劉利新(中山大學副教授)

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劉利新，博士，中山大學材料科學與工程學院副教授、博士生導師。

基本介紹

  • 中文名：劉利新
  • 畢業院校：德國杜塞道夫大學
  • 學位/學歷：博士
  • 專業方向：納米材料做為疫苗佐劑及載體的研究
  • 任職院校：中山大學
人物經歷,教育經歷,工作經歷,學科方向,榮譽獲獎,學術成果,科研項目,代表論著,會議論文,專 利,參編教材,會議獲獎,

人物經歷

教育經歷

1994年於吉林醫學院預防醫學專業畢業，獲醫學學士學位
1999年於中國科學院微生物研究所研究生畢業，獲理學碩士學位
2002年於德國杜塞道夫大學兒童血液腫瘤研究所，獲得醫學博士學位

工作經歷

2002 -2005 中國科學院微生物研究所工作 科研工作 助理研究員
2005-2007 中國科學院大學生命科學院 教學與科研工作 講師
2007-2014 中國科學院大學生命科學院 教學與科研工作 副教授
2014-至今 中山大學材料科學與工程學院 教學與科研工作 副教授

學科方向

納米材料做為疫苗佐劑及載體的研究，納米材料在自身免疫性疾病治療中套用研究。

榮譽獲獎

2006-2007學年，《分子病毒學》獲得中國科學院研究生院優秀課程
2007-2008學年，《分子病毒學》獲得中國科學院研究生院優良課程
2008學期，《分子病毒學》獲得中國科學院教學成果二等獎，排名第一

學術成果

科研項目

主持國家自然科學基金（21875290，30670889）；廣東省科技廳社會發展領域項目；中國科學院重要方向性項目集群項目子課題：新型愛滋病和病毒性肝炎靈長類動物模型的創建（KSCX2-EW-R-13）；中國科學院知識創新工程重要方向項目（生命科學領域“十二五”基礎前沿專項）子課題：微流控納米及順磁生物新技術研究（KSCX2-EW-J-29）；“十二五”國家科技支撐計畫課題：“亞健康狀態的評價指標及城市人口亞健康監測網路與資料庫的建立”子課題：亞健康狀態產生的分子學機制研究；省納米創新團隊項目主要成員，國家自然科學資金重點項目主要成員。

