黃仕強

黃仕強

黃仕強，男，博士學位，中國科學院動物研究所的研究員，博士生導師，中國科學院大學崗位教授，幹細胞再生與代謝研究組組長。

基本介紹

  • 中文名：黃仕強
  • 外文名：NG SHYH CHANG 
  • 民族：漢
  • 畢業院校：哈佛醫學院 
  • 職業：教師
  • 代表作品：探索肌肉再生的奧秘
  • 主要成就：幹細胞分化與再生過程中所需的代謝變化
人物簡介,個人簡歷,研究領域與方向,代表論著,

人物簡介

2005年，21歲的黃仕強背上行囊，遠赴美國普林斯頓大學求學。2013年，29歲的黃仕強拿到了美國哈佛大學醫學院的博士學位。2017年，黃仕強入職於中科院動物所。作為中科院動物所幹細胞與生殖生物學國家重點實驗室幹細胞再生與代謝研究組的組長，黃仕強長期致力於肌肉衰老等退行性疾病的機理研究，探索肌肉再生的奧秘，其多項研究成果發表在《科學》《自然醫學》等期刊上。被評為“2019中國科學院年度創新人物”。

個人簡歷

2008年於普林斯頓大學 Princeton University 獲得分子生物學理學學位（最高榮譽）。 2013年於哈佛醫學院 Harvard Medical School 獲得生物醫學博士學位。2013年至2017年擔任新加坡基因組研究所 Genome Institute of Singapore 研究組組長。他是開創幹細胞代謝領域的青年研究者之一，研究重點涉及幹細胞分化與再生過程中所需的代謝變化。他發現，成年哺乳類動物，包括人類體內有一種處於沉睡狀態的“青春”基因 Lin28，能通過代謝調控促使多種受創細胞組織重新修復。該成果發表在 Cell（2013），被國際多家主流媒體所報導。2016年，黃仕強研究組在肌肉干細胞代謝與臨床肌肉衰減症的研究中取得了突破，成果發表於 Nature Medicine，成為該期刊的封面文章，備受國際媒體關注。其他研究成果也發表在 Science、Cell、Cell Stem Cell、Cell Metabolism、Cell Reports、Genes Dev、Development等雜誌上。榮獲VcanBio中源協和生命醫學創新突破獎、Bill & Melinda Gates Foundation (BMGF) 蓋茨基金會與 Howard Hughes Medical Institute (HHMI) 霍華德休斯醫學院國際研究學者等獎項和榮譽；承擔中國科學院前沿科學重點研究項目、中國科學院戰略性先導科技專項等項目。

研究領域與方向

以肌肉組織和多種動物為模型，研究肌肉再生和老化過程中的幹細胞代謝。將肌肉干細胞生物學的最新進展、代謝組學與深度測序的最新技術相結合，以探索如何通過調節代謝系統來調節幹細胞的自我更新。這些新發現將用於治療老齡化人口中的退行性代謝性疾病，如2型糖尿病和肌肉衰減綜合症。

