姚鏡

姚 鏡：武漢大學生命科學學院細胞與發育生物學系教授。學科專業：細胞生物學、神經生物學研究方向：細胞膜離子通道的結構與功能

基本介紹

• 中文名：姚鏡
• 職業：武漢大學，生命科學學院，細胞與發育生物學系，教授
• 畢業院校：美國紐約州立布法羅大學生理與生物物理系
• 主要成就：細胞膜離子通道的結構與功能

學習經歷：
2006/09－2009/07，美國紐約州立布法羅大學生理與生物物理系，聯合培養博士生
2006/09－2009/07，華中科技大學生命科學與技術學院生物物理專業，博士
2002/09－2005/07，華中科技大學生命科學與技術學院生物物理專業，碩士
1996/09－2000/07，華中科技大學生命科學與技術學院生物技術專業，本科
主要工作經歷與任職情況：
2012/12-至今，武漢大學，生命科學學院，細胞與發育生物學系，教授
2011/10，受聘為湖北省楚天學者特聘教授
2011/02-2012/12，華中科技大學，生命科學與技術學院，分子生物物理教育部重點實驗室，教授
2005/10-2011/01，美國紐約州立布法羅大學，生理與生物物理系，先後擔任研究助理與博士後。

主要社會兼職：
中國生物物理學會膜生物物理專業委員會委員
中國生物物理學會神經生物物理與神經信息學專業委員會委員
主要研究領域及興趣：
目前，我們研究小組所感興趣的是一類與痛覺和溫度傳導相關的TRP離子通道的門控機制、通道蛋白的結構與功能之間的關係，以及膜離子通道通道在生理、病理中的功能等方面研究。主要從以下幾個方面開展：
(1) 溫度敏感型TRP通道的結構與功能之間的關係研究；
(2) 對與重要疾病相關的離子通道的功能調節進行研究；
(3) 與從事醫學遺傳學的研究人員合作，就離子通道類遺傳性疾病的致病機理進行研究；
(4) 圍繞與鈣離子相關的信號通路，對TRP通道在機體組織中的功能進行研究。
主持課題項目：
目前承擔有國家自然科學基金面上項目和教育部博士點新教師基金，作為研究骨幹參與國家重點基礎研究發展計畫（973計畫）。

代表性論文

1)Xiang Yang Zhang, Jingmin Wen, Wei Yang, Cheng Wang, Luna Gao, Liang Hong Zheng, Tao Wang, Kaikai Ran, Yulei Li, Xiangyang Li, Ming Xu, Junyu Luo, Shenglei Feng, Xixiang Ma, Hongying Ma, Zuying Chai, Zhuan Zhou, Jing Yao, Xue Zhang, Jing Yu Liu. Gain-of-Function Mutations in SCN11A Cause Familial Episodic Pain. Am. J. Hum. Genet. 2013 Nov 7; 93(5):957-66. Doi: 10.1016/j.ajhg.2013.09.016 (corresponding author)

2) Jing Yao, Beiying Liu and Feng Qin. Modular thermal sensors in temperature-gated transient receptor potential (TRP) channels. Proc. Natl. Aca. Sci. USA. 2011 Jul 5; 108(27):11109-14.

3)Beiying Liu, Jing Yao and Feng Qin. Hysteresis of Gating Underlines Sensitization of TRPV3 Channels. J Gen Physiol. 2011 Nov; 138(5):509-20.(equal contribution, Recommended by Faculty of 1000)

4)Jing Yao, Beiying Liu and Feng Qin. Pore turret of thermal TRP channels is not essential for temperature sensing. Proc. Natl. Aca. Sci. USA. 2010, Aug 10; 107(32):E125.

5)Jing Yao, Beiying Liu and Feng Qin. Kinetics and Energetic Analysis of Thermally Activated TRPV1 channels. Biophys. J. 2010 Sep 22; 99(6):1743-53.

6)Jing Yao, Beiying Liu and Feng Qin. Rapid temperature jump by infrared diode laser irradiation for patch-clamp studies.Biophys. J. 2009 May 6; 96(9): 3611-9.

7)Jing Yao and Feng Qin. Interaction with phosphoinositides confers adaptation of pain receptors TRPV1. PLos. Biol. 2009 Feb.24, 7 (2): e46.

8)Jing Yao, Xiang Chen, Hui Li, Yang Zhou, Lijun Yao, Gong Wu, Xiaoke Chen, Naixia Zhang, Zhuan Zhou, Tao Xu, Houming Wu, and Jiuping Ding. BmP09, a “Long Chain” scorpion peptide blocker of BK channels. J Biol Chem, 2005, 280: 14819-28.