代表論著

  1. Bo Peng, Huiyi Liang, Yuyan Li, Cong Dong, Jun Shen, Hai-Quan Mao, Kam W. Leong, Yongming Chen, and Liu, L.X.*Tuned Cationic Dendronized Polymer: Molecular Scavenger for Rheumatoid Arthritis Treatment, Angew. Chem. Int. Ed. 2019, 58:4254-4259.
  2. Huiyi Liang, Bo Peng, Cong Dong, Liu, L.X.*, Jiaji Mao, Song Wei, Xinlu Wang, Hanshi Xu, Jun Shen*, Hai-Quan Mao, Xiaohu Gao, Kam W. Leong*, Yongming Chen*, Cationic nanoparticle as an inhibitor of cell-free DNA-induced inflammation, Nature Communication, 2018, 9:4291-4305.
  3. Qiao, D.D.;Liu, L.X.*; Chen, Y.; Xue, C.B.; Gao, Q.; Mao, H.Q.*; Leong, K.W.*; Chen, Y.M., Potency of a Scalable Nanoparticulate Subunit Vaccine. Nano Letters. 2018, 18 (5), 3007-3016.
  4. Li, Z.Y; Zhou, F.; Li, Z.Y.; Lin, S.Y.; Chen, L.; Liu, L.X.; Chen, Y.M.*, Hydrogel Cross-Linked with Dynamic Covalent Bonding and Micellization for Promoting Burn Wound Healing. ACS applied materials & interfaces. 2018, 10 (30), 25194-25202.
  5. Chen, Y.; Zhou, H.B.; Sun, Z.Y.; Li, H.A.; Huang, H.U.; Liu, L.X.*; Chen, Y.M.*, Shell of amphiphilic molecular bottlebrush matters as unimolecular micelle. Polymer. 2018, 149, 316-324.
  6. He, Z.Y.; Liu, Z.J.; Tian, H.K.; Hu, Y.Z.; Liu, LX..; Leong, K.W.*; Mao, H. Q.*; Chen, Y.M.*, Scalable Production of Core-Shell Nanoparticles by Flash Nanocomplexation to Enhance Mucosal Transport for Oral Delivery of Insulin. Nanoscale. 2018, 10 (7), 3307-3319.
  7. Plummer, C. M.; Zhou, H.B.; Zhu, W.; Huang, H.H.; Liu, L.X.; Chen, Y.M.*, Mild Halogenation of Polyolefins Using An N-haloamide Reagent. Polymer Chemistry 2018, 9 (11), 1309-1317.
  8. Hu, Z.T.; Chen, Y.; Huang, H.H.; Liu, L.X.; Chen, Y.M.*, Well-Defined Poly(α-amino-δ-valerolactone) via Living Ring-Opening Polymerization. Macromolecules. 2018, 51 (7), 2526-2532.
  9. Zeng, Z.P.; Zhao, P.F.; Liu, L.X.*; Gao, X.H.; Mao, H.Q.; Chen, Y.M.*, Lipid Stabilized Solid Drug Nanoparticles for Targeted Chemotherapy. ACS applied materials & interfaces. 2018, 10 (30), 24969-24974.
  10. Li, H.A.; Liu, H.; Nie, T.Q.; Chen, Y.; Wang, Z.Y.*; Huang, H.H.; Liu, L.X.*; Chen, Y.M.*, Molecular Bottlebrush as A Unimolecular Vehicle with Tunable Shape for Photothermal Cancer Therapy. Biomaterials. 2018, 178, 620-629.
  11. Wu, X.L.; Wu, Y.D.; Wang, Z.Y.; Liu, L.X. *; Sun, C.X.; Chen, Y.M.; Wang, C.*, A Cascade-Targeting Nanocapsule for Enhanced Photothermal Tumor Therapy with Aid of Autophagy Inhibition. Advanced Healthcare Materials. 2018, 7 (11), e1800121.
  12. Chu, Y.H.; Li, H.A.; Huang, H.H.; Zhou, H.B.; Chen, Y.; Andreas, B.; Liu, L.X.*; Chen, Y.M.*, Uni-Molecular Nanoparticles of Poly(2-Oxazoline) Showing Tunable Thermoresponsive Behaviors. Journal of Polymer Science Part A-Polymer Chemistry. 2018, 56(2), 174-183.
  13. He, Z.Y.; Santos, J.L.; Tian, H.K.; Huang, H.H.; Hu, Y.Z.; Liu, L.X.; Leong, K.W.*; Chen, Y.M.*; Mao, H.Q.*, Scalable Fabrication of Size-Controlled Chitosan Nanoparticles for Oral Delivery of Insulin. Biomaterials. 2017, 130, 28-41.
  14. Peng, B.; Lai, X.Y.; Chen, L.; Lin, X.M.; Sun, C.X.; Liu, L.X.*; Qi, S.H.; Chen, Y.M.*; Leong, K.W.*, Scarless Wound Closure by a Mussel-Inspired Poly(amidoamine) Tissue Adhesive with Tunable Degradability. ACS Omega. 2017, 2(9), 6053−6062.
  15. Sun, Z.Y.; Huang, H.H.; Li, L.; Liu, L.X.*; Chen, Y.M.*, Polythioamides of High Refractive Index by Direct Polymerization of Aliphatic Primary Diamines in the Presence of Elemental Sulfu. Macromolecules. 2017, 50(21), 8505-8511.
  16. Yan, Y.C.; Huang, H.H.*; Zhu, W.; Liu, L.X.; Zhang, K.; Chen, Y.M.*, Synthesis of Amphiphilic Polymer Brushes with Mixed Side Chains and Their Emulsifying Function. Acta Polymerica Sinica. 2017, 9, 1531-1537.
  17. Xing Y.X.; Chu Q.Y.; Feng R.; Wang W.; Liu L.X.*; Lu Z.B*., hCLP46 Increases Smad3 Protein Stability via Inhibiting Its Ubiquitin-Proteasomal Degradation. Protein & Cell. 2015, 6(10), 767-770.
  18. Yang, G.L.; Zhang, R.; Huang, H.H.*; Liu, L.X.; Wang, L.*; Chen, Y.M.*, Synthesis of Novel Biobased Polyimides Derived from Isomannide with Good Optical Transparency, Solubility and Thermal Stability. RSC Advances. 2015, 5 (83), 67574-67582.
  19. Bai, R.; Zhang, X.J.; Li, Y.L.; Liu, J.P.; Zhang, H.B.; Xiao, W.L.; Pu, J.X.; Sun, H.D.; Zheng, Y.T.*;Liu, L.X*;., SJP-L-5, A Novel Small-Molecule Compound, Inhibits HIV-1 Infection by Blocking Viral DNA Nuclear Entry. BMC Microbiology. 2015, 15, 274-287.
  20. Zhang S.; Bai R.; Feng R.; Zhang H.; Liu L.X.* Detection and Evolutionary Analysis of Picobirnaviruses in Treated Wastewater. Microb Biotechnol. 2015, 8(3), 474-482.
  21. Wang, J.; Zhu, W.*; Liu, L.X*.; Chen, Y.M*.; Wang, C., Synthesis and Cellular Internalization of Spindle Hematite/Polymer Hybrid Nanoparticles. ACS Applied Materials & Interfaces. 2015, 7(9), 5454-5461.
