Antonio Vidal-Puig:人物經歷,研究方向,主要成就,

Antonio Vidal-Puig ，男，劍橋大學代謝研究所教授，致力於探索機體控制能量消耗、脂肪沉積以及控制能量氧化或儲存的機制。Antonio Vidal-Puig帶領團隊一直在進行脂肪組織的擴張與代謝綜合徵的發生髮展過程中的關係進行研究，切入脂肪組織分泌的脂肪毒性和/或脂肪因子的變化是否會影響骨骼肌、心臟、肝臟、大腦、β-細胞和巨噬細胞等其他器官對胰島素的敏感性，脂肪生成和脂肪組織重塑的改變是否可能成為改善與肥胖相關的代謝影響的關鍵因素，以及控制能量消耗和棕色脂肪激活的分子機制等進行探索。在Nature Medicine, Cell, Cell Metab 等雜誌發表SCI論文280餘篇，被引用46,400餘次，H指數= 114。

基本介紹

中文名：Antonio Vidal-Puig
教學職稱：教授

人物經歷,研究方向,主要成就,

人物經歷

2024年

Toh Chin Chye visiting professorship National University of Singapore.

2024年

Honorary Doctorate University Rey Juan Carlos Madrid.

2015年

Executive Master Business Administration (EMBA). Judge Institute Business School.

University of Cambridge

2014年

Fellow Academy of Medical Sciences (FMedSci)

2008年

Fellow Royal College of Physicians (FRCP)

1992年

Endocrinology, Metabolism, Nutrition Specialist, Spanish Ministry of Health

1992年

Ph.D. degree. Granada University School of Medicine, Granada, Spain.

1986年

M.D. degree. Valencia University School of Medicine Valencia, Spain. Magna Cum Laude

研究方向

專業領域

Vidal-Puig （TVPLab， http://tvp.mrl.ims.cam.ac.uk/）的研究闡明了肥胖與胰島素抵抗、糖尿病和心臟代謝併發症之間的分子機制，以及相關治療策略的開發。他的研究策略包括假設驅動和非偏倚系統方法的組合，廣泛使用動物模型、幹細胞生物學、人類生物樣本（包括誘導多能幹細胞）、複雜的組學技術和生物信息學整合。

Vidal-Puig’s (TVPLab, http://tvp.mrl.ims.cam.ac.uk/) research elucidates the molecular mechanisms linking obesity with insulin resistance, diabetes and cardiometabolic complications and on the development of related therapeutic strategies. His research strategies include a combination of hypothesis-driven and non-biased systems approaches that extensively use animal models, stem cell biology, human biological samples (including induced pluripotent stem cells), sophisticated omics technologies and bioinformatics integration.

Vidal-Puig 的實驗室創造力體現在“脂肪組織擴張性假說”和“脂毒性”的概念中，以解釋肥胖與心臟代謝併發症之間的關聯。他對四個研究領域的具體科學貢獻是：1）定義脂肪組織膨脹性和脂毒性假說（Vidal-Puig， JCI 1996 （Cit 513）， 1997 （Cit 766）;PLoS 遺傳學 2007 （cit 211）;2）提議使用能量耗散策略通過促進線粒體生物發生（PLoS Biol 等人 2006，Cit 198）、線粒體解偶聯（BBRC 1997，Cit 710，JBC 2000 Cit 639）和棕色脂肪分化和激活來逆轉脂毒性（Cell 2012，Cit 160）;3）確定下丘腦脂質代謝在控制能量穩態（Cell Metab 2008， Cit 277））和甲狀腺激素（Nature Medicine， 2010， Cit 266）和 BMP8b 控制棕色脂肪活化（Cell 2012）中的相關性;4）率先使用系統生物學和幹細胞方法來闡明特定脂質和網路在心臟代謝代謝綜合徵發展中的作用。

