陳彥(安徽大學生命科學學院副院長)

陳彥(安徽大學生命科學學院副院長)

陳彥，男，博士，現為安徽大學生命科學學院副院長、生物實驗教學中心主任、教授、博士生導師。

基本介紹

  • 中文名：陳彥
  • 畢業院校：合肥工業大學
  • 學位/學歷：博士
  • 專業方向：生命科學
  • 職務：安徽大學生命科學院副院長
人物經歷,學術兼職,研究方向,科研項目,學術成果,主要論文,授權發明專利,

人物經歷

1991─ 安徽大學生命科學學院，歷任講師（1992）、副教授（1998）、教授（2004）、博士生導師（2011），兼任生命科學學院副院長（2010）、
2004─2009合肥工業大學生物與食品工程學院，工學博士
1988─1991安徽大學生化微生物研究所，理學碩士
1984─1988安徽農業大學茶與食品科技學院（原安徽農學院茶業系），助教
1980─1984安徽農業大學茶與食品科技學院（原安徽農學院茶業系），農學學士

學術兼職

現為安徽省生態工程與生物技術重點實驗室主任，安徽省學術和技術帶頭人，安徽省生物化學與分子生物學學會副理事長，安徽省食用菌技術協會副會長。

研究方向

1、真菌活性多糖的結構與功能；
2、天然活性產物的抗腫瘤/抗衰老作用機制；
3、功能食品/保健品的開發與研究。

科研項目

1.國家自然科學基金項目（31271817），金福菇多糖抗衰老作用及其構效關係研究，2013─2016
2.安徽省教育廳重點科研項目(KJ2012A029)，黃精活性物質綜合製備新工藝的開發與研究，2012─2014
3.安徽省高校自然科學研究重點項目（KJ2011A017），特色功能性富硒米乳製品（飲料）開發，2011─2013
4.安徽省科技攻關項目（12010302054）“新型健康奶油生產關鍵技術研究”，2012-2013
5.石斛生物鹼製備工藝開發（企業委託項目）2013─2014
6.大米蛋白粉品質特性分析（企業委託項目）2013─2014

