葉劍敏，博士，2013年起聘為華南師範大學生命科學學院教授、博士生導師。1997年本科畢業於廈門大學生物系；2000年碩士畢業於中國科學院南海海洋研究所；2008年於美國威廉瑪麗學院獲海洋科學博士學位；同年進入美國維吉尼亞海洋研究所作博士後研究。2009年獲美國威廉瑪麗學院維吉尼亞海洋研究所最佳博士生論文獎。承擔主持國家自然科學基金面上項目和廣東省自然科學基金項目等。擔任廣東省優質環保水產養殖工程技術研究中心主任，中國水產學會魚病專業委員會委員，中國水產學會《水產學報》編委，《Frontiers in Immunology》Review Editor。主要從事硬骨魚免疫學的研究，包括抗體分泌細胞（如長壽命漿細胞）和記憶性B細胞的形成、分化和發育機制、IgM抗體結構與功能關係、及補體系統因子結構與功能的研究。
基本介紹
- 中文名：葉劍敏
- 國籍：中國
- 民族：漢
- 出生地：浙江
- 畢業院校：美國威廉瑪麗學院
- 學位/學歷：博士
- 職業：教師
- 專業方向：魚類免疫學，水產養殖
- 職務：博士生導師
- 教學職稱：教授
人物簡介,研究方向,講授課程,主持項目,論文專著,
人物簡介
研究方向
以尼羅羅非魚為研究材料，立足魚類細胞及分子免疫學研究熱點和前沿問題，結合免疫、細胞和分子生物學等手段重點開展如下研究：
（1） B細胞功能調控機制及體液免疫記憶機制魚類B細胞具有類似專職吞噬細胞的吞噬功能，在免疫保護中發揮重要的作用。我們最近發現魚類B細胞分化程度與其吞噬功能的強弱密切相關，並將開展魚類B細胞吞噬功能的調控機制與演化規律研究。另外，我們初步闡明魚類體液免疫記憶是由長壽命漿細胞和記憶性B細胞協同維持的。本研究方向將探究魚類B細胞的功能調控和演化機制，旨在闡述B細胞功能的生物演化規律，深化硬骨魚B細胞功能的調控理論體系。
（2） IgM抗體及補體分子結構和功能魚類IgM抗體具有四聚體同質異構體的結構多樣性。我們最近研究發現硬骨魚的免疫系統通過調控結合抗原的親和力大小來改變分泌的IgM抗體同質異構體結構的比例，從而影響其抗體的生物學功能；並將開展其結構影響功能的調控機制及適應性進化機制。同時，開展補體系統關鍵分子參與抵禦病原菌侵染的免疫應答的研究。
（3） 水產動物的健康養殖技術通過研究微生物調控與免疫預防等綠色健康的病害防控技術，開展水產經濟動物生態防治的健康養殖理論研究與技術研發。
迄今為止在JournalofImmunology和EuropeanJournalofImmunology等國際著名刊物上發表學術論文多篇。
講授課程
《水產養殖理論與實踐》，研究生，必修課
《魚類免疫學》，研究生，選修課
《免疫學》，本科生，必修課
《現代儀器進展》，本科生，必修課
主持項目
國家自然基金面上項目(31972818)，主持
廣東省農業農村廳重點項目(粵農2019A4)，主持廣東省海洋漁業廳重點項目(201701B04)，主持
廣東省自然科學基金面上項目(2019A1515012065)，主持
論文專著
1. Liting Wu, Shengli Fu, Xiaoxue Yin, Zheng Guo, Anli Wang, Jianmin Ye*. Long-lived plasma cells secrete high affinity antibodies responding to a T-dependent immunization in a teleost fish. 2019, Frontiers in Immunology. 02324. doi: 10.3389/fimmu.2019.02324.
2. Liting Wu, Linghe Kong, Yanjian Yang, Xia Bian, Siwei Wu, Bingxi Li, Xiaoxue Yin, Liangliang Mu, Jun Li, Jianmin Ye*. Effects of cell differentiation on the phagocytic activities of IgM B cells in a teleost fish. 2019, Frontiers in Immunology. 02225. doi: 10.3389/fimmu.2019.02225.
3. Enxu Zhou, Fangfang Yan, Bingxi Li, Meng Chen, Xiao Tu*, Siwei Wu, Hairong Wu, Xiufang Wei, Shengli Fu, Liting Wu, Zheng Guo, Jianmin Ye*. Molecular and functional characterization of IL-6 receptor (IL-6R) and glycoprotein 130 (gp130) in Nile tilapia (Oreochromis niloticus). 2020, Developmental and Comparative Immunology. 106, 103629.