Vidal-Puig’s lab creativity is reflected in the “adipose tissue expandability hypothesis” and the concept of “lipotoxicity” to explain the association between obesity and cardiometabolic complications. His specific scientific contributions to four lines of research are: 1) defining the adipose tissue expandability and lipotoxicity hypothesis (Vidal-Puig, JCI 1996 (Cit 513), 1997 (Cit 766); PLoS Genetics 2007 (Cit 211); 2) proposing the use of energy dissipating strategies to reverse lipotoxicity by promoting mitochondrial biogenesis (PLoS Biol et al 2006, Cit 198), mitochondrial uncoupling (BBRC 1997, Cit 710, JBC 2000 Cit 639)) and brown fat differentiation and activation (Cell 2012, Cit 160); 3) establishing the relevance of hypothalamic lipid metabolism in controlling energy homeostasis (Cell Metab 2008, Cit 277)) and thyroid hormone (Nature Medicine, 2010, Cit 266) and BMP8b controlling brown fat activation (Cell 2012); and 4) the pioneering use of systems biology and stem cell approaches to elucidate the role of specific lipids and networks in the development the cardiometabolic metabolic syndrome.

主要成就

發表論著

1. I Kamzolas, M Vacca, L Mørch Harder, S Rodriguez-Cuenca, L Tiniakos, ... A Vidal-Puig. An unbiased ranking of murine dietary models based on their proximity to human Metabolic Dysfunction–associated Steatotic Liver Disease (MASLD). Nat Metab (in press)

2. SM Oussaada, M Kilicarslan, BA de Weijer, PW Gilijamse, A Şekercan, S Virtue, IMC Janssen, A van de Laar, A Demirkiran, BA van Wagensveld, APJ Houdijk, A Jongejan, PD Moerland, J Verheij, TB Geijtenbeek, VW Bloks, MC de Goffau, JA Romijn, M Nieuwdorp, A Vidal-Puig, KW Ter Horst, MJ Serlie. Tissue-specific inflammation and insulin sensitivity in subjects with obesity. Diabetes Research and Clinical Practice (in press)

3. Tan J, Virtue S, Norris DM, Conway OJ, Yang M, Bidault G, Gribben C, Lugtu F, Kamzolas I, Krycer JR, Mills RJ, Liang L, Pereira C, Dale M, Shun-Shion AS, Baird HJ, Horscroft JA, Sowton AP, Ma M, Carobbio S, Petsalaki E, Murray AJ, Gershlick DC, Nathan JA, Hudson JE, Vallier L, Fisher-Wellman KH, Frezza C, Vidal-Puig A*, Fazakerley DJ. Limited oxygen in standard cell culture alters metabolism and function of differentiated cells. EMBO J. 2024 Apr 5. doi: 10.1038/s44318-024-00084-7. PMID: 38580776

4. Ng MY, Song ZJ, Venkatesan G, Rodriguez-Cuenca S, West JA, Yang S, Tan CH, Ho PC, Griffin JL, Vidal-Puig A, Bassetto M, Hagen T. Conjugating uncoupler compounds with hydrophobic hydrocarbon chains to achieve adipose tissue selective drug accumulation. T. Sci Rep. 2024 Feb 28;14(1):4932. doi: 10.1038/s41598-024-54466-2. PMID: 38418847

5. Yu Y, Yang J, Zheng L, Su H, Cao S, Jiang X, Liu X, Liu W, Wang Z, Meng F, Xu H, Wen D, Sun C, Song X, Vidal-Puig A, Cao L. Dysfunction of Akt/FoxO3a/Atg7 regulatory loop magnifies obesity-regulated muscular mass decline. Mol Metab. 2024 Mar;81:101892. doi: 10.1016/j.molmet.2024.101892. PMID: 38331318

6. Xu J, Cui L, Wang J, Zheng S, Zhang H, Ke S, Cao X, Shi Y, Li J, Zen K, Vidal-Puig A*, Zhang CY, Li L, Jiang X. Cold-activated brown fat-derived extracellular vesicle-miR-378a-3p stimulates hepatic gluconeogenesis in male mice. Nat Commun. 2023 Sep 6;14(1):5480. doi: 10.1038/s41467-023-41160-6. PMID: 37673898

7. Soria-Gondek A, Fernández-García P, González L, Reyes-Farias M, Murillo M, Valls A, Real N, Pellitero S, Tarascó J, Jenkins B, Galán M, Villarroya F, Koulman A, Corrales P, Vidal-Puig A, Cereijo R, Sánchez-Infantes D. Lipidome Profiling in Childhood Obesity Compared to Adults: A Pilot Study. Nutrients. 2023 Jul 27;15(15):3341. doi: 10.3390/nu15153341. PMID: 37571279