代表論著

  1. Zhu, H., Shah, S., Shyh-Chang, N., Shinoda, G., Einhorn, W. S., Viswanathan, S. R., Takeuchi, A., Grasemann, C., Rinn, J. L., Lopez, M. F., Hirschhorn, J. N., Palmert, M. R., and Daley, G. Q. (2010). Lin28a transgenic mice manifest size and puberty phenotypes identified in human genetic association studies. Nature Genetics 42, 626-30.
  2. Zhu, H.*, Shyh-Chang, N.*, Segre, A. V., Shinoda, G., Shah, S. P., Einhorn, W. S., Takeuchi, A., Engreitz, J. M., Hagan, J. P., Kharas, M. G., Urbach, A., Thornton, J. E., Triboulet, R., Gregory, R. I., DIAGRAM Consortium, MAGIC Investigators, Altshuler, D., and Daley GQ. (2011). The Lin28/let-7 axis regulates glucose metabolism. Cell 147, 81-94.
  3. Le, M. T.*, Shyh-Chang, N.*, Khaw, S. L., Chin, L., Teh, C., Tay, J., O'Day, E., Korzh, V., Yang, H., Lal, A., Lieberman, J., Lodish, H. F., and Lim, B. (2011). Conserved regulation of p53 network dosage by microRNA-125b occurs through evolving miRNA-target gene pairs. PLoS Genetics 7, e1002242.
  4. Shyh-Chang, N., Zheng, Y., Locasale, J. W. and Cantley, L. C. (2011). Human pluripotent stem cells decouple respiration from energy production. EMBO Journal 30, 4851-4852.
  5. Zhang, W. C., Shyh-Chang, N., Yang, H., Rai, A., Umashankar, S., Ma, S., Soh, B. S., Sun, L. L., Tai, B. C., Nga, M. E., Bhakoo, K. K., Jayapal, S. R., Nichane, M., Yu, Q., Ahmed, D. A., Tan, C., Sing, W. P., Tam, J., Thirugananam, A., Noghabi, M. S., Pang, Y. H., Ang, H. S., Mitchell, W., Robson, P., Kaldis, P., Soo, R. A., Swarup, S., Lim, E. H., and Lim, B. (2012). Glycine decarboxylase activity drives non-small cell lung cancer tumor-initiating cells and tumorigenesis. Cell 148, 259-72.
  6. Shinoda, G., Shyh-Chang, N., de Soysa, T. Y., Zhu, H., Seligson, M. T., Shah, S. P., Abo-Sido, N., Yabuuchi, A., Hagan, J. P., Gregory, R. I., Asara, J. M., Cantley, L. C., Moss, E. G., and Daley, G. Q. (2013). Fetal deficiency of Lin28 programs life-long aberrations in growth and glucose metabolism. Stem Cells. doi: 10.1002/stem.1423.
  7. Shyh-Chang, N., Locasale, J. W., Lyssiotis, C. A., Zheng, Y., Teo, R. Y., Ratanasirintrawoot, S., Zhang, J., Onder, T., Unternaehrer, J. J., Zhu, H., Asara, J. M., Daley, G. Q., and Cantley, L. C. (2013). Influence of threonine metabolism on S-adenosylmethionine and histone methylation. Science 339, 222-226.
  8. Shyh-Chang, N., Daley, G. Q., and Cantley, L. C. (2013). Stem cell metabolism during tissue development and aging. Development 12, 2535-47.
  9. Shyh-Chang, N. and Daley, G. Q. (2013). Lin28: Primal regulator of growth and metabolism in stem cells. Cell Stem Cell 12, 395-406.
  10. Shyh-Chang, N., Zhu, H., de Soysa, T. Y., Shinoda, G., Seligson, M. T., Tsanov, K. T., Nguyen L., Asara, J. M., Cantley, L. C., and Daley, G. Q. (2013). Lin28 enhances tissue repair by reprogramming cellular metabolism. Cell 155, 778-92.
  11. Shyh-Chang, N. and Daley, G. Q. (2015). Metabolic switches linked to pluripotency and embryonic stem cell differentiation. Cell Metabolism 21, 349-50
  12. Khaw, S. L., Min-Wen, C., Koh, C. G., Lim, B., and Shyh-Chang, N. (2015). Oocyte factors suppress mitochondrial polynucleotide phosphorylase to remodel the metabolome and enhance reprogramming. Cell Reports 12(7), 1080-8.