4. Yuan Li, Bingxi Li, Enxu Zhou, Shengli Fu, Yuhong Wang, Liting Wu, Yang Lei, Zheng Guo, Jianmin Ye*. CD38 plays roles in T cell-dependent response and B cell differentiation in Nile tilapia (Oreochromis niloticus). 2020, Developmental and Comparative Immunology. 103, 103515.
5. Xiaoxue Yin, Liangliang Mu, Kailiang Han, Hairong Wu, Zheng Guo, Jianmin Ye*. Expression and functional analysis of Nile tilapia transferrin receptors (TfRs) in host resistance to pathogenic bacteria and iron ion metabolism. 2020, Fish and Shellfish Immunology. 100, 407-417.
6. Liting Wu, Along Gao, Yang Lei, Jun Li, Kangsen Mai, Jianmin Ye*. SHP1 tyrosine phosphatase gets involved in host defense against Streptococcus agalactiae infection and BCR signaling pathway in Nile tilapia (Oreochromis niloticus). 2020, Fish and Shellfish Immunology. 99, 562-571.
7. Yanjian Yang, Bingxi Li, Linghe Kong, Yuan Li, Xiaoxue Yin, Shengli Fu, Zheng Guo, Liting Wu*, Kangsen Mai, Jianmin Ye*. BAFF gets involved in response to bacterial infection and promotes IgM B cell survival in Nile tilapia (Oreochromis niloticus). 2020, Aquaculture. 522, 735113.
8. Fangfang Yan, Enxu Zhou, Shuo Liu, Along Gao, Linghe Kong, Bingxi Li, Zheng Guo, Jinfeng Mo, Meng Chen*, Jianmin Ye*. Complement C1q subunit molecules from Xenopus laevis possess conserved function in C1q-immunoglobulin interaction. 2020, Developmental and Comparative Immunology. 103, 103532.
9. Liting Wu, Yanjian Yang, Linghe Kong, Xia Bian, Zheng Guo, Shengli Fu, Fang Liang, Bingxi Li, Jianmin Ye*. Comparative transcriptome analysis of the transcriptional heterogeneity in different IgM+ cell subsets from peripheral blood of Nile tilapia (Oreochromis niloticus). 2019, Fish and Shellfish Immunology. 93, 612-622.
10. Liangliang Mu, Hairong Wu, Kailiang Han, Liting Wu, Xia Bian, Bingxi Li, Zheng Guo, Xiaoxue Yin*, Jianmin Ye*. Molecular and functional characterization of a mannose-binding lectin/ficolin-associated protein (MAp44) from Nile tilapia (Oreochromis niloticus) involved in the immune response to bacterial infection. 2019, Developmental and Comparative Immunology. 101, 103438.
11. Shengli Fu, Mingmei Ding, Haisu Liu, Liting Wu, Bingxi Li, Anli Wang, Shaoan Liao*, Jianmin Ye*. Identification and characterization of caspase-7 in pufferfish (Takifugu obscurus) in response to bacterial infection and cell apoptosis. 2019, Aquaculture. 512, 73426.
12. Liangliang Mu, Xiaoxue Yin, Hairong Wu, Kailiang Han, Liting Wu, Mingmei Ding, Xia Bian, Bingxi Li, Shengli Fu, Fang Liang, Zheng Guo, Jianmin Ye*. Expression and functional characterization of a mannose-binding lectin associated serine protease-1 (MASP-1) from Nile tilapia (Oreochromis niloticus) in host defense against bacterial infection. 2019, Fish and Shellfish Immunology. 91, 68-77.
13. Shengli Fu, Mingmei Ding, Qingjian Liang, Yanjian Yang, Meng Chen, Xiufang Wei, Anli Wang, Shaoan Liao∗, Jianmin Ye*. The key differentially expressed genes and proteins related to immune response in the spleen of pufferfish (Takifugu obscurus) infected by Aeromonas hydrophila. 2019, Fish and Shellfish Immunology. 91, 1-11.
14. Liting Wu, Enxu Zhou, Along Gao, Linghe Kong, Siwei Wu, Xia Bian, Yuan Li, Bingxi Li, Shengli Fu, Zheng Guo∗ , Jianmin Ye*. Blimp-1 is involved in B cell activation and maturation in Nile tilapia (Oreochromis niloticus). 2019, Developmental and Comparative Immunology. 98, 137-147.
15. Liting Wu, Along Gao, Linghe Kong, Siwei Wu, Yanjian Yang, Xia Bian, Zheng Guo, Yuan Li, Bingxi Li, Xunbin Pan, Jianmin Ye*. Molecular characterization and transcriptional expression of a B cell transcription factor Pax5 in Nile tilapia (Oreochromis niloticus). 2019, Fish and Shellfish Immunology. 90, 165-172.