  22. Wang, J.; Liu, L.X.*; Zhu, W.; Chen, Y.M.*; Wang, C.*, Cancer Cell Uptake of Polymer Hydrogel Nanotubes. J. Biomed. Nanotechnol. 2014, 10, 3329-3336.
  23. Zhu, W.; Peng, B.; Wang, J.; Zhang, K.; Liu,L. X.*; Chen, Y. M.* Bamboo Leaf-Like Micro-Nano Sheets Self-Assembled by Block Copolymers as Wafers for Cells. acromolecular Bioscience. 2014, 14, 1764-70.
  24. Chu, Q.; Liu, L.X.*; Wang, W*., Overexpression of hCLP46 Enhances Notch Activation and Regulates Cell Proliferation in A Cell Type-Dependent Manner. Cell Prolif. 2013, 46 (3), 254-62.
  25. Cui, Y.; Wu, Y. S.; Liu, Y.; Yang, G. M.; Liu, L. X.; Fu, H. B.; Li, Z, B.; Wang, S.; Wang, Z. H.*; Chen, Y. M.*, PEGylated Nanoparticles of Diperylene Bisimides with High Efficiency of O-1(2) Generation. Dyes and Pigments. 2013, 97129-33.
  26. Zhao, P.; Yan, Y. C.; Feng, X. Q.; Liu, L.X.*; Wang, C.; Chen, Y. M.*, Highly Efficient Synthesis of Polymer Brushes with PEO and PCL as Side Chains via Click Chemistry. Polymer, 2012, 53, 1992-2000.
  27. Zhao, P.;Liu, L.X.*; Feng, X. Q.; Wang, C.*; Shuai, X. T.; Chen, Y. M.*, Molecular Nanoworm with PCL Core and PEO Shell as Non-Spherical Carrier for Drug Delivery. Macromol. Rapid Commun. 2012,33, 1351-5
  28. Zhu, W.; Li, Y. L.;Liu, L X.*; Chen, Y. M.*; Xi, F., Supramolecular Hydrogels as A Universal Scaffold for Stepwise Delivering Dox and Dox/cisplatin Loaded Block Copolymer Micelles. International Journal of Pharmaceutics. 2012, 437, 9-11.
  29. Zhu,W.; Li,Y. L.; Liu, L.X.;*Chen, Y. M.;*Wang,C.; Xi, F., Biamphiphilic Triblock Copolymer Micelles as A Multifunctional Platform for Anticancer Drug Delivery. J. Biomed. Mater. Res. Part A. 96A .2011, 330-340.
  30. Zhang, W. L.; Li, Y. L.; Liu, L.X.*; Sun, Q.; Shuai, X. T.; Zhu, W.; Chen, Y. M.*, Amphiphilic Toothbrush-like Copolymers Based on Poly(ethylene glycol) and Poly(ε-caprolactone) as Drug Carriers with Enhanced Properties. Biomacromolecules. 2010, 11, 1331-1338.
  31. Zhu, W.; Li, Y. L; Liu, L.X.*; Zhang, W.; Chen, Y. M.*; Xi, F., Supramolecular Hydrogels from Cisplatin-Loaded Block Copolymer Nanoparticles and α-Cyclodextrins with a Stepwise Delivery Property. Biomacromolecules. 2010, 11, 3086-3092.
  32. Li, Z.Q.; Liu, L.X.; Lv, F.X.; Ma, J.; Gao, G.X.*, Fusing ZAP to HIV RNA Binding Proteins to Inhibit HIV. Progress in Biochemistry and Biophysics. 2007, 34, 50-56.
  33. Ye, J.; Liu, L.X.; Gao, G.X.;* Fang, R.X.* Inhibition of SARS by Small Interfering RNAs Targeting the Leader RNA. Progress in Biochemistry and Biophysics 2007, 34, 1092-1100. (共為第一作者)
  34. Borrowski, A.; Dirkson, U.*; Liu, L.X. Shi, R. L; Goebal, U. Structure and Function of ETAA-16: A Novel Cell Surface Antigen in Ewing Tumors. Cancer Immunology Immunotherapy. 2006, 55, 363-374.
  35. Liu, L.X.; Chen, G.F.; Ji, X.; Gao, G.X.* ZAP is a CRM1 dependent protein. Biochemical and Biophysical Research Communications. 2004, 321, 517-523.
  36. Lan, J.; Song, M.S.; Pan, C.H.; Zhuang, G.Q.; Wang, Y.X.; Ma, W.Z.; Chu, Q.Y.; Lai, Q.X.; Xu, F.; Li, Y.L.; Liu, L.X.; Wang,W., Association between Dopaminergic Genes (SLC6A3 and DRD2) and Stuttering among Han Chinese. Journal of Human Genetics (Nature Publishing Group). 2009,54, 457-460.
  37. Ma, W.Z.; Du, J.; Chu, Q.Y.; Wang, Y.X.; Liu, L.X.; Song, M.S.; Wang, W., hCLP46 Regulates U937 Cell Proliferation via Notch Signaling Pathway. Biochemical and Biophysical Research Communication. 2011,408, 84-88.
  38. Wang, Y.X.; Chang, N.B.; Zhang, T.; Liu, H.; Ma, W.Z.; Chu, Q.Y.; Lai, Q.X.; Liu, L.X.; Wang, W., Overexpression of Human CAP10-like Protein 46 KD in T-acute Lymphoblastic Leukemia and Acute Myelogenous Leukemia. Genetic Testing and Molecular Biomarkers. 2010, 14, 127-33.
  39. Sheng A.; Lan J.; Wu H.; Lu J.; Wang Y.; Chu Q.; Jia Z.; Song M.; Liu L.X.; Wang W., A Clinical Case Control Study on the Association between Mannose-binding Lectin and Susceptibility to HIV-1 Infection among Northern Han Chinese population. International Journal of Immunogentics. Int J Immunogenet. 2010, 37, 445-54.
  40. 劉利新*，劉樹峰等。人Dcp2(脫帽酶2)克隆表達、多克隆抗體的製備及其套用。《中國科學院研究生院學報》2007,24: 362-367。
  41. 張恬，王有信，王嵬，劉利新*。人CD34+乾/祖細胞異常表達新基因hCLP46 的克隆，表達與功能分析。《中國科學院研究生院學報》2007,4:520-52
  42. 盛艾娟，劉利新，吳昊，王友信，彭曉霞，王嵬。中國北方漢族人群MBL與HIV易感性的研究。《南方醫科大學學報》2008,4:567-571。
  43. 盛艾娟；吳昊；蘭潔；路甲鵬；王友信；宋曼殳；武晶晶；劉利新；王嵬, 甘露糖結合凝集素與人類免疫缺陷病毒感染的關聯性研究(英文), 中國病毒病雜誌, 02期, pp 92-98, 2011.
  44. 張文娟，杜傑，常乃柏，張恬，王嵬，劉利新*。酵母雙雜交技術篩選與hCLP46蛋白相互作用的蛋白。《中國生物工程雜誌》2008,6:23-27。
  45. 李艷麗，鄭友唐，王嵬，劉利新﹡。利用假病毒技術研究抗HIV-1藥物的作用機制 。《微生物學通報》，2011,10:1507-1517。
  46. 徐峰，穆昕，王嵬，劉利新﹡ 。串聯親和純化技術篩選hCLP46的相互作用蛋白 。《中國科學院研究生院學報》2011,2:210-217（通訊作者）。
  47. 馮曉琴，徐峰，王嵬，劉利新﹡。通過對免疫共沉澱技術最佳化驗證蛋白質弱相互作用的研究。《中國科學院研究生院學報》，2013,30:18-23。

