基本介紹
- 中文名：王德壽
- 國籍：中國
- 民族：漢族
- 性別：男
人物簡介,人物經歷,學術成就,基因,酶,基因編碼,主要課題,主要學術論著目錄,
人物簡介
王德壽，男，1964年9月生。理學博士，教授，博士導師，中國動物學會理事，中國魚類學會副理事長，中國動物學會比較內分泌學分會理事，中國水產學會水產生物技術專業委員會委員，中國遺傳學會動物遺傳專業委員會委員，重慶動物學會理事長，重慶市水產學學術技術帶頭人。淡水魚類資源與生殖發育教育部重點實驗室主任，重慶市發改委淡水魚類新品種繁育工程實驗室主任，魚類的生殖和發育研究教育部創新團隊魚類生殖與生長調控方向帶頭人，西南大學生命科學學院院長。1988年在西南師範大學獲碩士學位後留校任教，1993年破格晉升為副教授。1996年從中山大學生命科學學院魚類室獲理學博士學位後回校工作，1998年晉升為教授。1998-2007年先後在以色列巴伊蘭大學、荷蘭烏德勒支大學比較內分泌研究小組、香港中文大學生化系和日本國立基礎生物學研究所生殖生物學研究室做博士後、訪問學者或合作研究。
主要從事魚類生殖和生長調控、特別是性別分化分子機制研究。從80年代中期開始對長江上游大鰭鱯和南方鮎等鮎形目魚類進行了系統研究。為將它們培育成為名、特、優新品種做了奠基性工作。近年來，對芳香化酶基因的表達調控做了開創性的工作，提出轉錄因子通過調節芳香化酶表達，控制雌激素水平從而決定性別分化方向的假說並加以證實。在遺傳育種方面，建立了分子標記選育遺傳全雄和超雄羅非魚的技術、轉基因和基因工程育種技術。在生長方面，與香港中文大學鄭漢其教授團隊合作，先後從多種硬骨魚類克隆了兩個生長激素受體（GHR1,GHR2），兩個促乳素受體（PRLR1,PRLR2）和三個類胰島素生長因子（IGF-1,IGF-2,IGF-3），且發現IGF-3僅在性腺表達，據此提出了魚類存在一個性腺特有的GH/GHR/IGF軸的假說以解釋魚類性腺的生長與身體的生長既相互聯繫又相互獨立的生理現象。先後主持863和973課題、國家自然科學基金重點、教育部重點、農業部948項目等20餘項。先後在PLOS Genetics、Scientific Reports、Genetics、Endocrinology、Molecular Endocrinology、Molecular and Cellular Endocrinology、Journal of Molecular Endocrinology、Journal of Endocrinology、General and Comparative Endocrinology、Biology of Reproduction、Biochemical and Biophysical Research Communications、Molecular Reproduction and development、BMC Molecular Biology、Gene Expression Patterns、Comparative Biochemistry and Physiology 、Zoological Science、Fish Physiology and Biochemistry、Journal of Fish Biology、《動物學報》和《水產學報》等國內外學術雜誌發表學術論文100餘篇，70餘篇被SCI收錄，總影響因子超過150，被SCI論文引用1500餘次。多次在國際學術會議上作特邀或大會發言。獲重慶市自然科學一等獎、科技進步一等獎和教學成果二等獎各一項。 獲得發明專利5項。
先後為本科和研究生主講分子生物學、脊椎動物學及實驗、比較生理學、魚類生理學、生物統計學、專業英語等課程。領銜申報獲準動物學重慶市市級精品課程。
人物經歷
1981.09-1988.07 西南師範大學 學士、碩士;
1993.09-1996.07 中山大學 博士;
1988.06-至今 西南(師範)大學副教授(1993)、教授(1998)、博導(2003);
1998.07-1999.08 以色列Bar-Iran大學 博後;
1999.09-2000.09 荷蘭烏德勒支大學 訪問學者;
2001.06-2001.09 香港中文大學 高級訪問學者;
2001.11-2007.10 日本國立基礎生物學研究所合作研究.