8. Pellegrinelli V, Figueroa-Juárez E, Samuelson I, U-Din M, Rodriguez-Fdez S, Virtue S, Leggat J, Çubuk C, Peirce VJ, Niemi T, Campbell M, Rodriguez-Cuenca S, Blázquez JD, Carobbio S, Virtanen KA, Vidal-Puig A*. Defective extracellular matrix remodeling in brown adipose tissue is associated with fibro-inflammation and reduced diet-induced thermogenesis. Cell Rep. 2023 Jun 13;42(6):112640. doi: 10.1016/j.celrep.2023.112640. PMID: 37318951

9. Mózes FE, Lee JA, Vali Y, Alzoubi O, Staufer K, Trauner M, Paternostro R, Stauber RE, Holleboom AG, van Dijk AM, Mak AL, Boursier J, de Saint Loup M, Shima T, Bugianesi E, Gaia S, Armandi A, Shalimar, Lupșor-Platon M, Wong VW, Li G, Wong GL, Cobbold J, Karlas T, Wiegand J, Sebastiani G, Tsochatzis E, Liguori A, Yoneda M, Nakajima A, Hagström H, Akbari C, Hirooka M, Chan WK, Mahadeva S, Rajaram R, Zheng MH, George J, Eslam M, Petta S, Pennisi G, Viganò M, Ridolfo S, Aithal GP, Palaniyappan N, Lee DH, Ekstedt M, Nasr P, Cassinotto C, de Lédinghen V, Berzigotti A, Mendoza YP, Noureddin M, Truong E, Fournier-Poizat C, Geier A, Martic M, Tuthill T, Anstee QM, Harrison SA, Bossuyt PM, Pavlides M; LITMUS investigators. Lancet Gastroenterol Hepatol. 2023 Jun 5:S2468-1253(23)00141-3. doi: 10.1016/S2468- 1253(23)00141-3. Online ahead of print. PMID: 37290471

10. Castellá M, Blasco-Roset A, Peyrou M, Gavaldà-Navarro A, Villarroya J, Quesada-López T, Lorente-Poch L, Sancho J, Szymczak F, Piron A, Rodríguez-Fernández S, Carobbio S, Goday A, Domingo P, Vidal-Puig A, Giralt M, Eizirik DL, Villarroya F, Cereijo R. Adipose tissue plasticity in pheochromocytoma patients suggests a role of the splicing machinery in human adipose browning. iScience. 2023 May 9;26(6):106847. doi: 10.1016/j.isci.2023.106847. eCollection 2023 Jun 16. PMID: 37250773

11. Amin A, Badenes M, Tüshaus J, de Carvalho É, Burbridge E, Faísca P, Trávníčková K, Barros A, Carobbio S, Domingos PM, Vidal-Puig A, Moita LF, Maguire S, Stříšovský K, Ortega FJ, Fernández-Real JM, Lichtenthaler SF, Adrain C. Semaphorin 4B is an ADAM17-cleaved adipokine that inhibits adipocyte differentiation and thermogenesis. Mol Metab. 2023 Apr 28;73:101731. doi: 10.1016/j.molmet.2023.101731. Online ahead of print. PMID: 37121509

12. Mocciaro G, Allison M, Jenkins B, Azzu V, Huang-Doran I, Herrera-Marcos LV, Hall Z, Murgia A, Susan D, Frontini M, Vidal-Puig A, Koulman A, Griffin JL, Vacca M. Non-alcoholic fatty liver disease is characterised by a reduced polyunsaturated fatty acid transport via free fatty acids and high-density lipoproteins (HDL). Mol Metab. 2023 Apr 19;73:101728. doi: 10.1016/j.molmet.2023.101728. Online ahead of print.PMID: 37084865

13. Lee J, Westphal M, Vali Y, Boursier J, Ostroff R, Alexander L, Chen Y, Fournier C, Geier A, Francque S, Wonders K, Tiniakos D, Bedossa P, Allison M, Papatheodoridis G, Cortez-Pinto H, Pais R, Dufour JF, Leeming DJ, Harrison S, Cobbold J, Holleboom AG, Yki-Järvinen H, Crespo J, Ekstedt M, Aithal GP, Bugianesi E, Romero-Gomez M, Karsdal M, Yunis C, Schattenberg JM, Schuppan D, Ratziu V, Brass C, Duffin K, Zwinderman K, Pavlides M, Anstee QM, Bossuyt PM; LITMUS investigators. Machine learning algorithm improves detection of NASH (NAS-based) and at-risk NASH, a development and validation study. Hepatology. 2023 Mar 31. doi: 10.1097/HEP.0000000000000364. Online ahead of print.PMID: 36994719

