魯金花，女，畢業於中國科學院動物研究所，博士，廈門大學生殖醫學助理教授。
基本介紹
- 中文名：魯金花
- 畢業院校：中國科學院動物研究所
- 學位/學歷：博士
- 職業：教師
- 專業方向：胚胎植入和胎盤發育
- 任職院校：廈門大學
研究方向,個人經歷,研究領域,學術成果,榮譽獎項,
研究方向
胚胎植入和胎盤發育
個人經歷
教育背景
2008.9-2013.7中國科學院動物研究所發育生物學專業 博士
2005.9-2008.7山東農業大學動物遺傳育種和繁殖專業 碩士
2001.9-2005.7山東農業大學動物科學專業 本科
工作經歷
2015.12-至今 廈門大學醫學院基礎醫學系生殖醫學 助理教授
2013.7-2015.12中國科學院動物研究所胚胎著床生理學研究組 博士後
研究領域
主要研究領域是胎盤發育的調控機制研究，以轉基因和組織特異性敲除小鼠模型以及滋養層幹細胞細胞係為研究手段，結合臨床病例研究胎盤發育過程中滋養層細胞增殖和譜系分化的調控機制，為妊娠相關疾病的預防和治療提供依據。
學術成果
論文
1、Jiang YF, Kong SB, He B, Wang BY, Wang HB*, Lu JH* (Co-correspondence). Uterine Prx2 restrains decidual differentiation through inhibiting lipolysis in mice. Cell Tiss Res. 2016
2、Lu JH, Zhang S, Nakano H, Wang SM, Simmons DG, Shuang BK, Wang Q, Shen LJ, Tu ZW, Wang WX, Wang BY, Wang HM, Wang YL, van Es JH, Clevers H, Leone G, Cross JC*, Wang HB*(*Co-correspondence). A positive feedback loop involving Gcm1 and Fzd5 directs chorionic branching morphogenesis in the placenta. PLoS Biol. 2013
3、Lu JH*, Wang Q*(*equal contribution), Wang BY, Wang FC, Wang HB. Developmental genes during placentation: insights from mouse mutants. Front Biol. 2011
4、Lu JH, Wang JZ, Wang HL, Sui HS, Liu Y, Li JJ, Liang B, Tan JH. Damaging effect of cumulus denudation on rabbit oocytes. Fertil Steril. 2010
5、Wang Q, Lu JH, Zhang S, Wang SM, Wang WX,, Wang BY, Wang FC, Chen Q, Duan EK, Kispert A, Wang HB. Wnt6 is essential for stromal cell proliferation during decidualization. Biol Reprod. 2013
6、Liu Y, Wang HL, Lu JH, Miao YL, Cao XY, Zhang L, Wu X, Wu F, Ding B, Wang R, Luo M, Li W, Tan JH. Rex Rabbit Somatic Cell Nuclear Transfer with In Vitro-Matured Oocytes. Cell Reprogram. 2016
7、Chen Q*, Zhang Y*( equal contribution), Lu JH, Wang Q, Wang SJ, Cao YJ, Wang HB*, Duan EK*(*Co-correspondence). Embryo-uterine cross-talk during implantation: The role of Wnt signaling. Mol Hum Reprod. 2009
8、Zhang S, Kong SB, Lu JH, Wang Q, Chen YJ, Wang WW, Wang BY, Wang HB. Deciphering the molecular basis of uterine receptivity. Mol Reprod Dev. 2013
9、Lu WG, Tu ZW, Wang SM, Lu JH, Wang Q, Wang WX, Wang BY, Wang HB, Ni HM, Guo Yong. Spatiotemporal expression of Wnt signaling pathway components during bovine placental development. Theriogenology. 2013
10、Tu ZW, Wang Q, Cui TT, Wang JR, Ran H, Bao HL, Lu JH, Wang BY, Lydon JP, DeMayo F, Zhang S, Kong SB*, Wu XM*, Wang HB*. Uterine RAC1 via Pak1-ERM signaling directs normal luminal epithelial integrity conducive to on-time embryo implantation in mice. Cell Death Differ. 2016
11、Zhang S, Kong SB, Wang BY, Cheng XH, Chen YJ, Wu WW, Wang Q, Shi JC, Zhang Y, Wang SM, Lu JH, Lydon JP, DeMayo F, Pear WS, Han H, lin HY, Li L, Wang HM, Wang YL, Li B, Chen Q, Duan EK, Wang HB (Co-correspondence). Uterine Rbpj is required for embryo-uterine orientation and decidual remodeling via Notch pathway-independent and -dependent mechanisms. Cell Res 2014
12、Fu Z*, Wang BY*, Wang SM*, Wu WW*(*equal contribution), Wang Q, Chen YJ, Kong SB, Lu JH, Tang ZZ, Ran H, Tu ZW, He B, Zhang S, Chen Q, Jin WZ, Duan EK, Wang HM, Wang YL, Li L, Wang FC*, Gao SR* , W HB*(*Co-correspondence). Integral proteomic analysis of blastocysts reveals key molecular machinery governing embryonic diapause and reactivation for implantation in mice. Biol Reprod. 2014
13、Wang HL, Sui HS, Liu Y, Miao DQ, Lu JH, Liang B, Tan JH. Dynamic changes of germinal vesicle chromatin configuration and transcriptional activity during maturation of rabbit follicles. Fertil Steril. 91(4 Suppl) 2009
14、Yu JN, Ma SF, Miao DQ, Tan XW, Liu XY, Lu JH, Tan JH. Effects of cell cycle status on the efficiency of liposome-mediated gene transfection in mouse fetal fibroblasts. J Reprod Dev.2006
主持課題
1、中國博士後科學基金第55批面上資助，Polycomb 蛋白Bmi-1對小鼠胚泡植入和子宮蛻膜化的調控，2014.5-2015.6
榮譽獎項
1、2015婦幼健康科學技術獎自然科學獎一等獎， 早期妊娠的分子調控（3/12）
2、2013中國科學院朱李月華優秀博士生獎
3、2013中國科學院三好學生及三好學生標兵
4、2013中國科學院動物研究所計畫生育生殖生物學國家重點實驗室優秀學生
5、2012 The 2nd SKLRB Symposium on Frontiers in Reproductive Biology Award for Excellent Poster Presentation
6、2012 The State Key Laboratory of Reproductive Biology Young Scholars Forum Award for Brilliant Speech
7、2003國家獎學金