學術成就
從上世紀80年代中期開始對長江流域中的鮎形目魚類進行了套用基礎和開發研究工作，內容涉及年齡與生長、食性、繁殖、胚胎髮育與胚後發育、生殖的神經內分泌調控、人工繁殖、性別決定與分化等領域。對大鰭鱯和粗唇鮠的生物學進行了深入系統的研究並獲得該魚人工繁殖的成功。提出以新型魚類催產劑取代類似物加腦垂體的方法誘導經濟鮎魚人工繁殖並在生產實踐中得到實際套用。在南方鮎、長吻鮠的苗種生產和養殖推廣方面做了大量工作，產生了可觀的經濟效益和社會效益。近年來主要以重要養殖魚類羅非魚和南方鮎為研究對象，從事魚類性別決定與分化和生長調控的分子機制研究，在芳香化酶的表達調控、減數分裂的控制、生長激素及其受體和類胰島素樣生長因子等方面取得了突出成績：
基因
1、從硬骨魚類克隆了一系列在性別決定通路上起重要作用的基因，首次提出轉錄因子通過調控芳香化酶的表達、控制雌激素水平而影響魚類性分化方向的假說，並用離體和在體研究加以證明（Molecular Endocrinology 為闡明脊椎動物尤其是魚類性別決定與分化分子機制提供了新思路。2007；BBRC），2004，第一作者；Journal of Endocrinology(JOE)2007a；FBP 2009,通訊作者
酶
2、從羅非魚等硬骨魚類克隆了類固醇合成途徑中居於核心位置的關鍵酶P450c17a-II，發現它才是真正參與魚類配子成熟誘導激素合成的酶，進一步闡明了魚類類固醇合成途徑和分子機制，並提出它可能與早期減數分裂調控相關（Endocrinology2007，指導博士生完成，排名第二；BBRC 2007，同等貢獻作者）。此外，還克隆了羅非魚和南方鮎生殖細胞和減數分裂的多種分子標記，為闡明魚類減數分裂調控機制及其在脊椎動物的演化趨勢奠定了基礎。
基因編碼
3、提出硬骨魚類普遍具有不同基因編碼的兩種GHR(JME 2006，同等貢獻作者)、PRLR(JOE 2007b，通訊作者)和三種IGF(BBRC 2008，第一作者)的假說並加以證實，提出在魚類性腺中可能存在特有的“GH/GHR/IGF-3”軸以解釋魚類性腺生長既依賴於身體生長又獨立於身體生長的分子機制；此外還克隆了多種轉錄因子(BBRC，2002，2004；2006，第一作者)和類固醇合成酶的複製基因(JME 2003；2005，同等貢獻作者)，開闢了魚類生殖和生長研究的新領域。
主要課題
近5年共發表SCI收錄論文30餘篇，其中第一作者及通訊作者11篇，同等貢獻作者3篇。論文被他引200餘次，單篇他引最高37次。近年來5次在國際學術會議上作大會（特邀）發言，現為多種國內外學術雜誌特約審稿人。主持863項目和973子課題各1項，國家自然科學基金3項，教育部重點項目和省市課題5項。
主要學術論著目錄
（按先英文後中文排列） *通訊作者
1. Li MH, Sun YL, Zhao JE, Shi HJ, Zeng S, Ye K, Jiang DN, Zhou LY, Sun LN, Tao WJ, Nagahama Y, Kocher TD, Wang DS*. 2015. A tandem duplicate of anti-Müllerian hormone with a missense SNP on the Y chromosome is essential for male sex determination in Nile tilapia, Oreochromis niloticus. PLoS Genetics. 11(11): e1005678. doi:10.1371/journal.pgen.1005678.(IF: 7.528)
2. Feng R, Fang L, Cheng Y, He X, Jiang W, Dong R, Shi H, Jiang D, Sun L, Wang D*. 2015. Retinoic acid homeostasis through aldh1a2 and cyp26a1 mediates meiotic entry in Nile tilapia (Oreochromis niloticus). Sci Rep. 15;5:10131. doi: 10.1038/srep10131.(IF: 5.578)
3. Qiu Y, Sun S, Charkraborty T, Wu L, Sun L, Wei J, Nagahama Y, Wang D, Zhou L. 2015. Figla Favors Ovarian Differentiation by Antagonizing Spermatogenesis in a Teleosts, Nile Tilapia (Oreochromis niloticus). PLoS One. 10(4):e0123900. (IF: 3.234)
4. Jia C, Zhou Y, Huang X, Peng X, Liu L, Zhou L, Jin L, Shi H, Wei J*, Wang D. 2015. The cellular protein expression of Foxp3 in lymphoid and non-lymphoid organs of Nile tilapia. Fish Shellfish Immunol. 45(2):300-306.(IF: 2.674)
5. Cheng YY, Tao WJ, Chen JL, Sun LN, Zhou LY, Song Q, Wang DS*. 2015 Genome-wide identification, evolution and expression analysis of nuclear receptor superfamily in Nile tilapia, Oreochromis niloticus. Gene. 569(1):141-152.(IF: 2.138)
6. Senthilkumaran B, Sreenivasulu G, Wang DS, Sudhakumari CC, Kobayashi T, Nagahama Y. 2015. Expression Patterns of CREBs in Oocyte Growth and Maturation of Fish. PLoS One. 10(12):e0145182. doi: 10.1371/ journal.pone.0145182. eCollection 2015.(IF: 3.234)
