董鹹池，男，博士，南京大學生命科學學院教授。
基本介紹
- 中文名：董鹹池
- 畢業院校：中國科學院
- 學位/學歷：博士
- 專業方向：免疫與凝血系統中重要蛋白質與蛋白質複合物的研究
- 任職院校：南京大學
人物經歷,研究方向,科研成果,
人物經歷
本科 南京大學 生命科學學院
博士 中國科學院 上海生命科學研究院
博士後 哈佛大學 醫學院
講師 哈佛大學 醫學院
教授 南京大學 生命科學學院
研究方向
免疫與凝血系統中重要蛋白質與蛋白質複合物的研究
科研成果
Dong X., Leksa N.C., Chhabra E.S., Arndt J.W., Lu Q., Knockenhauer K.E., Peter R., Springer T.A. (2019) The von Willebrand Factor D’D3 Assembly and Structural Principles for Factor VIII binding and Concatemer Biogenesis . Blood
Feng J.*, Dong X. *, Pinello J.F. *, Zhang J. *, Lu C., Iacob R.E., Engen J.R., Snell W.J., Springer T.A. (2018) Fusion surface structure, function, and dynamics of gamete fusogen HAP2 . Elife. 2018, 7, e39772
Dong X.*, Zhao B.*, Lin F. Lu C., Roger B.N., Springer T.A. (2018) High integrin αVβ6 affinity reached by hybrid domain deletion slows ligand-binding on-rate. Proc Natl Acad Sci115(7), E1429-E1436
Dong X.*, Zhao B.*, Iacob R.E., Zhu J., Koksal A.C., Lu C., Engen J.R., Springer T.A. (2017) Force Interacts with Macromolecular Structure in Activation of TGF- b . Nature 542, 55-59
Kotecha A., Wang Q., Dong X., Ilca S., Ondiviela M., Rao Z., Seago J., Charleston B., Fry E., Abrescia N., Springer A. *, Huiskonen J. *, Stuart D.* Rules of engagement between αvβ6 integrin and foot-and-mouth disease virus. Nature communication. 2017
Wang J, Dong X., Zhao B., Li J., Lu C., Springer T.A.* Atypical Interactions of Integrin αvβ8 with pro-TGF-β1, Proc Natl Acad Sci, 2017,
Dong X., Hudson N., Lu C., Springer T.A. (2014) Structural determinants of integrin β-subunit specificity for latent TGF-β . Nat. Struct. & Mol. Biol. 21 (12), 1091-1096
Blenner M.A., Dong X., Springer T.A. (2014) Towards the structural basis of regulation by force of von Willebrand factor binding to Glycoprotein Ib. J. Biol. Chem. 289, 5565-5579
Dong X., Mi L., Zhu J., Wang W., Hu P., Luo B. H., Springer T.A. (2012) αVβ3 Integrin crystal structures and their functional implications. Biochemistry 51, 8814-8828
Wang R., Zhu J., Dong X., Shi M., Lu C., Springer T.A. (2012) GARP regulates the bioavailability and activation of TGF-β. Mol. Biol. Cell. 23, 1129-1139
Chen H., Dong X., Zhou M., Shi H., Luo X. (2011) Docking-based virtual screening of potential human P2Y12 receptor antagonists. Acta. Biochim. Biophys. Sin.43, 400-408.
Zhou M.*, Dong X.*, Baldauf C., Chen H., Zhou Y., Springer T.A., Lu X., Zhong, C., Grater, F., Ding, J. (2011) A novel calcium-binding site of von Willebrand factor A2 domainregulates its cleavage by ADAMTS13. Blood. 117, 4623-4631.
Zhou B., Wang S., Xu L.X., Meng F.L., Xuan Y.J., Duan Y.M., Wang J.Y., Hu H., Dong X., Ding J., Zhou J.Q. (2010) SWR1 complex poises heterochromatin boundaries for antisilencing activity propagation. Mol. Cell. Biol. 30, 2391-2400.
Zhou M.*, Dong X.*, Shen N., Zhong C., Ding J. (2010) Crystal structures of Saccharomyces cerevisiae tryptophanyl-tRNA synthetase: new insights into the mechanism of tryptophan activation and implications for anti-fungal drug design. Nucleic Acids Res. 38, 3399-3413.
Dong X .*, Zhou M.*, Zhong C., Yang B., Shen N., Ding J. (2010) Crystal structure of Pyrococcus horikoshii tryptophanyl-tRNA synthetase and structure-based phylogenetic analysis suggest an archaeal origin of tryptophanyl-tRNA synthetase. Nucleic Acids Res. 38, 1401-1412. (Cover Story & Featured Article)
Dong X .*, Yang B.*, Li Y., Zhong C., Ding J. (2009) Molecular basis of the acceleration of the GDP-GTP exchange of human Ras homolog enriched in brain by human translationally controlled tumor protein. J. Biol. Chem. 284, 23754-23764.
