張琪，研究員，課題組長，博士生導師，中央組織部“青年千人計畫”獲得者。2014年5月至今在復旦化學系工作。主要工作集中於多肽化合物的化學生物學及特殊金屬酶學機制研究。以第一作者在Nature Chemical Biology、Proceedings of the National Academy of Science等雜誌上發表多篇有影響力的論文，研究成果被Science、Nature Chemical Biology、Faculty of 1000、Nature China等多個媒體予以專文亮點評述。
基本介紹
- 中文名：張琪
- 外文名：Qi Zhang
- 國籍：中國
- 民族：漢族
- 出生地：四川綿陽
- 出生日期：1981.1
- 職業：教師
- 畢業院校：復旦大學
學習經歷,工作經歷,研究領域,所獲榮譽,發表論文,
學習經歷
1999.9-2003.7 復旦大學化學系， 本科
2005.9-2010.7 中科院上海有機化學研究所，博士
工作經歷
2010.7-2011.2中科院上海有機化學研究所， 助理研究員。
2011.2-2014.5 伊利諾伊大學香檳分校 (University of Illinois at Urbana-Champaign)，博士後。
2014.5至今 復旦大學化學系， 研究員。
研究領域
多肽組學、天然產物化學生物學、金屬酶學。
所獲榮譽
2013年中央組織部“青年千人計畫”
2011年Reaxy Ph.D Prize, the finalist
1998年全國高中化學奧林匹克競賽, 四川省第一名
發表論文
Independent Investigator (Fudan University)
26. Substrate-controlled stereochemistry in natural product biosynthesis
Wei Ding, Yongzhen Li, and Qi Zhang*
ACS Chem. Biol. 2015, DOI: 10.1021/acschembio.5b00104
25. Evolution of threonine aldolases, a diverse family involved in the second pathway of glycine biosynthesis
Guangxiu Liu, Manxiao Zhang, Ximing Chen, Wei Zhang, Wei Ding*, Qi Zhang*
J. Mol. Evol., 2015, 80, 102-107
Postdoctoral Research (University of Illinois at Urbana-Champaign)
24. Expanded natural product diversity revealed by analysis of lanthipeptide-like gene clusters in Actinobacteria
Qi Zhang, James R. Doroghazi, Xiling Zhao, Mark C. Walker, and Wilfred A. van der Donk*
Appl. Environ. Microbiol., 2015, DOI: 10.1128/AEM.00635-15
23．Structure and mechanism of the tRNA-dependent lantibiotic dehydratase NisB
Manuel A. Ortega, Yue Hao, Qi Zhang, Mark C. Walker, Wilfred A. van der Donk* and Satish K. Nair*
Nature 2015, 517, 509-12
22. High Divergence of the Precursor Peptides in Combinatorial Lanthipeptide Biosynthesis
Qi Zhang, Xiao Yang, Huan Wang, and Wilfred A. van der Donk*
ACS Chem. Biol. 2014, 9，2686-2694
21. Structural investigation of ribosomally synthesized natural products by hypothetical structure enumeration and evaluation using tandem MS
Qi Zhang, Manuel A. Ortega, Yanxiang Shi, Huan Wang, Joel O. Melby, Douglas A. Mitchell, and Wilfred A. van der Donk*
Proc. Natl. Acad. Sci. 2014, 111,12031-12036
20. Substrate specificity of the lanthipeptide peptidase ElxP and the oxidoreductase ElxO
Manuel A. Ortega , Juan E. Velásquez , Neha Garg , Qi Zhang , Rachel Joyce , Satish K Nair , and Wilfred A. van der Donk*.
ACS Chem Biol., 2014, 9, 1718-1725
19. The glycosyltransferase involved in thurandacin biosynthesis catalyzes both O- and S-glycosylation
Huan Wang, Trent J Oman, Ran Zhang, Chantal V. Garcia De Gonzalo, Qi Zhang, and Wilfred A. van der Donk*
J. Am. Chem. Soc., 2014, 136, 84–87
18. Insights into the evolution of lanthipeptide biosynthesis.
Yi Yu, Qi Zhang, and Wilfred. A. van der Donk*
Protein Sci., 2013, 22,1478-1489
17. Evolution of lanthipeptide synthetases
Qi Zhang, Yi Yu, Juan E. Vélasquez, and Wilfred. A. van der Donk*
Proc. Natl. Acad. Sci., 2012, 109, 18361-18366.
16. Catalytic promiscuity of a bacterial α-N-methyltransferase
Qi Zhang and Wilfred. A. van der Donk*
FEBS Lett., 2012, 586, 3391-3397
15. Thioether Crosslinkages Created by a Radical SAM Enzyme
Qi Zhang* and Yi Yu*
ChemBioChem, 2012, 13, 1097-1099.