7. Zhang X, Wang H, Li M, Cheng Y, Jiang D, Sun L, Tao W, Zhou L, Wang Z, and Wang D*. 2014. Isolation of Doublesex- and Mab-3-Related Transcription Factor 6 and Its Involvement in Spermatogenesis in Tilapia. Biol Reprod. 91(6):136-145. (IF: 3.318)
8. Dong RR, Yang SJ, Feng RJ, Fang LL, Sun YL, Zhang YG, Xie XJ, Wang DS*. 2014. Complete feminization of catfish by feeding Limnodilus, an annelid worm collected in contaminated streams. Environmental Research. 133:371-379. (IF: 4.373)
9. Yu X, Wu L, Xie L, Yang S, Charkraborty T, Shi H, Wang D, Zhou L. 2014. Characterization of two paralogous StAR genes in a teleost, Nile tilapia (Oreochromis niloticus). Mol Cell Endocrinol. 392:152-162.(IF: 4.405)
10. Liu G, Luo F, Song Q, Wu L, Qiu Y, Shi H, Wang D, Zhou L. 2014. Blocking of progestin action disrupts spermatogenesis in Nile tilapia (Oreochromis niloticus). J Mol Endocrinol. 53:57-70.(IF: 3.081)
11. Wei J, Qi W, Zhou Y, Zhang X, Dong R, Zhou L, Wang D*. 2014. Establishment and characterization of an ovarian cell line from Southern catfish (Silurus meridionalis). Fish Physiol Biochem. 40:1383-1391.(IF:1.622).
12. Li J, Wu P, Liu Y, Wang D, Cheng CH. 2014. Temporal and spatial expression of the four Igf ligands and two Igf type 1 receptors in zebrafish during early embryonic development. Gene Expr Patterns. 15:104-111.(IF:1.380).
13. Sun YL, Jiang DN, Zeng S, Hu CJ, Ye K, Yang C, Yang SJ, Li MH, Wang DS*. 2014. Screening and characterization of sex-linked DNA markers and markerassisted selection in the Nile tilapia (Oreochromis niloticus), Aquaculture, 433:19-27. (IF:1.878)
14. Li M, Yang H, Zhao J, Fang L, Shi H, Li M, Sun Y, Zhang X, Jiang D, Wang D*. 2014. Efficient and heritable gene targeting in tilapia by CRISPR/Cas9. Genetics. 197:591-599.(IF:5.963).
15. Sun LN, Jiang XL, Xie QP, Yuan J, Huang BF, Tao WJ, Zhou LY, Nagahama Y, Wang DS*. 2014.Transdifferentiation of differentiated ovary into functional testis by long term treatment of aromatase inhibitor in Nile tilapia. Endocrinology. 155:1476-1488. (IF:4.503).
16. Yuan J, Tao W, Cheng Y, Huang B, Wang D*. 2014. Genome-wide identification, phylogeny, and gonadal expression of fox genes in Nile tilapia, Oreochromis niloticus. Fish Physiol Biochem. 40:1239-1252.(IF:1.622).
17. Li MH, Yang HH, Li MR, Sun YL, Jiang XL, Xie QP, Wang TR, Shi HJ, Sun LN, Zhou LY, Wang DS*. 2013. Antagonistic roles of Dmrt1 and Foxl2 in sex differentiation via estrogen production in tilapia as demonstrated by TALENs. Endocrinology. 154(12):4814-25. (IF:4.717).
18. Wei J, Yu L, Sun L, Zhang X, Li M, Qi W, Zhou L, Wang D*. 2013. Molecular cloning and expression analysis of Foxp3 from Nile tilapia. Vet Immunol Immunopathol. 155:48-56. (IF:1.88).
