基本介紹
- 中文名：何世豪
- 國籍：中國
- 籍貫：山東菏澤
人物經歷,個人生活,社會活動,科研成果,
人物經歷
作為從專科起步的逆襲者，何世豪曾經在專科學習過程中處於低谷狀態，但是憑藉自身的努力和刻苦，成功地完成了從專科升入本科的逆襲之路。升入本科後，他內心更加堅定想成長為一名神經外科醫生，一遍遍研讀醫學專業書籍，一次次專心臨床實習鍛鍊。終於如願，通過考研，進入首都醫科大學。但他未曾停下腳步，仍然不斷攀登醫學領域的一座座高峰。一路走來，他的勵志故事被《人民日報》健康客戶端、《中國青年報》《揚子晚報》《濟南時報》《南方都市報》、紅星新聞、澎湃新聞、丁香園、醫學界等百餘家主流媒體報導。
高考考入山東醫專，專升本成功上岸山東第一醫科大學。考研成功上岸首都醫科大學神經外科方向研究生。在讀研期間成功考取了執業醫師資格證，拿到了國家獎學金，並發表了5篇SCI和1篇中文核心，還順利考取了首都醫科大學的博士研究生。
2022年，赴史丹福大學訪學，主要從事煙霧病發病機制及認知障礙的相關基礎研究。
個人生活
父親是一名傳染病科的內科醫生，母親是鄉鎮醫生。
社會活動
2019年承擔了“一帶一路中國-南亞-東南亞神經外科論壇’”特別學術活動的現場英語翻譯工作，並主持首都醫科大學的英語演講比賽。
2021年作為天壇醫院神經外科博士生代表參與“青年服務國家-首都醫科⼤學赴陝西延安社會實踐團”義診志願服務。
科研成果
1.He S, Zhang J, Liu Z, Wang Y, Hao X, Wang X, Zhou Z, Ye X, Zhao Y, Zhao Y, Wang R. Upregulated Cytoskeletal Proteins Promote Pathological Angiogenesis in Moyamoya Disease. Stroke. 2023 Dec;54(12):3153-3164. doi: 10.1161/STROKEAHA.123.044476. Epub 2023 Oct 27. PMID: 37886851.
2.He S, Duan R, Liu Z, Ye X, Yuan L, Li T, Tan C, Shao J, Qin S, Wang R. Characteristics of cognitive impairment in adult asymptomatic moyamoya disease. BMC Neurol. 2020 Aug 31;20(1):322. doi: 10.1186/s12883-020-01898-8. PMID: 32867701; PMCID: PMC7457758.
3.He S, Liu Z, Xu Z, Duan R, Yuan L, Xiao C, Yi Z, Wang R. Brain Functional Network in Chronic Asymptomatic Carotid Artery Stenosis and Occlusion: Changes and Compensation. Neural Plast. 2020 Sep 23;2020:9345602. doi: 10.1155/2020/9345602. PMID: 33029129; PMCID: PMC7530486.
4.He S, Liu Z, Wei Y, Duan R, Xu Z, Zhang C, Yuan L, Li T, Ma N, Lou X, Liu X, Wang R. Impairments in brain perfusion, executive control network, topological characteristics, and neurocognition in adult patients with asymptomatic Moyamoya disease. BMC Neurosci. 2021 May 12;22(1):35. doi: 10.1186/s12868-021-00638-z. PMID: 33980154; PMCID: PMC8117595.
5.He S, Duan R, Liu Z, Zhang C, Li T, Wei Y, Ma N, Wang R. Altered functional connectivity is related to impaired cognition in left unilateral asymptomatic carotid artery stenosis patients. BMC Neurol. 2021 Sep 13;21(1):350. doi: 10.1186/s12883-021-02385-4. PMID: 34517833; PMCID: PMC8436468.
6.He S, Liang J, Xue G, Wang Y, Zhao Y, Liu Z, Hao X, Wei Y, Chen X, Wang H, Kang S, Wang R, Zhao Y, Ye X. RNA profiling of sEV (small extracellular vesicles)/exosomes reveals biomarkers and vascular endothelial dysplasia with moyamoya disease. J Cereb Blood Flow Metab. 2023 Jul;43(7):1194-1205. doi: 10.1177/0271678X231162184. Epub 2023 Mar 8. PMID: 36883376; PMCID: PMC10291455.
