蘇紀勇

蘇紀勇，男，博士，現任東北師範大學生命科學學院教授。主要研究與糖類相互作用的蛋白質，包括半乳糖凝集素家族、C型凝集素、糖苷水解酶和糖苷轉移酶。

基本介紹

個人經歷,研究方向,學術成果,

個人經歷

1999-2003 河北大學 生物技術專業 學士學位
2004-2007 南開大學 生物物理專業 碩士學位
2007-2011 德國圖賓根大學 生物學專業 博士學位
2011-2013 德國馬克斯普朗克 遺傳與發育研究所 博士後
2014至今 東北師範大學 生物化學與分子生物學專業 副教授 博士生導師

研究方向

主要研究與糖類相互作用的蛋白質，包括半乳糖凝集素家族、C型凝集素、糖苷水解酶和糖苷轉移酶。嘗試使用結構生物學的方法闡明各種凝集素的生物功能，及糖苷水解酶和糖苷轉移酶的催化劑機制，同時還進行蛋白質與多糖相互作用的生化研究。

學術成果

發表文章
  1. Su J*, Schlicker C, Forchhammer K. A third metal is required for catalytic activity of the signal-transducing protein phosphatase M tPphA. J Biol Chem. 2011 Apr 15;286(15):13481-8.
  2. 2. Su J*, Forchhammer K. The Role of Arg13 in Protein Phosphatase M tPphA from Thermosynechococcus elongatus. Enzyme Res. 2012;2012:272706.
  3. 3. Su J*, Forchhammer K. Determinants for substrate specificity of the bacterial PP2C protein phosphatase tPphA from Thermosynechococcus elongatus. FEBS J. 2013 Jan;280(2):694-707.
  4. 4. Su J*, Zhang T, Wang P, Liu F, Tai G, Zhou Y*. The water network in Galectin-3 ligand binding site guides inhibitor design. Acta Biochim Biophys Sin (Shanghai). 2015 Mar;47(3):192-8.
  5. 5. Si Y, Yuan Y, Wang Y, Gao J, Hu Y, Feng S, Su J*. Structural and Biochemical Characterization of a Cyanobacterial PP2C Phosphatase Reveals Insights into Catalytic Mechanism and Substrate Recognition. Catalysts 2016
  6. 6. Si Y, Feng S, Gao J, Wang Y, Zhang Z, Meng Y, Zhou Y, Tai G, Su J*. Human Galectin-2 interacts with carbohydrates and peptides non-classically: New insight from X-ray crystallography and hemagglutination. Acta Biochim Biophys Sin (Shanghai). 2016 .
  7. 7. Si Y, Wang Y, Gao J, Song C, Feng S, Zhou Y, Tai G, Su, J*. Crystallization of Galectin-8 Linker Reveals Intricate Relationship between the N-terminal Tail and the Linker. Int. J. Mol. Sci. 2016, 17, 2088.
  8. 8. Su J*, Wang Y, Si Y, Gao J, Song C, Cui L, Wu R, Tai G, Zhou Y*. Galectin-13, a different prototype galectin, does not bind β-galacto-sides and forms dimers via intermolecular disulfide bridges between Cys-136 and Cys-138. Sci Rep. 2018 Jan 17;8(1):980.
  9. 9. Su J*, Gao J, Si Y, Cui L, Song C, Wang Y, Wu R, Tai G, Zhou Y*. Galectin-10: a new structural type of prototype galectin dimer and effects on saccharide ligand binding. Glycobiology. 2018 Mar 1;28(3):159-168.
  10. 10. Zhang T, Miller MC, Zheng Y, Zhang Z, Xue H, Zhao D, Su J*, Mayo KH, Zhou Y, Tai G*. Macromolecular assemblies of complex polysaccharides with galectin-3 and their synergistic effects on function. Biochem J. 2017 Nov 9;474(22):3849-3868.
  11. 11. Su J*, Song C, Si Y, Cui L, Yang T, Li Y, Wang H, Tai G, Zhou Y*. Identification of key amino acid residues determining ligand binding specificity, homodimerization and cellular distribution of human Galectin-10. Glycobiology. 2018 Sep 20.
  12. 12. Su J*. A brief history of Charcot-Leyden crystal protein/Galectin-10 research. Molecules. 2018 Nov 09.
  13. 13. Su J*, Cui L, Si Y, Song C, Li Y, Yang T, Wang H, Tai G, Zhou Y*. Resetting the ligand binding site of placental protein 13/galectin-13 recovers its ability to bind lactose. Bioscience Reports. 2018 Nov 08.
  14. 14. Si Y, Wang X, Yang G, Yang T, Li Y, Ayala GJ, Li X, Wang H, Su J*. Crystal Structures of Pyrophosphatase from Acinetobacter baumannii: Snapshots of Pyrophosphate Binding and Identification of a Phosphorylated Enzyme Intermediate. Int J Mol Sci. 2019 Sep 6;20(18).
  15. 15. Yang T, Yao Y, Wang X, Li Y, Si Y, Li X, Ayala GJ, Wang Y, Mayo KH, Tai G, Zhou Y*, Su J*. Galectin-13/placental protein 13: redox-active disulfides as switches for regulating structure, function and cellular distribution. Glycobiology. 2019 Oct 4.
  16. 16. 馮是瓊 司雲龍 宋晨陽 王佩琦 蘇紀勇*. 限制性酶切提高E.coli Hfq蛋白晶體結構解析度. 中國生物化學與分子生物學學報 2015 Vol. 31 (10): 1102-1108
  17. 17. Structure of Thermosynechococcus elongatus Sucrose Phosphate Synthase With UDP and Sucrose-6-Phosphate Provides Insight Into Its Mechanism of Action Involving an Oxocarbenium Ion and the Glycosidic Bond. Front. Microbiol. 11:1050. Li Y, Yao Y, Yang G, Tang J, Ayala GJ, Li X, Zhang W, Han Q, Yang T, Wang H, Mayo KH and Su J* (2020)
  18. 18. Structure-function studies of galectin-14, an important effector molecule in embryology. Si Y, Li Y, Yang T, Li X, Ayala GJ, Mayo KH, Tai G, Su J*, Zhou Y*. FEBS J. 2020 Jun 11.

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