19. Dong R, Yang S, Jiao J, Wang T, Shi H, Zhou L, Zhang Y, Wang D*. 2013.Characterization of Stra8 in Southern catfish (Silurus meridionalis): evidence for its role in meiotic initiation. BMC Mol Biol. 22;14:11. doi: 10.1186/1471-2199-14-11. （IF: 2.80)
20. Tao W, Yuan J, Zhou L, Sun L, Sun Y, Yang S, Li M, Zeng S, Huang B,Wang D* 2013. Characterization of gonadal transcriptomes from Nile tilapia (Oreochromis niloticus) reveals differentially expressed genes. PLoS One. 8: e63604 (IF:4.09).
21. Zhou L, Charkraborty T, Yu X, Wu L, Liu G, Mohapatra S, Wang D*, Nagahama Y*.R-spondins are involved in the ovarian differentiation in a teleost, medaka (Oryzias latipes). BMC developmental Biology, 2012, 12:36 （doi:10.1186/1471-213X-12-36）.(IF:2.73).
22. Li M, Wu F, Gu Y, Wang T, Wang H, Yang S, Sun Y, Zhou L, Huang X, Jiao B, Cheng CH, Wang D*. 2012. Insulin-Like Growth Factor 3 Regulates Expression of Genes Encoding Steroidogenic Enzymes and Key Transcription Factors in the Nile Tilapia Gonad. Biol Reprod. 86:1-10. (IF:4.08)
23. Sun YL, Zeng S, Kai Ye K, Chao Yang C, Li MH, Huang BF, LiNa Sun LN, Zhou LY, Wang DS*. 2012. Involvement of FGF9/16/20 subfamily in female germ cell development of the Nile tilapia, Oreochromis niloticus. Fish Physiol Biochem. 38:1427-1439. (IF:1.60)
24. Huang BF, Sun YL, Wu FR, Liu ZH, Wang ZJ, Luo LF, Zhang YG, Wang DS* . 2011. Isolation, sequence analysis, and characterization of androgen receptor in Southern catfish, Silurus meridionalis. Fish Physiol Biochem. 37:593-601. (IF:1.60)
25. Li JZ, Liu ZH, Wang DS, Cheng CHK. 2011. Insulin-like growth factor 3 is involved in oocyte maturation in zebrafish. Biology of Reproduction. 84:476-486. (IF:3.87)
26. Han F, Wang ZJ, Wu FR,Liu ZH,Huang BF，Wang DS*. 2010. Characterization, phylogeny, alternative splicing and expression of Sox30 gene. BMC Molecular Biology. 11: 98. (IF:3.18)
27. Liu ZH, Zhang YG, Wang DS*. 2010 Studies on feminization, sex determination and differentiation of Southern catfish, Silurus meridionalis. Fish Physiology and Biochemistry. 36:223-235. (IF:1.60)
28. Sudhakumari CC, Senthilkumaran B, Raghuveer K, Wang DS, Kobayashi T, Kagawa H, Krishnaiah Ch, Dutta-Gupta A, Nagahama Y. 2010. Dimorphic expression of tryptophan hydroxylase in the brain of XX and XY Nile tilapia during early development. General and Comparative Endocrinology. 166:320-329.