7.He S, Wang Y, Liu Z, Zhang J, Hao X, Wang X, Zhou Z, Wang R, Zhao Y. Metabolomic signatures associated with pathological angiogenesis in moyamoya disease. Clin Transl Med. 2023 Dec;13(12):e1492. doi: 10.1002/ctm2.1492. PMID: 38037492; PMCID: PMC10689969.
8.He S, Duan R, Liu Z, Zhang C, Li T, Wei Y, Ma N, Wang R. Altered functional connectivity is related to impaired cognition in left unilateral asymptomatic carotid artery stenosis patients. BMC Neurol. 2021 Sep 13;21(1):350. doi: 10.1186/s12883-021-02385-4. PMID: 34517833; PMCID: PMC8436468.
9.He S, Hao X, Liu Z, Wang Y, Zhang J, Wang X, Di F, Wang R, Zhao Y. Association between DIAPH1 variant and posterior circulation involvement with Moyamoya disease. Sci Rep. 2023 Jul 3;13(1):10732. doi: 10.1038/s41598-023-37665-1. PMID: 37400591; PMCID: PMC10318013.
10.He S, Wang X, Niu H, Liu Z, Zhang J, Hao X, Wang Y, Zhou Z, Zhao Y, Wang R. Evaluation of cerebrovascular reactivity in moyamoya disease using oxygen-dependent magnetic resonance imaging. iScience. 2024 Jan 19;27(2):108923. doi: 10.1016/j.isci.2024.108923. PMID: 38323000; PMCID: PMC10844822.
11.Zhou Z, Wang Y, Zhang J, Liu Z, Hao X, Wang X, He S, Wang R. Characterization of PANoptosis-related genes and the immune landscape in moyamoya disease. Sci Rep. 2024 May 4;14(1):10278. doi: 10.1038/s41598-024-61241-w. PMID: 38704490; PMCID: PMC11069501.
12.Liu Z, He S, Xu Z, Duan R, Yuan L, Xiao C, Yi Z, Wang R. Association between white matter impairment and cognitive dysfunction in patients with ischemic Moyamoya disease. BMC Neurol. 2020 Aug 15;20(1):302. doi: 10.1186/s12883-020-01876-0. PMID: 32799829; PMCID: PMC7429789.
13.He S, Ye X, Duan R, Zhao Y, Wei Y, Wang Y, Liu Z, Hao X, Chen X, Hao Q, Wang H, Zhao Y, Wang R. Epigenome-Wide Association Study Reveals Differential Methylation Sites and Association of Gene Expression Regulation with Ischemic Moyamoya Disease in Adults. Oxid Med Cell Longev. 2022 Mar 24;2022:7192060. doi: 10.1155/2022/7192060. PMID: 35368875; PMCID: PMC8970806.
14.He S, Zhou Z, Zhang J, Wang Y, Liu Z, Hao X, Wang X, Ye X, Zhao Y, Wang R. Differential WNT4 expression among various subtypes of moyamoya disease results in alterations of microtubule stability. Clin Transl Med. 2024 Aug;14(8):e1797. doi: 10.1002/ctm2.1797. PMID: 39099102.
15.Han Z, Zhang J, Su Y, Zhou Z, Wang Y, Xu S, Zhao Y, He S, Wang R. Identification of oxidative phosphorylation-related genes in moyamoya disease by combining bulk RNA-sequencing analysis and machine learning. Front Genet. 2024 Jun 10;15:1417329. doi: 10.3389/fgene.2024.1417329. PMID: 38919950; PMCID: PMC11197386.
16.Liu Z, He S, Wei Y, Duan R, Zhang C, Li T, Ma N, Lou X, Wang R, Liu X. Changes of cerebral cortical structure and cognitive dysfunction in "healthy hemisphere" after stroke: a study about cortical complexity and sulcus patterns in bilateral ischemic adult moyamoya disease. BMC Neurosci. 2021 Nov 14;22(1):66. doi: 10.1186/s12868-021-00672-x. PMID: 34775949; PMCID: PMC8590755.