14. Wu Q, Wu J, Karim K, Chen X, Wang T, Iwama S, Carobbio S, Keen P, Vidal-Puig A, Kotter MR, Bassett A. Massively parallel characterization of CRISPR activator efficacy in human induced pluripotent stem cells and neurons. Mol Cell. 2023 Mar 3:S1097-2765(23)00114-4. doi: 10.1016/j.molcel.2023.02.011. PMID: 36917981

15. Aye CC, Hammond DE, Rodriguez-Cuenca S, Doherty MK, Whitfield PD, Phelan MM, Yang C, Perez-Perez R, Li X, Diaz-Ramos A, Peddinti G, Oresic M, Vidal-Puig A, Zorzano A, Ugalde C, Mora S. CBL/CAP Is Essential for Mitochondria Respiration Complex I Assembly and Bioenergetics Efficiency in Muscle Cells. Int J Mol Sci. 2023 Feb 8;24(4):3399. doi: 10.3390/ijms24043399. PMID: 36834818

16. Sen P, Govaere O, Sinioja T, McGlinchey A, Geng D, Ratziu V, Bugianesi E, Schattenberg JM, Vidal-Puig A, Allison M, Cockell S, Daly AK, Hyötyläinen T, Anstee QM, Orešič M. Quantitative modeling of human liver reveals dysregulation of glycosphingolipid pathways in nonalcoholic fatty liver disease. iScience. 2022 Aug 15;25(9):104949. doi: 10.1016/j.isci.2022.104949. PMID:36065182

17. Sabaté-Pérez A, Romero M, Sànchez-Fernàndez-de-Landa P, Carobbio S, Mouratidis M, Sala D, Engel P, Martínez-Cristóbal P, Villena JA, Virtue S, Vidal-Puig A, Palacín M, Testar X, Zorzano A. Autophagy-mediated NCOR1 degradation is required for brown fat maturation and thermogenesis. Autophagy. 2022 Aug 25:1-22. doi: 10.1080/15548627.2022.2111081. PMID:35947488

18. Li C, Feng Y, Fu Z, Deng J, Gu Y, Wang H, Wu X, Huang Z, Zhu Y, Liu Z, Huang M, Wang T, Hu S, Yao B, Zeng Y, Zhou CJ, Brown SDM, Liu Y, Vidal-Puig A, Dong Y, Xu Y. Human-specific gene CT47 blocks PRMT5 degradation to lead to meiosis arrest. Cell Death Discov. 2022 Aug 2;8(1):345. doi: 10.1038/s41420-022-01139-6. PMID: 35918318 PMCID: PMC9345867

19. Wei W, Chen Q, Liu M, Sheng Y, OuYang Q, Feng W, Yang X, Ding L, Su S, Zhang J, Fang L, Vidal-Puig A, Wang HY, Chen S. TRIM24 is an insulin-responsive regulator of P-bodies. Nat Commun. 2022 Jul 8;13(1):3972. doi: 10.1038/s41467-022-31735-0.PMID: 35803934

20. Zhai Q, Zeng Y, Gu Y, Li Z, Zhang T, Yuan B, Wang T, Yan J, Qin H, Yang L, Chen X, Vidal-Puig A, Xu Y. Time-restricted feeding entrains long-term behavioral changes through the IGF2-KCC2 pathway. iScience. 2022 Apr 18;25(5):104267. doi: 10.1016/j.isci.2022.104267. PMID:35521538 PMCID: PMC9062755

21. Pellegrinelli, V., Rodriguez-Cuenca, S., Rouault, C. Vidal-Puig A. Dysregulation of macrophage PEPD in obesity determines adipose tissue fibro-inflammation and insulin resistance. Nat Metab 4, 476–494 (2022). https://doi.org/10.1038/s42255-022-00561-5. PMID: 35478031