29. Wang DS*, Zhou LY, Kobayashi T, Matsuda M, Shibata Y, Sakai F and Nagahama Y. 2010. Doublesex- and Mab-3-Related Transcription Factor-1 repression of aromatase transcription, a possible mechanism favoring the male pathway in tilapia. Endocrinology. 151:1331-1340 (IF:4.99)
30. Zhang WL, Zhou LY, Senthilkumaran B, Huang BF, Sudhakumari C.C, Kobayashi T, Nagahama Y, Wang DS*. 2010. Molecular cloning of two isoforms of 11β-hydroxylase and their expressions in the Nile tilapia, Oreochromis niloticus. General and Comparative Endocrinology.165:34–41.(IF:3.10)
31. Wu FR, Zhou LY, Nagahama Y,Wang DS*. 2009. Duplication and distinct expression patterns of two thrombospondin-1 isoforms in teleost fishes. Gene Expression Patterns. 9:436–443 (IF:2.2)
32. Senthilkumaran B, Sudhakumari CC, Wang DS, Sreenivasulu G, Kobayashi T, Kobayashi HK, Yoshikuni M, Nagahama Y.2009. Novel 3beta-hydroxysteroid dehydrogenases from gonads of the Nile tilapia: Phylogenetic significance and expression during reproductive cycle. Molecular and Cellular Endocrinology. 299 : 146–152 (IF:3.0)
33. Wu FR, Zhang XY, Zhang WL, Huang BF, Liu ZH, Hu CJ, Wang DS*. 2009. Expression of three gonadotropin subunits in Southern catfish gonad and their possible roles during early gonadal development. Comparative Biochemistry and Physiology part A. 153:44-48. (IF:1.8)
34. de Waal P, Wang D, Nijenhuis W, Schulz R, Bogerd J. 2008 Functional characterization and expression analysis of the androgen receptor in zebrafish (Danio rerio) testis. Reproduction. 136: 225–234.（IF:3.0）
35. Wang DS*, Jiao B, Hu C, Huang X, Liu Z, Cheng CH. 2008 Discovery of a gonad-specific IGF subtype in teleost. Biochem Biophys Res Commun. 367:336-341.（IF:3.0）
36. Ijiri S, Kaneko H, Kobayashi T, Wang DS, Sakai F, Paul-Prasanth B, Nakamura M and Nagahama Y. 2008 Sexual Dimorphic Expression of Genes in Gonads During Early Differentiation of a Teleost Fish, the Nile Tilapia Oreochromis niloticus. Biology of Reproduction. 78:333-341.（IF: 3.7）
37. Zhou LY, Wang DS (equal contribution)., Shibata Y, Paul-Prasanth B, Suzuki A, Nagahama Y 2007 Characterization, expression and transcriptional regulation of P450c17-I and -II in the medaka. Biochemical and Biophysical Research Communications 362:619-625.. （IF:3.0）
38. Zhou LY, Wang DS, Kobayashi T, Yano A, Paul-Prasanth B, Suzuki A, Sakai F, Nagahama Y 2007 A novel type of P450c17, lacking the lyase activity is responsible for C21-steroid biosynthesis in the fish ovary and head kidney. Endocrinology. 148:4282-4291.（IF: 5.3）
39. Huang XG, Jiao BW, Fung CK, Ho WKK, Zhang Y, Chan CB, Lin HR,Wang DS, Cheng CHK. 2007 The presence of two distinct prolactin receptors in seabream with different tissue distribution patterns, signal transduction pathways and regulation of gene expression by steroid hormones. Journal of Endocrinology. 194:373-392（IF:3.0）
40. Liu ZH, Wu FR, Jiao BW, Zhang XY, Hu CJ, Huang BF, ZhouLY, Huang XG, Wang ZJ, Zhang YG, Nagahama Y, ChengCHK, Wang DS*. 2007 Molecular cloning of doublesex and mab-3-related transcription factor 1, forkhead transcription factor gene 2, and two types of cytochrome P450 aromatase in Southern catfish and their possible roles in sex differentiation. Journal of Endocrinology.194:223-241（IF:3.0）
41. Wang DS, Kobayashi T, Zhou LY, Paul-Prasanth B, Ijiri S, Sakai F,Okubo K, Morohashi K and Nagahama Y 2007 Foxl2 up-regulates aromatase gene transcription in a female-specific manner by binding to the promoter as well as interacting with ad4 binding protein/steroidogenic factor 1. Molecular Endocrinology. 21: 712-725. （IF:5.3）
42. Nakamoto M, Wang DS, Suzuki, A, Matsuda M, Nagahama Y, Shibata N. 2007. Dax1 suppresses P450arom expression in medaka ovarian follicles. Molecular Reproduction and Development. 74:1239-1246. (IF 2.5)
43. Ohmuro-Matsuyama Y, Okubo K, Matsuda M, Ijiri S, Wang DS, Guan G, Suzuki T, Matsuyama M, Morohashi K, Nagahama Y. 2007 Liver receptor homologue-1 (LRH-1) activates the promoter of brain aromatase (cyp19a2) in a teleost fish, the medaka, Oryzias latipes. Molecular Reproduction and Development. 74:1065-1071 .(IF 2.5)
44. Nakamoto M, Matsuda M, Wang DS, Nagahama Y, Shibata N. 2006. Molecular cloning and analysis of gonadal expression of Foxl2 in the medaka, Oryzias latipes. Biochemical and Biophysical Research Communications. 344:353-361. (IF 3.0)
45. Oshima Y, Kato T, Wang DS, Murakami T, Matsuda Y, Nagahama Y, Nakamura M, 2006. Promoter Activity and Chromosomal Location of the Rana rugosa P450 Aromatase (CYP19) Gene. Zoological Science. 23:79-85.(IF 1.2)
46. Jiao BW, Huang XG, Chan CB, Zhang L, Wang DS, Cheng CHK (equal contribution of all authors). 2006. The co-existence of two growth hormone receptors in teleost and their differential signal transduction, tissue distribution and hormonal regulation of expression in seabream. Journal of Molecular Endocrinology. 36:23-40.(IF 2.9)
47. Wang DS,Senthilkumaran B, SudhakumariCC, Sakai F, MatsudaM, Kobayashi T, Yoshikuni M, Nagahama Y. 2006. Molecular cloning, gene expression and characterization of the third estrogen receptor of the Nile tilapia, Oreochromis niloticus. Fish Physiology and Biochemistry, 31: 255-266.(IF 0.7)
48. Matsuda M, Wang D, Nagahama Y 2006. Functional differences between the sex-determining gene of medaka, DMY and DMRT1 which is a paralogous gene of DMY；Zoological Science； 23 (12):1223-1223.
