駱海明

駱海明，男，博士，華中科技大學武漢光電國家研究中心教授、博士生導師。

基本介紹

  • 中文名：駱海明
  • 國籍：中國
  • 畢業院校：華中科技大學
  • 學位/學歷：博士
  • 職業：教師
  • 專業方向：生物醫學工程
  • 職務：華中科技大學武漢光電國家研究中心博士生導師
  • 任職院校：華中科技大學武漢光電國家研究中心
  • 職稱：教授
個人經歷,研究方向,學術成果,專利,榮譽獎勵,

個人經歷

2013獲得華中科技大學生物醫學工程專業博士學位。2013-2015美國威斯康星大學麥迪遜分校博士後；2015-2018哈佛醫學院麻省總醫院研究員；2016-2018麻省理工大學麥戈文腦科學研究院研究會員。2018年3月回國，現任華中科技大學武漢光電國家研究中心工程科學學院教授、博士生導師。
教育經歷
  • 2007.9 ~ 2013.6 華中科技大學 - 生物醫學工程 - 博士學位 ；
  • 2003.9 ~ 2007.6 華中農業大學 - 植物科學與技術 - 學士學位 。
工作經歷
  • 2016.10-2018.3 麻省理工大學 -Department of Brain and Cognitive Sciences-Research Affiliate；
  • 2015.10-2018.3 哈佛醫學院麻省總醫院 -Research fellow；
  • 2013.10-2015.10 威斯康辛大學麥迪遜分校 -Wisconsin Institutes for Medical Research-博士後。

研究方向

目前主要研究方向老年痴呆症的診斷檢測與防治

學術成果

以第一作者/通訊作者在PNAS、Clinical Cancer Research、Journal of Nuclear Medicine、Biosensors & Bioelectronics、Theranostics、Journal of Nanobiotechnology等期刊上發表SCI論文20多篇。獲得授權美國發明專利1項、歐洲發明專利1項，中國發明專利5項，申請中國發明專利多項。
代表性論文（*為通訊作者）
1. Liu Ni, Liang Xiaohan, Yang Changwen, Hu Shun, Luo Qingming, Luo Haiming*. Dual-targeted magnetic mesoporous silica nanoparticles reduce brain amyloid-β burden via depolymerization and intestinal metabolism. Theranostics. 2022, 12: 6646-6664
2. Hu Shun, Yang Changwen, Li Yanqing, Luo Qingming, Luo Haiming*. Nanozyme sensor array based on manganese dioxide for the distinction between multiple amyloid β peptides and their dynamic aggregation process. Biosensor and Bioelectronics. 2022,199:113881
3. Ni Liu, Changwen Yang, Xiaohan Liang, Kai Cao, Jun Xie, Qingming Luo, Luo Haiming*. Mesoporous silica nanoparticle-encapsulated Bifidobacterium attenuates brain Aβ burden and improves olfactory dysfunction of APP/PS1 mice by nasal delivery. Journal of Nanobiotechnology. 2022, 20:439
4. Hu Shun, Yang Changwen, Luo Haiming*. Current trends in blood biomarker detection and imaging for Alzheimer's disease. Biosensor and Bioelectronics. 2022, 210:114278
5. Luo Haiming*, Yang Changwen, Kuang Dong, Chan W. Annie*. Visualizing dynamic changes in PD-L1 expression in non-small-cell lung carcinoma with radiolabeled recombinant human PD1. European Journal of Nuclear Medicine and Molecular Imaging. 2022, 49(8):2735-2745
6. Zhang Liding, Du Xuewei, Su Ying, Niu Shiqi, Li Yanqing, Liang Xiaohan, Luo Haiming*. Quantitative assessment of AD markers using naked eyes: point-of-care testing with paper-based lateral flow immunoassay. Journal of Nanobiotechnology. 2021, 19(1):366
7. Zhang Liding, Yang Changwen, Li Yanqing, Niu Shiqi, Liang Xiaohan, Zhang Zhihong, Luo Qingming, Luo Haiming*. Dynamic changes in the levels of amyloid-β42 species in the brain and periphery of APP/PS1 mice and their significance for Alzheimer's disease. Frontiers in Molecular Neuroscience. 2021, 14:723317
8. Liang Xiaohan, Luo Haiming*. Optical Tissue Clearing: Illuminating Brain Function and Dysfunction. Theranostics. 2021,11(7):3035-3051
9. Luo Haiming*, Lu Lisen, Liu Ni, Li Qingqing, Yang Xiaoquan, Zhang Zhihong*. Curcumin loaded sub-30 nm targeting therapeutic lipid nanoparticles for synergistically blocking nasopharyngeal cancer growth and metastasis. J Nanobiotechnology. 2021, 19(1):224.
10. Haiming Luo, Christopher G England, Sixiang Shi, Stephen A Graves, Reinier Hernandez, Bai Liu, Charles P Theuer, Hing C Wong, Robert J Nickles, Weibo Cai. Dual-targeting of tissue factor and CD105 for preclinical PET imaging of pancreatic cancer. Clinical Cancer Research, 22(15):3821-30, 2016.
11. Haiming Luo, Christopher G England, Stephen A Graves, Haiyan Sun, Glenn Liu, Robert J Nickles, Weibo Cai. PET of VEGFR2 in cancer with 64Cu-labeled ramucirumab. Journal of Nuclear Medicine, 57(2):285-90, 2016.
12. Haiming Luo#, Reinier Hernandez#, Hao Hong, Stephen A Graves, Yunan Yang, Christopher G England, Charles P Theuer, Robert J Nickles, Weibo Cai. Noninvasive brain cancer imaging with a bispecific antibody fragment, generated via click chemistry. Proc Natl Acad Sci U S A, 112(41):12806-11, 2015.
13. Haiming Luo, Hao Hong, Michael R Slater, Stephen A Graves, Sixiang Shi, Yunan Yang, Robert J Nickles, Frank Fan, Weibo Cai. PET of c-Met in cancer with 64Cu-labeled Hepatocyte Growth Factor. J Nucl Med, 56(5):758-63, 2015.
14. Haiming Luo, Lisen Lu, Fei Yang, Liang Wang, Xiaoquan Yang, Qingming Luo, Zhihong Zhang. Nasopharyngeal Cancer-Specific Therapy Based on Fusion Peptide-Functionalized Lipid Nanoparticles. ACS Nano, 8(5):4334-47, 2014
15. Haiming Luo#, Jiyun Shi#, Honglin Jin, Di Fan, Lisen Lu, Fan Wang, Zhihong Zhang. An (125)I-labeled octavalent peptide fluorescent nanoprobe for tumor-homing imaging in vivo. Biomaterials, 33(19):4842-50, 2012.