14. Answers to the Carbon-Phosphorus Lyase Conundrum
Qi Zhang and Wilfred. A. van der Donk*
ChemBioChem, 2012, 13, 627-629.
13. Radical-Mediated Enzymatic Methylation: A Tale of Two SAMS
Qi Zhang, Wilfred. A. van der Donk*, and Wen Liu*
Acc. Chem. Res., 2012, 45, 555-64.
Graduate Research (Shanghai Institute of Organic Chemistry)
12. Iterative type I polyketide synthase-associated aromatic product formation and modification in bacteria.
Qi Zhang, Bo Pang, Wei Ding, and Wen Liu*
ACS Catal., 2013, 3, 1439–1447
11. Biosynthesis of thiopeptide antibiotics and their pathway engineering
Qi Zhang and Wen Liu*
Nat. Prod. Rep., 2013, 30, 218-226
10. Genetic Enhancement of the Supply of the Unusual Polyketide Extender Units Improves FK506 Production in Streptomyces tsukubaensis via Utilization of Two Distinct Site-Specific Recombination Systems.
Dandan Chen, Qi Zhang, Qinglin Zhang, Peilin Cen, Zhinan Xu*, and Wen Liu*
Appl. Environ. Microbiol., 2012, 78, 5093-5103
9. Complex Biotransformations Catalyzed by Radical S-Adenosylmethionine Enzymes
Qi Zhang* and Wen Liu*
J. Biol. Chem., 2011, 286, 30245-30252.
8. Characterization of NocL Involved in Thiopeptide Nocathiacin I biosynthesis: A [4Fe-4S] Cluster and the Catalysis of a Radical S-Adenosylmethionine Enzyme
Qi Zhang, Dandan Chen, Jin Lin, Rijing, Liao, Wei Tong, and Wen Liu*
J. Biol. Chem., 2011, 286, 21287-21294.
7. Radical-Mediated Enzymatic Carbon Chain Fragmentation-Recombination.
Qi Zhang, Yuxue Li, Dandan Chen, Yi Yu, Lian Duan, Ben Shen, and Wen Liu*
Nat. Chem. Biol., 2011, 7, 154-160. [This paper was highlighted in (1) Science. 2011, 331, 1366; (2) Nat. Chem. Biol., 2011, 7, 133-134; (3) Faculty 1000, F1000.com/8771961; (4) Nature China 2011, doi: 10.1038/nchina.2011.9]
6. NosA Catalyzing Carboxyl-Terminal Amide Formation in Nosiheptide Maturation via an Enamine Dealkylation on the Serine-Extended Precursor Peptide
Yi Yu, Heng Guo, Qi Zhang, Lian Duan, Ying Ding, Rijing Liao, Chun Lei, Ben Shen, and Wen Liu*
J. Am. Chem. Soc., 2010, 132, 16324–16326.
5. Biosynthesis of 3-Methoxy-5-Methyl Naphthoic Acid and Its Incorporation into the Antitumor Antibiotic Azinomycin B.
Wei Ding, Wei Deng, Mancheng Tang, Qi Zhang, Gongli Tang, Yurong Bi and Wen Liu*
Mol. BioSyst., 2010, 6, 1071-1081.
4. Nosiheptide Biosynthesis Featuring a Unique Indole Side Ring Formation on the Characteristic Thiopeptide Framework.
Yi Yu, Lian Duan, Qi Zhang, Rijing Liao, Ying Ding, Haixue Pan, Evelyn Wendt-Pienkowski, Gongli Tang, Ben Shen and Wen Liu*
ACS Chem. Biol., 2009, 4, 855–864.
3. Thiopeptide Biosynthesis Featuring Ribosomally Synthesized Precursor Peptides and Conserved Posttranslational Modifications.
Rijing Liao, Lian Duan, Chun Lei, Haixue Pan, Ying Ding, Qi Zhang, Daijie Chen, Ben Shen, Yi Yu*, and Wen Liu*
Chem. Biol., 2009, 16, 141–147.
2. Characterization of the Azinomycin B Biosynthetic Gene Cluster Revealing a Different Iterative Type I Polyketide Synthase for Naphthoate Biosynthesis.
Qunfei Zhao, Qingli He, Wei Ding, Mancheng Tang, Qianjin Kang, Yi Yu, Wei Deng, Qi Zhang, Jie Fang, Gongli Tang, and Wen Liu*
Chem. Biol., 2008, 15, 693-705.
1. Cloning and Characterization of the Tetrocarcin A Gene Cluster From Micromonospora chalcea NRRL 11289 Reveals a Highly Conserved Strategy for Tetronate Biosynthesis in Spirotetronate Antibiotics.
Jie Fang, Yiping Zhang, Lijuan Huang, Xinying Jia, Qi Zhang, Xu Zhang, Gongli Tang and Wen Liu*
J. Bacteriology, 2008, 190, 6014-6025.