16. Liting Wu, Xia Bian, Linghe Kong, Xiaoxue Yin, Liangliang Mu, Siwei Wu, Along Gao, Xiufang Wei, Zheng Guo, Jianmin Ye*. B cell receptor accessory molecule CD79 gets involved in response against Streptococcus agalactiae infection and BCR signaling in Nile tilapia (Oreochromis niloticus). 2019, Fish and Shellfish Immunology. 87, 212-219.
17. Liting Wu, Shengli Fu, Xiaoxue Yin, Wenna Leng, Zheng Guo, Anli Wang, Jianmin Ye*. Affinity maturation occurs in channel catfish (Ictalurus punctaus) following immunization with a T-cell dependent antigen. 2019, Fish and Shellfish Immunology. 84, 781-786.
18. Xiaoxue Yin, Liangliang Mu, Shengli Fu, Liting Wu, Kailiang Han, Hairong Wu, Xia Bian, Xiufang Wei, Zheng Guo, Anli Wang, Jianmin Ye*. Expression and characterization of Nile tilapia (Oreochromis niloticus) secretory and membrane-bound IgM in response to bacterial infection. 2019, Aquaculture. 508, 214-222.
19. Xiaoxue Yin, Yanjian Yang, Kailiang Han, Liting Wu, Hairong Wu, Xia Bian, Xiufang Wei, Zheng Guo, Liangliang Mu*, Jianmin Ye*. Purification and functional characterization of serum transferrin from Nile tilapia (Oreochromis niloticus). 2019, Fish and Shellfish Immunology. 88, 36-46.
20. Xia Bian, Siwei Wu, Xiaoxue Yin, Liangliang Mu, Fangfang Yan, Linghe Kong, Zheng Guo, Liting Wu*, Jianmin Ye*. Lyn is involved in host defense against S. agalactiae infection and BCR signaling in Nile tilapia (Oreochromis niloticus). 2019, Developmental and Comparative Immunology. 96, 1-8.
21. Liangliang Mu, Xiaoxue Yin, Yanjian Yang, Liting Wu, Hairong Wu, Bingxi Li, Zheng Guo, Jianmin Ye*. Functional characterization of a mannose-binding lectin (MBL) from Nile tilapia (Oreochromis niloticus) in non-specific cell immunity and apoptosis in monocytes/macrophages. 2019, Fish and Shellfish Immunology. 87, 265-274.
22. Meng Chen, Shuo Liu, Fangfang Yan, Enxu Zhou, Xiaofang Zhong, Mingmei Ding, Jianmin Ye*. Complement 1q-binding protein from Nile tilapia (Oreochromis niloticus): Molecular characterization, expression pattern upon bacterial infection and its binding properties. 2019, Aquaculture. 500, 31-40.
23. Xiaoxue Yin, Liangliang Mu, Yuan Li, Liting Wu, Yanjian Yang, Xia Bian, Bingxi Li, Shaoan Liao, Yutao Miao, Jianmin Ye*. Identification and characterization of a B-type mannose-binding lectin from Nile Tilapia (Oreochromis niloticus) in response to bacterial infection. 2019, Fish and Shellfish Immunology. 84, 91-99.
24. Shuo Liu, Meng Chen, Fangfang Yan, Enxu Zhou, Bingxi Li, Shengli Fu, Xiaoxue Yin, Zheng Guo, Jianmin Ye*. Expression and functional analysis of polymeric immunoglobulin receptor in Nile tilapia (Oreochromis niloticus). 2019, Aquaculture. 500, 41-49.
25. Jian-An Xian, Xiu-Xia Zhang, An-Li Wang, Jun-Tao Li, Pei-Hua Zheng, Yao-Peng Lu, Dong-Mei Wang*, Jianmin Ye*. Oxidative burst activity in haemocytes of the freshwater prawn Macrobrachium rosenbergii. 2018, Fish and Shellfish Immunology. 73, 272-278.
26. Meng Chen, Mingmei Ding, Yuan Li, Xiaofang Zhong, Shuo Liu, Zheng Guo, Xiaoxue Yin, Shengli Fu, Jianmin Ye*. The complement component 1 q (C1q) in Nile tilapia (Oreochromis niloticus): Functional characterization in host defense against bacterial infection and effect on cytokine response in macrophages. 2018, Developmental and Comparative Immunology. 87, 98-108.
27. Liangliang Mu, Xiaoxue Yin, Yanhui Xiao, Xia Bian, Yanjian Yang, Liting Wu, Jianmin Ye*. A C-type lectin (CL11X1-like) from Nile tilapia (Oreochromis niloticus) is involved in host defense against bacterial infection. 2018, Developmental and Comparative Immunology. 84, 230-240.
28. Liangliang Mu, Xiaoxue Yin, Xia Bian, Liting Wu, Yanjian Yang, Xiufang Wei, Zheng Guo, Jianmin Ye*. Expression and functional characterization of collection-K1 from Nile tilapia (Oreochromis niloticus) in host innate immune defense. 2018, Molecular Immunology. 103, 21-34.
