基本介紹
個人簡介,研究方向,學術成果,
個人簡介
2012.9 — ：特聘副教授，蘇州大學醫學部藥學院
2009.5 — 2012.8：博士後研究助理，北卡羅來納大學教堂山分校藥學院
2009.1 — 2009.5；助理研究員，中科院上海有機所
2003.9 — 2009.1：研究生，中科院上海有機所
1999.9— 2003.7：本科， 廈門大學化學系
研究方向
（1）表觀遺傳蛋白和G蛋白偶聯受體小分子抑制劑的設計與合成
（2）表觀遺傳蛋白的化學生物學研究
（2）表觀遺傳蛋白的化學生物學研究
（3）癌症和神經疾病的“靶向治療”藥物研發
學術成果
曾參與國家自然科學基金、美國NCI、美國國防部等項目研究，發表SCI論文10多篇。
論文，*表示為通訊作者
1）Siarheyeva, A.; Senisterra, G.; Allali-Hassani, A.; Dong, A.; Dobrovetsky, E.; Wasney, Gregory A.; Chau, I.; Marcellus, R.; Hajian, T.; Liu, F.; Korboukh, I.; Smil, D.; Bolshan, Y.; Min, J.; Wu, H.; Zeng, H.; Loppnau, P.; Poda, G.; Griffin, C.; Aman, A.; Brown, Peter J.; Jin, J.; Al-awar, R.; Arrowsmith, Cheryl H.; Schapira, M.*; Vedadi, M.* "An Allosteric Inhibitor of Protein Arginine Methyltransferase 3" Structure 2012, 20, 1425.
2）Liu, F.; Barsyte-Lovejoy, D.; Allali-Hassani, A.; He, Y.; Herold, J. M.; Chen, X.; Yates, C. M.; Frye, S. V.; Brown, P. J.; Huang, J.; Arrowsmith, C. H.; Jin, J.* “Optimization of Cellular Activity of G9a Inhibitors 7-Aminoalkoxy-quinazolines”. J. Med. Chem. 2011, 54, 6139.
3） Yost, J. M.; Korboukh, I.; Liu, F.; Gao, C.; Jin, J. * “Targets in Epigenetics: Inhibiting the Methyl Writers of the Histone Code”. Curr. Chem. Genomics 2011, 5, 72. (The first four authors contributed equally to this review.)
4）Vedadi, M#.; Barsyte-Lovejoy, D#.; Liu, F#.; Rival-Gervier, S.; Allali-Hassani, A.; Labrie, V.; Wigle, T. J.; DiMaggio, P. A.; Wasney, G. A.; Siarheyeva, A.; Dong, A.; Tempel, W.; Wang, S.-C.; Chen, X.; Chau, I.; Mangano, T.; Huang, X.-P.; Simpson, C. D.; Pattenden, S. G.; Norris, J. L.; Kireev, D. B.; Tripathy, A.; Edwards, A.; Roth, B. L.; Janzen, W. P.; Garcia, B. A.; Petronis, A.; Ellis, J.; Brown, P. J.; Frye, S. V.; Arrowsmith, C. H.; Jin, J.* “A Chemical Probe Selectively Inhibits G9a and GLP Methyltransferase Activity in Cells”. Nature Chem. Biol. 2011, 7, 566. (The first three authors labeled with “#” contributed equally to this paper.)
5） Liu, F.; Chen, X.; Allali-Hassani, A.; Quinn, A. M.; Wigle, T. J.; Wasney, G. A.; Dong, A.; Senisterra, G.; Chau, I.; Siarheyeva, A.; Norris, J. L.; Kireev, D. B.; Jadhav, A.; Herold, J. M.; Janzen, W. P.; Arrowsmith, C. H.; Frye, S. V.; Brown, P. J.; Simeonov, A.; Vedadi, M.; Jin, J.* “Protein Lysine Methyltransferase G9a Inhibitors: Design, Synthesis, and Structure Activity Relationships of 2,4-Diamino-7-aminoalkoxy-quinazolines”. J. Med. Chem. 2010, 53, 5844.
6）Liu, F.; Chen, X.; Allali-Hassani, A.; Quinn, A. M.; Wasney, G. A.; Dong, A.; Barsyte, D.; Kozieradzki, I.;Senisterra, G.; Chau, I.; Siarheyeva, A.; Kireev, D. B.;Jadhav, A.; Herold, J. M.; Frye, S. V.; Arrowsmith, C. H.; Brown, P. J.; Simeonov, A.; Vedadi, M.; Jin, J.* “Discovery of a 2,4-Diamino-7-aminoalkoxyquinazoline as
a Potent and Selective Inhibitor of Histone Lysine Methyltransferase G9a”. J. Med. Chem. 2009, 52, 7950.
7）Ju, Y.; Liu, F.; Li. C. “Palladium-Catalyzed Sequential Cyanation/N-Addition/ N-Arylation in One-Pot: Efficient Synthesis of Luotonin A and Its Derivatives”. Org. Lett. 2009, 11, 3582.
8）Liu, F.; Li. C. “Intramolecular Formal [4 + 2] Cycloaddition of Nitriles with Amides Triggered by TMSOTf/Et3N: Highly Efficient Construction of Pyrrolo[1,2-a]pyrimidin-4(6H)-ones”. J. Org. Chem. 2009, 74, 5699.
9）Liu, F.; Liu, K.; Yuan, X.; Li. C. “5-Exo versus 6-Endo Cyclization of Primary Aminyl Radicals: An Experimental and Theoretical Investigation”. J. Org. Chem. 2007, 72, 10231.
10）Zhan, Z.; Lang, K.; Liu, F.; Hu, L. “Water Effects on SmI2 Reductions: A Novel Method for the Synthesis of Alkyl Thiols by SmI2-Promoted Reductions of Sodium Alkyl Thiosulfates and Alkyl Thiocyanates”. Syn. Commun. 2004, 34, 3203.
