Journal of Biomaterials Science, Polymer Edition, 23(1-4), 2012 , 167-184
2、Yan Su, Qianqian Su, Wei Liu, Marcus Lim, Jayarama Reddy Venugopal, Xiumei Mo, Seeram Ramakrishna, Salem S. Al-Deyab, Mohamed El-Newehy, Controlled release of bone morphogenetic protein 2 and dexamethasone loaded in core–shell PLLACL–collagen fibers for use in bone tissue engineering, Acta Biomaterialia 2012, 8, 763–771
3、LinpengFan,Hongsheng Wang, Kuihua Zhang, Chuanglong He, Zengxiao Cai, Xiumei Mo, Regenerated Silk Fibroin Nanofibrous Matrices Treated with 75% Ethanol Vapor for Tissue-Engineering ApplicationsJournal of Biomaterials Science, Polymer Edition, 2012, 23, 497-508
4、余丕軍，王露萍，郭妤，陳煒，莫秀梅, 膠原蛋白-殼聚糖複合納米纖維膜用於皮膚缺損的修復, 中國組織工程研究與臨床康復, 2011, 15(51):9561-9564
5、Chen Huang, Yanwei Tang, Xin Liu, Alessandra Sutti, Qinfei Ke, Xiumei Mo, Xungai Wang, Yosry Morsi and Tong Lin. Electrospinning of nanofibres with parallel line surface texture for improvement of nerve cell growth. Soft Matter, 2011, 7, 10812-7
6、Kuihua Zhang, Anlin Yin, Chen Huang, Chunyang Wang, Xiumei Mo. Degradation of electrospun SF/P(LLA-CL) blended nanofibrous scaffolds in vitro. Polymer Degradation and Stability 2011 96: 2266-75
7、A Owida, Rui Chen, S Patel, Yos Morsi, Xiumei Mo. Artery vessel fabrication using the combined fused deposition modeling and electrospinning techniques. Rapid Prototyping Journal. 2011;17:37-44
8、Cuanglong He, Xiaohong Xu, Fan Zhang, Lijun Cao, Wei Feng, Hongsheng Wang, Xiumei Mo. Fabrication of fibrinogen/P(LLA-CL) hybrid nanofibrous scaffold for potential soft tissue engineering applications. Journal of Biomedical Materials Research Part A. 2011;97A:339-47
9、Kuihua Zhang, Q-Z Yu, XiumeiMo. Fabrication and Intermolecular Interactions of Silk Fibroin/Hydroxybutyl Chitosan Blended Nanofibers. International Journal of Molecular Sciences. 2011;12:2187-99
10、Kuihua Zhang, Yongfang Qian, Hongsheng Wang, Lingpen Fan, Chen Huang, Xiumei Mo. Electrospun Silk Fibroin-Hydroxybutyl Chitosan Nanofibrous Scaffolds to Biomimic Extracellular Matrix. Journal of Biomaterials Science-Polymer Edition. 2011;22:1069-82
11、Fan Zhang, Chuanglong He, Lijun Cao, Feng W, Wang H, Mo X, et al. Fabrication of gelatin-hyaluronic acid hybrid scaffolds with tunable porous structures for soft tissue engineering. International Journal of Biological Macromolecules. 2011;48:474-81
12、Feng Chen, Ying-Jie Zhu, Kui-Hua Zhang, Jin Wu, Ke-Wei Wang, Qi-Li Tang, XiumeiMo. Europium-doped amorphous calcium phosphate porous nanospheres: preparation and application as luminescent drug carriers, Nanoscale Research Letters 2011, 6:67
13、Yan Su, Xiaoqiang Li, Yinan Liu, Qianqian Su, Marcus Lim,Wei Qiang and Xiumei Mo,Encapsulation and Controlled Release of Heparin from Electrospun Poly(L-Lactide-co-ε-Caprolactone) Nanofibers, Journal of Biomaterials Science-Polymer Edition. 22 (2011) 165–177
14、Chen Huang, Rui Chen, Qinfei Ke, Yosry Morsic, Kuihua Zhang, Xiumei Mo. Electrospun collagen–chitosan–TPU nanofibrous scaffolds for tissue engineered tubular grafts, Colloids and Surfaces B: Biointerfaces82 (2011) 307–315
15、Yong-Fang Qian, Kui-Hua Zhang, Feng Chen, Qin-Fei Keand Xiumei Mo.Cross-Linking of Gelatin and Chitosan Complex Nanofibers for Tissue-Engineering Scaffolds, Journal of Biomaterials Science 22 (2011) 1099–1113
16、Chun-Yang Wang, Kui-Hua Zhang, Cun-Yi Fan, Xiumei Mo, Hong-Jiang Ruan, Feng-Feng Li. Aligned natural–synthetic polyblend nanofibers for peripheral nerve regeneration, Acta Biomaterialia 7 (2011) 634–643
17、余丕軍，王露萍，郭妤，陳煒，莫秀梅，蛋白質-多糖複合納米纖維膜用於皮膚缺損修復實驗研究，中國醫學工程，2010，18(4), 1-4.