49. Ijiri, S; Wang, D; Nagahama, Y 2006 Gene expression profile in Nile tilapia gonad during sex differentiation.；Journal of Experimental Zoology Part A-Comparative Experimental Biology. 305A(2) : 135-135.
50. Sudhakumari CC, Senthilkumaran B, Kobayashi T, Kajiura-Kobayshi H, Wang DS, Yoshikuni M, Nagahama Y. (2005). Ontogenic expression patterns of several nuclear receptors and cytochrome P450 aromatases in brain and gonads of the Nile tilapia Oreochromis niloticus suggests their involvement in sex differentiation. Fish Physiology and Biochemistry. 31: 129-135.(IF 0.7)
51. Raghuveer K, Rahul G, Wang DS, Bogerd J, Kirubagaran R, Rasheeda MK, Sreenivasulu G, Bhattacharya N, Tarangini S, Nagahama Y, Senthilkumaran B (2005). Effect of methyl testosterone- and ethynyl estradiol-induced sex differentiation on catfish, Clarias gariepinus: Expression profiles of Dmrt1, cytochrome P450aromatases and 3beta-hydroxysteroid dehydrogenase. Fish Physiology and Biochemistry. 31: 143-147.(IF 0.7)
52. Rasheeda MK, Sreenivasulu G, Swapna I, Raghuveer K, Wang DS, Thangaraj K, Dutta-Gupta A, Senthilkumaran B (2005). Thiourea-induced alteration in the expression patterns of some steroidogenic enzymes in the air-breathing catfish Clarias gariepinus. Fish Physiology and Biochemistry. 31: 275-279.(IF 0.7)
53. Zhou LY,Wang DS, Senthilkumaran B, Yoshikuni M, Shibata Y, Kobayashi T, Sudhakumari CC, Nagahama Y (2005). Cloning, expression and characterization of three types of 17b-hydroxysteroid dehydrogenases from the Nile tilapia,Oreochromis niloticus. Journal of Molecular Endocrinology.35:103-116.(IF 2.5)
54. Wang DS, Kobayashi T, Zhou LY, Nagahama Y, 2004.Molecular cloning and gene expression of Foxl2 in the Nile tilapia, Oreochromis niloticus.Biochemical and Biophysical Research Communications 320: 83–89.(IF 3.0)
55. Jiang JQ, Wang DS (equal contribution),Senthilkumaran B, Kobayashi T, Kobayashi HK, Yamaguchi A, Ge W, Young G, Nagahama Y. (2003). Isolation, Characterization and Expression of 11b-Hydroxysteroid Dehydrogenase type 2 cDNAs from the Testes of Japanese Eel (Anguilla japonica) and Nile Tilapia (Orechromis niloticus). Journal of Molecular Endocrinology, 31: 305-315 .(IF 3.8)
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57. Fan HG, Wang DS, Kobayashi T, Senthilkumaran B, Sudhakumari CC, Yoshikuni M, Nagahama Y (2003). Molecular Cloning of the Three Gonadotropin Subunits and Early Expression of FSHb During Sex Differentiation of the Nile Tilapia, Oreochromis niloticus. Fish Physiology and Biochemistry. 28: 143-144.(IF 0.7)
58. Zhou LY, Senthilkumaran B, Wang DS, Sudhakumari CC, Kobayashi T, Kajiura-Kobayashi H, Matsuda M, Yoshikuni M, Nagahama Y (2003). Partial Cloning of the 17b-HSD-I from the Nile Tilapia Ovary and Its Expression Pattern During the Spawning Cycle. Fish Physiology and Biochemistry. 28:381-382.(IF 0.7)
59. Senthilkumaran B, Yoshiura Y, Oba Y, Sudhakumari CC, Wang DS, Kobayashi T, Yoshikuni M, Nagahama Y (2003). Steroidogenic Shift is a Critical Event for Ovarian Follicles to Undergo Final Maturation. Fish Physiology and Biochemistry. 28:313-315.(IF 0.7)
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68. 張未麗，劉智皓，吳風瑞，黃寶鋒，韓飛，孫運侶，王德壽(通訊作者). 2009. 轉錄因子GATA-2在脊椎動物發育過程中的作用. 四川動物. 28（6）：945-948.
