景王慧，女，現任西安交通大學醫學部藥學院教授、博士生導師，藥學院藥理學系主任，Chinese Medicine期刊第二屆青年編委。
基本介紹
人物經歷,研究方向,主要成就,學術成果,承擔項目,所獲榮譽,
人物經歷
2004.09—2008.07，山西醫科大學，藥學，學士學位。
2008.09—2010.07，澳門大學，中藥學，碩士學位。
2010.09—2014.07，澳門大學，生物醫藥，博士學位。
2015.03—2018.10，西安交通大學，講師。
2016.01—2017.12，美國加州大學歐文分校，博士後。
2018.10—2025.01，西安交通大學，副教授。
2021.10—2022.12，山西省忻州市中醫醫院，副院長（掛職）。
2025.01—至今，西安交通大學，教授。
研究方向
長期從事中藥有效性和可控性的研究，近年來專注於中藥新藥開發，疾病狀態下（特別是炎症性腸病）藥物代謝/轉運系統變化及機制，以及基於腸道菌群的中藥整體性作用物質基礎研究。
主要成就
學術成果
1. W Jing*; S Dong; Y Xu;S Wang*; Gut microbiota-derived tryptophan metabolites regulated by Wuji Wan to attenuate colitis through AhR signaling activation; Acta Pharmaceutica Sinica B; 2024
2. Luo,L., Luo, H*,Jing, W*. Tauroursodeoxycholic Acid Reverses Dextran Sulfate Sodium-Induced Colitisin Mice via Modulation of Intestinal Barrier Dysfunction and MicrobiomeDysregulation, JPharmacol Exp Ther, 2024, 390(1):116-124.
3. Xu,Y.,Jing.W*; Wang, L.,*; Wang, S.*A mannitol-modified emodin nano-drug restores the intestinal barrierfunction and alleviates inflammation in a mouse model of DSS-induced ulcerativecolitis;Chinese Medicine, 2023, 18(1):98.
4. Luo, H., Lu, H.*; Wang, Y.*; Jing, W.* Emerging pharmacotherapy for inflammatory bowel diseases. Pharmacol Res, 2022, 178:106146.
5. Jing, H., Yang, J.*, Wang, H.* Hyaluronic Acid-Melatonin Nanoparticles Improve the Dysregulated Intestinal Barrier, Microbiome and Immune Response in Mice with Dextran Sodium Sulfate-Induced Colitis; Journal of Biomedical Nanotechnology, 2022,18:175-184.
6. Dong, S., Jing, W.*, Lu, H.* and Wang, S.* Dihydromyricetin improves DSS-induced colitis in mice via modulation of fecal-bacteria-related bile acid metabolism. Pharmacological Research, 2021.
7. Jing, W., Luo, X., and Wang, S., Lu, H.*. Berberine improved the colitis in rats by the regulation of microbial tryptophan metabolites to activate AhR. Pharmacological Research, 2021.
8. Jing, W.*, Safarpour Y, Fu, Q.*, Wang, Y., Berberine upregulates P-glycoprotein in Caco-2 cells and experimental colitis rat colons via activation of Nrf2-mediated mechanisms. J Pharmacol Exp Ther, 2018.
9. Jing, W.*, Nunes ACF, Vaziri ND*, Phosphate binder, ferric citrate, attenuates anemia, renal dysfunction, oxidative stress, inflammation and fibrosis in 5/6 nephrectomized CKD rats. J Pharmacol Exp Ther, 2018, 367:129-137.
10. Suematsu Y, Jing W, Nunes A, Kashyap ML, Khazaeli M, Vaziri ND*, Moradi H*, LCZ696 (Sacubitril/Valsartan), An Angiotensin-Receptor Neprilysin Inhibitor, Attenuates Cardiac Hypertrophy, Fibrosis, and Vasculopathy in a Rat Model of Chronic Kidney Disease, J Card Fail, 2018, 4(4): 266-275.
11. Jing W*, Safarpour Y, Zhang T, Guo P, Chen G, Wu X, Fu Q*, Wang Y. Berberine Upregulates P-Glycoprotein in Human Caco-2 Cells and in an Experimental Model of Colitis in the Rat via Activation of Nrf2-Dependent Mechanisms, J Pharmacol Exp Ther, 2018, 366(2): 332-340.