22. Furse S, Virtue S, Snowden SG, Vidal-Puig A, Stevenson PC, Chiarugi D, Koulman A. Dietary PUFA drives various systems-level changes in lipid metabolism. Mol Metab. 2022 Feb 9;101457. doi: 10.1016/j.molmet.2022.101457. PMID: 35150907

23. Johnson K, Leary PJ, Govaere O, Barter MJ, Charlton SH, Cockell SJ, Tiniakos D, Zatorska M, Bedossa P, Brosnan MJ, Cobbold JF, Ekstedt M, Aithal GP, Clément K, Schattenberg JM, Boursier J, Ratziu V, Bugianesi E, Anstee QM, Daly AK; LITMUS Consortium Investigators. Increased serum miR-193a-5p during non-alcoholic fatty liver disease progression: Diagnostic and mechanistic relevance. JHEP Rep. 2021 Nov 25;4(2):100409. doi: 10.1016/j.jhepr.2021.100409. PMID: 35072021 PMCID: PMC8762473

24. Rao S, Yang X, Ohshiro K, Zaidi S, Wang Z, Shetty K, Xiang X, Hassan MI, Mohammad T, Latham PS, Nguyen BN, Wong L, Yu H, Al-Abed Y, Mishra B, Vacca M, Guenigault G, Allison MED, Vidal-Puig A, Benhammou JN, Alvarez M, Pajukanta P, Pisegna JR, Mishra L. β2-spectrin (SPTBN1) as a therapeutic target for diet-induced liver disease and preventing cancer development. Sci Transl Med. 2021 Dec 15;13(624):eabk2267. doi:10.1126/scitranslmed.abk2267. PMID: 34910547

25. Bidault G, Virtue S, Petkevicius K, Jolin H, Dugourd A, Guénantin AC, Leggat J, Mahler- Araujo B, Lam BY Marcella K. Ma, Dale M, Carobbio S, Kaser A, Fallon PG, Saez-Rodriguez J, McKenzie ANJ and Vidal-Puig A. SREBP1-induced fatty acid synthesis depletes macrophages antioxidant defenses to promote their alternative activation. Nat Metab. 2021 Sep;3(9):1150-1162. doi: 10.1038/s42255-021-00440-5. Epub 2021 Sep 16. PMID: 34531575

26. Cimino I, Rimmington D, Tung YCL, Lawler K, Larraufie P, Kay RG, Virtue S, Lam BYH, Fagnocchi L, Ma MKL, Saudek V, Zvetkova I, Vidal-Puig A, Yeo GSH, Farooqi IS, Pospisilik JA, Gribble FM, Reimann F, O'Rahilly S, Coll AP. Murine neuronatin deficiency is associated with a hypervariable food intake and bimodal obesity. Sci Rep. 2021 Sep 2;11(1):17571. doi: 10.1038/s41598-021-96278-8.PMID: 34475432

27. Rodriguez-Cuenca S, Lelliot CJ, Campbell M, Peddinti G, Martinez-Uña M, Ingvorsen C, Dias AR, Relat J, Mora S, Hyötyläinen T, Zorzano A, Oresic M, Bjursell M, Bohlooly-Y M, Lindén D and Vidal-Puig, A. Allostatic hypermetabolic response in PGC1α/β heterozygote mouse despite mitochondrial defects. FASEB J. 2021 Sep;35(9):e21752. doi: 10.1096/fj.202100262RR. PMID: 3436960

28. Tang P, Virtue S, Goie JYG, Png CW, Guo J, Li Y, Jiao H, Chua YL, Campbell M, Moreno- Navarrete JM, Shabbir A, Fernández-Real JM, Gasser S, Kemeny DM, Yang H, Vidal-Puig A, Zhang Y. Regulation of adipogenic differentiation and adipose tissue inflammation by interferon regulatory factor 3. Cell Death Differ. 2021 Jun 5. doi: 10.1038/s41418-021-00798-9. PMID: 34091599

29. Furse S, Williams HEL, Watkins AJ, Virtue S, Vidal-Puig A, Amarsi R, Charalambous M, Koulman A. A pipeline for making 31P NMR accessible for small- and large-scale lipidomics studies. Analytical and Bioanalytical Chemistry https://doi.org/10.1007/s00216-021-03430- 4. PMID: 34254158 PMCID: PMC8318958