會議論文

  1. Ru Bai, Shiwei Zhang, Hongxun Zhang, Lixin Liu. Ultracentrifugation as a direct method to concentrate viruses in sewage, 中國生態學學會微生物生態專業委員會2013年年會會議論文集，P71，成都，2013.11.15-18
  2. Shiwei Zhang, Ru Bai, Lixin Liu. Treated Wastewater from Poultry Farms Harbours Diverse Picobirnavirus Population，中國生態學學會微生物生態專業委員會2013年年會會議論文集，P70，成都，2013.11.15-18
  3. 楊金龍，張士偉，張洪勛，劉利新。玻璃棉濾器濃縮水體病毒方法的建立與最佳化。中國生態學學會微生物生態專業委員會2013年年會會議論文集，P86，成都，2013.11.15-18

專 利

  1. Therapeutic protein-loaded nanoparticle and method for preparing the same，申請號：PCT/US17/14080.
  2. 孫成新、劉利新、陳永明。一種鼠尾靜脈精準注射儀(ZL201621037464.0)
  3. 劉利新、高光俠。抗HIV病毒的多肽及其編碼基因與套用(200510114234.X).

參編教材

《抗病毒天然免疫》（舒紅兵主編）第三章內源性免疫：宿主限制因子。科學出版社，2009。

會議獲獎

Li, Y. L.; Gao, G. X.; Zheng, Y. T.; Liu, L. X.;* A simple methodforexploring the mechanisms for anti-HIV compounds. Abstract of 4th Ditan International Conference on Infectious Diseases. 2010 (獲得大會議AGD獎).

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