12. Jing W, Jabbari B, Vaziri ND*, Uremia induces upregulation of cerebral tissue oxidative/inflammatory cascade, down-regulation of Nrf2 pathway and disruption of blood brain barrier, Am J Transl Res, 2017, 10 (7): 2137-2147.
13. Jing W, Vaziri ND*, Nunes A, Suematsu Y, Farzaneh T, Khazaeli M, Moradi H*, LCZ696 (Sacubitril/valsartan) ameliorates oxidative stress, inflammation, fibrosis and improves renal function beyond angiotensin receptor blockade in CKD, Am J Transl Res, 2017, 9 (12): 5473-5484.
14. Jing W, Gao X, Hana B, Wei B, Hua N, Lia S, Yan R*, Wang Y, Mori Cortex regulates P-glycoprotein in Caco-2 cells and colons from colitic rats via gut bacteria dependent/independent mechanisms, RSC Adv, 2017,7: 2594-2605.
15. Jing W, Liu R, Du W, Luo Z, Guo P, Zhang T, Zeng A, Chang C, Fu Q*, Pharmacokinetic and Metabolic Characteristics of Herb-derived Khellactone Derivatives, A class of Anti-HIV and Anti-hypertensive Drug Candidates: A Review, Molecules, 2016, 21(3): 314.
16. Jing W, Yan R*, Wang Y*, A practical strategy for chemical profiling of herbal medicines using ultra-high performance liquid chromatography coupled with hybrid triple quadrupole-linear ion trap mass spectrometry: acase study of Mori Cortex. Anal Method, 2015, 7(2): 443-457.
17. Song Y, Jing W, Yan R, Wang Y*, A pretreatment free method for the determination of seven natural products in a high-salt matrix by online guard column extraction coupled with tandem mass spectrometry, Anal Methods, 2014, 6: 623-628.
18. Song Y, Jing W, Tu P, Wang Y*, Characterization of Peucedani Radix extract-derived angular-type pyranocoumarins in rats using ultra high performance liquid chromatography coupled with hybrid triple quadrupole-linear ion trap mass spectrometry, Anal Methods, 2014, 6: 5198-5206.
19. Song Y, Jing W, Tu P, Wang Y*, Development of enantiospecific and chemoselective methods for the determination of praeruptorin A enantiomers and their metabolites in rat plasma using chiral and achiral LC-MS/MS. Anal Methods, 2014, 6(13): 4831-4839.
20. Jing W, Song Y, Yan R*, Wang Y, Identification of cytochrome P450 isoenzymes involved in metabolism of (+)-praeruptorin A, a calcium channel blocker, by human liver microsomes using ultra high-performance liquid chromatography coupled with tandem mass spectrometry, J Pharm Biomed Anal, 2013, 77: 175-188.
21. Jing W, Song Y, Yan R, Bi H, Li P, Wang Y*, Transport and metabolism of (±)-praeruptorin A in Caco-2 cell monolayers, Xenobiotica, 2011, 41(1): 71-81.
承擔項目
景王慧先後主持國家級及省部級縱向項目9項，企事業單位橫向課題3項。
項目名稱 | 項目來源 | 項目時間 |
基於“腸道菌-Trp-AhR”軸解析戊己丸修復 UC 腸黏膜屏障的作用機制 | 國家自然科學基金面上項目 | 2022年—2025年 |
國際中藥質量標準 | 國家科技部高端外國專家引進項目 | 2021年—2022年 |
基於腸道菌群紊亂對腸屏障的影響探討黃連抗 UC的作用機制 | 中國博士後科學基金面上項目 | 2019年—2021年 |
脾胃中藥治療炎症性腸病的作用機制及開發 | 陝西省重點研發計畫一般項目 | 2022年—2023年 |
基於膽汁酸代謝調節探討白朮-白芍對 UC 的作用機制 | 上海交通大學系統生物醫學教育部重點實驗室開放課題 | 2020年—2021年 |
基於膽汁酸代謝與腸屏障功能關聯探討白朮-白芍對 UC的作用機制 | 陝西省中醫藥管理局項目 | 2019年—2020年 |
黃連通過腸道菌調節腸外排蛋白 P-gp 修復 UC 腸屏障損傷的作用機制研究 | 國家自然科學基金青年項目 | 2017年—2019年 |
所獲榮譽
- 中國中西醫結合學會科學技術獎（2017），一等獎（13/15）。