30. Mózes FE, Lee JA, Selvaraj EA, Jayaswal ANA, Trauner M, Boursier J, Fournier C, Staufer K, Stauber RE, Bugianesi E, Younes R, Gaia S, Lupșor-Platon M, Petta S, Shima T, Okanoue T, Mahadeva S, Chan WK, Eddowes PJ, Newsome PN, Wong VW, de Ledinghen V, Fan J, Shen F, Cobbold JF, Sumida Y, Okajima A, Schattenberg JM, Labenz C, Kim W, Lee MS, Wiegand J, Karlas T, Yılmaz Y, Aithal GP, Palaniyappan N, Cassinotto C, Aggarwal S, Garg H, Ooi GJ, Nakajima A, Yoneda M, Ziol M, Barget N, Geier A, Tuthill T, Brosnan MJ, Anstee QM, Neubauer S, Harrison SA, Bossuyt PM, Pavlides M; LITMUS Investigators. Diagnostic accuracy of non-invasive tests for advanced fibrosis in patients with NAFLD: an individual patient data meta-analysis. Gut. 2021 May 17:gutjnl-2021-324243. doi: 10.1136/gutjnl-2021-324243. PMID: 34001645

31. Selvaraj EA, Mózes FE, Ajmer Jayaswal AN, Zafarmand MH, Vali Y, Lee JA, Levick CK, Joseph Young LA, Palaniyappan N, Liu CH, Aithal GP, Romero-Gómez M, Brosnan MJ, Tuthill TA, Anstee QM, Neubauer S, Harrison SA, Bossuyt PM, Pavlides M; LITMUS Investigators. Diagnostic accuracy of elastography and magnetic resonance imaging in patients with NAFLD: a systematic review and meta-analysis. J Hepatol. 2021 May 12:S0168-8278(21)00309-3. doi:10.1016/j.jhep.2021.04.044. PMID: 33991635

32. Sanchez-Delgado G, Martinez-Tellez B, Acosta FM, Virtue S, Vidal-Puig A, Gil A, Llamas- Elvira JM, Ruiz JR. Brown Adipose Tissue Volume and Fat Content are Positively Associated with Whole-Body Adiposity in Young Men, Not in Women. Diabetes. 2021 Apr 15:db210011. doi: 10.2337/db21-0011. PMID: 33858825

33. Sandovici I, Hammerle CM, Virtue S, Vivas-Garcia Y, Izquierdo-Lahuerta A, Ozanne SE, Vidal-Puig A, Medina-Gómez G, Constância M. Autocrine IGF2 programmes β-cell plasticity under conditions of increased metabolic demand. Sci Rep. 2021 Apr 8;11(1):7717. doi: 10.1038/s41598-021-87292-x. PMID: 33833312. PMCID: PMC8032793

34. Whitehead A, Krause FN, Moran A, MacCannell ADV, Scragg JL, McNally BD, Boateng E, Murfitt SA, Virtue S, Wright J, Garnham J, Davies GR, Dodgson J, Schneider JE, Murray AJ, Church C, Vidal-Puig A, Witte KK, Griffin JL, Roberts L. Brown and beige adipose tissue regulate systemic metabolism through a metabolite interorgan signalling axis. Nature Com 12:1-21, 2021. PMID:33772024

35. Petkevicius K, Bidault G, Virtue S, Newland SA, Dale M, Dugourd A, Saez-Rodriguez J, Mallat Z, Vidal-Puig A. Macrophage beta2-adrenergic receptor is dispensable for the adipose tissue inflammation and function. Mol Metab 1012-20. 2021. PMID:22774223

36. Azzu V, Vacca M, Kamzolas I, Hall Z, Leslie J, Carobbio S, Virtue S, Davies SE, Lukasik A, Dale, Bohlooly-Y M, Acharjee A, Lindén D, Bidault G, Petsalaki E, Griffin JL, Oakley F, Allison MED, Vidal-Puig A. Suppression of insulin-induced gene 1 (INSIG1) function promotes hepatic lipid remodelling and restrains NASH progression. Mol Metab 1012-10. 2021. PMID:33722690

Antonio Vidal-Puig

基本介紹

人物經歷

研究方向

主要成就

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