教學工作
承擔本科生《分子生物學》《生物化學實驗》及研究生《現代分子生物學》課程的教學工作。
研究方向
重要蔬菜致病菌關鍵蛋白結構與功能研究。
科研項目
1.山東省重大科技創新工程“設施蔬菜重要卵菌病害高效精準綠色防控技術研創、最佳化與套用”(項目編號 2019JZZY010714),500萬元,2019年-2021年,主持。
2.科技基礎資源調查專項“我國主要沿海灘涂特色微生物資源調查”子課題“灘涂紅樹林生態系統特色枯枝腐生菌的資源調查” (項目編號2019FY1007044),9.5萬元,2019-2023年,主持。
3.國家重點研發計畫“耕地地力影響農業有害生物發生的機制與調控”子課題“華北地區設施環境因子對辣椒疫霉致病影響機制”(項目編號2017YFD02006038),110萬元,2017年-2021年,主持。
4.國家自然科學基金青年基金“辣椒疫黴菌效應蛋白RxLR23晶體結構及轉運機制研究”(項目編號31500121),22.8萬元,2016年-2018年,主持。
5.山東省優秀中青年科學家科研獎勵基金“辣椒疫黴菌效應蛋白RxLR12的晶體結構及轉運機制研究”(項目編號2015BSB01358),8萬元,2015年-2017年,主持。
6.中國博士後科學基金面上資助“硒代小分子衍生物在測定蛋白質結構中的套用研究”(資助編號20110491592),3萬元,2010年-2011年,主持。
7.山東省博士後創新項目專項資金“硒代小分子衍生物在解決相關蛋白質晶體結構相位問題中的套用研究”(資助編號201003056),2萬元,2010年-2011年,主持。
研究專利
1.朱春原,張夢妍,張修國。辣椒疫霉細胞分裂蛋白及其編碼基因與套用。專利授權號ZL 2014 1 0720137.4。
2.谷立川,朱春原,許素娟,陳穎,李冰清,一種c-di-GMP 的分離純化方法,2014. 3,中國,ZL 2011 1 0279973.X
發表論文
1.Li Zhao, Xiuguo Zhang, Xuefa Zhang, Weiwei Song, Xiuqi Li, Rui Feng, Cancan Yang, Zhenling Huang, Chunyuan Zhu*. Crystal structure of the RxLR effector PcRxLR12 from Phytophthora capsici, Biochemical and Biophysical Research Communications, 2018, 503, 1830-1835.
2.Chunyuan Zhu#, Xiaoyan Yang#, Rong Lv#, Zhuang Li, Xiaomeng Ding, Brett M. Tyler, Xiuguo Zhang*. Phytophthora capsici homologue of the cell cycle regulator SDA1 is required for sporangial morphology, mycelial growth and plant infection, Molecular Plant Pathology, 2016, 17(3), 369-387.
3.Li Fu#, Chunyuan Zhu#, Xiaomeng Ding#, Xiaoyan Yang, Paul F. Morris, Brett M. Tyler, Xiuguo Zhang*. Characterization of cell-death-inducing members of the pectate lyase gene family in Phytophthora capsici and their contributions to infection of pepper, Molecular Plant-Microbe Interactions, 2015, 28, 7, 766-775.
4.Guijun Shang#, Deyu Zhu#, Ning Li#, Junbing Zhang#, Chunyuan Zhu, Defen Lu, Cuilan Liu, Qian Yu, Yanyu Zhao, Sujuan Xu, Lichuan Gu*. Crystal structures of STING protein reveal basis for recognition of cyclic di-GMP, Nature Structural & Molecular Biology, 2012, 19(7), 725-727.
5.Chunyuan Zhu, Yan-Tuan Li*, Zhi-Yong Wu, Yu-Lan Song. Synthesis, crystal structure and antibacterial activity of a new binuclear copper(II) complex with N,N'-bis(N- hydroxyethylaminopropyl) oxamido as a bridging ligand, J. Coord. Chem., 2007, 60, 465-472
6.Chunyuan Zhu, Yan-Tuan Li*, Jian-Dong Wu, Zhi-Yong Wu, Xia Wu. Tris[(3- aminopropyl) dimethylammonium] decavanadate(V) hexahydrate, Acta Cryst. E63, 2007, m1777-m1778.
7.Chunyuan Zhu, Yan-Tuan Li*, Zhi-Yong Wu, Ning-Yu Xiao. Tris(N,N-dimethylethane -1,2-diammonium) decavanadate(V) pentahydrate, Acta Cryst. E63, 2007, m547-m549.
8.Chunyuan Zhu, Yan-Tuan Li*, Zhi-Yong Wu, Wei Sun. N,N’-Bis(2-ammonioethyl) oxamide diaquabis(oxalato-κ2O,O’)cuprate(II) dehydrate, Acta Cryst. E62, 2006, m3585-m3587.
9.Chunyuan Zhu, Yan-Tuan Li*, Zhi-Yong Wu, Man Jiang. Tris-(propane-1,3- diammonium) decavanadate 5.5-hydrate, Acta Cryst. E62, 2006, m3092-m3095.
10.Yan-Tuan Li*, Chunyuan Zhu, Zhi-Yong Wu, Man Jiang, Cui-Wei Yan. Synthesis, crystal structure, antibacterial activities and DNA-binding studies of a new μ-oxamido-bridged binuclear copper(II) complex, J. Coord. Chem., 2009, 62, 3795-3809.
11.Yan-Tuan Li*, Chunyuan Zhu, Zhi-Yong Wu, Man Jiang, Cui-Wei Yan. Synthesis, crystal structures and anticancer activities of two decavanadate compounds, Transition Met.Chem., 2010, 35, 597-603.
12.Yan-Tuan Li*, Chunyuan Zhu, Guo-Qiang Li, Cui-Wei Yan, Gui-Yun Xu. Synthesis and magnetism of copper(II)-lanthanide(III)-copper(II) heterotrinuclear complexes with N,N’-bis[2-(dimethylamino)ethyl] oxamidocopper(II), Transition Met. Chem., 2005, 30, 850-855.
13.Yan-Tuan Li*, Chunyuan Zhu, Cui-Wei Yan, Jian-Min Dou, Da-Qi Wang. Synthesis, characterization and magnetic studies of oxamido-bridged copper(II)-iron(III) heterobinuclear complexes, Polish J. Chem., 2005, 79, 1265-1273.
14.Shan Jin, Chunyuan Zhu, Minyong Li, Binghe Wang*. Identification of the first fluorescent α-amidoboronic acids that change fluorescent properties upon sugar binding, Bioorg. Med. Chem. Lett., 2009, 19, 1596-1599.
15.Shan Jin, Chunyuan Zhu, Yunfeng Cheng, Minyong Li, Binghe Wang*. Synthesis and carbohydrate binding studies of fluorescent α-amidoboronic acids and the corresponding bisboronic acids, Bioorg. Med. Chem., 2010, 18, 1449-1455.
16.Shan Jin, Minyong Li, Chunyuan Zhu, ViLinh Tran, Binghe Wang*. Computer-based de novo design, synthesis, and evaluation of boronic acid-based artificial receptors for selective recognition of dopamine, Chembiochem, 2008, 9, 1431-1438.