學術成果

主要論文

  1. Wen-Na Zhang, Ri-Na Su, Li-Li Gong, Wei-Wei Yang, Juan Chen, Rui Yang, Ya Wang, Wen-Juan Pan, Yong-Ming Lu,Yan Chen*. Structural characterization and in vitro hypoglycemic activity of a glucan from Euryale ferox Salisb. Seeds, Carbohydrate Polymers. 2019,209 :363–371
  2. Wei-Wei Yang, Li-MingWang, Li-Li Gong, Yong-Ming Lu, Wen-Juan Pan, Ya Wang, Wen-Na Zhang*,Yan Chen*. Structural characterization and antioxidant activities of a novel polysaccharide fraction from the fruiting bodies of Craterellus cornucopioides, International Journal of Biological Macromolecules. 2018,117:473–482
  3. Wan Li, Zheng-Nan Cai, Shomaila Mehmood, YaWang,Wen-Juan Pan, Wen-Na Zhang, Yong-Ming Lu*,Yan Chen*. Polysaccharide isolated from Sarcodon aspratus induces RAW264.7 activity via TLR4-mediated NF-κB and MAPK signaling pathways, International Journal of Biological Macromolecules. 2018,120:1039–1047
  4. Zheng-Nan Cai, Wan Li, Shomaila Mehmood, Wen-Juan Pan, Ya Wang, Fan-Ju Meng, Xiao-Fang Wang, Yong-Ming Lu*,Yan Chen*. Structural characterization, in vitro and in vivo antioxidant activities of aheteropolysaccharide from the fruiting bodies of Morchella esculenta, Carbohydrate Polymers. 2018,195:29-38
  5. Mingzhu Zhang, Rina Su, Qiong Zhang, Lei Hu, Xiaohe Tian,Yan Chen*. Hongping Zhou, Jieying Wu, Yupeng Tian*,Ultra-bright intercellular lipids pseudo di-BODIPY probe with lowmolecular weight, high quantum yield and large two-photon actioncross-sections, Sensors and Actuators B: Chemical, Sensors and Actuators B. 2018,261 :161-168
  6. Sajid Hussain, Wei Du,Mingzhu Zhang, Bin Fang, Guocui Zhang, Rina Su,Keqian Nan, Qiong Zhang, Xiaohe Tian*, Yupeng Tian* andYan Chen*.A series of two-photon absorption pyridinium sulfonate inner salts targeting endoplasmic reticulum (ER), inducing cellular stress and mitochondria-mediated apoptosis in cancer cells Journal of Materials Chemistry B. 2018,6, 1943-1950
  7. Wen-Juan Pan, Qiu-Ying Ding, Ya Wang, Dan-Dan Wang, Yong-Ming Lu, Wei-Wei Yang, Zheng-Nan Cai, Xiao-Du Cheng, Wen-Na Zhang,Yan Chen*.A bioactive polysaccharide TLH-3 isolated from Tricholoma lobayense .protects against oxidative stress-induced premature senescence in cells and mice , Journal of Functional Foods. 2018,42:159-170
  8. Mingzhu Zhang, Xiaohe Tian, Ya Wang, Dandan Wang, Wan Li , Lei Chen, Wenjun Pan, Shomaila Mehmood,Yan Chen*. Immunomodulating activity of the polysaccharide TLH-3 from Tricholomalobayense in RAW264.7 macrophages, International Journal of Biological Macromolecules. 2018,107:2679-2685
  9. Wan Li, Zheng-Nan Cai, Shomaila Mehmood, Ya Wang,Wen-Juan Pan, Wen-Na Zhang,Yong-Ming Lu*,Yan Chen*,Polysaccharide FMP-1 from Morchella esculenta attenuates cellular oxidative damage in human alveolar epithelial A549 cells through PI3K/AKT/Nrf2/HO-1 pathway, International Journal of Biological Macromolecules, 2018,120 :865–875
  10. Dan-Dan Wang, Qing-Xi Wu, Wen-Juan Pan, Sajid Hussain, Shomaila Mehmood andYan Chen*, A novel polysaccharide from the Sarcodon aspratus triggers apoptosis in Hela cells via induction of mitochondrial dysfunction, Food & Nutrition Research, 2018,62:1285
  11. Qing-Xi Wu*, Jun-Qi Yu, Wei Ying, Ting Su, Xiao-Du Cheng, Jin Zhao andYan Chen*. Cultivation of the Wild Ganoderma gibbosum Mycelia via Submerged Liquid Fermentation for Inter/Extra-Cellular Polysaccharides,InternationalJournalofAgriculture and Biology.2018,20(5): 1218-1224
  12. Qing-Xi Wu, Dan-Dan Wang,Ting Su, Xiao-Du Cheng, Xin Xu .Yan Chen*. Self-assembly of polyelectrolyte complexes microcapsules with natural polysaccharides for sustained drug release, Cellulose. 2017, 24:4949-4962
  13. Xiaohe Tian , Sajid Hussain, Hui Wang , Qiong Zhang , Meng Zhao ,Junyang Chen , Hui Zhang , Hongping Zhou ,Yan Chen*, Yupeng Tian*.A series of water-soluble pyridinium derivatives with two-photon absorption in the near infrared region for mitochondria targeting under stimulated emission depletion (STED) nanoscopy, Dyes and Pigments. 2017, 147: 90-98
  14. Yan Chen*, Xue-Hui Li, Li-Yuan Zhou, Wan Li, Liu Liu, Dan-Dan Wang, Wen-Na Zhang,Sajid Hussain, Xiao-He Tian, Yong-Ming Lu*.Structural elucidation of three antioxidative polysaccharides fromTricholoma lobayense, Carbohydrate Polymers. 2017,157 : 484–492
  15. Liming Wang &Yan Chen*. Efficient Biotransformation of Astragaloside IV to Cycloastragenol by Bacillus sp. LG-502, Applied Biochemistry and Biotechnology. 2017,183(4):1488-1502
  16. Yong-Ming Lu,Qiao-Yue Yang,Li-Ming Wang,Ming-Zhu Zhang,Wen-Qiang Guo,Zheng-Nan Cai,Dan-Dan Wang,Wei-Wei Yang,Yan Chen*. Enhanced Activity of Immobilized Horseradish Peroxidase by Carbon Nanospheres for Phenols Removal,CLEAN-Soil Air Water. 2017, 45(2):1600077
  17. Zhenyu Yue, Hai-Tao Li, Yabing Yang, Sajid Hussain, Chun-Hou Zheng, Junfeng Xia*,Yan Chen*.Identification of breast cancer candidate genes using gene co-expression and protein-protein interaction information, Oncotarget. 2016,7(24) : 36092 -36100
  18. Qiuying Ding, Dan Yang, Wenna Zhang, Yongming Lu, Mingzhu Zhang, Liming Wang,Xuehui Li, Liyuan Zhou, Qingxi Wu, Wenjuan Pan,Yan Chen*. Antioxidant and anti-aging activities of the polysaccharide TLH-3from Tricholoma lobayense, International Journal of Biological Macromolecules. 2016, 85: 133-140
  19. Xuehui Li, Yongming Lu, Wenna Zhang, Shixiong Yuan, Liyuan Zhou, Liming Wang,Qiuying Ding, Dandan Wang, Weiwei Yang, Zhengnan Cai,Yan Chen*.Antioxidant capacity and cytotoxicity of sulfated polysaccharideTLH-3 from Tricholoma lobayense, International Journal of Biological Macromolecules. 2016, 82: 913-919.
  20. Wenna Zhang, Yongming Lu, Yaping Zhang, Qiuying Ding, Sajid Hussain, Qingxi Wu, Wenjuan Pan &Yan Chen*. Antioxidant and antitumour activities of exopolysaccharide from liquid-cultured Grifola frondosa by chemical modification. International Journal of Food Science and Technology. 2016,51(4) : 1055-1061
  21. Liu Liu, Yongming Lu, Xuehui Li, Liyuan Zhou, Dan Yang, Liming Wang,Yan Chen*. A novel process for isolation and purification of the bioactivepolysaccharide TLH-3from Tricholoma lobayense,Process Biochemistry.2015,50 :1146–1151
  22. Zhenyu Yue,Wenna Zhang, Yongming Lu,Qiaoyue Yang, Qiuying Ding, Junfeng Xia*andYan Chen*. Prediction of cancer cell sensitivity to natural products based on genomic and chemical properties. PeerJ, 2015,3:e1425
  23. Yong-Ming Lu , Jian Pan,Wen-Na Zhang , Ai-Ling Hui , Wen-Qiang Guo, Li Huang, Qin-Jun Zhu ,Yan Chen*. Synthesis, in silico and in vivo blood brain barrier permeability of ginkgolide B cinnamate, Fitoterapia. 2015,106 :110-114
  24. Yan Chen, Meili Hu*, Cui Wang, Yuling Yang, Jianhua Chen, Jingna Ding, Wenqiang Guo. Characterization and in vitro antitumor activity of polysaccharides from the mycelium of Sarcodon aspratus ,International Journal of Biological Macromolecules. 2013,52:52-58
  25. Peilu Duan, Tianlong Zhai, Cunji Xu, Jingna Ding &Yan Chen*. A simple and effective method for detecting toxicity of chromium trioxide on Vicia faba, European Food Research and Technology. 2013, 236:517-521
  26. Meili Hu,Yan Chen*, Cui Wang, Huali Cui, Peilu Duan, Tianlong Zhai, Yuling Yang & Shaofei Li. Induction of apoptosis in HepG2 cells by polysaccharide MEP-II from the fermentation broth of Morchella esculent, Biotechnology Letters. 2013, 35:1-10