9)Lisi Wei, Su Chen, Xianju Huang, Jing Yao and Xiangming Liu. Material basis for inhibition of dragon’s blood on capsaicin-induced TRPV1 receptor currents in rat dorsal root ganglion neurons. Eur J Pharmacol. 2013 Feb 28; 702(1-3):275-84. doi: 10.1016/j.ejphar.2013.01.052. Epub 2013 Feb 8.

10)Panpan Hou, Wenping Zeng, Geliang Gan, Caixia Lv, Xiying Guo, Zheng Zhang, Haowen Liu, Ying Wu, Jing Yao, Aguan D., Wei, Sheng Wang and Jiuping Ding. Inter-α/β subunits coupling mediating pre-inactivation and augmented activation of BKCa(β2). Sci Rep. 2013 Apr 16; 3:1666. P1-8. doi: 10.1038/srep01666.

11)Ying Wu, Yongfeng Liu, Panpan Hou, Zonghe Yan, Wenjuan Kong, Beiying Liu , Xia Li, Jing Yao, Yuexuan Zhang, Feng Qin, Jiuping Ding. TRPV1 Channels Are Functionally Coupled with BK(mSlo1) Channels in Rat Dorsal Root Ganglion (DRG) Neurons. PLoS One. 2013 Oct 16; 8(10):e78203. doi: 10.1371/journal.pone.0078203.

12)Lu Zeng, Wenqiang Liu, Wenguo Feng, Xing Wang, Hui Dang, Luna Gao, Jing Yao and Xianqin Zhang. A novel donor splice-site mutation of major intrinsic protein gene associated with congenital cataract in a Chinese family. Mol Vis. 2013 Nov 14;19:2244-9.

13)Wei Wang, Feng Xiao, Xuhui Zeng, Jing Yao, Ming Yuchi and Jiuping Ding.Optimal Estimation of Ion-channel Kinetics from Macroscopic Currents. Plos One. 2012 Mar; 7(4):e35208. Epub 2012 Apr 20.

14)Cheng Wang, Yulei Li, Lei Shi, Jie Ren, Monica Patti, Tao Wang, João R M de Oliveira, María-Jesús Sobrido, Beatriz Quintáns, Miguel Baquero, Xiaoniu Cui, Xiang-Yang Zhang, Lianqing Wang, Haibo Xu, Junhan Wang, Jing Yao, Xiaohua Dai, Juan Liu, Lu Zhang, Hongying Ma, Yong Gao, Xixiang Ma, Shenglei Feng, Mugen Liu, Qing K Wang, Ian C Forster, Xue Zhang & Jing-Yu Liu. Mutations in SLC20A2 link familial idiopathic basal ganglia calcification with phosphate homeostasis.Nat Genet. 2012 Feb 12. 44(3):254-6. doi: 10.1038/ng.1077.

15)Beiying Liu, Jing Yao Yingwei Wang, Hui Li and Feng Qin. Proton inhibition of Unitary Currents of Vanilloid Receptors. J Gen Physiol. 2009 Aug 31; 134(3):243-58.(equal contribution)

16)Sujung Ryu, Beiying Liu, Jing Yao, Qiang Fu ang Feng Qin. Uncoupling proton activation of vanilloid receptor TRPV1. J Neurosci. 2007 Nov 21，27(47): 12797-807.(equal contribution)

17)Hui Li, Jing Yao, Xiaotian Tong, Zhaohua Guo, Ying Wu, Liang Sun, Na Pan, Houming Wu, Tao Xu, and Jiuping Ding. Interaction sites between the Slo1 pore and the NH₂ terminus of the β2 subunit, probed with a three-residue sensor. J Biol Chem, 2007, 282: 17720-8.(equal contribution)

18)Xiaotian Tong, Jing Yao, Feng He, Xiang Chen, X. Zheng, Chang Xie, Gong Wu, Naixia Zhang, Jiuping Ding and Houming Wu. NMR solution structure of BmK-betaIT, an excitatory scorpion beta-toxin without a 'hot spot' at the relevant position. Biochem Biophys Res Commun. 2006 Oct 27; 349(3): 890-9.(equal contribution)

19)Jing Yao, Hui Li, Geliang Gan, Ying Wu, and Jiuping Ding. Residue Phe266 in S5-S6 loop is not critical for Charybdotoxin binding to Ca-activated K (mSlo1) channels. Acta Pharmacologica Sinica, 2006, 27: 945-9.

These authors contributed equally to the work.