  13. Wu, L.*, Nguyen L. H.*, Zhou, K., de Soysa, T. Y., Li, L., Miller, J. B., Tian, J., Locker, J., Zhang, S., Shinoda, G., Seligson, M. T., Zeitels, L. R., Acharya, A., Wang, S. C., Mendell, J. T., He, X., Nishino, J., Morrison, S. J., Siegwart, D. J., Daley, G. Q., Shyh-Chang, N., Zhu, H. (2015). Precise let-7 expression levels balance organ regeneration against tumor suppression. eLife 10.7554
  14. Liu TM, Lee EH, Lim B, Shyh-Chang, N. (2015). Balancing Stem Cell Self-renewal and Differentiation with PLZF. Stem Cells doi: 10.1002/stem.2270.
  15. Jun-Hao ET, Gupta RR, Shyh-Chang, N. (2016). Lin28 and let-7 in the metabolic physiology of aging. Trends Endocrinol. Metab. S1043-2760(15)00251-9. doi: 10.1016/j.tem.2015.12.006.
  16. Min-Wen JC, Jun-Hao ET, Shyh-Chang, N. (2016). Stem cell mitochondria during aging. Seminars in Cell and Developmental Biology. doi:10.1016/j.semcdb.2016.02.005.
  17. Fukawa, T., Yan-Jiang, B.C., Min-Wen, J.C., Jun-Hao, E.T., Huang, D., Qian, C.N., Ong, P., Li, Z., Mohan, R.E., Wang, R.R., Kanayama, H., Lai, J.H., Chua, C., Ong, H.S., Tan, K.K., Ho, Y.S., Tan, I.B., Teh, B.T., Shyh-Chang, N. (2016).Excessive fatty acid oxidation induces muscle atrophy in cancer cachexia. Nature Medicine. 22(6), 666-71.
  18. Loh KM, Chen A, Koh PW, Deng TZ, Sinha R, Tsai JM, Barkal AA, Shen KY, Jain R, Morganti RM, Shyh-Chang N, Fernhoff NB, George BM, Wernig G, Salomon REA, Chen Z, Vogel H, Epstein JA, Kundaje A, Talbot WS, Beachy PA, Ang LT, Weissman IL. (2016). Mapping the Pairwise Choices Leading from Pluripotency to Human Bone, Heart, and Other Mesoderm Cell Types. Cell. 166, 451-467.
  19. Liu TM, Shyh-Chang N. (2017). SIRT2 and glycolytic enzyme acetylation in pluripotent stem cells. Nat Cell Biol. 19(5), 412-414.
  20. Andriani Y#, Chua JM#, Chua BY, Phang IY, Shyh-Chang N*, Tan WS*. (2017). Polyurethane acrylates as effective substrates for sustained in vitro culture of human myotubes. Acta Biomater. 57, 115-126.
  21. Shyh-Chang N and Huck-Hui Ng. (2017). The Metabolic Programming of Stem Cells. Genes Dev. 31(4), 336-346.
  22. Min-Wen JC, Yan-Jiang BC, Mishra S, Dai X, Magae J, Shyh-Chang N, Kumar AP, Sethi G. (2017). Molecular Targets of Ascochlorin and Its Derivatives for Cancer Therapy. Adv Protein Chem Struct Biol. 108, 199-225.
  23. Shyh-Chang N. (2017). Metabolic Changes During Cancer Cachexia Pathogenesis. Adv Exp Med Biol. 1026, 233-249.
  24. Usman WM, Pham TC, Kwok YY, Vu LT, Ma V, Peng B, Chan YS, Wei L, Chin SM, Azad A, He AB, Leung AYH, Yang M, Shyh-Chang N, Cho WC, Shi J, Le MTN. (2018). Efficient RNA drug delivery using red blood cell extracellular vesicles. Nat Commun. 9, 2359.
  25. Zhang X, Liu Z, Liu X, Wang S, Zhang Y, He X, Sun S, Ma S, Shyh-Chang N, Liu F, Wang Q, Wang X, Liu L, Zhang W, Song M, Liu GH, Qu J. (2019). Telomere-dependent and telomere-independent roles of RAP1 in regulating human stem cell homeostasis. Protein Cell. doi: 10.1007/s13238-019-0610-7
  26. Chua MJ, Yildirim ED, Tan JE, Chua YB, Low SC, Ding SLS, Li CW, Jiang Z, Teh BT, Yu K, Shyh-Chang N. (2019). Assessment of different strategies for scalable production and proliferation of human myoblasts. Cell Prolif. e12602. doi: 10.1111/cpr.12602.
  27. Li CW*, Yu K#, Shyh-Chang N#, Li GX, Jiang LJ, Yu SL, Xu LY, Liu RJ, Guo ZJ, Xie HY, Li RR, Ying J, Li K, Li DJ. (2019). Circulating factors associated with sarcopenia during ageing and after intensive lifestyle intervention. J Cachexia Sarcopenia Muscle. doi: 10.1002/jcsm.12417.

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