69. 韓飛，劉智皓，吳風瑞，黃寶鋒，張未麗，周 宏，王德壽(通訊作者). 2008. 維甲酸和Cyp26 基因家族與生殖細胞分化. 細胞生物學雜誌. 31(3): 355−360.
70. 胡重江，吳風瑞，劉智皓，黃寶鋒，張耀光，王德壽(通訊作者). 2008. 南方鮎Vasa兩種亞型cDNA的克隆及其表達研究. 動物學報. 54(6): 1051-1060
71. 張修月，劉智皓，王德壽（通訊作者）. 2008. 南方鮎受精細胞學觀察. 四川動物. 27（1）：7-11.
72. 黃寶鋒, 劉智皓, 吳風瑞, 王德壽（通訊作者）. 2008. 雄激素受體的結構和功能. 四川動物. 27（2）：307-310.
73. 徐吉山，王德壽，張耀光. 2007.大鰭鱯卵巢濾泡細胞發育的組織學研究.大理學院學報.6：10-14.
74. 章力，黃希貴，焦保衛，吳風瑞，王德壽(通訊作者). 2006. 南方鮎兩種生長激素受體的結構分析及其組織分布和激素調節. 動物學報. 52（6）：1096-1106.
75. 吳風瑞, 張修月, 王德壽(通訊作者). 2006. 人工誘導南方鮎雌核發育的最適參數.動物學雜誌 41:27-31.
76. 劉智皓，張修月，王德壽 (通訊作者). 2005. 脊椎動物基因組與基因複製研究進展[J].四川動物. 2005，24(4):672-677.
77. 章立，黃希貴，王德壽(通訊作者). 2005魚類胰島素樣生長因子（IGF）系統的研究進展；動物學雜誌； 40（2）:99-105.
78. 張修月，焦保衛，吳天利, 金燦彪, 王德壽(通訊作者). 2005南方鯰性腺分化的組織學觀察.動物學雜誌. 40（1）:41-48.
79. 周林燕，張修月，王德壽 (通訊作者). 2004. 脊椎動物性別決定和分化的分子機制研究進展. 動物學研究. 25(1): 81-88.
80. 黃希貴， 焦保衛， 王德壽(通訊作者). 2004. 生長激素促分泌素受體(GHS-R)的發現及影響.動物學雜誌. 39（2）：84-88.
81. 鄧思平, 王德壽(通訊作者), 張耀光, 焦保衛. 2004. 南方鯰生殖周期中腦垂體和血清促性腺激素水平的含量變化. 西南師範大學學報. 29(4)654-658.
82. 鄧思平，王德壽(通訊作者)，張耀光，吳天利. 2003. LHRH-A和hCG對南方鯰血清促性腺激素水平的影響，湛江海洋大學學報. 23(1):13-16.
83. 周林燕，焦保衛，王德壽(通訊作者). 2003. 哺乳動物性別決定研究進展. 海南大學學報. 21（1）：78-84.
84. 鄧思平，王德壽(通訊作者)，張耀光，吳天利. 2003. 外源激素對南方鯰血清促性腺激素水平的影響. 西南師範大學學報（自然科學版）. 28(4):614-617.
85. 鄧思平，王德壽(通訊作者)，張耀光，吳天利. 2003.誘導南方鯰排卵過程中血清促性腺激素水平的變化. 山地農業生物學報. 22(3):214-217.
86. 焦保衛, 王德壽(通訊作者), 鄧思平. 2002. 爬行動物溫度性別決定研究進展. 動物學雜誌. 35(4) :74-78.