專利

1. 駱海明、張立定。用於檢測人澱粉樣蛋白-β雙抗夾心ELISA檢測試劑盒。專利號：ZL202011227418.8
2. 駱海明、駱清銘、張立定。用於檢測人澱粉樣蛋白-β的膠體金免疫層析試紙及其製備。專利號：ZL202110067679.6
3. 駱海明、劉妮、胡順、曹凱。一種用於清除β-澱粉樣蛋白的特異性捕獲載體及其套用。專利號：ZL202110345476.9
4. 駱海明、劉妮、胡順、曹凱，楊昌文。納米材料用於製備鼻腔納米製劑腦靶向遞送腸道藥物套用。（專利授權通知）
5.駱海明、張立定。分泌抗絲氨酸磷酸化tau蛋白單克隆抗體的雜交瘤細胞株。（專利授權通知）
  • 6. 一種具有協同靶向診療鼻咽癌功能的多肽和攜帶此多肽的納米顆粒及其套用, 專利號：ZL 201210185089.4, 發明人：駱清銘 張智紅 駱海明；
  • 7. 一種具有多價效應和納米尺寸效應的多肽螢光探針的構建方法及其套用, 專利號：ZL 200910310366.8, 發明人：駱清銘 張智紅 駱海明；
  • 8. POLYPEPTIDE WITH FUNCTION OF TARGETED DIAGNOSIS AND THERAPY OF NASOPHARYNGEAL CARCINOMA, NANOPARTICLES CARRYING SAME AND USE THEREOF, Patent No.: EP2860193B1, Date of Patent: Nov. 15, 2017, Inventor: Qingming Luo, Zhihong Zhang, Haiming Luo;
  • 9. A DUAL-TARGETED THERAPEUTIC PEPTIDE FOR NASOPHARYNGEAL CARCINOMA, NANOPARTICLES CARRYING SAME AND USES THEREOF, Patent No.: US 9,371,364 B2, Date of Patent: Jun. 21, 2016, Inventor: Qingming Luo, Zhihong Zhang, Haiming Luo.

榮譽獎勵

1. 2014湖北省優秀博士學位論文;
2. 2015美國核醫學與分子影像學年會SNMMI放射性藥物科學理事會RPSC的Travel Grant Award;
3. 2016中美核醫學與分子影像學協會CASNM年會青年科學家獎
4. 2018湖北省第八批“百人計畫”；

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