王昭春的研究小組確定了人類肝細胞癌(HCC)的細胞遺傳模式,並首次對腫瘤發展過程中一致的基因組和結構變化進行了系統分析。
下一代測序的出現使他們確定了HCC的空間和時間克隆異質性模式,強調了其進化路徑。在開發實驗模型時,她的研究小組開發了一系列14種HCC細胞系,這些細胞系來自在外科學系接受HCC根治性手術的中國本地患者。王昭春及其團隊已開始建立來自原發性HCC、
結直腸癌、
膠質母細胞瘤和
軟組織肉瘤患者的類器官的三維培養系統。這些離體模型對於當代腫瘤學研究中的功能生物學和新藥開發研究至關重要。
Ding XF, He M, Chan AW, Song QX, Sze SC, Chen H, Man MK, Man K, Chan S, Lai P, Wang X, Wong N*. Genomic and epigenomic features of primary and recurrent hepatocellular carcinomas. Gastroenterology 2019; 157:1630-1645
Chen H, Gao F, He M, Ding XF, Wong AM, Sze S, Yu A, Sun T, Chan AW, Wang X*, Wong N*. Long-read RNA sequencing identifies novel splice variants in hepatocellular carcinoma and tumor-specific isoforms. Hepatology. 2019; 70:1011-1025
Lau CC, Sun TT, Ching AK, He M, Li JW, Wong AM, Co NN, Chan AW, Li PS, Lung RW, Tong JH, Lai PB, Chan HL, To KF, Chan TF, Wong N*. Viral-human chimeric transcript predisposes risk to liver cancer development and progression. Cancer Cell. 2014; 25:335-49.
Law PT, Qin H, Ching AK, Lai KP, Co NN, He M, Lung RW, Chan AW, Chan TF, Wong N*. Deep sequencing of small RNA reveals novel non-coding RNAs in HCC. J Hepatol 2013; 58:1165-73
Chung KY, Cheng IK, Ching AK, Chu JH, Lai PB, Wong N*. BOP1 plays an oncogenic role in HCC by promoting epithelial-to-mesenchymal transition. Hepatology 2011; 54:307-18
Wong Q, Lung R, Law P, Lai PB, Chan K, To KF, Wong N*. MicroRNA-223 is commonly repressed in HCC and potentiates expression of Stathmin1. Gastroenterology 2008, 135:257-69
Gho J, Ip WK, Chan KY, Lai PB, To KF, Wong N*. Re-expression of transcription factor ATF5 in hepatocellular carcinoma induces G2/M arrest. Cancer Research 2008, 68:6743-6751
Pang EY, Bai AH, To KF, Sy SM, Wong NL, Lai PB, Squire JA, Wong N*. Identification of PFTAIRE protein kinase 1, a novel cell division cycle-2 related gene, in the motile phenotype of hepatocellular carcinoma cells. Hepatology 2007; 46:436-45
Poon T, Wong N, Lai PB, Rattray M, Johnson PJ, Sung JJ. A Tumor Progression Model for HCC - bioinformatic analysis of genomic data. Gastroenterology 2006, 131:1262-70.
Wong N, Lai PB, Pang E, Leung TW, Lau JW, Johnson PJ. A comprehensive karyotypic study on human hepatocellular carcinoma by Spectral Karyotyping. Hepatology 2000, 32:1060-1068