29. Xiufang Wei, Bingxi Li, Liting Wu, Xiaoxue Yin, Xiaofang Zhong, Yuan Li, Yuhong Wang, Zheng Guo, Jianmin Ye*. Interleukin-6 gets involved in response to bacterial infection and promotes antibody production in Nile tilapia (Oreochromis niloticus). 2018, Developmental and Comparative Immunology. 89, 141-151.
30. Xia Bian, Liting Wu, Liangliang Mu, Xiaoxue Yin, Xiufang Wei, Xiaofang Zhong, Yanjian Yang, Junru Wang, Yuan Li, Zheng Guo, Jianmin Ye*. Spleen tyrosine kinase from Nile tilapia (Oreochromis niloticus): Molecular characterization, expression pattern upon bacterial infection and the potential role in BCR signaling and inflammatory response. 2018, Fish and Shellfish Immunology. 82, 162-172.
31. Xiaoxue Yin, Liangliang Mu, Xia Bian, Liting Wu, Bingxi Li, Jing Liu, Zheng Guo, Jianmin Ye*. Expression and functional characterization of transferrin in Nile tilapia (Oreochromis niloticus) in response to bacterial infection. 2018, Fish and Shellfish Immunology. 74, 530-539.
32. Shengli Fu, Mingmei Ding, Yanjian Yang, Jingrong Kong, Yuan Li, Zheng Guo, Anli Wang*, Jianmin Ye*. Molecular cloning, characterization and expression analysis of caspase-6 in puffer fish (Takifugu obscurus). 2018, Aquaculture. 490, 311-320.
33. Xiaofang Zhong, Meng Chen, Mingmei Ding, Meiqi Zhong, Bingxi Li, Yuhong Wang, Shengli Fu, Xiaoxue Yin, Zheng Guo, Jianmin Ye*. C1r and C1s from Nile tilapia (Oreochromis niloticus): Molecular characterization, transcriptional profiling upon bacterial and IFN-γ inductions and potential role in response to bacterial infection. 2017, Fish and Shellfish Immunology. 70, 240-251.
34. Liangliang Mu, Xiaoxue Yin, Jing Liu, Liting Wu, Xia Bian, Yuhong Wang, Jianmin Ye*. Identification and characterization of a mannose-binding lectin from Nile tilapia (Oreochromis niloticus). 2017, Fish and Shellfish Immunology. 67, 244-253.
35. Mingmei Ding, Meng Chen, Xiaofang Zhong, Yuhong Wang, Shengli Fu, Xiaoxue Yin, Zheng Guo, Jianmin Ye*. Identification and characterization of C1 inhibitor in Nile tilapia in response to pathogenic bacteria. 2017, Fish and Shellfish Immunology. 61, 152-162.
36. Meng Chen, Mingmei Ding, Yuhong Wang, Xiaoxue Yin, Shengli Fu, Zheng Guo, Anli Wang*, Jianmin Ye*.Complement C1Q has a novel tetrameric structure in Nile tilapia (Oreochromis niloticus). 2016, Fish and Shellfish Immunology. 53, 102-103.
37. Liting Wu, Shengli Fu, Xiaoxue Yin, Zheng Guo, Anli Wang*, Jianmin Ye*. Long-lived plasma cells secret antibodies possessing high affinity in channel catfish. 2016, Fish and Shellfish Immunology. 53, 75.
38. Jianmin Ye, Ilsa Kaattari, Cuiyan Ma, Stephen Kaattari*. The teleost humoral immune response. 2013, Fish and Shellfish Immunology. 36, 1719-1728.
39. Cuiyan Ma*, Jianmin Ye *, Stephen Kaattari. Differential compartmentalization of memory B cells versus plasma cells in salmonid fish. 2013, European Journal of Immunology. 43, 360-370.
40. Jianmin Ye, Ilsa Kaattari, Stephen Kaattari*. Plasmablasts and plasma cells: reconsidering teleost immune system organization. 2011, Developmental and Comparative Immunology. 35, 1273-1281.
41. Jianmin Ye, Ilsa Kaattari, Stephen Kaattari*. The differential dynamics of antibody subpopulation expression during affinity maturation in a teleost. 2011, Fish and Shellfish Immunology. 30, 372-377.
42. Jianmin Ye, Erin Bromage, Ilsa Kaattari, Stephen Kaattari*. Transduction of binding affinity by B lymphocytes: a new dimension in immunological regulation. 2011, Developmental and Comparative Immunology. 35, 982-990.
43. Jianmin Ye, Erin Bromage, Stephen Kaattari*. The strength of B cell interaction with antigen determines the degree of IgM disulfide polymerization. 2010, Journal of Immunology. 18, 844-850.