18、Feng Chen1, Peng Huang, Xiu-MeiMo.Electrospinning of Heparin Encapsulated P(LLA-CL) Core/Shell Nanofibers,Nano Biomedicine And Engineering 2010,2,84-90
19、Zonggang Chen, Peiwei Wang, B. Wei, Xiumei. Mo, F.Z. Cui. Electrospun collagen–chitosan nanofiber: A biomimetic extracellular matrix for endothelial cell and smooth muscle cell. Acta Biomaterialia. 2010，6，372-382.
20、Kuihua Zhang, Yongfang Qian, Hongsheng Wang, Lingpen Fan, Chen Huang, AnlinYin, Xiumei Mo. Genipin-crosslinked silk fibroin/hydroxybutyl chitosan nanofibrous scaffolds for tissue-engineering application. Journal of Biomedical Materials Research Part A. 2010;95A:870-81
21、Xiaoqiang Li, Yan Su, SP Liu, LJ Tan, Xiumei Mo. Ramakrishna S. Encapsulation of proteins in poly(L-lactide-co-caprolactone) fibers by emulsion electrospinning. Colloids and Surfaces B-Biointerfaces. 2010;75:418-24
22、Rui Chen, Qinfei Ke, XiumeiMo. Preparation and Study of TPU/Collagen Complex Nanofiber via Electrospinning. Aatcc Review. 2010;10:59-63
23、XiumeiMo, Hiroo Iwata, Yoshito Ikada. A tissue adhesives evaluated in vitro and in vivo analysis. Journal of Biomedical Materials Research Part A. 2010;94A:326-32
24、Zengxiao Cai, Xiumei Mo, Kui-hua Zhang, Lin-peng Fan, An-lin Yin, Chuang-long He and Hong-sheng Wang, Fabrication of Chitosan/Silk Fibroin Composite Nanofibers for Wound-dressing Applications, Int. J. Mol. Sci. 2010, 11, 3529-3539
25、Kuihua Zhang, Hongsheng Wang, Chen Huang, Yan Su, Xiumei Mo, Yoshito Ikada.Fabrication of silk fibroin blended P(LLA-CL) nanofibrous scaffolds for tissue engineering.J Biomed Mater Res A. 2010, 93(3):984-993
26、Kuihua ZHANG, Xiumei Mo, Chen HUANG, Chuanglong HE, Hongsheng WANG. Electrospun scaffolds from silk fibroin and their cellular compatibility. J Biomed Mater Res A.2010, 93(3): 976-983
27、Cai-jiu Gao, Kui-Hua Zhang, Wei Liu, Xu Zhou, Xiumei Mo. Electrospun Scaffolds from Gelatin/Hyaluronic Acid and their cellular compatibility. Nonlinear Science Letters D, 1, 67-72, 2010
28、Kui-Hua Zhang, Hong-Sheng Wang, Cai-Jiu Gao, Lin-Peng Fan, XiumeiMo. Fabrication of Electrospinning Silk Fibroin and its blend nanofibrous Scaffolds for Soft Tissue Engineering. Nonlinear Science Letters D, 1, 53-58, 2010
29、Rui Chen, Xiaoqiang Li, Qinfei Ke, Chuanglong He, Xiumei Mo. Fabrication and characterization of collagen (shell) /thermoplastic polyurethane (core) composite nanofibers by coaxial electrospinning. e-Polymers, 2010, No009: 1-8
30、Rui Chen, Chen Huang, Qinfei Ke, Chuanglong He, Hongsheng Wang, Xiumei Mo. Preparation and Characterization of Coaxial Electrospun Thermoplastic Polyurethane/Collagen Compound Nanofibers for Tissue Engineering Applications. Colloids and Surfaces B: Biointerfaces. 2010, 79,315-325
31、Rui Chen, Lijun Qiu, Qinfei Ke, and XiumeiMo. Electrospinning Thermoplastic Polyurethane-contained Collagen Nanofibers for Tissue Engineering Applications. Journal of Biomaterials science: Polymer Edition, 2009, 20(11): 1513-36
32、R. Chen, Y. Morsi, A. Owida, X.M Mo and Q.F Ke. Electrospinning of Thermoplastic Polyurethane Tubular Scaffold For The Construction of Artificial Blood Vessels. International Journal of Artificial Organ, 2009 July, 32(7): 459
33、Rui Chen, Qinfei Ke, XiumeiMo.Preparation and Study of TPU-Collagen Complex Nanofiber via Electrospinning. AATCC Review, March/April, 2010, 59-66
