李默怡

李默怡,女,現任東南大學副教授、碩士生導師。佛羅里達大學博士畢業。研究方向為:神經發育與退行性疾病的分子機理;環路發育及功能的遺傳控制機制。

基本介紹

  • 中文名:李默怡
  • 職業:教師
人物經歷,研究方向,近期代表論文,

人物經歷

1996年9月 — 2000年6月 學士, 微生物專業,華中農業大學
2000年9月 — 2003年6月 碩士, 生化工程專業,華中科技大學
2003年8月 — 2008年5月 博士, 植物病理專業,佛羅里達大學
2009年1月 — 2013年7月 博士後,佛羅里達大學
2014年1月 — 2016年2月 博士後,東南大學生命科學與技術學院
2016年2月 副研究員,東南大學生命科學與技術學院

研究方向

  1. 神經發育與退行性疾病的分子機理
  2. 環路發育及功能的遺傳控制機制

近期代表論文

  1. Li M*, Zhuang Y*, Batra R, Thomas JD, Li M, Nutter CA, Scotti MM, Carter HA, Wang ZJ, Huang XS, Pu CQ, Swanson MS, Xie W. HNRNPA1-induced spliceopathy in a transgenic mouse model of myotonic dystrophy. (2020) Proc. Natl. Acad. Sci. U.S.A. 117(10):5472-5477. * co-first author; # Co-corresponding author
  2. Xing G*, Li M* (co-first author), Sun Y, Rui M, Zhuang Y, Lv H, Han J, Jia Z, Xie W. Neurexin-Neuroligin 1 regulates synaptic morphology and function via the WAVE regulatory complex in Drosophila neuromuscular junction. (2018) eLife;7: e30457
  3. Liang X, Liberti D, Li M, Kim YT, Hutchens A, Wilson R, Rollins JA. Oxaloacetate acetylhydrolase gene mutants of Sclerotinia sclerotiorum do not accumulate oxalic acid, but do produce limited lesions on host plants. (2015) Mol. Plant Pathol. 16: 559-571.
  4. Batra R, Charizanis K, Manchanda M, Mohan A, Li M, Finn D J, Goodwin M, Zhang C, Sobczak K, Thornton C A., and Swanson MS. Loss of MBNL Leads to Disruption of Developmentally Regulated Alternative Polyadenylation in RNA Mediated Disease. (2014) Mol. Cell. 56: 311-322
  5. Lee KY*, Li M* (co-first author), Manchanda M, Batra R, Charizanis K, Mohan A, Warren SA, Finn D, Hong H, Ashraf H, Kasahara H, Chamberlain CM, Ranum LPW and Swanson MS. Compound loss of muscleblind-like function in myotonic dystrophy. (2013) EMBO Mol. Med. 5:1887-1900
  6. Poulos MG, Batra R, Li M, Yuan Y, Zhang C, Darnell RB and Swanson MS. Progressive impairment of muscle regeneration in muscleblind-like 3 Isoform knockout mice. (2013) Hum. Mol. Genet. 22: 3547-3558
  7. Warren SA, Briggs LE, Zeng H, Chuang J, Chang Eileen, Terada R, Li M, Swanson MS, Wood CE, Spinale FG, Maupine-Furlow J, McMullen JR, Moss R, Kasahara H. Myosin light chain phosphorylation is critical for adaptation to cardiac stress. (2012) Circulation. 126: 2575-2588
  8. Li M, Liang X, and Rollins JA. Sclerotinia sclerotiorum gamma-glutamyl transpeptidase (Ss-Ggt1) is required for regulating glutathione accumulation and proper development of sclerotia and compound appressoria. (2012) Mol. Plant Microbe In. 25: 412-420
  9. Li M and Rollins JA. The development-specific ssp1 and ssp2 genes of Sclerotinia sclerotiorum encode lectins with distinct yet compensatory regulation. (2010) Fungal Genet. Biol. 47: 531-538
  10. Li M and Rollins JA. The development-specific protein (Ssp1) from Sclerotinia sclerotiorum is encoded by a novel gene expressed exclusively in sclerotium tissues. (2009) Mycologia. 101: 34-43

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