許執恆，男，1966年4月出生，研究員，博士生導師。1989年獲上海第二軍醫大學醫學學士系學位，1999年獲美國新澤西Rutgers大學博士學位。1999-2005在美國哥倫比亞大學神經生物學和精神病中心做博士後及高級研究助理。先後獲得美國NIH的 Ruth L. Kirschstein National Research Service Award (2002-03)及Rutgers大學Bush Fellowship (1997-1999)和Waksman Fellowship (1993-1997)，2005年中國科學院“百人計畫”入選者，2007年國家傑出青年科學基金獲得者。
基本介紹
- 中文名：許執恆
- 國籍：中國
- 主要成就：2007國家傑出青年科學基金
- 性別：男
主要研究方向,主要研究內容包括,主要論著目錄,
主要研究方向
利用本課題組在生化與細胞生物學方面的優勢，結合不同的模式動物，進行神經和腫瘤生物學研究，爭取在闡明細胞凋亡信號轉導通路和相關重要疾病發生的分子機制方面有所突破。由於細胞凋亡與腫瘤、神經發育及神經退行性疾病密切相關，這一研究將有助於我們為疾病的預防和治療提供理論依據，同時為個體正常發育的分子機理提供新見解。
主要研究內容包括
1) 用分子、生化和細胞生物學為手段研究PJAC蛋白激酶複合體新成員在細胞凋亡信號傳導通路中的作用與調節機制，進一步揭示JNK信號傳導通路在神經發育和腫瘤及神經退行性疾病病理過程中的意義。
2) 通過免疫共沉澱、酵母雙雜交和生物信息學手段來研究一組與人類神經退行性疾病相關的基因和蛋白質，如LRRK2。
3) 建立和利用模式動物（果蠅和小鼠）研究腫瘤和帕金森氏病的發病機制。
主要論著目錄
(* 通訊作者)：
1.Liu S, Yu M, He Y, Xiao L,…, and Xu Z* (2008) Melittin prevents liver cancer cell metastasis through inhibition of the Rac1-dependent
pathway. Hepatology 47(6) 1964-73
2.Qiao HX, Hao CJ, Li Y, He X, Chen RS, Cui J, Xu Z*, Li W*.（2008）JNK activation mediates the apoptosis of xCT-deficient cells. Biochem Biophys Res Commun 370(4):584-8.
3.Liu S， Sun YM et al., (2008) Down-regulated NM23-H1 expression is associated with intracranial invasion of nasopharyngeal
carcinoma. Bri J Cancer 98(2):363-9
4.Sun Y, Yang T, Xu Z* (2007) The JNK Pathway and Neuronal Migration. J Genetics and Genomics 34(11): 957-965
5.Wilhelm M, Kukekov NV, Xu Z, Greene LA (2007) Identification of POSH2, a novel homologue of the c-Jun N-terminal kinase scaffold
protein POSH. Dev Neurosci. 29(4-5):355-62.
6.Wang L, Zhang Y, Li H, Xu Z, Santella RM, Weinstein IB. (2007) Hint1 Inhibits Growth and Activator Protein-1 Activity in Human Colon
Cancer Cells. Cancer Res. 67(10):4700-4708.
7.Cui J, Zhang M, Zhang YQ, Xu Z* (2007) JNK pathway: diseases and therapeutic potential. Acta Pharmacol Sin. 28(5):601-8.
8.Welhelm M, Xu Z., and Greene L （2007）Proapoptotic Nix activates the JNK pathway by interacting with POSH and mediates death in a
Parkinson disease model. J Biol Chem. 282(2):1288-95.
9.Xu Z.*, Sproul A., Wang WY, and Greene L. (2006) SIAH1 Interacts with the Scaffold Protein POSH to Promote JNK Activation and
Apoptosis. J Biol Chem. 281(1):303-12. (* Corresponding author)
10.Kukekov, N*., Xu Z.*, and Greene(2006) Direct interaction of the molecular scaffolds POSH and JIP is required for apoptotic activation of
JNKs. J Biol Chem. 281(22):15517-24. (* Equal contribution)
11.Tang G, Xu Z, Goldman JE. (2006) Synergistic effects of the SAPK/JNK & the proteasome pathways on GFAP accumulation in
Alexander disease. J Biol Chem. 281(50):38634-43
12.Xu Z.*, Kukekov, N., and Greene L (2005) A stability-based self-amplifying feed forward loop mechanism for regulation of the apoptotic
JNK pathway. Mol Cell Biol. 25(22):9949-59. (* Corresponding author)
13.Xu Z.* and Greene L. (2006) Regulation of the apoptotic JNK pathway. Methods Enzymol 406:479-89. (* Corresponding author)
14.Zheng S.*, Xu Z.*¨, and Longey J. (2005) Cbl-b/Cbl regulates c-Kit receptor stability through the proteasomal pathway in mast cells.
Blood 105(1):226-32. (* Equal contribution, ¨ Corresponding author).
15.Hanlon SE, Xu Z, Norris DN, Vershon AK. (2004) Analysis of the meiotic role of the mitochondrial ribosomal proteins Mrps17 and
Mrpl37 in Saccharomyces cerevisiae. Yeast. 21(15):1241-52.
16.Kim K., Kim B., Xu Z, and Kim S. (2004). Mixed lineage kinase (MLK) 3-activated p38 MAP kinase mediates TGF-Beta-induced
apoptosis in hepatoma cells. J Biol Chem. 279(28):29478-84.
17.Xu Z., Kukekov N., and Greene LA (2003). POSH (plenty of SH3’s) Acts as a Scaffold for a Multiprotein Complex that Mediates JNK
Activation in Apoptotic Death. EMBO J 15; 22(2): 252-61
18.Xu Z, Maroney AC, Dobrzanski P, Greene LA (2001). The MLK family mediates c-Jun N-terminal kinase activation in neuronal apoptosis.
Mol Cell Biol. 21(14): 4713-24.
19.Maroney AC, Finn JP, Connors TJ, Durkin JT, Angeles T, Gessner G, Xu Z, Meyer SL, Savage MJ, Greene LA, Scott RW, Vaught JL (2001). Cep-1347 (KT7515), a semisynthetic inhibitor of the mixed lineage kinase family. J Biol Chem. 276(27): 25302-8.
20.Troy CM, Rabacchi SA, Xu Z, Shelanski ML, Greene LA (2001). beta-Amyloid-induced neuronal apoptosis requires c-Jun N-terminal
kinase activation. J Neurochem. 77(1):157-64.
21.Xu Z., and Norris D. (1999). The SFP1 gene product of S. cerevisiae regulates G2/M transitions in the mitotic cell cycle and in response
to DNA damage. Genetics 150(4): 1419-28.
