沈傑(南開大學藥學院副教授)

沈傑，南開大學藥學院副教授

基本介紹

• 中文名：沈傑
• 畢業院校：中國科學技術大學
• 學位/學歷：博士後
• 專業方向：抗癌類藥物的合成和設計
• 職務：副教授
• 性別：男

基本信息

沈傑，男，36歲，南開大學藥學院副教授

沈傑副教授

1992－1996中國科學技術大學 化學物理系 本科

1997－2000中國科學技術大學 化學系 碩士

2000－2002美國Wayne State University，博士（轉學）

2002－2007美國The Ohio State University，化學博士

2007－2008 美國The Ohio State University，博士後

2009－至今南開大學藥學院 副教授

主要研究對象：抗癌類藥物的合成和設計；所研究過的藥物分子包括：rebeccamycin analogs，anthracycline analogs，HDACi，geldanamycin analogs 和GST-targeting drugs

發表論文

1 Shen, J.; Woodward, R.; Kedenburg, J. P.; Liu, X.; Chen, M. Histone Deacetylase Inhibitor through Click Chemistry. J. Med. Chem. 2008, 51(23), 7417-7427.

2 Li, M.; Shen, J.; Liu, X.; Shao, J.; Yi, W.; Chow, C. S.; Wang, P. G. Identification of a New  1,2-Fucosyltransferase Involved in O-Antigen Biosynthesis of Escherichia coli O86:B7 and Formation of H-Type 3 Blood Group Antigen. Biochemistry, 2008，47(44), 11590-11597。

3 Yi, W.; Shen, J.; Zhou, G.; Li, J.; Wang, P. G. Bacterial Homologue of Human Blood Group A Transferase. Journal of the American Chemical Society 2008, 130(44), 14420-14421.

4 Li, M.; Liu, X.; Shao, J.; Shen, J.; Jia, Q.; Yi, W.; Song, J. K.; Woodward, R.; Chow, C. S.; Wang, P. G. Characterization of a Novel  1,2-Fucosyltransferase of Escherichia coli O128:B12 and Functional Investigation of Its Common Motif. Biochemistry, 2008, 47(1), 378-387.

5 Cui, H.; Shen, J.; Lu, D.; Zhang, T.; Zhang, W.; Sun, D.; Wang, P. G. 4-Aryl-1,3,2-oxathiazolylium-5-olate: a novel GST inhibitor to release JNK and activate c-Jun for cancer therapy. Cancer Chemotherapy and Pharmacology, 2008, 62(3), 509-515.

6 Battisti RF, Zhong Y, Fang L, Gibbs S, Shen J, Nadas J, Zhang G, Sun D. “Modifying the Sugar Moieties of Daunorubicin Overcomes P-gp-Mediated Multidrug Resistance”. Molecular Pharmaceutics, 2007, 4,140-153.

7 Fang L, Battisti RF,Cheng H, Reigan P, Xin Y, Shen J, Ross D, Chan KK, Martin EW, Jr., Wang PG, Sun D. “Enzyme Specific Activation of Benzoquinone Ansamycin Prodrugs Using HuCC49DCH2-b-Galactosidase Conjugates”. Journal of Medicinal Chemistry, 2006, 49, 6290-6297.

8 Yi W, Bystricky P, Yao Q, Guo H, Zhu L, Li H, Shen J, Li M, Ganguly S, Bush CA, Wang PG. “Two different O-polysaccharides from Escherichia coli O86 are produced by different polymerization of the same O-repeating unit”. Carbohydrate Research, 2005, 341,100-108.

9 Yi W, Shao J, Zhu L, Li M, Singh M, Lu Y, Lin S, Li H, Ryu K, Shen J, et al. “Escherichia coli O86 O-antigen biosynthetic gene cluster and stepwise enzymatic synthesis of human blood group B antigen tetrasaccharide”. Journal of the American Chemical Society 2005, 127, 2040-2041.

10 Zhang G, Fang L, Zhu L, Aimiuwu JE, Shen J, Cheng H, Muller MT, Lee GE, Sun D, Wang PG. “Syntheses and Biological Activities of Disaccharide Daunorubicins”. Journal of Medicinal Chemistry, 2005, 48:5269-5278.

11 Zhang G, Shen J, Cheng H, Zhu L, Fang L, Luo S, Muller MT, Lee GE, Wei L, Du Y, et al. “Syntheses and Biological Activities of Rebeccamycin Analogs with Uncommon Sugars” Journal of Medicinal Chemistry, 2005, 48:2600-2611.

12 Postema, Maarten H. D.; Piper, Jared L.; Liu, Lei; Shen, J; Faust, Marcus; Andreana, Peter. “Synthesis and Partial Biological Evaluation of a Small Library of Differentially-Linked  -C-Disaccharides” Journal of Organic Chemistry, 2003, 68: 4748-4754.

申請專利

點擊化學合成具有分支結構的組蛋白去乙醯化酶抑制劑， 王鵬，沈傑，尹正.