授權發明專利

  1. 陳彥,王亞,程乃嘉,李雪慧,周禮元,蔡正楠,郭文強.一種兼具抗腫瘤作用的抗氧化劑及其製備方法,2018.12.28,中國發明專利ZL201610573418.0
  2. 陳彥,楊丹,劉柳,王亞,徐利,陸永明,張亞萍.一種高純度蘿蔔硫素的製備方法,2017.06.20,中國發明專利ZL201410632932.8
  3. 陳彥,楊喬月,陸永明.一種以固定化酶去除工業廢水中撲息熱痛的方法,2017.06.13,中國發明專利ZL201510455090.8
  4. 陳彥,王亞,徐利,郭文強,陸永明,李紹飛.一種金釵石斛多糖和總鹼的提取分離方法，2017.02.08，中國發明專利ZL201410628418.7
  5. 陳彥,劉柳,郭文強,王亞,陸永明.一種以金福菇為原料提取分離金福菇多糖TLH-3的方法,2016.02.17,中國發明專利ZL201410318373.3
  6. 陳彥,翟天龍,段培魯,丁兢娜,徐存吉,郭文強,王萌萌.一種植物與微生物多糖的純物理製備方法，2015.12.09,中國發明專利ZL201210471031.6（已轉讓）
  7. 陳彥,段培魯,翟天龍,丁兢娜,徐存吉,張蕾,郭璐璐.一種促進醒酒和防醉的中藥提取物復配製劑及其製備方法和套用,2015.10.21,中國發明專利ZL201210319130.2（已轉讓）
  8. 陳彥,郭文強,王亞.一種石斛飲料的製備方法,2015.08.05,中國發明專利ZL201310462318.7 （已轉讓）
  9. 陳彥,王亞,郭文強.一種銀杏鮮汁原液的製備方法,2015.08.05,中國發明專利ZL201310462280.3（已轉讓）
  10. 陳彥,王翠,王瑞君,胡美麗,段培魯,翟天龍.一種天然抗氧化劑金福菇多糖 的製備方法,2014.02.12,中國發明專利ZL201210014537.4（已轉讓）
  11. 陳彥,徐存吉,王萌萌,李紹飛,江明星,劉增武,徐利.一種以棕櫚油為基油的低反式脂肪酸冰淇淋專用油脂的製備方法,2013.10.16,中國發明專利ZL201210232641.0
  12. 陳彥,孫文秀,王子堯,祝慶軍.一種同步浸提、分項製取丹皮中各活性成分的製備方法,2011.06.22,中國發明專利ZL200810195489.7（已轉讓）
  13. 陳彥,王亞.一種食用植物油中殘留DNA的提取方法,2011.03.30,中國發明專利ZL200710025573.X（已轉讓）

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