87. 陳細香，金燦彪，徐吉山，王德壽(通訊作者). 2002. 大鰭鱯消化系統胚後發育的組織學研究. 西南師範大學學報（自然科學版）. 27（2）：239-243.
88. 王德壽，林浩然. 2001. 誘導大鰭鱯和長吻鮠排卵過程中血清GTH水平的變化研究. 水生生物學報. 25（2）185-190.
89. 鄧思平, 吳天利, 王德壽 (通訊作者), 張耀光. 2000. 溫度對南方鮎幼魚生長與發育的影響. 西南師範大學學報. 25(6)674-679.
90. 王德壽(通訊作者), 江宗秀，2000. 魚類性外激素的研究進展. 水生生物學報. 24（3）282- 288.
91. 王德壽(通訊作者)，吳天利，張耀光. 2000. 魚類性別決定及其機制研究進展. 西南師範大學學報 . 25(3)276-304.
92. 王德壽, 林浩然, 張為民. 1999. 大鰭鱯腦垂體和血清生長激素水平的季節變化. 水產學報， 23（1）：1-5.
93. 王德壽，林浩然，蒲德永，張耀光等. 1998. 注射促黃體素釋放激素類似物和地歐酮誘導大鰭鱯和長吻鮠排卵的研究. 動物學研究. 19 (3) ：177-183.
94. 王德壽 林浩然 H.J.Th. Goos，1998. 大鰭鱯促性腺激素分泌調控的研究. 動物學報， 44（3）：322-328.
95. 王德壽, 林浩然, H.J.Th.Goos, 1997. 大鰭鱯腦垂體和血清促性腺激素(GTH)水平的季節變化. 魚類學論文集(第六輯). 科學出版社(京). 第29-35頁.
96. 張耀光, 王德壽, 1996. 短尾擬鱨分類地位的探討. 水生生物學報. 20(4):379-382.
97. 王德壽，林浩然. 1996. 鯰類生殖內分泌研究. 水產學報. 20(2): 151-158.
98. 王德壽，田懷軍，蒲德永. 1995. 粗唇鮠生物學的初步研究. 西南師範大學學 報. 20(1): 59-65.
99. 張耀光，王德壽. 1995. 嘉陵江鱨科魚類骨學研究( I )－韋伯氏器的比較. 西南師範大學學報. 20(1): 53-58.
100. 張耀光，王德壽. 1995. 嘉陵江鱨科魚類骨學研究(II)－脊柱及附肢骨的比較. 西南師範大學學報. 20(2): 167-175.
101. 張耀光，王德壽. 1995. 嘉陵江鱨科魚類骨學研究(III)－頭骨的比較. 西南師範大學學報, 20(3): 284-292.
102. 金燦彪，何學福，王德壽. 1994. 大鰭鱯個體生殖力的研究. 西南師範大學學報. 19(2)：311-315.
103. 蔣國福，王德壽. 1993. 家雞有三個睪丸的解剖記錄. 四川動物. 12(1): 42.
104. 王德壽，羅泉笙. 1993. 嘉陵江大鰭鱯的年齡和生長的研究. 水生生物學報. 17(2):157-165.
105. 龍祥平，王德壽. 1993. 南方鯰仔稚魚期齒髮育的組織學和組織化學. 西南師範大學學報. 18(3): 346-350.
106. 龍祥平，王德壽，田懷軍. 1993. 南方鯰、大鰭鱯鰾發育的組織學研究. 水產學報. 17(4): 340-343.
107. 王德壽，羅泉笙. 1992. 大鰭鱯的繁殖生物學. 水產學報. 16(1): 50-59.
108. 王德壽, 楊松林, 1992. 大鰭鱯的可量性狀、長重關係和肥滿度. 西南師範大學學報. 17(4): 510-515.
109. 張耀光, 王德壽, 羅泉笙. 1992. 大鰭鱯的胚胎髮育. 西南師範大學學報. 16(2): 223-229.
110. 王德壽, 羅泉笙, 劉少英. 1990. 大鰭鱯頭骨形態的觀察. 西南師範大學學報. 15(3): 399-404.
111. 王德壽, 1987. 南方大口鯰顱骨形態的研究. 西南師範大學學報. （1）130-137.
出版專著：
何學福、張耀光主編，王德壽、洪錫鈞、羅泉笙副主編。四川經濟鮎類研究。西南師範大學出版社。1998年7月。
