基本介紹

中文名：孫成
性別：男

人物經歷,研究方向,獲獎情況,學術論文,研究成果,

人物經歷

教授、博士生導師、中科大第一附屬醫院器官移植免疫實驗室主任。中華醫學會器官移植學分會委員，《中國免疫學雜誌》編委。

研究方向

1. 人類肝臟NK細胞免疫屬性及功能調控，

2. 生物大數據分析肝臟時空異質性，

3. 人NK細胞免疫治療靶點發現與驗證。

獲獎情況

2012年，獲中國科技大學生命學院博士學位，中國科學院院長獎獲得者。

2014年，獲中國免疫學會青年學者獎。

2015年，獲美國腫瘤免疫治療協會(Society for Immunotherapy of Cancer, USA)國際青年學者獎。

2020年，獲安徽省傑出青年基金支持國家基金委優秀青年基金支持。

學術論文

1. Sun H(#), Huang Q, Huang M, Wen H, Lin R, Zheng M, Qu K, Li K, Wei H, Xiao W, Sun R, Tian Z(*), Sun C(*). Human CD96 correlates to NK cell exhaustion and predicts the prognosis of human hepatocellular carcinoma. Hepatology. 2018 Nov 8. doi: 10.1002/hep.30347.

2. Sun C(#), Lan P(#), Han Q(#), Huang M, Zhang Z, Xu G, Song J, Wang J, Wei H, Zhang J, Sun R, Zhang C, Tian Z(*). Oncofetal gene SALL4 reactivation by hepatitis B virus counteracts miR-200c in PD-L1-induced T cell exhaustion. Nature Communications. 2018 Mar 28;9(1):1241.

3. Sun H(#), Liu L, Huang Q, Liu H, Huang M, Wang J, Wen H, Lin R, Qu K, Li K, Wei H, Xiao W, Sun R, Tian Z, Sun C(*). Accumulation of Tumor-Infiltrating CD49a NK Cells Correlates with Poor Prognosis for Human Hepatocellular Carcinoma. Cancer Immunol Res. 2019 Sep;7(9):1535-1546.

4. Sun H(#), Xu J, Huang Q, Huang M, Li K, Qu K, Wen H, Lin R, Zheng M, Wei H, Xiao W, Sun R, Tian Z(*), Sun C(*). Reduced CD160 Expression Contributes to Impaired NK-cell Function and Poor Clinical Outcomes in Patients with HCC. Cancer Res. 2018 Sep 19.CAN-18-1049.

5. Sun C(#), Fu B, Gao Y, Liao X, Sun R, Tian Z(*), Wei H(*). TGF-β1 down-regulation of NKG2D/DAP10 and 2B4/SAP expression on human NK cells contributes to HBV persistence. PLoS Pathogens. 2012;8(3):e1002594.

6. Sun C(#)(*), Xu J, Huang Q, Huang M, Wen H, Zhang C, Wang J, Song J, Zheng M, Sun H, Wei H, Xiao W, Sun R, Tian Z(*). High NKG2A Expression Contributes to NK Cell Exhaustion and Predicts a Poor Prognosis of Patients with Liver Cancer. Oncoimmunology. Volume 6, 2017 6(1):e1264562.

7. Sun C(#), Sun H, Zhang C, Tian Z(*). NK cell receptor imbalance and NK cell dysfunction in HBV infection and hepatocellular carcinoma. Cell Mol Immunol. 2015 May;12(3):292-302.

8. Sun C(#), Sun HY, Xiao WH, Zhang C, Tian Z(*). Natural killer cell dysfunction in hepatocellular carcinoma and NK cell-based immunotherapy. Acta Pharmacol Sin. 2015 Oct;36(10):1191-9.

9. Wu T(#), Li F, Chen Y, Wei H, Tian Z, Sun C(*), Sun R(*). CD4 T Cells Play a Critical Role in Microbiota-Maintained Anti-HBV Immunity in a Mouse Model. Front Immunol. 2019 Apr 30;10:927.

10. Sun H(#)(*), Sun C(*). The Rise of NK Cell Checkpoints as Promising Therapeutic Targets in Cancer Immunotherapy. Front Immunol. 2019 Oct 17;10:2354.

11. Sun H(#), Song J, Weng C, Xu J, Huang M, Huang Q, Sun R, Xiao W, Sun C(*). Association of decreased expression of the macrophage scavenger receptor MARCO with tumor progression and poor prognosis in human hepatocellular carcinoma. J Gastroenterol Hepatol. 2017 May;32(5):1107-1114.

12. Sun H(#), Xu J, Huang M, Huang Q, Sun R, Xiao W, Sun C(*). CD200R, a co-inhibitory receptor on immune cells, predicts the prognosis of human hepatocellular carcinoma. Immunol Lett. 2016 Oct;178:105-13.

13. Yuwei Wu(#), Jinyu Wang(#), Xiaodong Zheng, Yongyan Chen, Mei Huang, Qiang Huang, Weihua Xiao, Haiming Wei, Zhigang Tian, Rui Sun(*)，Sun C(*) Establishment and Preclinical Therapy of Patient-derived Hepatocellular Carcinoma Xenograft Model. Immunol Lett. Volume 223, July 2020

14. Sun C(#), Xu J, Song J, Liu C, Wang J, Weng C, Sun H, Wei H, Xiao W, Sun R, Tian Z(*). The predictive value of centre tumour CD8 T cells in patients with hepatocellular carcinoma: comparison with Immunoscore. Oncotarget. 2015 Nov 3;6(34):35602-15.

15. Sun H(#), Sun C, Tian Z, Xiao W. NK cells in immunotolerant organs. Cell Mol Immunol. 2013 May;10(3):202-12.

16. Sun H(#)(*), Sun C, Xiao W, Sun R. Tissue-resident lymphocytes: from adaptive to innate immunity. Cell Mol Immunol. 2019 Mar;16(3):205-215.

研究成果

2025年3月13日凌晨，中國科學技術大學對外發布預測肝癌復發新突破：該校教授孫成研究組與合作者開發了預測肝癌復發的“TIMES”評分系統，實現了對肝細胞癌復發風險的預測，準確率達82.2%。

孫成(中國科學技術大學教授、博士生導師、中科大第一附屬醫院器官移植免疫實驗室主任)