34、Rui CHEN, Yosry MORSI, Shital PATEL, Qinfei KE, Xiumei MO Novel Approach via Combination of Electrospinning and FDM for Tri-leaflet Heart Valve Scaffold Fabrication. Frontier Materials Science of China. 2009，3（4）：359-366
35、Yan Su, Xiaoqiang Li, Hongsheng Wang, Chuanglong He, and Xiumei Mo. Fabrication and Characterizations of Biodegradable Nanofibrous Mats by Mix and Coaxial Electrospinning of Poly(L-lactid-co-ε-caprolactone). Journal of Materials Science: Materials in Medicine. 2009 C, 2009, 20:2285–2294
36、Yan Su, Xiaoqiang Li , Suiping Liu, XiumeiMoand Ram Seeram. Controlled Release of Dual drugs from Emulsion Electrospun Nanofibrous Mats. Colloids and interfaces B: Biointerfaces, 2009, 73 (2): 376-381
37、Yan Su, Xiaoqiang Li, Lingjiang Tan Cheng Huang, XiumeiMo. Electrospun Poly(L-lactide-co-ε-caprolactone) nanofibers for encapsulating and sustained releasing proteins. Polymer. 2009, 17 (50): 4212-4219
38、Yongfang Qian, Xiaoqiang Li, Xiumei Mo. Fabrication and characterization of Polycaprolactone/Chlorophyllin sodium copper salt nanofibrous mats from 2,2,2-trifluoroethanol solution by electrospinning. Iranian Polymer Journal. 2009, 18(3): 265-274
39、Zonggang Chen, Bo Wei, Xiumei Mo, Fu-zhai Cui. Diameter Control of Electrospun Chitosan-Collagen Fibers.Polym. Sci Part B: Polym. Phys. 2009, 47:1949-1955
40、Zonggang Chen, Bo Wei, Xiumei Mo, C.T. Lim, S. Ramakrishna, Fuzhai Cui. Mechanical properties of electrospun collagen–chitosan complex single fibers and membrane. Materials Science and Engineering C. 2009, 29:2428–2435
41、Xiaoqiang Li, Yan Su, Xu Zhou and XiumeiMo. Distribution of Sorbitan Monooleate in poly(l-lactide-co-caprolactone) nanofibers from emulsion electrospinning. Colloids and Surfaces B: Biointerfaces, 2009, 69: 221-224
42、Huihua Huang, Chuanglong He, Hongsheng Wang, XiumeiMo. Preparation of Core-shell Biodegradable microfibers for long-term Drug delivery.J Biomed Mater Res A. 2009, 90A（4）:1243–1251
43、Xiaoqiang Li, Yan Su, Chuanglong He, Hongsheng Wang, and XiumeiMo. A Study of the Electrospinning of an H2O–Acetone–PCL Ternary System. Polymers & Polymer Composites, 2009, 17(1) : 37-40
44、Xiaoqiang Li, Yan Su, Rui Chen, Chuanglong He, Hongsheng Wang, Xiumei Mo. Fabrication and Properties of Core-Shell Structure P(LLA-CL) Nanofibers by Coaxial Electrospinning. J Appl Polym Sci, 2009,111: 1564–1570
45、Xiaoqiang Li, Yan Su, Chuanglong He, Hongsheng Wang, Fong Hao, and Xiumei Mo. Sorbitan Monooleate and Poly(L-lactide-co-ε-caprolactone) Electrospun Nanofibers for Endothelial Cell Interactions. J Biomed Mater Res A. 2009, Dec 1, 878-885
46、Feng Chen, Yan Su, Xiumei Mo, et al, Biocompatibility, Alignment Degree and Mechanical Properties of an Electrospun Chitosan-P(LLA-CL) Fibrous Scaffold,Journal Of Biomaterials Science-Polymer Edition20 (14) , 2117-2128,2009
47、張鵬雲，張建松，徐曉紅，莫秀梅，何創龍， 生物交聯劑京尼平對靜電紡明膠納米纖維膜改性的影響。中國組織工程研究與臨床康復. 13（8），1495－99，2009
48、張建松，張鵬雲，徐曉紅，莫秀梅，何創龍，王紅聲， 兩種聚（左選乳酸－己內酯）靜電紡納米纖維膜的性能比較。中國組織工程研究與臨床康復. 13（8），1500－04，2009。
49、邱立軍 , 王紅聲 , 何創龍 , 莫秀梅。聚(左旋乳酸-己內酯)/Fe304取向超細纖維的製備及生物相容性。中國組織工程研究與臨床康復.13（12），2222，2009
國際交流
與新加坡國立大學（National University of Singapore），美國維吉尼亞聯邦大學（Virginia Commonwealth University），澳大利亞斯文伯恩技術大學（Swinburne University of Technology），日本奈良醫科大學（Nara Medical University），澳大利亞迪肯大學（Deakin University）,沙特國王大學(King Saud University) 有合作科研和教學。
